Article ; Online: Single is not combined: The role of Co and Ni bioavailability on toxicity mechanisms in liver and brain cells.
2024 Volume 357, Page(s) 142091
Abstract: The two trace elements cobalt (Co) and nickel (Ni) are widely distributed in the environment due to the increasing industrial application, for example in lithium-ion batteries. Both metals are known to cause detrimental health impacts to humans when ... ...
| Abstract | The two trace elements cobalt (Co) and nickel (Ni) are widely distributed in the environment due to the increasing industrial application, for example in lithium-ion batteries. Both metals are known to cause detrimental health impacts to humans when overexposed and both are supposed to be a risk factor for various diseases. The individual toxicity of Co and Ni has been partially investigated, however the underlying mechanisms, as well as the interactions of both remain unknown. In this study, we focused on the treatment of liver carcinoma (HepG2) and astrocytoma (CCF-STTG1) cells as a model for the target sites of these two metals. We investigated their effects in single and combined exposure on cell survival, cell death mechanisms, bioavailability, and the induction of oxidative stress. The combination of CoCl |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Cobalt/toxicity ; Humans ; Nickel/toxicity ; Oxidative Stress/drug effects ; Hep G2 Cells ; Liver/drug effects ; Liver/metabolism ; Cell Survival/drug effects ; Apoptosis/drug effects ; Brain/metabolism ; Brain/drug effects ; Biological Availability ; Cell Line, Tumor | |||||
| Chemical Substances | Cobalt (3G0H8C9362) ; Nickel (7OV03QG267) | |||||
| Language | English | |||||
| Publishing date | 2024-04-20 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 120089-6 | |||||
| ISSN | 1879-1298 ; 0045-6535 ; 0366-7111 | |||||
| ISSN (online) | 1879-1298 | |||||
| ISSN | 0045-6535 ; 0366-7111 | |||||
| DOI | 10.1016/j.chemosphere.2024.142091 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 2540: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.