Article ; Online: Beta-hydroxy-beta-methylbutyrate associated with low-intensity exercise training improves skeletal muscle regeneration through the IGF-Akt pathway.
2022 Volume 55, Page(s) e11597
Abstract: The effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation associated with exercise training at different intensities and frequencies on skeletal muscle regeneration of muscle-injured rats was investigated. Male Wistar rats were divided into ... ...
| Abstract | The effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation associated with exercise training at different intensities and frequencies on skeletal muscle regeneration of muscle-injured rats was investigated. Male Wistar rats were divided into sedentary and trained groups. The sedentary groups were subdivided into non-injured (SED-Ct), non-injured supplemented with HMB (SED-Ct-HMB), injured (SED), and injured with HMB (SED-HMB), and the trained groups were injured, supplemented with HMB, and then divided into training three times a week without load (HT3) or with load (HT3L) and training five times a week without load (HT5) and with load (HT5L). The rats received a daily dose of HMB associated with 60 min of swimming with or without 5% body mass load for 14 days. On the 15th day, cryoinjury was performed in the right tibialis anterior muscle (TA), and 48 h later, supplementation and training continued for 15 days. After the last session, the TA was dissected and a cross-sectional area (CSA) of muscle fibers was used to determine the percentage of CSA fibers and connective tissue (%CT), as well as the total and phosphorylated protein contents. SED-HMB showed increased CSA and decreased %CT and TGF-β when compared to SED. HT3 showed increased CSA and reduced %CT accompanied by increased IGF-1/Akt, myogenin, and MuRF1, and decreased TGF-β. The CSA of HT5L also increased, but at the cost of a higher %CT compared to the other groups. Our results demonstrated that HMB associated with training without load and with lower frequency per week may be a valuable strategy for skeletal muscle regeneration. |
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| MeSH term(s) | Animals ; Dietary Supplements ; Insulin-Like Growth Factor I ; Male ; Muscle, Skeletal/growth & development ; Physical Conditioning, Animal ; Proto-Oncogene Proteins c-akt ; Rats ; Rats, Wistar ; Regeneration ; Valerates |
| Chemical Substances | Valerates ; insulin-like growth factor-1, rat ; beta-hydroxyisovaleric acid (3F752311CD) ; Insulin-Like Growth Factor I (67763-96-6) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) |
| Language | English |
| Publishing date | 2022-01-05 |
| Publishing country | Brazil |
| Document type | Journal Article |
| ZDB-ID | 786234-9 |
| ISSN | 1414-431X ; 0100-879X |
| ISSN (online) | 1414-431X |
| ISSN | 0100-879X |
| DOI | 10.1590/1414-431X2021e11597 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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