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Book: Interleukin-10 in health and disease

Fillatreau, Simon

(Current topics in microbiology and immunology ; 380)

2014

Author's details	Simon Fillatreau ... ed
Series title	Current topics in microbiology and immunology ; 380
Collection
Keywords	Il-10 polymorphisms ; TLR triggering ; IL-10 expression ; Counter-regulation of immunity ; Anti-inflammatory cytokine ; Viral IL-10 homologs ; Interleukin-10 ; Maintenance of immune homeostasis ; Intestinal immunity ; Tr1 cells ; Innate microbial recognition ; Interleukin 10
Language	English
Size	VIII, 238 S.
Publisher	Springer
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT018351782
ISBN	978-3-662-43491-8 ; 3-662-43491-1 ; 9783662434925 ; 366243492X
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus.

Fillatreau, Simon

Cell reports. Medicine

2023 Volume 4, Issue 1, Page(s) 100903

Abstract: B cells and autoantibodies have well-described pathological roles in systemic lupus erythematosus (SLE). Bradford et al. ...

Abstract	B cells and autoantibodies have well-described pathological roles in systemic lupus erythematosus (SLE). Bradford et al.
MeSH term(s)	Male ; Humans ; Interferon Type I ; Autoantibodies ; B-Lymphocytes ; Lupus Erythematosus, Systemic
Chemical Substances	Interferon Type I ; Autoantibodies
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2022.100903
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Article ; Online: Regulatory functions of B cells and regulatory plasma cells.

Fillatreau, Simon

Biomedical journal

2019 Volume 42, Issue 4, Page(s) 233–242

Abstract: B cells critically contribute to health through the production of antibodies that provide a vital line of defence against infectious agents. In addition, B cells are known to play an integrative role in immunity, acting as crucial antigen-presenting ... ...

Abstract	B cells critically contribute to health through the production of antibodies that provide a vital line of defence against infectious agents. In addition, B cells are known to play an integrative role in immunity, acting as crucial antigen-presenting cells for T cells, and being an important source of cytokines that can target multiple cell types including stromal cells, innate cells, and adaptive lymphocytes. This review focuses on the role of B cells as negative regulators of immunity through the production of interleukin-10 (IL-10) in autoimmune, infectious, and malignant diseases. It discusses the phenotypes of the B cell subsets most competent to produce IL-10 in vitro and to exert suppressive functions in vivo upon adoptive transfer in recipient mice, the signals and transcription factors regulating IL-10 expression in B cells, and the recent identification of plasmocytes, including short-lived plasmablasts and long-lived plasma cells, as an important source of IL-10 in secondary lymphoid organs and inflamed tissues in vivo during mouse and human diseases. With our increasing knowledge of this non-canonical B cell function a coherent framework starts emerging that will help monitoring and targeting this B cell function in health and disease.
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; Cell Differentiation/immunology ; Cytokines/metabolism ; Humans ; Immunity/immunology ; Plasma Cells/cytology ; T-Lymphocytes/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2019-09-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2698541-X
ISSN	2320-2890 ; 2319-4170
ISSN (online)	2320-2890
ISSN	2319-4170
DOI	10.1016/j.bj.2019.05.008
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Article ; Online: Natural regulatory plasma cells.

Fillatreau, Simon

Current opinion in immunology

2018 Volume 55, Page(s) 62–66

Abstract: B cells can generate several types of antibody-secreting cells, including plasmablasts that divide and are short lived, as well as plasma cells that do not proliferate and can persist for extended time periods. Here, we discuss the identification of a ... ...

Abstract	B cells can generate several types of antibody-secreting cells, including plasmablasts that divide and are short lived, as well as plasma cells that do not proliferate and can persist for extended time periods. Here, we discuss the identification of a novel subset of non-dividing plasma cells specialized in the production of interleukin(IL)-10. These cells develop at steady state, including in germ-free mice, via a mechanism dependent on the B cell receptor for antigen and possibly involving the recognition of damaged cells. They are characterized by the expression of the inhibitory receptor LAG-3, and also express CD200, PD-L1, as well as PD-L2. Their specialized epigenome allows them to produce IL-10 within hours after stimulation, which altogether qualify these cells as natural regulatory plasma cells.
MeSH term(s)	Animals ; Humans ; Interleukin-10/immunology ; Plasma Cells/immunology
Chemical Substances	Interleukin-10 (130068-27-8)
Language	English
Publishing date	2018-10-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2018.09.012
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Article ; Online: Regulatory B cells gain muscles with a leucine-rich diet.

