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Article ; Online: Temporomandibular Disorders: Current and Future Concepts in Diagnosis and Management.

Ferrillo, Martina

2023 Volume 59, Issue 2

Abstract: Temporomandibular disorders (TMD) are musculoskeletal and/or neuromuscular conditions relating to muscles, joints, and the associated structures of the stomatognathic system [ ... ]. ...

Abstract	Temporomandibular disorders (TMD) are musculoskeletal and/or neuromuscular conditions relating to muscles, joints, and the associated structures of the stomatognathic system [...].
MeSH term(s)	Humans ; Temporomandibular Joint Disorders ; Muscles
Language	English
Publishing date	2023-01-24
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59020223
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Article ; Online: The effect of vertical skeletal proportions, skeletal maturation, and age on midpalatal suture maturation: a CBCT-based study.

Ferrillo, Martina / Daly, Kieran / Pandis, Nikolaos / Fleming, Padhraig S

Progress in orthodontics

2024 Volume 25, Issue 1, Page(s) 4

Abstract: Background: Midpalatal suture (MPS) maturation may be influenced by a range of parameters including age, gender, and vertical skeletal pattern. We therefore aimed to evaluate the effect of Frankfurt-mandibular angle (FMA), skeletal maturation, and age ... ...

Abstract	Background: Midpalatal suture (MPS) maturation may be influenced by a range of parameters including age, gender, and vertical skeletal pattern. We therefore aimed to evaluate the effect of Frankfurt-mandibular angle (FMA), skeletal maturation, and age on the timing of MPS maturation. Methods: In this cross-sectional study, cone-beam computed tomography (CBCT) and lateral cephalograms were used to assess the MPS and cervical vertebral maturation (CVM) stage. A proportional odds logistic regression model was used to assess associations between age adjusted for gender and MPS maturation, and a regression analysis was performed to analyze the effect of vertical pattern on these associations. Results: A total of 201 patients (84 male and 117 female) with a mean age of 13.48 (SD 1.94) were included. With increasing age, the odds of belonging to a higher maturation stage increased (OR: 2.14; 95% CI 1.789; 2.567; P < 0.001); however, no association between FMA and MPS maturation was observed (OR: 1.01; 95% CI 0.964; 1.051; P = 0.76). A strong correlation between MPS maturation and CVM stage was not reported. Males had a higher probability of belonging to a lower MPS maturation stage (OR: 0.24; 95% CI 0.136; 0.415; P < 0.001). Conclusions: Based on this cross-sectional analysis, midpalatal sutural maturation classification is associated with chronological age and occurs later in males. Neither CVM staging nor variation in vertical skeletal proportions were useful predictors of midpalatal maturation stage.
MeSH term(s)	Humans ; Male ; Female ; Adolescent ; Cross-Sectional Studies ; Spiral Cone-Beam Computed Tomography ; Cranial Sutures/diagnostic imaging ; Palatal Expansion Technique ; Cone-Beam Computed Tomography/methods ; Sutures
Language	English
Publishing date	2024-02-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2040711-7
ISSN	2196-1042 ; 1600-9975 ; 1723-7785 ; 1399-7513
ISSN (online)	2196-1042 ; 1600-9975
ISSN	1723-7785 ; 1399-7513
DOI	10.1186/s40510-023-00504-0
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Zs.A 5560: Show issues

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Article ; Online: The effect of vertical skeletal proportions on overbite changes in untreated adolescents: a longitudinal evaluation.

Ferrillo, Martina / Pandis, Nikolaos / Fleming, Padhraig S

The Angle orthodontist

2023 Volume 94, Issue 1, Page(s) 25–30

Abstract: Objectives: To evaluate the change in overbite within an untreated cohort from 9 to 18 years of age and to compare age-related changes in overbite depth based on vertical skeletal proportion.: Materials and methods: Lateral cephalograms were obtained ...

