LIVIVO - Search results -

Search results

Result 1 - 10 of total 19

Search options

Article ; Online: The effect of non-specific binding of Pd(II) complexes with N-heteroaromatic hydrazone ligands on the protein structure

Mijin Nemanja D. / Milošević Jelica / Filipović Nenad R. / Mitić Dragana / Anđelković Katarina / Polović Natalija Đ. / Todorović Tamara R.

Journal of the Serbian Chemical Society, Vol 87, Iss 10, Pp 1143-

2022 Volume 1156

Abstract: Previously, the cytotoxic actions of five Pd(II) complexes with bidentate N-heteroaromatic chelators (complexes 1–5) on a palette of several cancer cell lines were investigated. However, the results of the cytotoxic activity did not correlate with the ... ...

Abstract	Previously, the cytotoxic actions of five Pd(II) complexes with bidentate N-heteroaromatic chelators (complexes 1–5) on a palette of several cancer cell lines were investigated. However, the results of the cytotoxic activity did not correlate with the hydrophobic character of the complexes. To gain further insight into the structure–activity relationship, essential for the design of novel potential drugs, other factors, such as non-specific interactions with cellular proteins, have to be taken into account. To explore the potential non-specific influence of the complexes on protein structures, ovalbumin (OVA) was chosen as a model system to mimic cellular non-specific crowding environments with high protein concentrations. A Fourier-transform infrared spectroscopy study implied that the binding of 3 and 4 led to only moderate alternations in the secondary structures of the protein, without the possibility to penetrate into hydrophobic core of the protein and disruption of protein native fold. Contrary, the effect of complex 5 on OVA secondary structures was concentration- dependent. While the lower concentration of complex 5 had no effect on OVA structure, a doubled concentration of complex 5 led to complete disruption of the content native-like secondary structures. The concentration-dependent effect of complex 5 on the changes in secondary structures and considerable increase in the exposure of OVA hydrophobic surfaces to water may be related to a potential crosslinking that leads to OVA aggregation.
Keywords	ovalbumin model system ; protein aggregation ; dmso effect ; ligand hydrophobicity ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer.

Podolski-Renić, Ana / Čipak Gašparović, Ana / Valente, Andreia / López, Óscar / Bormio Nunes, Julia H / Kowol, Christian R / Heffeter, Petra / Filipović, Nenad R

European journal of medicinal chemistry

2024 Volume 270, Page(s) 116363

Abstract: Overcoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In this respect, Schiff base-related compounds (bearing a ... ...

Abstract	Overcoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In this respect, Schiff base-related compounds (bearing a R
MeSH term(s)	Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Schiff Bases/pharmacology ; Schiff Bases/chemistry ; Drug Resistance, Multiple ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Neoplasms/drug therapy
Chemical Substances	Coordination Complexes ; Schiff Bases ; Antineoplastic Agents
Language	English
Publishing date	2024-03-29
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2024.116363
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 784: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Structural study of Pt(II) and Pd(II) complexes with quinoline-2-carboxaldehyde thiosemicarbazone

Ristić Predrag G. / Rodić Marko V. / Filipović Nenad R. / Mitić Dragana M. / Anđelković Katarina K. / Todorović Tamara R.

Journal of the Serbian Chemical Society, Vol 86, Iss 4, Pp 393-

2021 Volume 406

Abstract: Two square–planar complexes, [PtLCl] (1) and [PdLCl] (2), were synthesized with quinoline-2-carboxaldehyde thiosemicarbazone ligand (HL), and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. In both complexes, L- is ...

Abstract	Two square–planar complexes, [PtLCl] (1) and [PdLCl] (2), were synthesized with quinoline-2-carboxaldehyde thiosemicarbazone ligand (HL), and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. In both complexes, L- is coordinated tridentately via the same donor atom set, while the fourth coordination site is occupied by a chloride ion. However, the complexes are not isostructural due to different types of non-covalent intermolecular interactions. These interactions were analyzed using Hirshfeld surfaces and two-dimensional fingerprint plots.
Keywords	single crystal x-ray diffraction ; non-covalent interactions ; n-hetero-aromatic schiff base ; chelate complexes ; Chemistry ; QD1-999
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition.

