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Article: The 8

Lancia, Andrea / Merizzoli, Elisa / Filippi, Andrea Riccardo

2019 Volume 7, Issue Suppl 6, Page(s) S205

Language	English
Publishing date	2019-09-05
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm.2019.07.02
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Article ; Online: Future perspectives of radiation therapy for Hodgkin Lymphoma: Risk-adapted, response-adapted, and safer than before.

Saddi, Jessica / Barcellini, Amelia / Gotti, Manuel / Mazzacane, Alessandro / Tolva, Alessandra / Lazic, Tanja / Arcaini, Luca / Zecca, Marco / Orlandi, Ester / Filippi, Andrea Riccardo

Hematological oncology

2024 Volume 42, Issue 3, Page(s) e3269

Abstract: Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, ... ...

Abstract	Classical Hodgkin lymphoma is a lymphoproliferative disease with a good prognosis mainly seen in young people. Nevertheless secondary malignancy, cardiac disease and infertility may affect the long survivors with significant impact on quality of life, morbidity and overall survival. In the last decades several treatment strategies were evaluated to reduce the toxicity of first line treatment such as avoiding radiotherapy or its reduction in terms of dosage and extension. Many trials including interim Positron Emission Tomography evaluation fail to compare efficacy between combined modality treatment versus chemotherapy alone in particular in early stage disease. In this review we analyze which subset of patients could take advantage from proton therapy in terms of toxicity and cost effectiveness.
MeSH term(s)	Humans ; Hodgkin Disease/radiotherapy ; Proton Therapy/adverse effects ; Proton Therapy/methods
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.3269
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Article ; Online: Letter from Italy: First practical indications for radiation therapy departments during COVID-19 outbreak.

Filippi, Andrea Riccardo / Russi, Elvio / Magrini, Stefano Maria / Corvò, Renzo

International journal of radiation oncology, biology, physics

2020 Volume 107, Issue 3, Page(s) 597–599

MeSH term(s)	COVID-19 ; Caregivers ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Outbreaks ; Hospital Departments ; Humans ; Italy/epidemiology ; Neoplasms/radiotherapy ; Pandemics/prevention & control ; Patient Safety ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Radiotherapy
Keywords	covid19
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Editorial
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2020.03.007
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Article: Intrathoracic core needle biopsy and repeat biopsy for PD-L1 evaluation in non-small cell lung cancer.

Stella, Giulia Maria / Bortolotto, Chandra / Filippi, Andrea Riccardo

Journal of thoracic disease

2018 Volume 10, Issue Suppl 33, Page(s) S4031–S4033

Language	English
Publishing date	2018-10-22
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd.2018.09.92
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Article ; Online: Unmet needs in the management of unresectable stage III non-small cell lung cancer: a review after the 'radio talk' webinars.

Borghetti, Paolo / Guerini, Andrea Emanuele / Sangalli, Claudia / Piperno, Gaia / Franceschini, Davide / La Mattina, Salvatore / Arcangeli, Stefano / Filippi, Andrea Riccardo

Expert review of anticancer therapy

2022 Volume 22, Issue 5, Page(s) 549–559

Abstract: Introduction: Stage III non-small cell lung cancer (NSCLC) is a variable entity, encompassing bulky primary tumors, nodal involvement, or both. Multidisciplinary evaluation is essential to discuss multiple treatment options, to outline optimal ... ...

Abstract	Introduction: Stage III non-small cell lung cancer (NSCLC) is a variable entity, encompassing bulky primary tumors, nodal involvement, or both. Multidisciplinary evaluation is essential to discuss multiple treatment options, to outline optimal management, and to examine the main debated topics and critical issues not addressed by current trials and guidelines that influence daily clinical practice. Areas covered: From March to 5 May 2021 ,meetings were scheduled in a webinar format titled 'Radio Talk' due to the COVID-19 pandemic; the faculty was composed of 6 radiation oncologists from 6 different Institutions of Italy, all of them were the referring radiation oncologist for lung cancer treatment at their respective departments and were or had been members of AIRO (Italian Association of Radiation Oncology) Thoracic Oncology Study Group. The topics covered included: pulmonary toxicity, cardiac toxicity, radiotherapy dose, fractionation and volumes, unfit/elderly patients, multidisciplinary management. Expert opinion: The debate was focused on the unmet needs triggered by case reports, personal experiences and questions; the answers were often not univocal; however, the exchange of opinion and the contribution of different centers confirmed the role of multidisciplinary management and the necessity that the most critical issues should be investigated in clinical trials.
MeSH term(s)	Aged ; COVID-19 ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Neoplasm Staging ; Pandemics ; Radiation Oncologists
Language	English
Publishing date	2022-04-25
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1080/14737140.2022.2069098
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Article: Malignant Pleural Mesothelioma: Genetic and Microenviromental Heterogeneity as an Unexpected Reading Frame and Therapeutic Challenge.

