Article ; Online: Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
2022 Volume 8, Issue 1, Page(s) eabj7615
Abstract: Enteroviruses are globally prevalent human pathogens responsible for many diseases. The nonstructural protein 2C is a AAA+ helicase and plays a key role in enterovirus replication. Drug repurposing screens identified 2C-targeting compounds such as ... ...
| Abstract | Enteroviruses are globally prevalent human pathogens responsible for many diseases. The nonstructural protein 2C is a AAA+ helicase and plays a key role in enterovirus replication. Drug repurposing screens identified 2C-targeting compounds such as fluoxetine and dibucaine, but how they inhibit 2C is unknown. Here, we present a crystal structure of the soluble and monomeric fragment of coxsackievirus B3 2C protein in complex with ( |
|---|---|
| Language | English |
| Publishing date | 2022-01-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2810933-8 |
| ISSN | 2375-2548 ; 2375-2548 |
| ISSN (online) | 2375-2548 |
| ISSN | 2375-2548 |
| DOI | 10.1126/sciadv.abj7615 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.