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  1. Article: Anidulafungin versus fluconazole in the treatment of Candida albicans chorioretinitis

    Ruiz-Arranz, Celia / Pérez-Blázquez, Eugenio / De Pablo-Cabrera, Almudena / Ferro-Osuna, Manuel

    Asociación Española de Micología Revista iberoamericana de micología. 2021 Oct., Dec., v. 38, no. 4

    2021  

    Abstract: Candida albicans chorioretinitis is the most common cause of endogenous fungal endophthalmitis. Echinocandins are recommended as first-line therapy in the treatment of invasive candidiasis (IC), but in clinically stable patients with IC and ... ...

    Abstract Candida albicans chorioretinitis is the most common cause of endogenous fungal endophthalmitis. Echinocandins are recommended as first-line therapy in the treatment of invasive candidiasis (IC), but in clinically stable patients with IC and endophthalmitis caused by Candida species susceptible to azole compounds these are the first-line treatment due to their better intraocular penetration.A 42-year-old woman admitted to hospital for duodenal perforation after gastrointestinal surgery and treated with broad-spectrum antibiotics developed C. albicans candidemia. According to protocol, an antifungal treatment with anidulafungin was given. The patient presented no visual symptoms but on routinary ophthalmoscopic examination multiple bilateral chorioretinal lesions were observed. Systemic therapy was changed to fluconazole, with good systemic and ocular results.Azole compounds are the first-line therapy for endophthalmitis associated with candidemia. However, clinical guidelines often propose echinocandins as the first option for IC. In some cases, C. albicans chorioretinitis will require a change in the systemic treatment to assure better intraocular penetration. According to the current evidence and our own experience, routine funduscopy is not necessary in all IC patients. However, we do recommend fundus examination in patients with visual symptoms or those unable to report them (paediatric patients and patients with an altered level of consciousness), and in those who are being treated with echinocandins in monotherapy.
    Keywords Candida albicans ; anidulafungin ; candidemia ; candidiasis ; consciousness ; fluconazole ; fungi ; gastrointestinal system ; hospitals ; patients ; surgery ; women
    Language English
    Dates of publication 2021-10
    Size p. 188-191.
    Publishing place Elsevier España, S.L.U.
    Document type Article
    ISSN 1130-1406
    DOI 10.1016/j.riam.2021.05.002
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Anidulafungin versus fluconazole in the treatment of Candida albicans chorioretinitis.

    Ruiz-Arranz, Celia / Pérez-Blázquez, Eugenio / De Pablo-Cabrera, Almudena / Ferro-Osuna, Manuel

    Revista iberoamericana de micologia

    2021  Volume 38, Issue 4, Page(s) 188–191

    Abstract: Background: Candida albicans chorioretinitis is the most common cause of endogenous fungal endophthalmitis. Echinocandins are recommended as first-line therapy in the treatment of invasive candidiasis (IC), but in clinically stable patients with IC and ... ...

    Abstract Background: Candida albicans chorioretinitis is the most common cause of endogenous fungal endophthalmitis. Echinocandins are recommended as first-line therapy in the treatment of invasive candidiasis (IC), but in clinically stable patients with IC and endophthalmitis caused by Candida species susceptible to azole compounds these are the first-line treatment due to their better intraocular penetration.
    Case report: A 42-year-old woman admitted to hospital for duodenal perforation after gastrointestinal surgery and treated with broad-spectrum antibiotics developed C. albicans candidemia. According to protocol, an antifungal treatment with anidulafungin was given. The patient presented no visual symptoms but on routinary ophthalmoscopic examination multiple bilateral chorioretinal lesions were observed. Systemic therapy was changed to fluconazole, with good systemic and ocular results.
    Conclusions: Azole compounds are the first-line therapy for endophthalmitis associated with candidemia. However, clinical guidelines often propose echinocandins as the first option for IC. In some cases, C. albicans chorioretinitis will require a change in the systemic treatment to assure better intraocular penetration. According to the current evidence and our own experience, routine funduscopy is not necessary in all IC patients. However, we do recommend fundus examination in patients with visual symptoms or those unable to report them (paediatric patients and patients with an altered level of consciousness), and in those who are being treated with echinocandins in monotherapy.
    MeSH term(s) Adult ; Anidulafungin ; Candida albicans ; Candidiasis, Invasive ; Child ; Chorioretinitis/drug therapy ; Female ; Fluconazole/therapeutic use ; Humans
    Chemical Substances Fluconazole (8VZV102JFY) ; Anidulafungin (9HLM53094I)
    Language English
    Publishing date 2021-11-14
    Publishing country Spain
    Document type Case Reports
    ISSN 2173-9188
    ISSN (online) 2173-9188
    DOI 10.1016/j.riam.2021.05.002
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  3. Article: Post COVID-19 Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis.

    Rojas-Correa, Daniela Ximena / Reche-Sainz, José Alberto / Insausti-García, Alfredo / Calleja-García, Cristina / Ferro-Osuna, Manuel

    Neuro-ophthalmology (Aeolus Press)

    2021  Volume 46, Issue 2, Page(s) 115–121

    Abstract: Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relatively common. Although some may be consequences of direct cellular viral invasion (neurotropism), many represent post-infectious inflammation mediated by ...

