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  1. Article ; Online: Chikungunya

    William M. de Souza / Guilherme S. Ribeiro / Shirlene T.S. de Lima / Ronaldo de Jesus / Filipe R.R. Moreira / Charles Whittaker / Maria Anice M. Sallum / Christine V.F. Carrington / Ester C. Sabino / Uriel Kitron / Nuno R. Faria / Scott C. Weaver

    The Lancet Regional Health. Americas, Vol 30, Iss , Pp 100673- (2024)

    a decade of burden in the Americas

    2024  

    Abstract: Summary: In the Americas, one decade following its emergence in 2013, chikungunya virus (CHIKV) continues to spread and cause epidemics across the region. To date, 3.7 million suspected and laboratory-confirmed chikungunya cases have been reported in 50 ... ...

    Abstract Summary: In the Americas, one decade following its emergence in 2013, chikungunya virus (CHIKV) continues to spread and cause epidemics across the region. To date, 3.7 million suspected and laboratory-confirmed chikungunya cases have been reported in 50 countries or territories in the Americas. Here, we outline the current status and epidemiological aspects of chikungunya in the Americas and discuss prospects for future research and public health strategies to combat CHIKV in the region.
    Keywords Chikungunya virus ; Arbovirus ; Mosquito-borne virus ; Alphavirus ; Americas ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Multilocus phylogeny and statistical biogeography clarify the evolutionary history of major lineages of turtles

    Pereira, Anieli G / Carlos G. Schrago / Filipe R.R. Moreira / Juliana Sterli

    Molecular phylogenetics and evolution. 2017 Aug., v. 113

    2017  

    Abstract: Despite their complex evolutionary history and the rich fossil record, the higher level phylogeny and historical biogeography of living turtles have not been investigated in a comprehensive and statistical framework. To tackle these issues, we assembled ... ...

    Abstract Despite their complex evolutionary history and the rich fossil record, the higher level phylogeny and historical biogeography of living turtles have not been investigated in a comprehensive and statistical framework. To tackle these issues, we assembled a large molecular dataset, maximizing both taxonomic and gene sampling. As different models provide alternative biogeographical scenarios, we have explicitly tested such hypotheses in order to reconstruct a robust biogeographical history of Testudines. We scanned publicly available databases for nucleotide sequences and composed a dataset comprising 13 loci for 294 living species of Testudines, which accounts for all living genera and 85% of their extant species diversity. Phylogenetic relationships and species divergence times were estimated using a thorough evaluation of fossil information as calibration priors. We then carried out the analysis of historical biogeography of Testudines in a fully statistical framework. Our study recovered the first large-scale phylogeny of turtles with well-supported relationships following the topology proposed by phylogenomic works. Our dating result consistently indicated that the origin of the main clades, Pleurodira and Cryptodira, occurred in the early Jurassic. The phylogenetic and historical biogeographical inferences permitted us to clarify how geological events affected the evolutionary dynamics of crown turtles. For instance, our analyses support the hypothesis that the breakup of Pangaea would have driven the divergence between the cryptodiran and pleurodiran lineages. The reticulated pattern in the ancestral distribution of the cryptodiran lineage suggests a complex biogeographic history for the clade, which was supposedly related to the complex paleogeographic history of Laurasia. On the other hand, the biogeographical history of Pleurodira indicated a tight correlation with the paleogeography of the Gondwanan landmasses.
    Keywords biogeography ; data collection ; databases ; fossils ; genes ; loci ; models ; nucleotide sequences ; phylogeny ; species diversity ; Testudines ; topology ; turtles
    Language English
    Dates of publication 2017-08
    Size p. 59-66.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 33610-5
    ISSN 1095-9513 ; 1055-7903
    ISSN (online) 1095-9513
    ISSN 1055-7903
    DOI 10.1016/j.ympev.2017.05.008
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Introduction, Dispersal, and Predominance of SARS-CoV-2 Delta Variant in Rio Grande do Sul, Brazil

    Thaís Regina y Castro / Bruna C. Piccoli / Andressa A. Vieira / Bruna C. Casarin / Luíza F. Tessele / Richard S. Salvato / Tatiana S. Gregianini / Leticia G. Martins / Paola Cristina Resende / Elisa C. Pereira / Filipe R. R. Moreira / Jaqueline G. de Jesus / Ana Paula Seerig / Marcos Antonio O. Lobato / Marli M. A. de Campos / Juliana S. Goularte / Mariana S. da Silva / Meriane Demoliner / Micheli Filippi /
    Vyctoria M. A. Góes Pereira / Alexandre V. Schwarzbold / Fernando R. Spilki / Priscila A. Trindade

    Microorganisms, Vol 11, Iss 12, p

    A Retrospective Analysis

    2023  Volume 2938

    Abstract: Mutations in the SARS-CoV-2 genome can alter the virus’ fitness, leading to the emergence of variants of concern (VOC). In Brazil, the Gamma variant dominated the pandemic in the first half of 2021, and from June onwards, the first cases of Delta ... ...