Abbott, David Michael / Bortolotto, Chandra / Benvenuti, Silvia / Lancia, Andrea / Filippi, Andrea Riccardo / Stella, Giulia Maria

Cancers

2020 Volume 12, Issue 5

Abstract: Mesothelioma is a malignancy of serosal membranes including the peritoneum, pleura, pericardium and the tunica vaginalis of the testes. Malignant mesothelioma (MM) is a rare disease with a global incidence in countries like Italy of about 1.15 per 100, ... ...

Abstract	Mesothelioma is a malignancy of serosal membranes including the peritoneum, pleura, pericardium and the tunica vaginalis of the testes. Malignant mesothelioma (MM) is a rare disease with a global incidence in countries like Italy of about 1.15 per 100,000 inhabitants. Malignant Pleural Mesothelioma (MPM) is the most common form of mesothelioma, accounting for approximately 80% of disease. Although rare in the global population, mesothelioma is linked to industrial pollutants and mineral fiber exposure, with approximately 80% of cases linked to asbestos. Due to the persistent asbestos exposure in many countries, a worldwide progressive increase in MPM incidence is expected for the current and coming years. The tumor grows in a loco-regional pattern, spreading from the parietal to the visceral pleura and invading the surrounding structures that induce the clinical picture of pleural effusion, pain and dyspnea. Distant spreading and metastasis are rarely observed, and most patients die from the burden of the primary tumor. Currently, there are no effective treatments for MPM, and the prognosis is invariably poor. Some studies average the prognosis to be roughly one-year after diagnosis. The uniquely poor mutational landscape which characterizes MPM appears to derive from a selective pressure operated by the environment; thus, inflammation and immune response emerge as key players in driving MPM progression and represent promising therapeutic targets. Here we recapitulate current knowledge on MPM with focus on the emerging network between genetic asset and inflammatory microenvironment which characterize the disease as amenable target for novel therapeutic approaches.
Language	English
Publishing date	2020-05-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12051186
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Article ; Online: In Reply to Scarpelli et al.

Specht, Lena / Wong, Jeffrey Y C / Filippi, Andrea Riccardo / Dabaja, Bouthaina Shbib / Yahalom, Joachim

International journal of radiation oncology, biology, physics

2020 Volume 108, Issue 5, Page(s) 1396

MeSH term(s)	Humans ; Lymphoma ; Whole-Body Irradiation
Language	English
Publishing date	2020-11-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2020.07.2315
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Article ; Online: Rationale and Design of a Single-Arm, Phase 2, Multi-Center Study of Chemo-Immunotherapy Followed by Hypo-Fractionated RT and Maintenance Immunotherapy in Patients With Unresectable Stage III NSCLC: The DEDALUS Trial.

Filippi, Andrea Riccardo / Agustoni, Francesco / Arcangeli, Stefano / Cortinovis, Diego / Ferrari, Alessandra / Cicognini, Daniela / Saddi, Jessica / Klersy, Catherine / Pedrazzoli, Paolo / Malapelle, Umberto / Grossi, Francesco

Clinical lung cancer

2023 Volume 24, Issue 3, Page(s) e122–e125

Abstract: Introduction/background: This single-arm, phase 2, multi-center, study aims to assess the safety and efficacy of a regimen of induction chemo-immunotherapy followed by de-intensified, hypo-fractionated thoracic radiotherapy (RT) given concurrently with ... ...

Abstract	Introduction/background: This single-arm, phase 2, multi-center, study aims to assess the safety and efficacy of a regimen of induction chemo-immunotherapy followed by de-intensified, hypo-fractionated thoracic radiotherapy (RT) given concurrently with durvalumab and maintenance durvalumab in patients with unresectable, stage III NSCLC. Material and methods: we will enroll 45 patients with unresectable stage III NSCLC, any PD-L1, deemed ineligible for concurrent CRT by a thoracic oncology multidisciplinary team, and candidate to sequential chemoradiation followed by durvalumab. Results: Primary endpoint is safety, defined by the incidence of grade 3 and 4 possibly related adverse events (PRAEs) within 6 months from the initiation of treatment. The secondary objectives are PFS and OS (median and 12 months). Ancillary endpoints are molecular response evaluated by cfDNA isolation baseline, after chemo-immuno RT and at progression, and radiomics analysis on CT scans at baseline and before maintenance. Conclusion: DEDALUS phase 2 trial explores the safety and efficacy of a novel sequence of chemo-radiation (with de-intensified RT) plus the anti-PD-L1 agent durvalumab in patients with stage III unresectable NSCLC who are candidates to sequential chemoradiation plus maintenance immunotherapy.
MeSH term(s)	Humans ; Lung Neoplasms/therapy ; Immunotherapy ; Chemoradiotherapy ; Induction Chemotherapy ; Carcinoma, Non-Small-Cell Lung/therapy
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Multicenter Study ; Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2022.12.015
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Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Renewed interest for low-dose radiation therapy in follicular lymphomas: From biology to clinical applications.

