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  1. AU="Filice, Monica"
  2. AU=Brennan Stephen O
  3. AU="Luteran, A"
  4. AU="Pretorius, Zacharias A."
  5. AU="Yagoubi, N"
  6. AU="Nawawi, A"
  7. AU="Moore, Alexander I G"
  8. AU="Kim, Jaehoon"
  9. AU="Pańczyszyn, Elżbieta"
  10. AU="Patrick Lam"
  11. AU="Cole, Sam Wilson"
  12. AU=Emr Scott
  13. AU="Dehal, A (Kaiser Permanente Panorama City Medical Center)"
  14. AU=Sterk P J
  15. AU="Baeza, Josue"
  16. AU="Rau, Fiona"
  17. AU="Chu, Chu"
  18. AU=Yang Yifan
  19. AU="Qu, Fa-Jun"
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  31. AU="Borm, Frank J"
  32. AU="Nguyen L. Vuong"
  33. AU="Pozner, Jason N"
  34. AU="Vikash R. V. Tatayah"
  35. AU=Carneiro Flvia R.G.
  36. AU="Harrison, Tina"
  37. AU="Hanxin Lu"
  38. AU="Pinto, Bernardo I"
  39. AU=Marek Martin
  40. AU="Rachmilewitz, Eliezer"
  41. AU="Marc S Cortese"
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  1. Article: Clinical features and outcomes of patients with stable or unstable chest pain and no-obstructive coronary artery disease.

    Cambise, Nello / Telesca, Alessandro / Tremamunno, Saverio / Felici, Tamara / De Vita, Antonio / Filice, Monica / Ingrasciotta, Gessica / Ruscio, Eleonora / Crea, Filippo / Lanza, Gaetano A

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 951183

    Abstract: Background: Coronary microvascular dysfunction can be responsible for both stable angina and acute coronary syndrome (ACS). There are scarce data, however, about comparisons of clinical characteristics and outcomes of these 2 groups of patients.: ... ...

    Abstract Background: Coronary microvascular dysfunction can be responsible for both stable angina and acute coronary syndrome (ACS). There are scarce data, however, about comparisons of clinical characteristics and outcomes of these 2 groups of patients.
    Materials and methods: We studied 47 consecutive patients who underwent coronary angiography for angina syndromes and showed no obstructive stenosis. Patients were divided in 2 groups, according to their clinical presentation, i.e., stable angina (
    Results: Clinical characteristics and exercise test results of the 2 groups were largely similar. Ach testing induced epicardial or microvascular spasm in 6 (50.0%) and 10 (58.8%) stable and NSTE-ACS patients, respectively (
    Conclusion: Clinical characteristics and exercise and Ach testing results are similar in angina patients with no-obstructive coronary artery disease with a stable or NSTE-ACS presentation. Stable patients show a worse symptomatic outcome irrespective of Ach test results.
    Language English
    Publishing date 2022-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.951183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coronary microvascular dysfunction and findings of heart failure with preserved ejection fraction in patients with microvascular angina.

    Filice, Monica / Golino, Michele / Denora, Marialessia / Ruscio, Eleonora / Ingrasciotta, Gessica / Lamendola, Priscilla / Manfredonia, Laura / Villano, Angelo / Bisignani, Antonio / Ravenna, Salvatore E / DE Vita, Antonio / Lanza, Oreste / Crea, Filippo / Lanza, Gaetano A

    Minerva medica

    2022  Volume 113, Issue 5, Page(s) 838–845

    Abstract: Background: Coronary microvascular dysfunction (CMD) may cause symptoms of myocardial ischemia (microvascular angina [MVA]), but recent studies suggested that it might also contribute to the syndrome of heart failure with preserved ejection fraction ( ... ...

