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Article ; Online: Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: insights from the START Study

De Luca, Leonardo / Temporelli, Pier Luigi / Gulizia, Michele Massimo / Gonzini, Lucio / Ammaturo, Tiziana Anita / Tedesco, Luigi / Pede, Silvia / Oliva, Fabrizio / Gabrielli, Domenico / Colivicchi, Furio / Averna, Maurizio R. / Maggioni, A.P. / Lucci, D. / Lorimer, A. / Orsini, G. / Gonzini, L. / Fabbri, G. / Priami, P. / Maras, P. /
Ramani, F. / Falcone, C. / Passarelli, I. / Mauri, S. / Calabrò, P. / Bianchi, R. / Di Palma, G. / Mascia, F. / Vetrano, A. / Fusco, A. / Proia, E. / Colivicchi, F. / Aiello, A. / Tomai, F. / Licitra, R. / Petrolini, A. / Bosco, B. / Magliari, F. / Callerame, M. / Mazzella, T. / Lettica, G.V. / Coco, G. / Incao, F. / Marinacci, L. / D'Addario, S. / Tartaglione, S.N. / Ubaldi, S. / Sanchez, F.A. / Costa, P. / Manca, G. / Failla, M. / Scherillo, M. / Procaccini, V. / Formigli, D. / Senni, M. / Luminita, E.M. / Bonomo, P. / Mossa, C. / Corda, S. / Colavita, A.R. / Trevisonno, G. / Vizzari, G. / Cosentino, N. / Formaro, C. / Paolillo, C. / Nalin, I.L. / De Rosa, F.M. / Fontana, F. / Fuscaldo, G.F. / Passamonti, E. / Bertella, E. / Calvaruso, E.V. / Varani, E. / Tani, F. / Cicchitelli, G. / Gabrielli, D. / Paoloni, P. / Marziali, A. / Campo, G. / Tebaldi, M. / Biscaglia, S. / Biase, M Di / Brunetti, N.D. / Gallotta, A.M. / Mattei, L. / Marini, R. / Balsemin, F. / Urbano, M.D. / Naio, R. / Vicinelli, P. / Arena, G. / Mazzini, M. / Gigli, N. / Miserrafiti, B. / Monopoli, A. / Mortara, A. / Delfino, P. / Chioffi, M.M. / Mariño, P. / Gravellone, M. / Barbieri, L. / Ledda, A. / Geraci, G. / Carmina, M.G. / Raisaro, A.E. / Di Giacomo, C. / Somaschini, A. / Fasano, M.L. / Sannazzaro, M. / Arcieri, R. / Pantaleoni, M. / Leuzzi, C. / Gorlato, G. / Greco, G. / Chiera, A. / Ammaturo, T.A. / Malanchini, G. / Del Corral, M.P. / Tedesco, L. / Pede, S. / Urso, L.G. / Piscione, F. / Galasso, G. / Provasoli, S. / Fattore, L. / Lucca, G. / Cresti, A. / Cardillo, A. / Fera, M.S. / Vennettilli, F. / Gaudio, C. / Paravati, V. / Caldarola, P. / Locuratolo, N. / Verlato, R. / De Conti, F. / Turiano, G. / Preti, G. / Moretti, L. / Silenzi, S. / Colonna, G. / Picciolo, A. / Nicosia, A. / Cascone, C. / Di Sciascio, G. / Mangiacapra, F. / Russo, A. / Mastroianno, S. / Esposito, G. / Cosmi, F. / D'Orazio, S. / Costantini, C. / Lanari, A. / De Rosa, P. / Esposito, L. / Bilato, C. / Valle, C Dalla / Ceresa, M. / Colombo, E. / Pennisi, V. / Casciola, G. / Driussi, M. / Bisceglia, T. / Scalvini, S. / Rivadossi, F. / Volpe, M. / Comito, F. / Scorzoni, D. / Grimoldi, P. / Lagioia, R. / Santoro, D. / De Cesare, N. / Comotti, T. / Poli, A. / Martina, P. / Musolino, M.F. / Multari, E.I. / Bilardo, G. / Scalchi, G. / Olivieri, C. / Caranci, F. / Pavan, D. / Ganci, G. / Mariani, A. / Falchetti, E. / Lanzillo, T. / Caccavale, A. / Bongo, A.S. / Rizzi, A. / Favilli, R. / Maffei, S. / Mallardo, M. / Fulgione, C. / Bordin, F. / Bonmassari, R. / Battaia, E. / Puzzo, A. / Vianello, G. / D'Arpino, A. / Romei, M. / Pajes, G. / Petronzelli, S. / Ghezzi, F. / Brigido, S. / Pignatelli, L. / Brscic, E. / Sori, P. / Russo, M. / Biancolillo, E. / Ignone, G. / De Giorgio, N.A. / Campaniello, C. / Ponticelli, P. / Margonato, A. / Gerosa, S. / Cutaia, A. / Casalicchio, C. / Bartolomucci, F. / Larosa, C. / Spadafina, T. / Putignano, A. / De Cristofaro, R. / Bernardi, L. / Sommariva, L. / Celestini, A. / Bertucci, C.M. / Marchetti, M. / Grisolia, E Franceschini / Ammendolea, C. / Carini, M. / Scipione, P. / Politano, M. / Rubino, G. / Reina, C. / Peccerillo, N. / Paloscia, L. / D'Alleva, A. / Petacchi, R. / Pignalosa, M. / Lucchetti, D. / Di Palma, F. / La Mastra, R.A. / Amico, A.F. / Filippis, M De / Fontanella, B. / Zanini, G. / Casolo, G. / Del Meglio, J. / Parato, V.M. / Genovesi, E. / D'Alimonte, A. / Miglioranza, A. / Alessandri, N. / Moscariello, F. / Mauro, C. / Sasso, A. / Caso, P. / Petrillo, C. / Napoletano, C. / Paparoni, S.R. / Bernardo, V. / Serdoz, R. / Rotunno, R. / Oppo, I. / Aloisio, A. / Aurelio, A. / Licciardello, G. / Cassaniti, L. / Gulizia, M.M. / Francese, G.M. / Marcassa, C. / Temporelli, P.L. / Villani, R. / Zorzoli, F. / Mileto, F. / Vecchis, M De / Scolozzi, D. / Lupi, G. / Caruso, D. / Rebulla, E. / La Fata, B. / Anselmi, M. / Girardi, P. / Borruso, E. / Ferrantelli, G. / Sassone, B. / Bressan, S. / Capriolo, M. / Pelissero, E. / Piancastelli, M. / Gobbi, M. / Cocco, F. / Bruno, M.G. / Berti, S. / Lo Surdo, G. / Tanzi, P. / De Rosa, R. / Vilei, E. / De Iaco, M.R. / Grassi, G. / Zanella, C. / Marullo, L. / Alfano, G. / Pelaggi, P. / Talarico, R. / Tuccillo, B. / Irace, L. / Proietti, F. / Di Croce, G. / Di Lorenzo, L. / Zarrilli, A. / Bongini, M. / Ranise, A. / Aprile, A. / Fornengo, C. / Capogrosso, V. / Tranghese, A. / Golia, B. / Marziano, A. / Roncon, L. / Picariello, C. / Bagni, E. / Leci, E. / Gregorio, G. / Gatto, F. / Piemonte, F. / Gervasio, F. / Navazio, A. / Guerri, E. / Belmonte, E. / Marino, F. / Di Belardino, N. / Di Nuzzo, M.R. / Epifani, M. / Comolatti, G. / Conconi, B. / Benea, D. / Casu, G. / Merella, P. / Ammirati, M.A. / Corrado, V.M. / Spagnolo, D. / Caico, S.I. / Bonizzato, S. / Margheri, M. / Corrado, L. / Antonicelli, R. / Ferrigno, C. / Merlino, A. / Nassiacos, D. / Antonelli, A. / Marchese, A. / Uguccioni, M. / Villella, A. / Bechi, S. / Lo Bianco, F. / Bedogni, F. / Negro, L. / Donato, L. / Statile, D. / Cassin, M. / Fedele, F. / Granatelli, A. / Calcagno, S. / Politi, A. / Pani., A.

