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Article: Specialized pro-resolving lipid mediators and resolution of viral diseases.

Ferri, Giulia / Mucci, Matteo / Mattoscio, Domenico / Recchiuti, Antonio

2023 Volume 168, Page(s) 106762

Abstract: The COVID-19 pandemics has made sparkly evident the importance of acute inflammation and its timely resolution to protect humans from pathogenic viruses while sparing them from collateral damages due to an uncontrolled immune response. It is clear now ... ...

Abstract	The COVID-19 pandemics has made sparkly evident the importance of acute inflammation and its timely resolution to protect humans from pathogenic viruses while sparing them from collateral damages due to an uncontrolled immune response. It is clear now that resolution of inflammation is an active process regulated by endogenous specialized proresolving lipid mediators (SPM) biosynthesized from essential polyunsaturated fatty acids. Accruing evidence indicates that SPM are produced during viral infections and play key roles in controlling the magnitude and duration of the inflammatory response and in regulating adaptive immunity. Here, we reviewed biosynthesis and bioactions of SPM in virus-mediated human diseases. Harnessing SPM and their proresolutive actions can help in providing new therapeutic approaches to current and future human viral diseases by controlling infection, stimulating host immunity, and protecting from organ damage.
MeSH term(s)	Humans ; COVID-19 ; Inflammation/drug therapy ; Inflammation/pathology ; Eicosanoids ; Inflammation Mediators ; Docosahexaenoic Acids
Chemical Substances	Eicosanoids ; Inflammation Mediators ; Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1426962-4
ISSN	2212-196X ; 1098-8823 ; 0090-6980
ISSN (online)	2212-196X
ISSN	1098-8823 ; 0090-6980
DOI	10.1016/j.prostaglandins.2023.106762
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Article ; Online: Gene Expression of the D-Series Resolvin Pathway Predicts Activation of Anti-Tumor Immunity and Clinical Outcomes in Head and Neck Cancer.

Mattoscio, Domenico / Ferri, Giulia / Miccolo, Claudia / Chiocca, Susanna / Romano, Mario / Recchiuti, Antonio

International journal of molecular sciences

2022 Volume 23, Issue 12

Abstract: In human medicine, the progression from early neoplasia development to either complete resolution of tumorigenesis and associated inflammation or chronicity and fatal outcomes remain difficult to predict. Resolution of inflammation is an active process ... ...

Abstract	In human medicine, the progression from early neoplasia development to either complete resolution of tumorigenesis and associated inflammation or chronicity and fatal outcomes remain difficult to predict. Resolution of inflammation is an active process that stimulates the termination of the inflammatory response and promotes return to homeostasis, while failure in resolution contributes to the development of a number of diseases. To understand how resolution pathways contribute to tumorigenesis, we defined and employed a cumulative score based on the expression level of genes involved in synthesis, signaling, and metabolism of the D-series resolvin (RvD). This score was used for comparative analyses of clinical, cellular, and molecular features of tumors, based on RNA-sequencing (RNA-seq) datasets collected within The Cancer Genome Atlas (TCGA) program. Our results indicate that higher RvD scores are associated with better clinical outcome of patients with head and neck squamous cell carcinoma (HNSC), and with molecular and cellular signatures indicative of enhanced anti-tumor immunity and better response to immune-checkpoint inhibitors (ICI), also in human papilloma virus (HPV) negative HNSC subtypes. Thus, higher activity of the RvD pathway identifies patients with improved resolution and a more efficient immune reaction against cancer.
MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinogenesis ; Carcinoma, Squamous Cell/metabolism ; Cell Transformation, Neoplastic ; Gene Expression ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Humans ; Inflammation ; Squamous Cell Carcinoma of Head and Neck
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2022-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23126473
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Article ; Online: Mass fractal dimension from 2D microscopy images via an aggregation model with variable compactness.

Ferri, Giulia / Humbert, Severine / Schweitzer, Jean-Marc / Digne, Mathieu / Lefebvre, Veronique / Moreaud, Maxime

Journal of microscopy

2022 Volume 286, Issue 1, Page(s) 31–41

Abstract: Microscopy-image analysis provides precious information on size and structure of colloidal aggregates and agglomerates. The structure of colloids is often characterized using the mass fractal ... ...