Ciammella, Patrizia / Luminari, Stefano / Arcaini, Luca / Filippi, Andrea Riccardo

Hematological oncology

2018 Volume 36, Issue 5, Page(s) 723–732

Abstract: Follicular lymphoma (FL) is the most common subtype of indolent non-Hodgkin lymphoproliferative disorders. Treatment strategies for FL may include several therapeutic choices, ranging from a "watchful waiting" approach to stem cell transplantation, ... ...

Abstract	Follicular lymphoma (FL) is the most common subtype of indolent non-Hodgkin lymphoproliferative disorders. Treatment strategies for FL may include several therapeutic choices, ranging from a "watchful waiting" approach to stem cell transplantation, mostly depending on staging, age, risk factors, and disease burden at diagnosis. The high radiosensitivity of FL compared with other solid tumors has been known since the beginning of radiotherapy treatment in lymphoma patients. Doses of 24 to 40 Gy were considered appropriate in first line curative treatment for localized disease (stages I-II), but several publications investigating low-dose radiotherapy (LDRT) of 4Gy (2 × 2Gy) reported an overall response rate surprisingly high. Due to its high local efficacy and negligible toxicity, LDRT might be offered to both early and advanced stage FL patients in combination with new agents, at diagnosis or after several lines of systemic therapy. The aim of this review is to summarize and discuss the current knowledge on LDRT for FL and its potential application in a curative setting in combination with new drugs for both early and advanced disease.
MeSH term(s)	Animals ; Disease-Free Survival ; Humans ; Lymphoma, Follicular/mortality ; Lymphoma, Follicular/pathology ; Lymphoma, Follicular/radiotherapy ; Neoplasm Staging ; Radiotherapy Dosage ; Survival Rate
Language	English
Publishing date	2018-08-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.2538
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Article ; Online: Recent advancement on PD-L1 expression quantification: the radiologist perspective on CT-guided FNAC.

Casale, Silvia / Bortolotto, Chandra / Stella, Giulia Maria / Filippi, Andrea Riccardo / Gitto, Salvatore / Bottinelli, Olivia Maria / Carnevale, Sergio / Morbini, Patrizia / Preda, Lorenzo

Diagnostic and interventional radiology (Ankara, Turkey)

2021 Volume 27, Issue 2, Page(s) 214–218

Abstract: Purpose: We aimed to evaluate the feasibility, accuracy, and safety of Programmed Death-1/ Programmed Death-Ligand 1 (PD-1/ PD-L1) expression quantification in cytology cell-block samples obtained through transthoracic CT-guided fine-needle aspiration ... ...

Abstract	Purpose: We aimed to evaluate the feasibility, accuracy, and safety of Programmed Death-1/ Programmed Death-Ligand 1 (PD-1/ PD-L1) expression quantification in cytology cell-block samples obtained through transthoracic CT-guided fine-needle aspiration cytology (FNAC) from the interventional radiologist's perspective. Methods: We performed a consecutive unselected series of 361 CT-guided biopsies of pulmonary nodules and masses which came to our observation from June 2017 to October 2018. For each case, exhaustive clinical, morphologic, molecular and tomographic data were available. All the material obtained was fixed in formalin to obtain a cell-block for the pathologist, who performed immunohistochemical analysis to detect PD-L1 expression levels on each sample. Results: Of all the analyzed samples, 93.6% (338/361) were defined to be diagnostic, including neoplastic (72%, 260/361) and non-neoplastic lesions (21.6%, 78/361); only 6.4% (23/361) of them resulted in nondiagnostic specimens. Non-small cell lung cancer (NSCLC) accounted for 73.8% of neoplastic lesions (192/260): most of them were adenocarcinoma (83%, 160/192), followed by squamous carcinoma (14%, 27/192) and poorly differentiated carcinoma (3%, 5/192). In 96% of NSCLC (184/192), the diagnosis was reached either in the absence of complications or with early minor complications. PD-L1 expression was evaluated in all 192 NSCLC cytology specimens: 180 immunostainings were found to be adequate for PD-L1 testing. In 76% of cases, PD-L1 expression level was lower than 50%. Conclusion: The findings of our study indicate that PD-L1 quantification using a cell-block approach on CT-guided FNAC is a feasible and safe technique and should be taken into account alongside with core biopsy approach, especially in case of advanced disease and/or fragile and older patients.
MeSH term(s)	B7-H1 Antigen/genetics ; Carcinoma, Non-Small-Cell Lung ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/genetics ; Radiologists ; Tomography, X-Ray Computed
Chemical Substances	B7-H1 Antigen
Language	English
Publishing date	2021-01-15
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2184145-7
ISSN	1305-3612 ; 1305-3612
ISSN (online)	1305-3612
ISSN	1305-3612
DOI	10.5152/dir.2021.19545
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