    Abstract Mutations in the SARS-CoV-2 genome can alter the virus’ fitness, leading to the emergence of variants of concern (VOC). In Brazil, the Gamma variant dominated the pandemic in the first half of 2021, and from June onwards, the first cases of Delta infection were documented. Here, we investigate the introduction and dispersal of the Delta variant in the RS state by sequencing 1077 SARS-CoV-2-positive samples from June to October 2021. Of these samples, 34.7% were identified as Gamma and 65.3% as Delta. Notably, 99.2% of Delta sequences were clustered within the 21J lineage, forming a significant Brazilian clade. The estimated clock rate was 5.97 × 10 −4 substitutions per site per year. The Delta variant was first reported on 17 June in the Vinhedos Basalto microregion and rapidly spread, accounting for over 70% of cases within nine weeks. Despite this, the number of cases and deaths remained stable, possibly due to vaccination, prior infections, and the continued mandatory mask use. In conclusion, our study provides insights into the Delta variant circulating in the RS state, highlighting the importance of genomic surveillance for monitoring viral evolution, even when the impact of new variants may be less severe in a given region.
    Keywords genomic surveillance ; viral lineages ; variants of concern ; genome analysis ; phylogeny ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Implementation of genomic surveillance of SARS-CoV-2 in the Caribbean

    Nikita S D Sahadeo / Soren Nicholls / Filipe R R Moreira / Áine O'Toole / Vernie Ramkissoon / Charles Whittaker / Verity Hill / John T McCrone / Nicholas Mohammed / Anushka Ramjag / Arianne Brown Jordan / Sarah C Hill / Risha Singh / Sue-Min Nathaniel-Girdharrie / Avery Hinds / Nuala Ramkissoon / Kris V Parag / Naresh Nandram / Roshan Parasram /
    Zobida Khan-Mohammed / Lisa Edghill / Lisa Indar / Aisha Andrewin / Rhonda Sealey-Thomas / Pearl McMillan / Ayoola Oyinloye / Kenneth George / Irad Potter / John Lee / David Johnson / Shawn Charles / Narine Singh / Jacquiline Bisesor-McKenzie / Hazel Laws / Sharon Belmar-George / Simone Keizer-Beache / Sharra Greenaway-Duberry / Nadia Ashwood / Jerome E Foster / Karla Georges / Rahul Naidu / Marsha Ivey / Stanley Giddings / Rajini Haraksingh / Adesh Ramsubhag / Jayaraj Jayaraman / Chinnaraja Chinnadurai / Christopher Oura / Oliver G Pybus / Joy St John / Gabriel Gonzalez-Escobar / Nuno R Faria / Christine V F Carrington

    PLOS Global Public Health, Vol 3, Iss 2, p e

    Lessons learned for sustainability in resource-limited settings.

    2023  Volume 0001455

    Abstract: The COVID-19 pandemic highlighted the importance of global genomic surveillance to monitor the emergence and spread of SARS-CoV-2 variants and inform public health decision-making. Until December 2020 there was minimal capacity for viral genomic ... ...

    Abstract The COVID-19 pandemic highlighted the importance of global genomic surveillance to monitor the emergence and spread of SARS-CoV-2 variants and inform public health decision-making. Until December 2020 there was minimal capacity for viral genomic surveillance in most Caribbean countries. To overcome this constraint, the COVID-19: Infectious disease Molecular epidemiology for PAthogen Control & Tracking (COVID-19 IMPACT) project was implemented to establish rapid SARS-CoV-2 whole genome nanopore sequencing at The University of the West Indies (UWI) in Trinidad and Tobago (T&T) and provide needed SARS-CoV-2 sequencing services for T&T and other Caribbean Public Health Agency Member States (CMS). Using the Oxford Nanopore Technologies MinION sequencing platform and ARTIC network sequencing protocols and bioinformatics pipeline, a total of 3610 SARS-CoV-2 positive RNA samples, received from 17 CMS, were sequenced in-situ during the period December 5th 2020 to December 31st 2021. Ninety-one Pango lineages, including those of five variants of concern (VOC), were identified. Genetic analysis revealed at least 260 introductions to the CMS from other global regions. For each of the 17 CMS, the percentage of reported COVID-19 cases sequenced by the COVID-19 IMPACT laboratory ranged from 0·02% to 3·80% (median = 1·12%). Sequences submitted to GISAID by our study represented 73·3% of all SARS-CoV-2 sequences from the 17 CMS available on the database up to December 31st 2021. Increased staffing, process and infrastructural improvement over the course of the project helped reduce turnaround times for reporting to originating institutions and sequence uploads to GISAID. Insights from our genomic surveillance network in the Caribbean region directly influenced non-pharmaceutical countermeasures in the CMS countries. However, limited availability of associated surveillance and clinical data made it challenging to contextualise the observed SARS-CoV-2 diversity and evolution, highlighting the need for development of ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 306
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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