Abstract	Objectives: To evaluate the change in overbite within an untreated cohort from 9 to 18 years of age and to compare age-related changes in overbite depth based on vertical skeletal proportion. Materials and methods: Lateral cephalograms were obtained from the American Association of Orthodontists Foundation (AAOF) Craniofacial Growth Legacy Collection Project. All cephalometric outcome measures were assessed at ages 9-11 (T1), 13-15 (T2), and 17-19 (T3) years. Generalized estimating equation (GEE) regression models were fit to examine the effect of MP-SN on overbite adjusted for age and gender. Results: A total of 130 subjects from the Denver, Bolton Brush, and Oregon Growth Studies were included. Overbite was relatively constant from T1 to T3 irrespective of facial type, with a minor decrease (0.15 mm) being observed overall. There was a transient increase between T1 and T2 (0.31 mm) that was canceled out by changes during later adolescence. Based on the GEE regression model adjusted for time and gender, a minor but statistically significantly greater reduction in overbite arose as MP-SN increased (coefficient = -0.080; 95% confidence interval -0.12, -0.04; P < .01). Conclusions: In hyperdivergent subjects, a marginal decrease in overbite was observed from 9 to 18 years of age, with a transient increase from the period spanning 9-11 years to 13-15 years, which was negated in later adolescence. There are limited data to suggest that observation of vertical growth is required in most patients with marginally increased vertical facial proportions in the juvenile and pubertal phases.
MeSH term(s)	Humans ; Adolescent ; Child ; Overbite/therapy ; Malocclusion, Angle Class II ; Cephalometry ; Face/anatomy & histology ; Outcome Assessment, Health Care
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	390289-4
ISSN	1945-7103 ; 0003-3219
ISSN (online)	1945-7103
ISSN	0003-3219
DOI	10.2319/042823-310.1
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Article ; Online: QuantiFERON-TB Gold conversion is not uncommon in patients with psoriasis undergoing anti-tumour necrosis factor-α therapy.

Megna, M / Ruggiero, A / Ferrillo, M / Fabbrocini, G

The British journal of dermatology

2020 Volume 183, Issue 5, Page(s) 977–978

MeSH term(s)	Humans ; Interferon-gamma Release Tests ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/drug therapy ; Psoriasis/drug therapy ; Tuberculin Test ; Tumor Necrosis Factor-alpha
Chemical Substances	Tumor Necrosis Factor-alpha
Language	English
Publishing date	2020-08-26
Publishing country	England
Document type	Letter
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.19310
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Article ; Online: Oral health-related quality of life in elderly: an umbrella review of systematic reviews from a multidisciplinary rehabilitation point-of-view.

Ferrillo, M / Migliario, M / Agostini, F / Marotta, N / Santilli, G / Boffano, P / Scaturro, D / Letizia Mauro, G / Ammendolia, A / de Sire, A

La Clinica terapeutica

2024 Volume 175, Issue 1, Page(s) 73–82

Abstract: Background: Poor oral health is highly prevalent among elderlies and may impact quality of life of elderly people. In this scenario, oral health has been often linked to general health and chronic disorders, including distinct features of frailty. The ... ...

Abstract	Background: Poor oral health is highly prevalent among elderlies and may impact quality of life of elderly people. In this scenario, oral health has been often linked to general health and chronic disorders, including distinct features of frailty. The aim of the present umbrella review of systematic reviews was to assess the scientific literature on the correlation between oral health related quality of life (OHRQoL) and elderly to present a multidisciplinary approach to these complex patients. Methods: We performed a literature search of the databases Pub-Med/Medline, Scopus, Web of Science, and Physiotherapy Evidence Database electronic databases. Two independent reviewers performed the literature research from the inception to 25th November 2023 and screened the studies for eligibility. Results: The search resulted in a total of 676 results eligible articles. After removal of duplicates and full-text screening, a total of 3 systematic reviews were considered to meet the inclusion criteria and were included for this review. Conclusions: Frailty is very common in elderly such as a poor oral health. In this scenario, malnutrition and bad lifestyle habits may affect not only the determinism of many systemic non-communicable diseases but also oral health quality. Taken together, the findings of this umbrella review of systematic reviews showed a strict correlation between the frailty, typical condition of ageing people, and a poor OHRQoL. Therefore, it is mandatory to implement the oral health prevention with specific protocols of oral rehabilitation to improve the OHRQoL in elderly.
MeSH term(s)	Aged ; Humans ; Aging ; Frailty ; Life Style ; Quality of Life ; Systematic Reviews as Topic ; Oral Health ; Frail Elderly
Language	English
Publishing date	2024-02-15
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	123320-8
ISSN	1972-6007 ; 0009-9074
ISSN (online)	1972-6007
ISSN	0009-9074
DOI	10.7417/CT.2024.5036
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Article: Reliability of dental calcification compared to hand-wrist X-ray to evaluate skeletal maturation in growing subjects: a systematic review.

