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  1. Article ; Online: Immune-Neurovascular Interactions in Experimental Perinatal and Childhood Arterial Ischemic Stroke.

    Mallard, Carina / Ferriero, Donna M / Vexler, Zinaida S

    Stroke

    2024  Volume 55, Issue 2, Page(s) 506–518

    Abstract: Emerging clinical and preclinical data have demonstrated that the pathophysiology of arterial ischemic stroke in the adult, neonates, and children share similar mechanisms that regulate brain damage but also have distinct molecular signatures and ... ...

    Abstract Emerging clinical and preclinical data have demonstrated that the pathophysiology of arterial ischemic stroke in the adult, neonates, and children share similar mechanisms that regulate brain damage but also have distinct molecular signatures and involved cellular pathways due to the maturational stage of the central nervous system and the immune system at the time of the insult. In this review, we discuss similarities and differences identified thus far in rodent models of 2 different diseases-neonatal (perinatal) and childhood arterial ischemic stroke. In particular, we review acquired knowledge of the role of resident and peripheral immune populations in modulating outcomes in models of perinatal and childhood arterial ischemic stroke and the most recent and relevant findings in relation to the immune-neurovascular crosstalk, and how the influence of inflammatory mediators is dependent on specific brain maturation stages. Finally, we discuss the current state of treatments geared toward age-appropriate therapies that signal via the immune-neurovascular interaction and consider sex differences to achieve successful translation.
    MeSH term(s) Child ; Adult ; Infant, Newborn ; Pregnancy ; Humans ; Female ; Male ; Ischemic Stroke ; Arteries ; Brain Injuries ; Central Nervous System ; Inflammation Mediators
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.043399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Swaiman's pediatric neurology

    Swaiman, Kenneth F. / Ashwal, Stephen / Ferriero, Donna M. / Schor, Nina Felice / Finkel, Richard S. / Gropman, Andrea L. / Pearl, Phillip L. / Shevell, Michael I.

    principles and practice

    2018  

    Title variant Pediatric neurology
    Author's details Kenneth F. Swaiman, Stephen Ashwal, Donna M. Ferriero, Nina F. Schor, Richard S. Finkel, Andrea L. Gropman, Phillipp L. Pearl, Michael I. Shevell
    Language English
    Size XXVI, 1403 Seiten, Illustrationen, Diagramme
    Edition Sixth edition
    Publisher Elsevier
    Publishing place Edingburgh
    Publishing country Great Britain
    Document type Book
    Note Frühere Auflagen mehrbändig
    HBZ-ID HT019346312
    ISBN 978-0-323-37101-8 ; 0-323-37101-9
    Database Catalogue ZB MED Medicine, Health

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    2017 A 1212 available for loan (reading room) Lesesaal EG
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  3. Article ; Online: Stem cells for perinatal stroke.

    Gonzalez, Fernando / Ferriero, Donna M

    The Lancet. Neurology

    2022  Volume 21, Issue 6, Page(s) 497–499

    MeSH term(s) Female ; Humans ; Pregnancy ; Risk Factors ; Stem Cells ; Stroke/therapy
    Language English
    Publishing date 2022-04-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(22)00142-9
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  4. Article ; Online: MRI at term equivalent in preterm infants: the wise choice.

    Ferriero, Donna M

    Pediatric research

    2018  Volume 84, Issue 6, Page(s) 791–792

    MeSH term(s) Algorithms ; Brain ; Echoencephalography ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Imaging
    Language English
    Publishing date 2018-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-018-0068-y
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  5. Book: Pediatric neurology / 2 / Kenneth F. Swaiman ; Stephen Ashwal ; Donna M. Ferriero

    Swaiman, Kenneth F. / Ashwal, Stephen / Ferriero, Donna M.

    principles and practice

    2006  

    Collection Pediatric neurology
    Language English
    Size XX S., S. 1184 - 2407, CV S. : Ill., graph. Darst.
    Edition 4. ed., 1. print
    Publisher Mosby
    Publishing place St. Louis u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014467490
    Database Catalogue ZB MED Medicine, Health

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  6. Book: Pediatric neurology / 1 / Kenneth F. Swaiman ; Stephen Ashwal ; Donna M. Ferriero

    Swaiman, Kenneth F. / Ashwal, Stephen / Ferriero, Donna M.

    principles and practice

    2006  

    Collection Pediatric neurology
    Language English
    Size XX, 1180, CV S. : Ill., graph. Darst.
    Edition 4. ed., 1. print
    Publisher Mosby
    Publishing place St. Louis u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014467487
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: The importance of not increasing confusion around neonatal encephalopathy and hypoxic-ischemic encephalopathy.

    Gunn, Alistair J / Soul, Janet S / Vesoulis, Zachary A / Ferriero, Donna M

    Pediatric research

    2023  Volume 95, Issue 4, Page(s) 871–872

    MeSH term(s) Infant, Newborn ; Humans ; Hypoxia-Ischemia, Brain/complications ; Brain ; Infant, Newborn, Diseases/therapy
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-03001-6
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  8. Article ; Online: The Vulnerable Newborn Brain: Imaging Patterns of Acquired Perinatal Injury.