Nutrition, Metabolism and Cardiovascular Diseases. 2023 Aug. 07

2023  

Abstract: Elevated triglyceride (TG) levels seem to identify subjects at increased cardiovascular risk, independent of LDL-C levels. We sought to evaluate the predictive role of hypertriglyceridemia, defined as TG levels ≥150 mg/dl, in very high risk (VHR) ... ...

Abstract Elevated triglyceride (TG) levels seem to identify subjects at increased cardiovascular risk, independent of LDL-C levels. We sought to evaluate the predictive role of hypertriglyceridemia, defined as TG levels ≥150 mg/dl, in very high risk (VHR) patients with chronic coronary syndromes (CCS) treated with statins. Using the data from the STable Coronary Artery Diseases RegisTry (START) study, an Italian nationwide registry, we assessed the association between the TG levels and baseline clinical characteristics, pharmacological treatment and major adverse cardio-cerebrovascular events (MACCE) at 1 year in a large cohort of statin-treated patients at VHR. Of the 4751 consecutive patients with CCS enrolled in the registry and classified as VHR, 2652 (55.8%) had TG values available (mean 120.6±54.9) and were treated with at least a statin at baseline: 2019 (76.1%) with TG <150 and 633 (23.9%) with TG ≥150 mg/dl. At 1 year from enrolment, MACCE occurred in 168 (6.3%) patients, without differences between the two groups of TG (5.9 vs 7.6%; p=0.14). At multivariable analysis, hypertriglyceridemia did not result as independent predictor of the MACCE (hazard ratio: 1.16; 95% confidence intervals: 0.82-1.64; p=0.42). In the present large, nationwide cohort of consecutive CCS patients at VHR with statin-controlled LDL-C levels, hypertriglyceridemia was present in around 24% of cases and did not result as predictor of MACCE at 1 year. Further studies with a longer follow-up and larger sample size are needed to better define the prognostic role of TG levels when intensive LDL lowering therapies are used.
Keywords coronary vessels ; hazard ratio ; hypertriglyceridemia ; metabolism ; nutrition ; risk ; sample size ; triacylglycerols ; LDL-C ; management ; treatment ; statin ; ezetimibe
Language English
Dates of publication 2023-0807
Publishing place Elsevier B.V.
Document type Article ; Online
Note Pre-press version
ZDB-ID 1067704-5
ISSN 0939-4753
ISSN 0939-4753
DOI 10.1016/j.numecd.2023.07.036
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Zs.A 3149: Show issues Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)
Database NAL-Catalogue (AGRICOLA)

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Zs.A 3149: Show issues Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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