Ferrillo, M / Migliario, M / Curci, C / Roccuzzo, A / Invernizzi, M / de Sire, A

Journal of biological regulators and homeostatic agents

2021 Volume 35, Issue 2, Page(s) 717–723

MeSH term(s)	Cephalometry ; Cervical Vertebrae ; Hand ; Humans ; Reproducibility of Results ; Wrist ; X-Rays
Language	English
Publishing date	2021-04-29
Publishing country	Italy
Document type	Letter ; Systematic Review
ZDB-ID	639196-5
ISSN	1724-6083 ; 0393-974X
ISSN (online)	1724-6083
ISSN	0393-974X
DOI	10.23812/21-106-L
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Article ; Online: An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation.

Cantelli, Mariateresa / Ferrillo, Maria / Granger, Corinne / Fabbrocini, Gabriella

Journal of cosmetic dermatology

2021 Volume 21, Issue 4, Page(s) 1523–1532

Abstract: Background: Melasma is a common skin disorder characterized by alterations in normal skin pigmentation. The objective was to evaluate the efficacy and safety of a skin whitening serum containing niacinamide, hydroxyphenoxy propionic acid, dipotassium ... ...

Abstract	Background: Melasma is a common skin disorder characterized by alterations in normal skin pigmentation. The objective was to evaluate the efficacy and safety of a skin whitening serum containing niacinamide, hydroxyphenoxy propionic acid, dipotassium glycyrrhizate, glycolic acid, and 4-n-butylresorcinol applied twice daily combined with a spot-preventing SPF50+ sunscreen for treatment of melasma. Methods: Twelve healthy Caucasian women with melasma (Fitzpatrick skin types II-IV) were enrolled in this pilot clinical study. Efficacy evaluations were performed at baseline and weeks 4, 8, and 12 of treatment and included clinical and instrumental assessments. Results: All endpoints for melasma hyperpigmentation showed a statistically significant improvement from baseline to the end of the study. There was only one dropout. No signs of irritation or discomfort were observed at baseline, w4, w8, or w12. An overall improvement in melasma was observed both clinically and on reflectance confocal microscopy (RCM). Conclusion: This topical skin whitening serum had favorable outcomes for the treatment of melasma hyperpigmentation in adult women, as demonstrated on investigator and instrumental assessments. The results of this pilot study need to be confirmed in randomized, controlled studies with a larger sample size.
MeSH term(s)	Adult ; Female ; Humans ; Hyperpigmentation/drug therapy ; Hyperpigmentation/etiology ; Hyperpigmentation/prevention & control ; Melanosis/diagnosis ; Melanosis/drug therapy ; Pilot Projects ; Prospective Studies ; Skin Lightening Preparations/chemistry ; Skin Lightening Preparations/therapeutic use ; Sunscreening Agents/adverse effects ; Treatment Outcome
Chemical Substances	Skin Lightening Preparations ; Sunscreening Agents
Language	English
Publishing date	2021-06-25
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14271
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Article ; Online: Botulinum Toxin for Pain Relief in Cancer Patients: A Systematic Review of Randomized Controlled Trials.

Lippi, Lorenzo / de Sire, Alessandro / Turco, Alessio / Ferrillo, Martina / Kesikburun, Serdar / Baricich, Alessio / Carda, Stefano / Invernizzi, Marco

Toxins

2024 Volume 16, Issue 3

Abstract: Cancer pain is one of the most disabling symptoms complained by cancer patients, with a crucial impact on physical and psychological well-being. Botulinum neurotoxins (BoNTs) type A and B have emerged as potential interventions for chronic pain; however, ...