Manfroi, Benoît / Fillatreau, Simon

Immunity

2022 Volume 55, Issue 6, Page(s) 970–972

Abstract: Regulatory B cells infiltrate the microenvironment of solid tumors. However, their identification and characterization remain incomplete. In this issue of Immunity, Wang and colleagues characterize a new subset of leucine-induced regulatory B cells ... ...

Abstract	Regulatory B cells infiltrate the microenvironment of solid tumors. However, their identification and characterization remain incomplete. In this issue of Immunity, Wang and colleagues characterize a new subset of leucine-induced regulatory B cells involved in colorectal cancer (CRC) immunoevasion in mice and humans.
MeSH term(s)	Animals ; B-Lymphocytes, Regulatory ; Colorectal Neoplasms ; Diet ; Leucine ; Mice ; Muscles ; Neoplasms ; Tumor Microenvironment
Chemical Substances	Leucine (GMW67QNF9C)
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2022.05.011
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Article ; Online: B cells and their cytokine activities implications in human diseases.

Fillatreau, Simon

Clinical immunology (Orlando, Fla.)

2017 Volume 186, Page(s) 26–31

Abstract: B cells are the only cell type that can give rise to antibody-producing cells, and the only cell type whose selective depletion can, today, lead to an improvement of a wide range of immune-mediated inflammatory diseases, including disorders not primarily ...

Abstract	B cells are the only cell type that can give rise to antibody-producing cells, and the only cell type whose selective depletion can, today, lead to an improvement of a wide range of immune-mediated inflammatory diseases, including disorders not primarily driven by autoantibodies. Here, I discuss this paradoxical observation, and propose that the capacity of B cells to act as cytokine-producing cells explains how they can control monocyte activity and subsequently disease pathogenesis. Together with current data on the effect of anti-CD20 B cell-depleting reagents in the clinic, this novel knowledge on B cell heterogeneity opens the way for novel safer and more efficient strategies to target B cells. The forthcoming identification of disease-relevant B cell subsets is awaited to permit their monitoring and specific targeting in a personalized medicine approach.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/immunology ; B-Lymphocytes/immunology ; Cytokines/immunology ; Humans ; Multiple Sclerosis/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2017-07-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2017.07.020
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Article: Regulatory roles of B cells in infectious diseases.

Fillatreau, Simon

Clinical and experimental rheumatology

2016 Volume 34, Issue 4 Suppl 98, Page(s) 1–5

Abstract: B lymphocytes provide essential mechanisms of protection against infectious diseases. The secretion of specific antibodies by long-lived plasma cells is thought to account for the improved resistance afforded by most successful vaccines against pathogens. ...

Abstract	B lymphocytes provide essential mechanisms of protection against infectious diseases. The secretion of specific antibodies by long-lived plasma cells is thought to account for the improved resistance afforded by most successful vaccines against pathogens. Accordingly, a goal in vaccine development is to induce potent B cell responses in order to drive the efficient formation of long-lived antibody-secreting cells. However, the roles of activated B cells are complex in infectious diseases. It was recently observed that activated B cells could also negatively regulate host defence mechanisms, both during primary infection and, after vaccination, upon secondary challenge, via mechanisms involving their production of the anti-inflammatory cytokines interleukin (IL)-10 and IL-35. Remarkably, the B cells expressing IL-10 and IL-35 in vivo were distinct subsets of IgMhiCD19+CD138hi antibody-secreting cells. A better understanding of the diverse roles of these distinct antibody-secreting cell subsets in immunity and immunological memory, as well as of the signals controlling their generation, might help the rational development of better prophylactic and therapeutic vaccines.
MeSH term(s)	Animals ; Antibodies/immunology ; Antibodies/metabolism ; B-Lymphocytes, Regulatory/immunology ; B-Lymphocytes, Regulatory/metabolism ; Communicable Diseases/immunology ; Communicable Diseases/metabolism ; Communicable Diseases/therapy ; Cytokines/immunology ; Cytokines/metabolism ; Host-Pathogen Interactions ; Humans ; Immunity, Humoral ; Immunologic Memory ; Immunotherapy/methods ; Lymphocyte Activation ; Phenotype ; Vaccination ; Vaccines/immunology ; Vaccines/therapeutic use
Chemical Substances	Antibodies ; Cytokines ; Vaccines
Language	English
Publishing date	2016-07
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article ; Online: Pathogenic functions of B cells in autoimmune diseases: IFN-γ production joins the criminal gang.

