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  1. Article ; Online: Is parathyroid allotransplantation a viable option in the treatment of permanent hypoparathyroidism? A review of the literature.

    Gadelha, Daniel Duarte / Filho, Wellington Alves / Brandão, Marjorie Azevedo Jales / Montenegro, Renan Magalhães

    Endocrine

    2022  Volume 80, Issue 2, Page(s) 253–265

    Abstract: Background: The standard clinical treatment for hypoparathyroidism, replacement of calcium and vitamin metabolites (calcitriol), has been used for decades; however, evidence points to its inefficiency in acting on the pathophysiology of the disease, ... ...

    Abstract Background: The standard clinical treatment for hypoparathyroidism, replacement of calcium and vitamin metabolites (calcitriol), has been used for decades; however, evidence points to its inefficiency in acting on the pathophysiology of the disease, which may precipitate or aggravate conditions already related to hypoparathyroidism. Therapies based on recombinant human parathyroid hormone have emerged in recent years but still have low availability due to their high cost. Parathyroid allotransplantation (Pt-a) has been reported as a strategy for treating more severe cases.
    Methods: This narrative review highlights relevant aspects of conventional permanent hypoparathyroidism treatment and provides a comprehensive and critical review of the reports of applications of Pt-a, especially those carried out in recent years. Particular focus is placed on the following key points: parathyroid immunogenicity, immunosuppression regimens (short-term or chronic), techniques to reduce the expression of immunogenic molecules, follow-up time, and reductions in calcium and vitamin D supplementation.
    Conclusion: Pt-a has been considered a safe and relatively low-cost therapy and is believed to have the potential to cure the disease, in addition to treating symptoms. However, there is considerable heterogeneity in treatment protocols; therefore, more studies are required to improve the standardization of the procedure and thus improve the consistency of outcomes.
    MeSH term(s) Humans ; Calcium/therapeutic use ; Hypocalcemia/drug therapy ; Parathyroid Hormone/therapeutic use ; Hypoparathyroidism/drug therapy ; Hypoparathyroidism/diagnosis ; Parathyroid Glands/surgery ; Calcitriol/therapeutic use
    Chemical Substances Calcium (SY7Q814VUP) ; Parathyroid Hormone ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2022-12-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-022-03292-5
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    Zs.A 3884: Show issues Location:
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  2. Article ; Online: Barrier device prototype for open tracheotomy during COVID-19 pandemic.

    Filho, Wellington Alves / Teles, Tulio Sampaio Pontes Grangeiro / da Fonseca, Márcio Ribeiro Studart / Filho, Francisco Januário Farias Pereira / Pereira, Glebert Monteiro / Pontes, Alan Breno Moura / de Paula, Eliane Maria da Silva / Nunes, Andre Alencar Araripe / Ferreira, Luis Alberto Albano

    Auris, nasus, larynx

    2020  Volume 47, Issue 4, Page(s) 692–696

    Abstract: Objective: To present a low-cost prototype for a barrier enclosure device which can be used during open surgeries such as tracheotomy.: Methods: We provide detailed description of a novel device called COVID-Box, developed by The Surgical Airway Team ...

    Abstract Objective: To present a low-cost prototype for a barrier enclosure device which can be used during open surgeries such as tracheotomy.
    Methods: We provide detailed description of a novel device called COVID-Box, developed by The Surgical Airway Team for COVID-19 Pandemic, a temporary task force formed by Walter Cantídio University Hospital. Safety guidelines for performing tracheotomies in COVID-19 patients are also stated.
    Results: Our prototype device provides greater hand mobility than previous barrier devices reported, making it more suitable for airway surgical procedures, such as tracheotomy. The curved shaped format and the customizable access ports provides ergonomics, without compromising safety.
    Conclusion: The COVID-Box appears to be an efficient, reproduceable, low-cost barrier enclosure device that can be used for open tracheotomies in ICU patients during the COVID-19 pandemic.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Tracheotomy/instrumentation ; Tracheotomy/methods
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2020.05.003
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  3. Article: Barrier device prototype for open tracheotomy during COVID-19 pandemic

    Filho, Wellington Alves / Teles, Tulio Sampaio Pontes Grangeiro / da Fonseca, Márcio Ribeiro Studart / Filho, Francisco Januário Farias Pereira / Pereira, Glebert Monteiro / Pontes, Alan Breno Moura / de Paula, Eliane Maria da Silva / Nunes, Andre Alencar Araripe / Ferreira, Luis Alberto Albano

    Auris Nasus Larynx

    Abstract: Objective: To present a low-cost prototype for a barrier enclosure device which can be used during open surgeries such as tracheotomy. Methods: We provide detailed description of a novel device called COVID-Box, developed by The Surgical Airway Team for ... ...