Abstract	Microscopy-image analysis provides precious information on size and structure of colloidal aggregates and agglomerates. The structure of colloids is often characterized using the mass fractal dimension
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	219263-9
ISSN	1365-2818 ; 0022-2720
ISSN (online)	1365-2818
ISSN	0022-2720
DOI	10.1111/jmi.13088
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Zs.A 838: Show issues

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Article: Maternal, newborn and breast milk concentrations of elexacaftor/tezacaftor/ivacaftor in a F508del heterozygous woman with cystic fibrosis following successful pregnancy.

Ripani, Pietro / Mucci, Matteo / Pantano, Stefano / Di Sabatino, Maria / Collini, Francesca / Ferri, Giulia / Romano, Mario / Recchiuti, Antonio

Frontiers in medicine

2023 Volume 10, Page(s) 1274303

Abstract: With the introduction of elexacaftor/tezacaftor/ivacaftor (ETI), more women with cystic fibrosis (CF) are likely to grow families. Hence, an understanding long-term safety and effects of CFTR modulators on fertile women and children while monitoring ... ...

Abstract	With the introduction of elexacaftor/tezacaftor/ivacaftor (ETI), more women with cystic fibrosis (CF) are likely to grow families. Hence, an understanding long-term safety and effects of CFTR modulators on fertile women and children while monitoring their concentrations is crucial. Here, we report on the development of an improved LC-MS/MS methodology to measure ETI concentrations in maternal and child blood and breastmilk, applied in one case of successful pregnancy of a 30-year-old woman with CF (F508del/R334W). We observed that ETI remains stable in breastmilk, is absorbed by the infant and can be detected in child plasma. Our results confirm accumulating evidence of a successful pregnancy in women treated with CFTR modulators without significant side effects on the child and provide valuable analytical procedures suitable for the post-marketing evaluation of CFTR modulators in pregnant and lactating women, as well as in their infants.
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1274303
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Article: Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medullary collecting duct cells, independently of nephrocystin-1 and nephrocystin-4.

Garfa Traoré, Meriem / Roccio, Federica / Miceli, Caterina / Ferri, Giulia / Parisot, Mélanie / Cagnard, Nicolas / Lhomme, Marie / Dupont, Nicolas / Benmerah, Alexandre / Saunier, Sophie / Delous, Marion

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1254691

Abstract: Renal epithelial cells are subjected to fluid shear stress of urine flow. Several cellular structures act as mechanosensors-the primary cilium, microvilli and cell adhesion complexes-that directly relay signals to the cytoskeleton to regulate various ... ...

Abstract	Renal epithelial cells are subjected to fluid shear stress of urine flow. Several cellular structures act as mechanosensors-the primary cilium, microvilli and cell adhesion complexes-that directly relay signals to the cytoskeleton to regulate various processes including cell differentiation and renal cell functions. Nephronophthisis (NPH) is an autosomal recessive tubulointerstitial nephropathy leading to end-stage kidney failure before adulthood.
Language	English
Publishing date	2023-10-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1254691
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Article ; Online: WDR5 is required for DUX4 expression and its pathological effects in FSHD muscular dystrophy.

Mocciaro, Emanuele / Giambruno, Roberto / Micheloni, Stefano / Cernilogar, Filippo M / Andolfo, Annapaola / Consonni, Cristina / Pannese, Maria / Ferri, Giulia / Runfola, Valeria / Schotta, Gunnar / Gabellini, Davide

Nucleic acids research

2023 Volume 51, Issue 10, Page(s) 5144–5161

Abstract: Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent neuromuscular disorders. The disease is linked to copy number reduction and/or epigenetic alterations of the D4Z4 macrosatellite on chromosome 4q35 and associated with aberrant ... ...

Abstract	Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent neuromuscular disorders. The disease is linked to copy number reduction and/or epigenetic alterations of the D4Z4 macrosatellite on chromosome 4q35 and associated with aberrant gain of expression of the transcription factor DUX4, which triggers a pro-apoptotic transcriptional program leading to muscle wasting. As today, no cure or therapeutic option is available to FSHD patients. Given its centrality in FSHD, blocking DUX4 expression with small molecule drugs is an attractive option. We previously showed that the long non protein-coding RNA DBE-T is required for aberrant DUX4 expression in FSHD. Using affinity purification followed by proteomics, here we identified the chromatin remodeling protein WDR5 as a novel DBE-T interactor and a key player required for the biological activity of the lncRNA. We found that WDR5 is required for the expression of DUX4 and its targets in primary FSHD muscle cells. Moreover, targeting WDR5 rescues both cell viability and myogenic differentiation of FSHD patient cells. Notably, comparable results were obtained by pharmacological inhibition of WDR5. Importantly, WDR5 targeting was safe to healthy donor muscle cells. Our results support a pivotal role of WDR5 in the activation of DUX4 expression identifying a druggable target for an innovative therapeutic approach for FSHD.
MeSH term(s)	Humans ; Gene Expression Regulation ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Muscle Cells/metabolism ; Muscle, Skeletal/metabolism ; Muscular Dystrophy, Facioscapulohumeral/metabolism ; Transcription Factors/metabolism
Chemical Substances	Homeodomain Proteins ; Intracellular Signaling Peptides and Proteins ; Transcription Factors ; WDR5 protein, human ; DUX4L1 protein, human
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad230
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Zs.A 1067: Show issues