    Abstract Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are relatively common. Although some may be consequences of direct cellular viral invasion (neurotropism), many represent post-infectious inflammation mediated by autoimmune mechanisms. We herein report the case of a 69-year-old diabetic male who presented with bilateral sub-acute, progressive loss of vision 45 days after suffering a presumed SARS-CoV-2 related pneumonia. He had bilateral optic disc oedema. Magnetic resonance imaging showed uniform contrast enhancement of both optic nerves without spinal cord involvement. He tested positive for SARS-CoV-2 IgG and myelin oligodendrocyte glycoprotein (MOG) IgG antibodies. He was treated with intravenous methylprednisolone for 5 days. The optic disc oedema resolved within 6 weeks with improvement in visual acuity, although optic atrophy developed by week 16. The MOG-IgG antibody test turned negative after 24 weeks.
    Language English
    Publishing date 2021-05-24
    Publishing country England
    Document type Case Reports
    ZDB-ID 604820-1
    ISSN 1744-506X ; 0165-8107
    ISSN (online) 1744-506X
    ISSN 0165-8107
    DOI 10.1080/01658107.2021.1916044
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  4. Article ; Online: Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state.

    Insausti-García, Alfredo / Reche-Sainz, José Alberto / Ruiz-Arranz, Celia / López Vázquez, Ángel / Ferro-Osuna, Manuel

    European journal of ophthalmology

    2020  Volume 32, Issue 1, Page(s) NP168–NP172

    Abstract: Introduction: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading ... ...

    Abstract Introduction: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading to venous insufficiency and compression of the central retina vein. The disease affects healthy young adults and commonly has a benign course, however, if complications such as macular edema or ischemia appears, treatment should be instituted immediately to avoid poor prognosis.
    Case report: A 40-year old white male patient consulted for a slight decrease in the sensitivity of the visual field in his left eye (OS). Visual acuities (VA) were 20/20 in both eyes. OS fundus examination showed dilated and tortuous retinal vessels, disc edema, and retinal hemorrhages. The patient was diagnosed with papillophlebitis. OS VA decreased to 20/200 due to macular edema, and he was treated with a intravitreal dexamethasone implant. An exhaustive and interdisciplinary exploration process was performed, identifying a recent disease and recovery of Covid-19 as the only factor of inflammation and coagulation alteration. Other systemic diseases were excluded. We also describe a rapid decrease in disc and macular edema after intravitreal dexametasone injection, which could support the inflammatory hypothesis.
    Conclusion: The importance of this case lies in the possible association of papillophlebitis with the new Covid-19 disease. We believe that the inflammatory reaction and the coagulation alteration present in our patient due to Sars-Cov2 coronavirus may have acted as risk factors for the development of papillophlebitis.
    MeSH term(s) Adult ; COVID-19 ; Humans ; Inflammation ; Macular Edema ; Male ; RNA, Viral ; Retinal Vein Occlusion ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120947591
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  5. Article: Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state

    Insausti-García, Alfredo / Reche-Sainz, José Alberto / Ruiz-Arranz, Celia / López Vázquez, Ángel / Ferro-Osuna, Manuel

    Eur J Ophthalmol

    Abstract: INTRODUCTION: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading ... ...

    Abstract INTRODUCTION: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading to venous insufficiency and compression of the central retina vein. The disease affects healthy young adults and commonly has a benign course, however, if complications such as macular edema or ischemia appears, treatment should be instituted immediately to avoid poor prognosis. CASE REPORT: A 40-year old white male patient consulted for a slight decrease in the sensitivity of the visual field in his left eye (OS). Visual acuities (VA) were 20/20 in both eyes. OS fundus examination showed dilated and tortuous retinal vessels, disc edema, and retinal hemorrhages. The patient was diagnosed with papillophlebitis. OS VA decreased to 20/200 due to macular edema, and he was treated with a intravitreal dexamethasone implant. An exhaustive and interdisciplinary exploration process was performed, identifying a recent disease and recovery of Covid-19 as the only factor of inflammation and coagulation alteration. Other systemic diseases were excluded. We also describe a rapid decrease in disc and macular edema after intravitreal dexametasone injection, which could support the inflammatory hypothesis. CONCLUSION: The importance of this case lies in the possible association of papillophlebitis with the new Covid-19 disease. We believe that the inflammatory reaction and the coagulation alteration present in our patient due to Sars-Cov2 coronavirus may have acted as risk factors for the development of papillophlebitis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #690616
    Database COVID19

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  6. Article ; Online: Papillophlebitis in a COVID-19 patient

    Insausti-García, Alfredo / Reche-Sainz, José Alberto / Ruiz-Arranz, Celia / López Vázquez, Ángel / Ferro-Osuna, Manuel

    European Journal of Ophthalmology

    Inflammation and hypercoagulable state

    2020  , Page(s) 112067212094759

    Abstract: Introduction: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading ... ...