    Ferriero, Donna M

    Neonatology

    2016  Volume 109, Issue 4, Page(s) 345–351

    Abstract: Background: Over the past two decades, imaging techniques have allowed for better visualization of the newborn brain. This has enabled us to detect patterns, understand mechanisms and guide diagnosis and treatment.: Objectives: The purpose of this ... ...

    Abstract Background: Over the past two decades, imaging techniques have allowed for better visualization of the newborn brain. This has enabled us to detect patterns, understand mechanisms and guide diagnosis and treatment.
    Objectives: The purpose of this review is to discuss imaging characteristics of acquired perinatal brain injury.
    Methods: Through literature review and the author's research, this review assesses published data on the distinct imaging patterns that occur in the neonatal period due to acquired brain insults.
    Results: In the term brain, susceptibility to hypoxia-ischemia, hypoglycemia and hyperbilirubinemia results in unique patterns of injury. Stroke commonly occurs in the newborn period. Infections, especially viral, have distinct patterns of white matter injury. In the preterm brain, white matter injury occurs commonly and is affected by postnatal growth, stress and infection. The cerebellum is uniquely vulnerable during this period, with resultant hemorrhages in almost half of preterm infants. Cerebellar growth is affected by intraventricular hemorrhage, drugs and placental pathology. Periventricular hemorrhagic infarction is the most serious consequence of the spectrum of intraventricular hemorrhage and results in profound disabilities.
    Conclusions: Taken together, the acquired perinatal brain injuries can have lifelong devastating consequences, so the search for therapies must continue.
    MeSH term(s) Brain/physiopathology ; Brain Injuries/diagnostic imaging ; Cerebral Hemorrhage/diagnostic imaging ; Humans ; Infant, Newborn ; Infant, Premature ; Leukomalacia, Periventricular/diagnostic imaging ; Magnetic Resonance Imaging ; Stroke/diagnostic imaging ; Term Birth
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000444896
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  9. Article ; Online: Cholesterol in Brain Development and Perinatal Brain Injury: More than a Building Block.

    Lu, Fuxin / Ferriero, Donna M / Jiang, Xiangning

    Current neuropharmacology

    2021  Volume 20, Issue 7, Page(s) 1400–1412

    Abstract: The central nervous system (CNS) is enriched with important classes of lipids, in which cholesterol is known to make up a major portion of myelin sheaths, besides being a structural and functional unit of CNS cell membranes. Unlike in the adult brain, ... ...

    Abstract The central nervous system (CNS) is enriched with important classes of lipids, in which cholesterol is known to make up a major portion of myelin sheaths, besides being a structural and functional unit of CNS cell membranes. Unlike in the adult brain, where the cholesterol pool is relatively stable, cholesterol is synthesized and accumulated at the highest rate in the developing brain to meet the needs of rapid brain growth at this stage, which is also a critical period for neuroplasticity. In addition to its biophysical role in membrane organization, cholesterol is crucial for brain development due to its involvement in brain patterning, myelination, neuronal differentiation, and synaptogenesis. Thus any injuries to the immature brain that affect cholesterol homeostasis may have long-term adverse neurological consequences. In this review, we describe the unique features of brain cholesterol biosynthesis and metabolism, cholesterol trafficking between different cell types, and highlight cholesterol-dependent biological processes during brain maturation. We also discuss the association of impaired cholesterol homeostasis with several forms of perinatal brain disorders in term and preterm newborns, including hypoxic-ischemic encephalopathy. Strategies targeting the cholesterol pathways may open new avenues for the diagnosis and treatment of developmental brain injury.
    MeSH term(s) Adult ; Brain/metabolism ; Brain Injuries/metabolism ; Central Nervous System/metabolism ; Cholesterol/metabolism ; Female ; Humans ; Hypoxia-Ischemia, Brain/metabolism ; Infant, Newborn ; Pregnancy
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2021-11-11
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X19666211111122311
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  10. Article ; Online: American Pediatric Society 2015 Presidential Address: leaky pipes, glass ceilings, and changing landscapes-time to renovate the pediatric house.

    Ferriero, Donna M

    Pediatric research

    2015  Volume 78, Issue 5, Page(s) 589–593

    Abstract: Presented at the PAS Annual Meeting, 25-28 April 2015, San Diego, CA. ...

    Abstract Presented at the PAS Annual Meeting, 25-28 April 2015, San Diego, CA.
    MeSH term(s) Biomedical Research/education ; Biomedical Research/standards ; Biomedical Research/trends ; Career Choice ; Career Mobility ; Diffusion of Innovation ; Education, Medical/trends ; Female ; Forecasting ; Humans ; Male ; Motivation ; Pediatrics/education ; Pediatrics/standards ; Pediatrics/trends ; Physicians, Women/standards ; Physicians, Women/trends ; Sexism/trends ; Women, Working
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Addresses ; Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/pr.2015.151
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