Ćurčić, Vladimir / Olszewski, Mateusz / Maciejewska, Natalia / Višnjevac, Aleksandar / Srdić-Rajić, Tatjana / Dobričić, Vladimir / García-Sosa, Alfonso T / Kokanov, Sanja B / Araškov, Jovana B / Silvestri, Romano / Schüle, Roland / Jung, Manfred / Nikolić, Milan / Filipović, Nenad R

Archiv der Pharmazie

2023 Volume 357, Issue 2, Page(s) e2300426

Abstract: Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer ... ...

Abstract	Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a-c), 2-quinoline (2a-c), and 8-hydroxy-2-quinolyl moiety (3a-c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
MeSH term(s)	Humans ; Hydrazones ; Structure-Activity Relationship ; HEK293 Cells ; Drug Screening Assays, Antitumor ; Quinolines/pharmacology ; Quinolines/chemistry ; Thiazoles ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation ; Neoplasms
Chemical Substances	Hydrazones ; Quinolines ; Thiazoles ; Antineoplastic Agents
Language	English
Publishing date	2023-11-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202300426
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uf I Zs.4: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cobalt Complex with Thiazole-Based Ligand as New

Borges, Anabela / Simões, Manuel / Todorović, Tamara R / Filipović, Nenad R / García-Sosa, Alfonso T

Molecules (Basel, Switzerland)

2018 Volume 23, Issue 6

Abstract: Pseudomonas ... ...

Abstract	Pseudomonas aeruginosa
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Cobalt/chemistry ; Ligands ; Luminescence ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Oligopeptides/biosynthesis ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/pathogenicity ; Pseudomonas aeruginosa/physiology ; Pyocyanine/biosynthesis ; Quorum Sensing ; Thiazoles/chemistry ; Thiazoles/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Ligands ; Oligopeptides ; Thiazoles ; Cobalt (3G0H8C9362) ; pyoverdin (8062-00-8) ; Pyocyanine (9OQM399341)
Language	English
Publishing date	2018-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules23061385
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters.

Marković, Sanja B / Maciejewska, Natalia / Olszewski, Mateusz / Višnjevac, Aleksandar / Puerta, Adrián / Padrón, José M / Novaković, Irena / Kojić, Snežana / Fernandes, Henrique S / Sousa, Sérgio F / Ramotowska, Sandra / Chylewska, Agnieszka / Makowski, Mariusz / Todorović, Tamara R / Filipović, Nenad R

European journal of medicinal chemistry

2022 Volume 238, Page(s) 114449

Abstract: The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has ... ...

Abstract	The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carcinoma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Cadmium/pharmacology ; Cell Line, Tumor ; Cisplatin/pharmacology ; Coordination Complexes/pharmacology ; Coordination Complexes/therapeutic use ; Humans ; Hydrazones/pharmacology ; Hydrazones/therapeutic use ; Ligands ; Neoplasms/drug therapy ; Sulfur/pharmacology ; Sulfur/therapeutic use
Chemical Substances	Antineoplastic Agents ; Coordination Complexes ; Hydrazones ; Ligands ; Cadmium (00BH33GNGH) ; Sulfur (70FD1KFU70) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-05-12
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2022.114449
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 784: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification.

Bjelogrlić, Snežana K / Todorović, Tamara R / Kojić, Milan / Senćanski, Milan / Nikolić, Milan / Višnjevac, Aleksandar / Araškov, Jovana / Miljković, Marija / Muller, Christian D / Filipović, Nenad R

Journal of inorganic biochemistry

2019 Volume 199, Page(s) 110758

Abstract: Anticancer activity of Pd complexes 1-5 with bidentate N-heteroaromatic hydrazone ligands was investigated on human acute monocytic leukemia (THP-1; cells in a suspension) and human mammary adenocarcinoma (MCF-7; two-dimensional layer and three- ... ...

