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  1. Conference proceedings: PI-RADS 3 Läsionen im multiparametrischen MRT der Prostata (mpMRT) – biopsieren?

    Hegele, A. / Figiel, J. / Mahnken, A.

    2021  , Page(s) 21swdgu43

    Event/congress 61. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V.; sine loco [digital]; Südwestdeutsche Gesellschaft für Urologie e.V.; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-06-08
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21swdgu43
    Database German Medical Science

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  2. Article ; Online: Kidney Hypertrophy in Living Kidney Donors and Their Corresponding Recipients.

    Steden, Kilian / Figiel, Jens / Hoyer, Joachim / Kamalanabhaiah, Sahana R

    Transplantation proceedings

    2022  Volume 54, Issue 3, Page(s) 627–631

    Abstract: Background: In this long-term study we compared kidney volume changes and function between living kidney donors and their corresponding recipients via magnetic resonance imaging after 3 to 8 years post transplantation.: Methods: For measurement of ... ...

    Abstract Background: In this long-term study we compared kidney volume changes and function between living kidney donors and their corresponding recipients via magnetic resonance imaging after 3 to 8 years post transplantation.
    Methods: For measurement of the kidney volume in magnetic resonance imaging images we used 3DSlicer. Statistical analysis was performed via t test and correlation.
    Results: A profound volume increase was observed in both transplanted and orthotopic kidney. The volume increase of the orthotopic kidneys was with 58 cm³ ± 23.8 cm³ SD (41%) greater than in the corresponding transplanted kidneys with 43 cm³ ± 36.9 cm³ SD (30%).
    Conclusions: This study detected a persistent volume increase in both orthotopic and transplanted kidneys after donation. Neither significant increases of hypertension or proteinuria were observable or could be correlated to renal hypertrophy.
    MeSH term(s) Humans ; Hypertrophy ; Kidney/diagnostic imaging ; Kidney Transplantation/adverse effects ; Living Donors ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Tissue Donors
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.11.040
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    Zs.A 835: Show issues Location:
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  3. Article ; Conference proceedings: Selektive Thermoablation von Lebermetastasen zur Progressionskontrolle bei fortgeschrittenen GEP-NEN

    Mahnken, A / Matrood, S / Rinke, A / Gress, T / Figiel, J

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2021  Volume 193, Issue S 01

    Event/congress 102. Deutscher Röntgenkongress der Deutschen Röntgengesellschaft e. V., Online, 2021-03-27
    Language German
    Publishing date 2021-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-0041-1723166
    Database Thieme publisher's database

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  4. Article ; Online: Characteristics of familial pancreatic cancer families with additional colorectal carcinoma.

    Lehman, Bettina / Matthäi, Elvira / Gercke, Norman / Denzer, Ulrike W / Figiel, Jens / Hess, Timo / Slater, Emily P / Bartsch, Detlef K

    Familial cancer

    2023  Volume 22, Issue 3, Page(s) 323–330

    Abstract: Familial pancreatic cancer (FPC) is a rare hereditary tumor entity with broad phenotypic heterogeneity, including colorectal carcinoma (CRC) in some families. The underlying factors for this co-occurrence are still not well evaluated. FPC families in the ...

    Abstract Familial pancreatic cancer (FPC) is a rare hereditary tumor entity with broad phenotypic heterogeneity, including colorectal carcinoma (CRC) in some families. The underlying factors for this co-occurrence are still not well evaluated. FPC families in the National Case Collection of Familial Pancreatic Cancer with an additional occurrence of CRC were analyzed regarding the phenotype, genotype and recommendation for a clinical screening program. The total cohort of 272 FPC families included 30 (11%) families with at least one CRC case. The proportion of affected family members with PDAC was 16.1% (73/451) compared to 9.3% of family members with CRC (42/451, p < 0.01). Females were affected with PDAC in 49% (36/73) and CRC in 38% (16/42). The median age of PDAC was 63 compared to 66 years in CRC, whereas 8 (26.6%) of families had an early onset of PDAC and 2 (6.7%) of CRC. Seventeen families had 2 or more affected generations with PDAC and 6 families with CRC. Eleven (9.6%) of affected patients had both PDAC and CRC. Potentially causative germline mutations (2 ATM, 1 CDKN2a, 1 MLH1, 1 PALB2) were detected in 5 of 18 (27.7%) analyzed cases. These findings provide a step forward to include the phenotypic and genotypic characteristics of FPC-CRC families for the genetic counseling and management of these families. Nevertheless, results need to be verified in a larger patient cohort beforehand.
    MeSH term(s) Female ; Humans ; Genetic Predisposition to Disease ; Pancreatic Neoplasms/diagnosis ; Germ-Line Mutation ; Genotype
    Language English
    Publishing date 2023-01-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1502496-9
    ISSN 1573-7292 ; 1389-9600
    ISSN (online) 1573-7292
    ISSN 1389-9600
    DOI 10.1007/s10689-023-00328-1
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    Zs.A 6099: Show issues Location:
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  5. Article ; Conference proceedings: MRT-gesteuerte Kryoablation des fokalen Prostatakarzinoms