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Article ; Online: Resolvin D1 improves airway inflammation and exercise capacity in cystic fibrosis lung disease.

Ferri, Giulia / Serano, Matteo / Isopi, Elisa / Mucci, Matteo / Mattoscio, Domenico / Pecce, Romina / Protasi, Feliciano / Mall, Marcus A / Romano, Mario / Recchiuti, Antonio

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2023 Volume 37, Issue 11, Page(s) e23233

Abstract: Mucus plugging and non-resolving inflammation are inherent features of cystic fibrosis (CF) that may lead to progressive lung disease and exercise intolerance, which are the main causes of morbidity and mortality for people with CF. Therefore, ... ...

Abstract	Mucus plugging and non-resolving inflammation are inherent features of cystic fibrosis (CF) that may lead to progressive lung disease and exercise intolerance, which are the main causes of morbidity and mortality for people with CF. Therefore, understanding the influence of mucus on basic mechanisms underlying the inflammatory response and identifying strategies to resolve mucus-driven airway inflammation and consequent morbidity in CF are of wide interest. Here, we investigated the effects of the proresolving lipid mediator resolvin (Rv) D1 on mucus-related inflammation as a proof-of-concept to alleviate the burden of lung disease and restore exercise intolerance in CF. We tested the effects of RvD1 on inflammatory responses of human organotypic airways and leukocytes to CF mucus and of humanized mice expressing the epithelial Na + channel (βENaC-Tg) having CF-like mucus obstruction, lung disease, and physical exercise intolerance. RvD1 reduced pathogenic phenotypes of CF-airway supernatant (ASN)-stimulated human neutrophils, including loss of L-selectin shedding and CD16. RNASeq analysis identified select transcripts and pathways regulated by RvD1 in ASN-stimulated CF bronchial epithelial cells that are involved in sugar metabolism, NF-κB activation and inflammation, and response to stress. In in vivo inflammation using βENaC TG mice, RvD1 reduced total leukocytes, PMN, and interstitial Siglec-MΦ when given at 6-8 weeks of age, and in older mice at 10-12 weeks of age, along with the decrease of pro-inflammatory chemokines and increase of anti-inflammatory IL-10. Furthermore, RvD1 treatment promoted the resolution of pulmonary exacerbation caused by Pseudomonas aeruginosa infection and significantly enhanced physical activity and energy expenditure associated with mucus obstruction, which was impaired in βENaC-Tg mice compared with wild-type. These results demonstrate that RvD1 can rectify features of CF and offer proof-of-concept for its therapeutic application in this and other muco-obstructive lung diseases.
MeSH term(s)	Humans ; Mice ; Animals ; Cystic Fibrosis/genetics ; Exercise Tolerance ; Lung/metabolism ; Inflammation/metabolism
Chemical Substances	resolvin D1
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202301495R
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 296: Show issues

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Article ; Online: Home fetal heart rate monitoring in anti Ro/SSA positive pregnancies: Literature review and case report.

Milazzo, Roberta / Ligato, Elisa / Laoreti, Arianna / Ferri, Giulia / Basili, Ludovica / Serati, Lisa / Brucato, Antonio / Cetin, Irene

European journal of obstetrics, gynecology, and reproductive biology

2021 Volume 259, Page(s) 1–6

Abstract: Anti-Ro/SSA antibodies are associated with a risk of 1-2 % to develop complete atrioventricular block (AVB) in fetuses of positive mothers. Complete AVB is irreversible, but studies suggest that anti-inflammatory treatment during the transition period ... ...