    Abstract Background: Coronary microvascular dysfunction (CMD) may cause symptoms of myocardial ischemia (microvascular angina [MVA]), but recent studies suggested that it might also contribute to the syndrome of heart failure with preserved ejection fraction (HFpEF). In this study we assessed the relation of CMD with findings of HFpEF in MVA patients.
    Methods: We enrolled 36 consecutive patients with MVA, in whom we assessed: 1) coronary blood flow (CBF) response to adenosine and cold pressor test (CPT) by color-Doppler echocardiography of the left anterior descending coronary artery; 2) complete echocardiographic examination; 3) N-terminal-pro-B-natriuretic peptide (NT-proBNP); 4) grade of dyspnea by the modified Medical Research Scale.
    Results: Among patients, 15 had definite HFpEF findings (group 1), 12 had equivocal HFpEF findings (group 2) and 9 had no evidence of HFpEF findings (group 3). Group 1 patients were older, had more cardiovascular risk factors and higher NT-proBNP levels (P=0.018), and showed a higher prevalence of diastolic dysfunction. Left ventricle dimensions and systolic function, however, did not differ among groups. Dyspnea was also not significantly different among groups (P=0.19). CBF to adenosine was 1.85±0.47, 1.78±0.40 1.49±0.32 in group 1, 2 and 3, respectively (P=0.13). Similarly, CBF response to CPT was 1.57±0.4, 1.49±0.2 and 1.45±0.3 in the 3 groups, respectively (P=0.74). Both CBF response to adenosine and CPT showed no relation with the severity of dyspnea symptoms.
    Conclusions: Our data suggest that in patients with MVA there is no relation between the grade of impairment of coronary microvascular dilatation and findings of HFpEF.
    MeSH term(s) Humans ; Heart Failure/complications ; Stroke Volume ; Myocardial Ischemia ; Adenosine
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-02-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.21.07135-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.132: Show issues Location:
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  3. Article ; Online: Relation of vascular dilator function and cardiac autonomic function with coronary angiography findings in patients with non-ST segment elevation acute coronary syndrome.

    Lanza, Gaetano Antonio / Ruscio, Eleonora / Ingrasciotta, Gessica / Felici, Tamara / Filice, Monica / De Vita, Antonio / Tremamunno, Saverio / Villano, Angelo / Crea, Filippo

    European heart journal. Acute cardiovascular care

    2020  

    Abstract: Background: A sizeable number of patients with a diagnosis of non-ST segment elevation acute coronary syndrome show non-obstructive coronary artery disease. In this study we assessed whether differences in vascular and cardiac autonomic function exist ... ...

    Abstract Background: A sizeable number of patients with a diagnosis of non-ST segment elevation acute coronary syndrome show non-obstructive coronary artery disease. In this study we assessed whether differences in vascular and cardiac autonomic function exist between non-ST segment elevation acute coronary syndrome patients with obstructive or non-obstructive coronary artery disease.
    Methods and results: Systemic endothelium-dependent and independent vascular dilator function (assessed by flow-mediated dilation and nitrate-mediated dilation of the brachial artery, respectively) and cardiac autonomic function (assessed by time-domain and frequency-domain heart rate variability parameters) were assessed on admission in 120 patients with a diagnosis of non-ST segment elevation acute coronary syndrome. Patients were divided into two groups according to coronary angiography findings: (a) 59 (49.2%) with obstructive coronary artery disease (≥50% stenosis in any epicardial arteries); (b) 61 (50.8%) with non-obstructive coronary artery disease. No significant differences between the two groups were found in both flow-mediated dilation (5.03 ± 2.6 vs. 5.40 ± 2.5%, respectively;
    Conclusions: Among patients admitted with a diagnosis of non-ST segment elevation acute coronary syndrome we found no significant differences in systemic vascular dilator function and cardiac autonomic function between those with obstructive coronary artery disease and those with non-obstructive coronary artery disease.
    Language English
    Publishing date 2020-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1177/2048872620918714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Relation of endothelial and cardiac autonomic function with left ventricle diastolic function in patients with type 2 diabetes mellitus.