    Figiel, J / König, A / Hegele, A / Mahnken, A

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2018  Volume 190, Issue S 01

    Event/congress 99. Deutscher Röntgenkongress, Leipzig, 2018-05-09
    Language German
    Publishing date 2018-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-0038-1641314
    Database Thieme publisher's database

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  6. Article: Interventionell-radiologische Therapien in der Behandlung von neuroendokrinen Tumoren

    Viniol, S. / König, A. / Figiel, J. / Mahnken, A. H.

    Journal Onkologie

    2019  Volume 19, Issue 2, Page(s) 42–50

    Language German
    Document type Article
    ZDB-ID 2108287-X
    ISSN 1618-7687
    Database Current Contents Medicine

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    Zs.A 6162: Show issues Location:
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  7. Article ; Online: Diffusion weighted MRI of osteoid osteomas: Higher ADC values after radiofrequency ablation.

    Rheinheimer, S / Görlach, J / Figiel, J / Mahnken, A H

    European journal of radiology

    2016  Volume 85, Issue 7, Page(s) 1284–1288

    Abstract: Purpose: Feasibility of diffusion weighted MRI (DWI) pre- and post-radiofrequency ablation (RFA) in patients with osteoid osteoma (OO).: Material and methods: Ten patients (1 female, 24±9years) received RFA of OO (mean size 8.7±3.2mm). Two OO ... ...

    Abstract Purpose: Feasibility of diffusion weighted MRI (DWI) pre- and post-radiofrequency ablation (RFA) in patients with osteoid osteoma (OO).
    Material and methods: Ten patients (1 female, 24±9years) received RFA of OO (mean size 8.7±3.2mm). Two OO recurred, in one of these a second RFA was performed. A 1.5T DWI (b=50, 400, and 800s/mm(2)) and a fat saturated DCE MRI were obtained the day before and after RFA. In DWI, the mean apparent diffusion coefficient (ADC) was recorded. With DCE MRI, signal-to-noise ratio, contrast-to-noise ratio, absolute signal intensity (SI), relative SI, and SI ratio were documented. All parameters were compared pre- and post-RFA using paired Wilcoxon rank test.
    Results: ADC values were significantly higher post-ablation, 1.6±0.5μm(2)/ms versus 1.3±0.6μm(2)/ms (p<0.05). Perfusion was significantly reduced after ablation [SNR, CNR, SI, %SI, and SI OO/SI muscle]; post-RFA: 55±13, 27±20, 757±534, 102±16, and 1.6±0.2; pre-RFA: 88±37, 65±22, 1038±755, 226±51, and 2.0±0.5 (p<0.05).
    Discussion: DWI is feasible in OO. ADC values increased and contrast enhancement decreased after RFA of OO. This may be explained by RFA-induced necrosis and devascularization.
    MeSH term(s) Adult ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/surgery ; Catheter Ablation ; Diffusion Magnetic Resonance Imaging/methods ; Feasibility Studies ; Female ; Humans ; Male ; Osteoma, Osteoid/diagnostic imaging ; Osteoma, Osteoid/surgery ; Signal-To-Noise Ratio ; Statistics, Nonparametric ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2016-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2016.03.028
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    Zs.A 1630: Show issues Location:
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  8. Article ; Online: Pull-out strength evaluation of cement augmented iliac screws in osteoporotic spino-pelvic fixation.

    Oberkircher, Ludwig / Masaeli, Adrian / Hack, Juliana / Figiel, Jens / Bliemel, Christopher / Ruchholtz, Steffen / Krüger, Antonio

    Orthopaedics & traumatology, surgery & research : OTSR

    2021  Volume 107, Issue 7, Page(s) 102945

    Abstract: Introduction: Spino-pelvic fixation has been widely accepted for surgical treatment of sacral tumor, scoliosis surgery and pelvic fractures. Cement augmentation of screws is an option to improve implant stability in osteoporotic bone quality. Aim of the ...