    Abstract Objective: To present a low-cost prototype for a barrier enclosure device which can be used during open surgeries such as tracheotomy. Methods: We provide detailed description of a novel device called COVID-Box, developed by The Surgical Airway Team for COVID-19 Pandemic, a temporary task force formed by Walter Cantídio University Hospital. Safety guidelines for performing tracheotomies in COVID-19 patients are also stated. Results: Our prototype device provides greater hand mobility than previous barrier devices reported, making it more suitable for airway surgical procedures, such as tracheotomy. The curved shaped format and the customizable access ports provides ergonomics, without compromising safety. Conclusion: The COVID-Box appears to be an efficient, reproduceable, low-cost barrier enclosure device that can be used for open tracheotomies in ICU patients during the COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #209719
    Database COVID19

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  4. Article ; Online: Barrier device prototype for open tracheotomy during COVID-19 pandemic

    Filho, Wellington Alves / Teles, Tulio Sampaio Pontes Grangeiro / da Fonseca, Márcio Ribeiro Studart / Filho, Francisco Januário Farias Pereira / Pereira, Glebert Monteiro / Pontes, Alan Breno Moura / de Paula, Eliane Maria da Silva / Nunes, Andre Alencar Araripe / Ferreira, Luis Alberto Albano

    Auris Nasus Larynx

    2020  Volume 47, Issue 4, Page(s) 692–696

    Keywords Surgery ; Otorhinolaryngology ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2020.05.003
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    Zs.A 1675: Show issues Location:
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  5. Article ; Online: Quality of life after surgery in secondary hyperparathyroidism, comparing subtotal parathyroidectomy with total parathyroidectomy with immediate parathyroid autograft: Prospective randomized trial.

    Filho, Wellington Alves / van der Plas, Willemijn Y / Brescia, Marilia D G / Nascimento, Climerio P / Goldenstein, Patricia T / Neto, Ledo M Massoni / Arap, Sergio S / Custodio, Melani R / Bueno, Rodrigo O / Moyses, Rosa M A / Jorgetti, Vanda / Kruijf, Schelto / Montenegro, Fabio L M

    Surgery

    2018  Volume 164, Issue 5, Page(s) 978–985

    Abstract: Background: No prospective randomized data exist about the impact of various strategies of parathyroidectomy in secondary hyperparathyroidism patients on quality of life and its possible relationship with metabolic status after the operation.: Method!# ...

    Abstract Background: No prospective randomized data exist about the impact of various strategies of parathyroidectomy in secondary hyperparathyroidism patients on quality of life and its possible relationship with metabolic status after the operation.
    Method: In a prospective randomized trial, the Short Form 36 Health Survey Questionnaire was applied to 69 patients undergoing parathyroidectomy through various approaches: subtotal parathyroidectomy (n = 23), total parathyroidectomy (PTx) with autotransplantation of 45 fragments (n = 25) and PTx with autotransplantation of 90 fragments (n = 21). The questionnaire was completed at three moments: (1) preoperatively, (2) 6 months after surgery, and (3) 12 months after surgery.
    Results: Quality of life improved significantly in the physical component summary score in all three groups. Subtotal parathyroidectomy scores changed from 30.6 preoperatively to 51.7 6 months after surgery and 53.7 12 months after surgery. Total arathyroidectomy with autotransplantation of 45 fragments scores changed from 33.8 preoperatively to 52.6 6 months after surgery and 55.2 12 months after surgery. Total parathyroidectomy with autotransplantation of 90 fragments scores changed from 31.8 preoperatively to 50.5 6 months after surgery and 55.2 12 months after surgery (all groups P < .0001). No significant difference was detected in the physical component summary score change among the three groups. The physical component summary score was negatively correlated to age, parathormone, and alkaline phosphatase preoperatively.
    Conclusion: Parathyroidectomy significantly improves quality of life in hemodialysis patients with secondary hyperparathyroidism, regardless of the type of operation.
    MeSH term(s) Adult ; Age Factors ; Female ; Follow-Up Studies ; Humans ; Hyperparathyroidism, Secondary/blood ; Hyperparathyroidism, Secondary/etiology ; Hyperparathyroidism, Secondary/surgery ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Parathyroid Glands/transplantation ; Parathyroid Hormone/blood ; Parathyroidectomy/adverse effects ; Parathyroidectomy/methods ; Preoperative Period ; Prospective Studies ; Quality of Life ; Renal Dialysis/adverse effects ; Surveys and Questionnaires/statistics & numerical data ; Transplantation, Autologous/adverse effects ; Transplantation, Autologous/methods ; Treatment Outcome
    Chemical Substances Parathyroid Hormone
    Language English
    Publishing date 2018-08-03
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2018.06.032
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  6. Article ; Online: Corrigendum to "Quality of life after surgery in secondary hyperparathyroidism comparing subtotal parathyroidectomy to total parathyroidectomy with immediate parathyroid autograft - a prospective randomized trial" [Surgery 164 (2018) 978-985].

    Filho, Wellington Alves / van der Plas, Willemijn Y / Brescia, Marilia D G / Nascimento, Climerio P / Goldenstein, Patricia T / Neto, Ledo M Massoni / Arap, Sergio S / Custodio, Melani R / Bueno, Rodrigo O / Moyses, Rosa M A / Jorgetti, Vanda / Kruijff, Schelto / Montenegro, Fabio L M

    Surgery

    2018  Volume 165, Issue 2, Page(s) 497

    Language English
    Publishing date 2018-11-28
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2018.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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