    Tremamunno, Saverio / De Vita, Antonio / Villano, Angelo / Melita, Veronica / Ingrasciotta, Gessica / Ruscio, Eleonora / Filice, Monica / Bisignani, Antonio / Ravenna, Salvatore Emanuele / Tartaglione, Linda / Rizzo, Gaetano Emanuele / Di Leo, Mauro / Felici, Tamara / Pitocco, Dario / Lanza, Gaetano Antonio

    Diabetes/metabolism research and reviews

    2021  Volume 38, Issue 2, Page(s) e3484

    Abstract: Background and aims: Diabetes mellitus (DM) is a risk factor for left ventricle (LV) diastolic dysfunction. Aim of this study was to investigate whether endothelial and/or autonomic dysfunction are associated with LV diastolic dysfunction in DM patients. ...

    Abstract Background and aims: Diabetes mellitus (DM) is a risk factor for left ventricle (LV) diastolic dysfunction. Aim of this study was to investigate whether endothelial and/or autonomic dysfunction are associated with LV diastolic dysfunction in DM patients.
    Methods: We studied 84 non-insulin-dependent type 2 DM (T2DM) patients with no heart disease by assessing: 1) LV diastolic function by echocardiography; 2) peripheral vasodilator function, by measuring flow-mediated dilation (FMD) and nitrate-mediate dilation (NMD); 3) heart rate variability (HRV) on 24-h Holter electrocardiographic monitoring.
    Results: Twenty-five patients (29.8%) had normal LV diastolic function, while 47 (55.9%) and 12 (14.3%) showed a mild and moderate/severe diastolic dysfunction, respectively. FMD in these 3 groups was 5.25 ± 2.0, 4.95 ± 1.6 and 4.43 ± 1.8% (p = 0.42), whereas NMD was 10.8 ± 2.3, 8.98 ± 3.0 and 8.82 ± 3.2%, respectively (p = 0.02). HRV variables did not differ among groups. However, the triangular index tended to be lower in patients with moderate/severe diastolic dysfunction (p = 0.09) and a significant correlation was found between the E/e' ratio and both the triangular index (r = -0.26; p = 0.022) and LF amplitude (r = -0.29; p = 0.011).
    Conclusions: In T2DM patients an impairment of endothelium-independent, but not endothelium-dependent, dilatation seems associated with LV diastolic dysfunction. The possible role of cardiac autonomic dysfunction in diastolic dysfunction deserves investigation in larger populations of patients.
    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diastole/physiology ; Endothelium ; Heart Ventricles ; Humans ; Ventricular Function, Left
    Language English
    Publishing date 2021-07-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.3484
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2119: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Microvascular Angina　- Long-Term Exercise Stress Test Follow-up.

    Lanza, Gaetano A / Filice, Monica / De Vita, Antonio / Villano, Angelo / Manfredonia, Laura / Lamendola, Priscilla / Crea, Filippo

    Circulation journal : official journal of the Japanese Circulation Society

    2017  Volume 82, Issue 4, Page(s) 1070–1075

    Abstract: Background: A sizeable proportion of patients with primary stable microvascular angina (MVA; exercise-induced angina, positive exercise stress test [EST], normal coronary arteries) have recurrent symptoms during follow-up. There have been no previous ... ...