    Abstract Introduction: Spino-pelvic fixation has been widely accepted for surgical treatment of sacral tumor, scoliosis surgery and pelvic fractures. Cement augmentation of screws is an option to improve implant stability in osteoporotic bone quality. Aim of the present study is to compare iliac screw fixation without cement fixation and two cement application options in a biomechanical testing.
    Hypothesis: Cement augmentation of iliac screws leads to superior pull-out strength.
    Material and methods: Thirty female and osteoporotic human iliac bones were used. Three operation treatment groups were generated: Screw fixation (cannulated screws) without cement augmentation [Operation treatment (OT) A], screw fixation with cement augmentation before screw placement (cannulated screws) (OT B) and screw fixation with perforated screws and cement augmentation after screw placement (OTC). Pull-out tests were performed with a rate of 6mm/min. A load versus displacement curve was generated. Maximum pull-out force (N) was measured in the load-displacement curve.
    Results: Paired group 1 (OT A vs. OT B): Screw fixation without cement augmentation: 592.6N±335.07 and screw fixation with cement augmentation before screw placement: 996N±287.43 (p=0.0042). Paired group 2 (OT A vs. OT C): screw fixation without cement augmentation: 716.2N±385.86 and fenestrated screw fixation with cement augmentation after screw placement: 1324.88N±398.76 (p=0.0489). Paired group 3 (OT B vs. OT C): Screw fixation with cement augmentation before screw placement: 1077.2±486.66 and fenestrated screw fixation with cement augmentation after screw placement: 1298.2N±726.19 (p=0.3286).
    Discussion: Regarding iliac screw fixation for spino-pelvic ostesynthesis in osteoporotic bone, cement augmentation is significantly superior to solid iliac screw fixation respecting pull-out-strength. Nevertheless, further biomechanical studies are needed to verify these findings.
    Level of evidence: Not applicable; biomechanical cadaver study.
    MeSH term(s) Biomechanical Phenomena ; Bone Cements ; Bone Screws ; Cadaver ; Female ; Humans ; Ilium/surgery ; Osteoporotic Fractures/diagnostic imaging ; Osteoporotic Fractures/surgery ; Pelvis
    Chemical Substances Bone Cements
    Language English
    Publishing date 2021-04-22
    Publishing country France
    Document type Journal Article
    ISSN 1877-0568
    ISSN (online) 1877-0568
    DOI 10.1016/j.otsr.2021.102945
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  9. Article ; Online: "Leaving the placenta

    Boekhoff, Jelena / Arabin, Birgit / Figiel, Jens / Köhler, Siegmund

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2018  Volume 33, Issue 2, Page(s) 341–343

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Adult ; Cesarean Section/methods ; Conservative Treatment/methods ; Female ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Imaging ; Placenta/pathology ; Placenta Accreta/diagnostic imaging ; Placenta Accreta/therapy ; Postpartum Hemorrhage/therapy ; Pregnancy ; Ultrasonography, Prenatal
    Language English
    Publishing date 2018-07-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2018.1488960
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    Zs.A 3510: Show issues Location:
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  10. Article ; Online: Focal Therapy for Renal Cancer: Comparative Trends in the USA and Germany from 2006 to 2020 and Analysis of the German Health Care Landscape.

    Flegar, Luka / Thoduka, Smita George / Mahnken, Andreas H / Figiel, Jens / Heers, Hendrik / Aksoy, Cem / Eisenmenger, Nicole / Groeben, Christer / Huber, Johannes / Zacharis, Aristeidis

    Urologia internationalis

    2023  Volume 107, Issue 4, Page(s) 396–405

    Abstract: Introduction: The aim of the study was to investigate trends of FT for in-patient treatment of renal RCC in the USA and Germany.: Methods: We analyzed the SEER database for the USA and the nationwide German hospital billing database each from 2006 to ...

    Abstract Introduction: The aim of the study was to investigate trends of FT for in-patient treatment of renal RCC in the USA and Germany.
    Methods: We analyzed the SEER database for the USA and the nationwide German hospital billing database each from 2006 to 2019 for a RCC diagnosis in combination with FT, radical nephrectomy, and partial nephrectomy. FT was defined as radiofrequency ablation (RFA) or cryotherapy. Linear regression analysis was performed to detect changes over time.
    Results: For the USA, we included 7,318 FT cases. The share of FT increased from 2.4% in 2006 to 6.4% in 2019 (p < 0.001). For Germany, we identified 2,920 FT cases. The share of FT increased from 0.7% in 2006 to 2.0% in 2019 (p < 0.001). The number of RFAs in the USA steadily increased by 227% from a total of 93 in 2006 to 304 in 2019 while the number of cryotherapies in the USA steadily increased by 289% from a total of 127 in 2006 to 494 in 2019 (p < 0.001). The number of RFAs in Germany increased by 344% from a total of 59 in 2006 to 262 in 2019 (p < 0.001) while the number of cryotherapies steadily increased by 43% from a total of 54 in 2006 to 77 in 2019 (p < 0.001). In Germany, RFA is significantly more performed than cryotherapy while in the USA cryotherapy is more frequently applied.
    Conclusion: We observed a constant increase of FT in the USA and Germany for RCC in-patient treatment with a higher share in the USA.
    MeSH term(s) Humans ; United States ; Male ; Carcinoma, Renal Cell/surgery ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/surgery ; Kidney ; Nephrectomy ; Delivery of Health Care ; Prostatic Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000528559
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