    Abstract Introduction: Papillophlebitis is a rare condition characterized by venous congestion and optic disc edema, which has been suggested to occur as a consequence of inflammation of the retinal veins or, possibly, the capillaries of the optic disc, leading to venous insufficiency and compression of the central retina vein. The disease affects healthy young adults and commonly has a benign course, however, if complications such as macular edema or ischemia appears, treatment should be instituted immediately to avoid poor prognosis. Case report: A 40-year old white male patient consulted for a slight decrease in the sensitivity of the visual field in his left eye (OS). Visual acuities (VA) were 20/20 in both eyes. OS fundus examination showed dilated and tortuous retinal vessels, disc edema, and retinal hemorrhages. The patient was diagnosed with papillophlebitis. OS VA decreased to 20/200 due to macular edema, and he was treated with a intravitreal dexamethasone implant. An exhaustive and interdisciplinary exploration process was performed, identifying a recent disease and recovery of Covid-19 as the only factor of inflammation and coagulation alteration. Other systemic diseases were excluded. We also describe a rapid decrease in disc and macular edema after intravitreal dexametasone injection, which could support the inflammatory hypothesis. Conclusion: The importance of this case lies in the possible association of papillophlebitis with the new Covid-19 disease. We believe that the inflammatory reaction and the coagulation alteration present in our patient due to Sars-Cov2 coronavirus may have acted as risk factors for the development of papillophlebitis.
    Keywords Ophthalmology ; General Medicine ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120947591
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Evaluation of Anxiety Levels in Patients Undergoing Intravitreal Injections and Associated Risk Factors Related to the Disease.

    Herranz-Heras, Juan-Carlos / de-Pablo-Cabrera, Almudena / Alonso-Martín, Beatriz / de-Lucas-Viejo, Beatriz / de-Castro-Liébana, Marta / Mencía-Gutiérrez, Enrique / Ferro-Osuna, Manuel-Jesús / Romero, Carmen / Sambricio, Javier

    Journal of ophthalmology

    2020  Volume 2020, Page(s) 4375390

    Abstract: Purpose: To analyze patients' anxiety levels using the Visual Analog Scale for Anxiety (VASA), in regard to intravitreal injection treatment and to determine possible associated risk factors related to the disease and treatment characteristics.: ... ...

    Abstract Purpose: To analyze patients' anxiety levels using the Visual Analog Scale for Anxiety (VASA), in regard to intravitreal injection treatment and to determine possible associated risk factors related to the disease and treatment characteristics.
    Methods: Cross-sectional observational study with consecutive sampling of patients who were going to receive an intravitreal injection. Subjects completed the VASA prior to the procedure, and afterwards, their data were collected from the electronic medical history. Analysis was performed through a linear regression model.
    Results: Fifty-five men and forty-seven women were enrolled. The mean age was 73.9 ± 12.4 years (mean ± standard deviation (SD)), and the mean ± SD of previous injections was 12.8 ± 12. The most frequent pathologies found were age-related macular degeneration with 46.1% and diabetic macular edema with 36.3%. The median of anxiety levels measured in millimeters (mm) was 16 (interquartile range: 0-48). In univariate models, women presented a mean of 10.8 mm of anxiety more than men (
    Conclusions: Sex and age may have an influence on anxiety levels. BCVA and the number ofinjections received did not seem to have an influence on our patients anxiety levels.
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2020/4375390
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  8. Article ; Online: Perforating Ocular Wounds in Occupational Accidents

    Mencía-Gutiérrez, Enrique / Gutiérrez-Díaz, Esperanza / Gutiérrez-Díaz, Antonio / Ferro-Osuna, Manuel

    Ophthalmologica - International Journal of Ophthalmology

    1988  Volume 197, Issue 2, Page(s) 103–197

    Abstract: We review 77 patients with perforating ocular wounds due to occupational accidents seen in our hospital over a period of 5 years. Industrial accidents were the most frequent cause (61.04%), followed by agricultural (25.97%) and services trade (12.98%). ... ...

    Abstract We review 77 patients with perforating ocular wounds due to occupational accidents seen in our hospital over a period of 5 years. Industrial accidents were the most frequent cause (61.04%), followed by agricultural (25.97%) and services trade (12.98%). Seventy-five patients were males (97.40%), with a mean age of 32.88 years. The cornea was statistically the most frequent location (p < 0.001). The nasal quadrants were more frequently affected than the temporal ones (p < 0.001) and the upper quadrants were also more affected than the lower ones, especially in the cornea (p < 0.001). Fifty-two percent had intraocular foreign bodies; industrial accidents were responsible of 65% of these injuries. They were significantly more frequent in summer than in autumn (p < 0.001) and spring (p < 0.001). We discuss the prognosis of these injuries and the circumstances that may influence in their occurrence, stressing the importance of prevention programs.
    Keywords Industrial injuries ; Perforating ocular wounds ; Intraocular foreign body ; Prevention
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 209735-7
    ISSN 1423-0267 ; 0030-3755 ; 0030-3755
    ISSN (online) 1423-0267
    ISSN 0030-3755
    DOI 10.1159/000309927
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