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  1. Article ; Online: An approach to identifying quality research antibodies.

    Groff, Katherine / Allen, David / Fiebig, Michael / Cosson, Pierre / Casey, Warren / Clippinger, Amy J

    BioTechniques

    2022  Volume 73, Issue 4, Page(s) 167–170

    MeSH term(s) Antibodies, Monoclonal
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2022-09-23
    Publishing country England
    Document type Editorial
    ZDB-ID 48453-2
    ISSN 1940-9818 ; 0736-6205
    ISSN (online) 1940-9818
    ISSN 0736-6205
    DOI 10.2144/btn-2022-0071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2435: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Thesis: Immunstatus und klinische Befunde bei HIV-1-seropositiven [HIV-seropositiven] und seronegativen Patienten der AIDS-Ambulanz der Universitäts-Hautklinik Köln

    Fiebig, Michael R.

    1990  

    Title variant Immunstatus und klinische Befunde bei HIV-1-seropositiven und seronegativen Patienten der AIDS-Ambulanz der Universitäts-Hautklinik Köln
    Author's details vorgelegt von Michael Rudolf Fiebig
    Keywords HIV Seropositivity ; Antibody Formation ; Immunity, Cellular ; Acquired Immunodeficiency Syndrome
    Size III, 89 S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 1990
    HBZ-ID HT003520754
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    90 D 1148 order for loan Magazin

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  3. Book ; Thesis: Untersuchung des Abbrandverhaltens von Dieselruß

    Fiebig, Michael

    2012  

    Author's details vorgelegt von Michael Fiebig
    Language German
    Size XII, 120 S., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Hochsch., Diss.--Aachen, 2012
    Note Literaturverz. S. 100 - 109
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article ; Online: Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper.

    Sørensen, Christoffer V / Fernández, Julián / Adams, Anna Christina / Wildenauer, Helen H K / Schoffelen, Sanne / Ledsgaard, Line / Pucca, Manuela B / Fiebig, Michael / Cerni, Felipe A / Tulika, Tulika / Voldborg, Bjørn G / Karatt-Vellatt, Aneesh / Morth, J Preben / Ljungars, Anne / Grav, Lise M / Lomonte, Bruno / Laustsen, Andreas H

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 173

    Abstract: Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent ... ...

    Abstract Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent models. Here, we use phage display technology to discover a human monoclonal antibody and show that this antibody causes antibody-dependent enhancement of toxicity (ADET) of myotoxin II from the venomous pit viper, Bothrops asper, in a mouse model of envenoming that mimics a snakebite. While clinical ADET related to snake venom has not yet been reported in humans, this report of ADET of a toxin from the animal kingdom highlights the necessity of assessing even well-known antibody formats in representative preclinical models to evaluate their therapeutic utility against toxins or venoms. This is essential to avoid potential deleterious effects as exemplified in the present study.
    MeSH term(s) Mice ; Animals ; Humans ; Neurotoxins/toxicity ; Bothrops asper ; Antibody-Dependent Enhancement ; Bothrops ; Antibodies, Monoclonal/toxicity
    Chemical Substances Neurotoxins ; Antibodies, Monoclonal
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42624-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparative Life Cycle Transcriptomics Revises Leishmania mexicana Genome Annotation and Links a Chromosome Duplication with Parasitism of Vertebrates.

    Fiebig, Michael / Kelly, Steven / Gluenz, Eva

    PLoS pathogens

    2015  Volume 11, Issue 10, Page(s) e1005186

    Abstract: Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms, which are adapted to survive and replicate in the harsh conditions ...