Abstract	Cancer pain is one of the most disabling symptoms complained by cancer patients, with a crucial impact on physical and psychological well-being. Botulinum neurotoxins (BoNTs) type A and B have emerged as potential interventions for chronic pain; however, their role in these patients is still debated. Thus, this systematic review of randomized controlled trials aimed at assessing the effects of BoNT treatment for cancer pain to guide physicians in an evidence-based approach integrating BoNT in cancer care. Out of 5824 records, 10 RCTs satisfied our eligibility criteria and were included in the present work for a total of 413 subjects with several cancer types (breast, head and neck, esophageal, and thoracic/gastric cancers). While some studies demonstrated significant pain reduction and improved quality of life post-BoNT-A injections, outcomes across different cancer types were inconclusive. Additionally, several effects were observed in functioning, dysphagia, salivary outcomes, esophageal strictures, gastric emptying, and expansions. This review emphasizes the need for further standardized research to conclusively establish the efficacy of BoNT in comprehensive cancer pain management.
MeSH term(s)	Humans ; Pain Management ; Cancer Pain ; Quality of Life ; Randomized Controlled Trials as Topic ; Stomach Neoplasms ; Chronic Pain
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins16030153
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Article ; Online: Efficacy of rehabilitative therapies on otologic symptoms in patients with temporomandibular disorders: A systematic review of randomised controlled trials.

Ferrillo, Martina / Marotta, Nicola / Viola, Pasquale / Chiarella, Giuseppe / Fortunato, Leonzio / Ammendolia, Antonio / Giudice, Amerigo / de Sire, Alessandro

Journal of oral rehabilitation

2024

Abstract: Background: The term temporomandibular disorder (TMD) indicates a set of musculoskeletal conditions involving temporomandibular joint (TMJ), masticatory musculature, and related anatomical structures. Pain is the most common clinical manifestation of ... ...

Abstract	Background: The term temporomandibular disorder (TMD) indicates a set of musculoskeletal conditions involving temporomandibular joint (TMJ), masticatory musculature, and related anatomical structures. Pain is the most common clinical manifestation of TMD, and the auditory system might be involved and affected, through tinnitus, dizziness, otalgia and ear fullness sensation. Objectives: The aim of this systematic review of randomised controlled trails (RCTs) was to evaluate the efficacy of rehabilitative approaches on otologic symptoms in patients with TMD. Methods: PubMed, Scopus and Web of Science were systematically searched from the inception until 8th October 2023 to identify RCTs presenting participants with a diagnosis of TMD associated with otologic signs and symptoms, rehabilitative approaches as interventions, and modification of the otological symptoms as outcome. Results: Out of 931 papers suitable for title/abstract screening, 627 articles were assessed for eligibility. Five studies were included reporting the efficacy of occlusal splint therapy, low-level laser therapies, and physical therapy in patients diagnosed whit secondary otalgia or tinnitus associated with TMD. No RCTs evaluating other otologic symptoms, ear fullness, dizziness or vertigo were found. Conclusions: Results of this systematic review suggested that rehabilitative approaches might be effective in improving secondary otalgia and tinnitus in TMD patients. Thus, further RCTs with a higher level of evidence and more representative samples should be conducted to better understand the effects of TMD therapy on otologic complains.
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	187079-8
ISSN	1365-2842 ; 0305-182X
ISSN (online)	1365-2842
ISSN	0305-182X
DOI	10.1111/joor.13716
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Article: Hair Aging and Hair Disorders in Elderly Patients.

Villani, Alessia / Ferrillo, Maria / Fabbrocini, Gabriella / Ocampo-Garza, Sonia Sofía / Scalvenzi, Massimiliano / Ruggiero, Angelo

International journal of trichology

2023 Volume 14, Issue 6, Page(s) 191–196

Abstract: Hair loss in elderly patients is a common complaint. It can be related to different conditions that affect patients' quality of life and represents a challenge for dermatologists. It affects both men and women during the aging process with an estimated ... ...

Abstract	Hair loss in elderly patients is a common complaint. It can be related to different conditions that affect patients' quality of life and represents a challenge for dermatologists. It affects both men and women during the aging process with an estimated percentage of balding after 65 years of age of 53% and 37%, respectively. Androgenetic alopecia, frontal fibrosing alopecia, senile alopecia, and erosive pustular dermatosis of the scalp are the hair diseases most frequently described in this age group. The objective of this review is to summarize the current knowledge about alopecia affecting elderly patients, differentiating between chronological hair aging signs and pathological changes, to help clinicians, offer an adequate management of these disorders to their patients.
Language	English
Publishing date	2023-01-31
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2570982-3
ISSN	0974-9241 ; 0974-7753
ISSN (online)	0974-9241
ISSN	0974-7753
DOI	10.4103/ijt.ijt_90_21
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