Abstract	Anti-Ro/SSA antibodies are associated with a risk of 1-2 % to develop complete atrioventricular block (AVB) in fetuses of positive mothers. Complete AVB is irreversible, but studies suggest that anti-inflammatory treatment during the transition period from a normal fetal heart rate (FHR) to an AVB might stop this progression and restore sinus rhythm. The most efficient method for diagnostic evaluation of this arrhythmia is the pulsed-Doppler fetal echocardiography. However, weekly or bi-weekly recommended fetal echocardiographic surveillance can rarely identify an AVB in time for treatment success, also because the transition from a normal rhythm to a third degree AVB is very fast. Daily FHR monitoring in a medical facility could increase the chances of identifying the AVB onset but is difficult to realize. For this reason, an alternative method of FHR monitoring, performed directly by mothers in their home context, has been recently proposed. We present a case report utilizing this approach and review the current evidence about this condition.
MeSH term(s)	Atrioventricular Block/diagnostic imaging ; Echocardiography ; Female ; Fetus ; Heart Rate, Fetal ; Humans ; Pregnancy ; Prenatal Care
Language	English
Publishing date	2021-01-28
Publishing country	Ireland
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2021.01.031
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Zs.A 837: Show issues

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Article: Coma Recovery Scale-Revised With and Without the Emotional Stimulation of Caregivers.

Formisano, Rita / Contrada, Marianna / Iosa, Marco / Ferri, Giulia / Schiattone, Sara / Aloisi, Marta

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2019 Volume 46, Issue 5, Page(s) 607–609

Abstract: The Coma Recovery Scale-Revised (CRS-R) is the gold standard of responsiveness assessment in patients with disorder of consciousness. The purpose of this study is to search for the efficacy of the caregivers' involvement in the evaluation of ... ...

Abstract	The Coma Recovery Scale-Revised (CRS-R) is the gold standard of responsiveness assessment in patients with disorder of consciousness. The purpose of this study is to search for the efficacy of the caregivers' involvement in the evaluation of responsiveness in these patients. Responsiveness assessment was performed in 15 patients with CRS-R. The CRS-R was administered with and without the emotional stimulation of the primary caregiver at different times. Our preliminary findings seem to suggest that, including also the caregivers during CRS-R assessment, may obtain better responsiveness scoring than that obtained by professionals and might reduce the misdiagnosis rate.
MeSH term(s)	Adolescent ; Adult ; Caregivers ; Coma ; Disability Evaluation ; Emotions ; Female ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Young Adult
Language	English
Publishing date	2019-07-29
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2019.227
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Zs.A 1203: Show issues

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Article ; Online: Epeleuton, a novel synthetic ω-3 fatty acid, reduces the hypoxia/reperfusion stress in a mouse model of sickle cell disease.

Mattè, Alessandro / Federti, Enrica / Recchiuti, Antonio / Hamza, Moayed / Ferri, Giulia / Riccardi, Veronica / Ceolan, Jacopo / Passarini, Alice / Mazzi, Filippo / Siciliano, Angela / Bhatt, Deepak L / Coughlan, David / Climax, John / Gremese, Elisa / Brugnara, Carlo / De Franceschi, Lucia

Haematologica

2023

Abstract: Inflammatory vasculopathy is critical in sickle cell disease (SCD)-associated organ damage. An imbalance between pro-inflammatory and pro-resolving mechanisms in response to different triggers such as hypoxia/reoxygenation or infections has been proposed ...

Abstract	Inflammatory vasculopathy is critical in sickle cell disease (SCD)-associated organ damage. An imbalance between pro-inflammatory and pro-resolving mechanisms in response to different triggers such as hypoxia/reoxygenation or infections has been proposed to contribute to SCD disease progression. Administration of specialized pro-resolving lipid mediators may provide an effective therapeutic strategy to target inflammatory vasculopathy and to modulate inflammatory response. Epeleuton (15 hydroxy eicosapentaenoic acid ethyl ester) is a novel orally administered second-generation ω-3 fatty acid with a favorable clinical safety profile. In this study we show that epeleuton re-programs the lipidomic pattern of target organs for SCD towards a pro-resolving pattern. This protects against systemic and local inflammatory response and improves red cell features, resulting in reduced hemolysis and sickling compared with vehicle treated SCD mice. In addition, epeleuton prevents the hypoxia/reoxygenation induced activation of NF-kB with downregulation of NLRP3 inflammasome in lung, kidney, and liver. This was associated with down-regulation of vascular activation markers in epeleuton treated SCD mice when compared to vehicle treated animals. Collectively our data support the potential therapeutic utility of epeleuton and provide the rationale for the design of clinical trials to evaluate the efficacy of epeleuton in patients with SCD.
Language	English
Publishing date	2023-12-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.284028
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