    Abstract Background: A sizeable proportion of patients with primary stable microvascular angina (MVA; exercise-induced angina, positive exercise stress test [EST], normal coronary arteries) have recurrent symptoms during follow-up. There have been no previous studies, however, on the long-term results of EST and their correlation with symptom outcome.Methods and Results:Follow-up EST was performed in 71 MVA patients at an average of 16.2 years (range, 5-25 years) from the first EST. Angina status was assessed on weekly frequency of angina episodes and nitroglycerin consumption and by whether symptoms had worsened, improved, or remained unchanged over time. At follow-up EST, 41 patients (group 1) had exercise-induced ischemia, whereas 30 patients (group 2) had negative EST. Compared to group 2, group 1 patients more frequently had exercise-induced dyspnea, and had a greater maximum ST-segment depression and a lower coronary blood flow response to adenosine and cold pressor test, but group 2 patients had a more frequent history of rest angina. No differences between the 2 groups were found at follow-up in angina status or change in symptom status during follow-up.
    Conclusions: Electrocardiogram results improve significantly in a sizeable proportion of patients with MVA. Changes in EST results, however, were not associated with clinical outcome.
    MeSH term(s) Adenosine/pharmacology ; Adult ; Coronary Circulation/drug effects ; Dyspnea ; Electrocardiography ; Exercise Test ; Female ; Follow-Up Studies ; Humans ; Ischemia ; Male ; Microvascular Angina/diagnosis ; Microvascular Angina/pathology ; Microvascular Angina/physiopathology ; Middle Aged ; Nitroglycerin/therapeutic use
    Chemical Substances Nitroglycerin (G59M7S0WS3) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2017-09-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-17-0657
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  6. Article ; Online: Six-Year Outcome of Subjects Without Overt Heart Disease With an Early Repolarization/J Wave Electrocardiographic Pattern.

    Lanza, Gaetano Antonio / Argirò, Alessia / Mollo, Roberto / De Vita, Antonio / Spera, Francesco / Golino, Michele / Rota, Elisabetta / Filice, Monica / Crea, Filippo

    The American journal of cardiology

    2017  Volume 120, Issue 11, Page(s) 2073–2077

    Abstract: Early repolarization" (ER) is a frequent finding at standard electrocardiogram (ECG). In this study we assessed whether ER is associated with an increased risk of events, as recently suggested by some studies. We prospectively enrolled 4,176 consecutive ...

    Abstract "Early repolarization" (ER) is a frequent finding at standard electrocardiogram (ECG). In this study we assessed whether ER is associated with an increased risk of events, as recently suggested by some studies. We prospectively enrolled 4,176 consecutive subjects without any heart disease who underwent routine ECG recording. ER was diagnosed in case of typical concave ST-segment elevation ≥0.1 mV; a J wave was diagnosed when the QRS showed a notch or a slur in its terminal part. In this study we compared the 6-year outcome of all 687 subjects with ER/J wave and 687 matched subjects without ER/J wave (controls). Both groups included 335 males and 352 females, and age was 48.8 ± 18 years. Overall, 145 deaths occurred (11%), only 11 of which attributed to cardiac causes. No sudden death was reported. Cardiac deaths occurred in 5 (0.8%) and 6 (0.9%) ER/J wave subjects and controls, respectively (odds ratio [OR] 0.85, 95% confidence interval [CI] 0.26 to 2.80, p = 0.79). Both ER (OR 1.68, 95% CI 0.21 to 13.3, p = 0.62) and J wave (OR 0.91, 95% CI 0.28 to 3.00, p = 0.88) showed no association with cardiac death. Total mortality was 11.5% in the ER/J wave group and 10.6% in the control group (OR 1.10, 95% CI 0.78 to 1.56, p = 0.58). Both ER (OR 0.44, 95% CI 0.16 to 1.24, p = 0.12) and J wave (OR 1.20, 95% CI 0.85 to 1.70, p = 0.30) showed also no association with all-cause death. In subjects without any evidence of heart disease, we found no significant association of ER/J wave with the risk of cardiac, as well as all-cause, death at medium-term follow-up.
    Language English
    Publishing date 2017-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2017.08.028
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  7. Article ; Online: Primary Stable Microvascular Angina: A Long-Term Clinical Follow-Up Study.

    Lanza, Gaetano Antonio / Filice, Monica / De Vita, Antonio / Lamendola, Priscilla / Villano, Angelo / Spera, Francesco / Golino, Michele / Rota, Elisabetta / Argirò, Alessia / Crea, Filippo

    Circulation

    2017  Volume 135, Issue 20, Page(s) 1982–1984

    MeSH term(s) Female ; Follow-Up Studies ; Humans ; Male ; Microvascular Angina
    Language English
    Publishing date 2017-05-11
    Publishing country United States
    Document type Letter
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.027685
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