Abstract	Anticancer activity of Pd complexes 1-5 with bidentate N-heteroaromatic hydrazone ligands was investigated on human acute monocytic leukemia (THP-1; cells in a suspension) and human mammary adenocarcinoma (MCF-7; two-dimensional layer and three-dimensional spheroid tumor model) cell lines. For the Pd(II) complexes with condensation products of ethyl hydrazainoacetate and quinoline-8-carboxaldehyde (complex 1) and 2-formylpyridine (complex 3), for which apoptosis was determined as a mechanism of anticancer activity, further investigation revealed that they arrest the cell cycle in G0/G1 phase, induce generation of reactive oxygen species and inhibit Topoisomerase I in vitro. In silico studies corroborate experimental findings that these complexes show topoisomerase inhibition activity in the micromolar range and indicate binding to a DNA's minor groove as another potential target. Based on the results obtained by circular dichroism and fluorescence spectroscopy measurements, the most active complexes are suitable to be delivered to a blood stream via human serum albumin.
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cisplatin/pharmacology ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Crystallography, X-Ray ; DNA Damage/drug effects ; DNA Topoisomerases, Type I/metabolism ; Humans ; Hydrazones/chemistry ; MCF-7 Cells ; Molecular Structure ; Palladium/chemistry ; Protein Binding ; Serum Albumin, Human/metabolism ; Structure-Activity Relationship ; THP-1 Cells
Chemical Substances	Antineoplastic Agents ; Coordination Complexes ; Hydrazones ; Palladium (5TWQ1V240M) ; DNA Topoisomerases, Type I (EC 5.99.1.2) ; Cisplatin (Q20Q21Q62J) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2019-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2019.110758
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 1730: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone

Đorđević Ivana S. / Vukašinović Jelena / Todorović Tamara R. / Filipović Nenad R. / Rodić Marko V. / Lolić Alekandar / Portalone Gustavo / Zlatović Mario / Grubišić Sonja

Journal of the Serbian Chemical Society, Vol 82, Iss 7-8, Pp 825-

A combined experimental and theoretical study

2017 Volume 839

Abstract: Cobalt(III) complexes derived from thio- and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis- ... ...

Abstract	Cobalt(III) complexes derived from thio- and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio- and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD–DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172035 and Grant no. 172055]
Keywords	Х-ray crystal structure ; cobalt(III) ; Schiff base ; antioxidant activity ; DFT ; Fukui ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Synthesis, antioxidant and antimicrobial activity of carbohydrazones

Božić Aleksandra R. / Filipović Nenad R. / Novaković Irena T. / Bjelogrlić Snežana K. / Nikolić Jasmina B. / Drmanić Saša Ž. / Marinković Aleksandar D.

Journal of the Serbian Chemical Society, Vol 82, Iss 5, Pp 495-

2017 Volume 508

Abstract: Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in ... ...

Abstract	Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide–water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172013]
Keywords	carbohydrazones ; antibacterial ; antifungal ; antioxidant activity ; isomers ; Chemistry ; QD1-999
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Serbian Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

Božić, Aleksandra / Marinković, Aleksandar / Bjelogrlić, Snežana / Todorović, Tamara R / Cvijetić, Ilija N / Novaković, Irena / Muller, Christian D / Filipović, Nenad R

RSC advances. 2016 Nov. 02, v. 6, no. 106

2016

Abstract: A comparative study of antitumor activity of mono- and bis-quinoline based (thio)carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells ( ... ...

Abstract	A comparative study of antitumor activity of mono- and bis-quinoline based (thio)carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells (AsPC-1). Thiocarbohydrazones (TCHs) revealed superior pro-apoptotic activity over carbohydrazones (CHs) on both tested cell phenotypes, also displaying multi-target profile activities. Programmed cell death triggered by TCHs was partially caspase-dependent, mainly caspase-8 related. Activity against cancer stem cells (CSCs) was evaluated on 2D monolayers and 3D spheroidal models, where two out of three tested bis-TCHs successfully stimulated apoptosis accompanied by a reduction in size of treated spheres. Additionally, all bis-TCHs induced significant decrease in percentage of CD44-expressing AsPC-1 cells that indicate on their ability to induce reprogramming of CSC phenotype. Current results highly support further assessment of bis-TCHs in order to specify their specific targets in cancer cells and particularly in the CSCs subpopulation.
Keywords	adenocarcinoma ; antineoplastic activity ; apoptosis ; caspase-8 ; human cell lines ; leukemia ; models ; neoplasm cells ; phenotype ; quinoline ; stem cells
Language	English
Dates of publication	2016-1102
Size	p. 104763-104781.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c6ra23940d
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Your last searches

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED