Article ; Online: Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination.
2023 Volume 96, Issue 1, Page(s) e29317
Abstract: People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected ... ...
| Abstract | People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose-sparing i.d. vaccination was superior to s.c. vaccination and promoted T-cell polyfunctionality, and the expression of the gut-homing marker α4β7 integrin on lymphocytes. HIV-1-infected individuals with CD4 T-cell counts ≤500/mm |
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| MeSH term(s) | Humans ; HIV-1 ; HIV Infections ; CD4-Positive T-Lymphocytes ; Vaccination | |||||
| Language | English | |||||
| Publishing date | 2023-12-27 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 752392-0 | |||||
| ISSN | 1096-9071 ; 0146-6615 | |||||
| ISSN (online) | 1096-9071 | |||||
| ISSN | 0146-6615 | |||||
| DOI | 10.1002/jmv.29317 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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