    Abstract Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms, which are adapted to survive and replicate in the harsh conditions of the phagolysosome of mammalian macrophages. Here, we used Illumina sequencing of poly-A selected RNA to characterise and compare the transcriptomes of L. mexicana promastigotes, axenic amastigotes and intracellular amastigotes. These data allowed the production of the first transcriptome evidence-based annotation of gene models for this species, including genome-wide mapping of trans-splice sites and poly-A addition sites. The revised genome annotation encompassed 9,169 protein-coding genes including 936 novel genes as well as modifications to previously existing gene models. Comparative analysis of gene expression across promastigote and amastigote forms revealed that 3,832 genes are differentially expressed between promastigotes and intracellular amastigotes. A large proportion of genes that were downregulated during differentiation to amastigotes were associated with the function of the motile flagellum. In contrast, those genes that were upregulated included cell surface proteins, transporters, peptidases and many uncharacterized genes, including 293 of the 936 novel genes. Genome-wide distribution analysis of the differentially expressed genes revealed that the tetraploid chromosome 30 is highly enriched for genes that were upregulated in amastigotes, providing the first evidence of a link between this whole chromosome duplication event and adaptation to the vertebrate host in this group. Peptide evidence for 42 proteins encoded by novel transcripts supports the idea of an as yet uncharacterised set of small proteins in Leishmania spp. with possible implications for host-pathogen interactions.
    MeSH term(s) Adaptation, Physiological/genetics ; Animals ; Chromosome Duplication ; Gene Expression Profiling ; Genome, Protozoan/genetics ; Host-Pathogen Interactions/genetics ; Leishmania mexicana/genetics ; Leishmaniasis/genetics ; Leishmaniasis/parasitology ; Life Cycle Stages/genetics ; Mice ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Protozoan Proteins/genetics ; Transcriptome ; Vertebrates/parasitology
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2015-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1005186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Discovery of a Recombinant Human Monoclonal Immunoglobulin G Antibody Against α-Latrotoxin From the Mediterranean Black Widow Spider (

    Føns, Sofie / Ledsgaard, Line / Nikolaev, Maxim V / Vassilevski, Alexander A / Sørensen, Christoffer V / Chevalier, Manon K / Fiebig, Michael / Laustsen, Andreas H

    Frontiers in immunology

    2020  Volume 11, Page(s) 587825

    Abstract: Widow spiders are among the few spider species worldwide that can cause serious envenoming in humans. The clinical syndrome resulting ... ...

    Abstract Widow spiders are among the few spider species worldwide that can cause serious envenoming in humans. The clinical syndrome resulting from
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Black Widow Spider/immunology ; Female ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin G/pharmacology ; Male ; Pyramidal Cells/drug effects ; Pyramidal Cells/physiology ; Rats, Wistar ; Spider Venoms/immunology ; Spider Venoms/toxicity
    Chemical Substances Antibodies, Monoclonal ; Immunoglobulin G ; Spider Venoms ; alpha-latrotoxin (65988-34-3)
    Language English
    Publishing date 2020-11-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.587825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SLaP mapper: a webserver for identifying and quantifying spliced-leader addition and polyadenylation site usage in kinetoplastid genomes.

    Fiebig, Michael / Gluenz, Eva / Carrington, Mark / Kelly, Steven

    Molecular and biochemical parasitology

    2014  Volume 196, Issue 2, Page(s) 71–74

    Abstract: The Kinetoplastida are a diverse and globally distributed class of free-living and parasitic single-celled eukaryotes that collectively cause a significant burden on human health and welfare. In kinetoplastids individual genes do not have promoters, but ... ...

    Abstract The Kinetoplastida are a diverse and globally distributed class of free-living and parasitic single-celled eukaryotes that collectively cause a significant burden on human health and welfare. In kinetoplastids individual genes do not have promoters, but rather all genes are arranged downstream of a small number of RNA polymerase II transcription initiation sites and are thus transcribed in polycistronic gene clusters. Production of individual mRNAs from this continuous transcript occurs co-transcriptionally by trans-splicing of a ∼39 nucleotide capped RNA and subsequent polyadenylation of the upstream mRNA. SLaP mapper (Spliced-Leader and Polyadenylation mapper) is a fully automated web-service for identification, quantitation and gene-assignment of both spliced-leader and polyadenylation addition sites in Kinetoplastid genomes. SLaP mapper only requires raw read data from paired-end Illumina RNAseq and performs all read processing, mapping, quality control, quantification, and analysis in a fully automated pipeline. To provide usage examples and estimates of the quantity of sequence data required we use RNAseq obtained from two different library preparations from both Trypanosoma brucei and Leishmania mexicana to show the number of expected reads that are obtained from each preparation type. SLaP mapper is an easy to use, platform independent webserver that is freely available for use at http://www.stevekellylab.com/software/slap. Example files are provided on the website.
    MeSH term(s) Algorithms ; Genome, Protozoan ; Internet ; Leishmania mexicana/genetics ; Polyadenylation ; RNA, Spliced Leader/genetics ; Trypanosoma brucei brucei/genetics
    Chemical Substances RNA, Spliced Leader
    Language English
    Publishing date 2014-08-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 756166-0
    ISSN 1872-9428 ; 0166-6851
    ISSN (online) 1872-9428
    ISSN 0166-6851
    DOI 10.1016/j.molbiopara.2014.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2437: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Particulate emissions from diesel engines: correlation between engine technology and emissions.

    Fiebig, Michael / Wiartalla, Andreas / Holderbaum, Bastian / Kiesow, Sebastian

    Journal of occupational medicine and toxicology (London, England)

    2014  Volume 9, Issue 1, Page(s) 6

    Abstract: In the last 30 years, diesel engines have made rapid progress to increased efficiency, environmental protection and comfort for both light- and heavy-duty applications. The technical developments include all issues from fuel to combustion process to ... ...

    Abstract In the last 30 years, diesel engines have made rapid progress to increased efficiency, environmental protection and comfort for both light- and heavy-duty applications. The technical developments include all issues from fuel to combustion process to exhaust gas aftertreatment. This paper provides a comprehensive summary of the available literature regarding technical developments and their impact on the reduction of pollutant emission. This includes emission legislation, fuel quality, diesel engine- and exhaust gas aftertreatment technologies, as well as particulate composition, with a focus on the mass-related particulate emission of on-road vehicle applications. Diesel engine technologies representative of real-world on-road applications will be highlighted.Internal engine modifications now make it possible to minimize particulate and nitrogen oxide emissions with nearly no reduction in power. Among these modifications are cooled exhaust gas recirculation, optimized injections systems, adapted charging systems and optimized combustion processes with high turbulence. With introduction and optimization of exhaust gas aftertreatment systems, such as the diesel oxidation catalyst and the diesel particulate trap, as well as NOx-reduction systems, pollutant emissions have been significantly decreased. Today, sulfur poisoning of diesel oxidation catalysts is no longer considered a problem due to the low-sulfur fuel used in Europe. In the future, there will be an increased use of bio-fuels, which generally have a positive impact on the particulate emissions and do not increase the particle number emissions.Since the introduction of the EU emissions legislation, all emission limits have been reduced by over 90%. Further steps can be expected in the future. Retrospectively, the particulate emissions of modern diesel engines with respect to quality and quantity cannot be compared with those of older engines. Internal engine modifications lead to a clear reduction of the particulate emissions without a negative impact on the particulate-size distribution towards smaller particles. The residual particles can be trapped in a diesel particulate trap independent of their size or the engine operating mode. The usage of a wall-flow diesel particulate filter leads to an extreme reduction of the emitted particulate mass and number, approaching 100%. A reduced particulate mass emission is always connected to a reduced particle number emission.
    Language English
    Publishing date 2014-03-07
    Publishing country England
    Document type Journal Article
    ISSN 1745-6673
    ISSN 1745-6673
    DOI 10.1186/1745-6673-9-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Diodengepumpte Festkörperlaser im Spektralbereich um 2[my]m für Anwendungen in der Lasermedizin

    Fiebig, Michael

    1998  

    Abstract: Diode-pumped solid state lasers, quasi-3-level system, laser ... ...

    Author's details von Michael Fiebig
    Abstract Diode-pumped solid state lasers, quasi-3-level system, laser medicine
    Language German
    Size Online-Ressource, graph. Darst
    Edition [Electronic ed.]
    Publisher Universitätsbibliothek u. Technische Informationsbibliothek
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Hannover, 1998
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book ; Online ; Thesis: Diodengepumpte Festkörperlaser im Spektralbereich um 2[my]m für Anwendungen in der Lasermedizin

    Fiebig, Michael

    1998  

    Abstract: Diode-pumped solid state lasers, quasi-3-level system, laser ... ...

    Author's details von Michael Fiebig
    Abstract Diode-pumped solid state lasers, quasi-3-level system, laser medicine
    Language German
    Size Online-Ressource, graph. Darst
    Edition [Electronic ed.]
    Publisher Universitätsbibliothek u. Technische Informationsbibliothek
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Hannover, 1998
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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