Fillatreau, Simon

European journal of immunology

2015 Volume 45, Issue 4, Page(s) 966–970

Abstract: B-cell depletion therapy has emerged as a powerful strategy to intercept the progression of T-cell-mediated autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, or relapsing remitting multiple sclerosis. However, its mode of action remains ... ...

Abstract	B-cell depletion therapy has emerged as a powerful strategy to intercept the progression of T-cell-mediated autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, or relapsing remitting multiple sclerosis. However, its mode of action remains incompletely defined, reflecting our incomplete understanding of the pathogenic functions of B cells in such pathologies. B cells can contribute to immune responses through the production of antibodies, presentation of antigen to T cells, and production of cytokines. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2015. 45: 988-998], Olalekan et al. demonstrate that IFN-γ production by B cells is essential for the development of arthritis in mice. Lack of IFN-γ expression in B cells results in reduced autoimmune T-cell responses and autoantibody levels, impacting the arthritogenic reaction akin to that in B-cell depletion therapy. Together with other reports, the article by Olalekan et al. emphasizes the importance of cytokine-producing B cells in the pathogenesis of autoimmune diseases. In this commentary, I discuss how these findings shed new light on the roles of B cells as drivers of autoimmune pathogenesis, and how they more generally contribute to our understanding of the role of B cells in immunity.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Autoimmunity/immunology ; B-Lymphocytes/immunology ; Cytokines/biosynthesis ; Cytokines/immunology ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/therapy ; Humans ; Interferon-gamma/biosynthesis ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Lymphocyte Depletion ; Mice ; Multiple Sclerosis, Relapsing-Remitting/immunology ; Multiple Sclerosis, Relapsing-Remitting/therapy ; T-Lymphocytes/immunology
Chemical Substances	Cytokines ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2015-04
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201545544
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Article ; Online: Regulatory plasma cells.

Fillatreau, Simon

Current opinion in pharmacology

2015 Volume 23, Page(s) 1–5

Abstract: B cells can regulate immunity negatively or positively. Identifying the B cell subsets mediating these antagonistic activities, and the molecular mechanisms governing their differentiation, might enable the development of novel approaches to target B ... ...

Abstract	B cells can regulate immunity negatively or positively. Identifying the B cell subsets mediating these antagonistic activities, and the molecular mechanisms governing their differentiation, might enable the development of novel approaches to target B cells therapeutically. The suppressive functions of B cells are primarily mediated through their production of interleukin (IL)-10 and IL-35. Recent studies have shown that distinct sets of IgM(+)CD19(+)CD138(hi) plasma cells were the major B cell subsets producing these cytokines in a regulatory manner in vivo during autoimmune and infectious diseases. This review summarizes current knowledge on these 'regulatory plasma cells', and discusses the emerging data showing that the mechanisms involved in their generation partly overlap with those controlling the differentiation of 'effector regulatory T cells'.
MeSH term(s)	Animals ; Autoimmune Diseases/immunology ; B-Lymphocytes/physiology ; Humans ; Interferon Regulatory Factors/physiology ; Interleukin-10/physiology ; Interleukins/physiology ; Plasma Cells/physiology ; Positive Regulatory Domain I-Binding Factor 1 ; Repressor Proteins/physiology ; T-Lymphocytes, Regulatory/physiology
Chemical Substances	IL10 protein, human ; Interferon Regulatory Factors ; Interleukins ; Repressor Proteins ; interferon regulatory factor-4 ; interleukin-35, human ; Interleukin-10 (130068-27-8) ; PRDM1 protein, human (138415-26-6) ; Positive Regulatory Domain I-Binding Factor 1 (EC 2.1.1.-)
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2015.04.006
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Article ; Online: Monocyte-derived dendritic cells identified as booster of T follicular helper cell differentiation.

Fillatreau, Simon

EMBO molecular medicine

2014 Volume 6, Issue 5, Page(s) 574–576

Abstract: Adjuvants play an essential role in the induction of acquired immunity upon vaccination with protein antigen. In this issue of EMBO Molecular Medicine, a classical type of adjuvant made of DNA oligonucleotide containing CpG motifs, which has already been ...

Abstract	Adjuvants play an essential role in the induction of acquired immunity upon vaccination with protein antigen. In this issue of EMBO Molecular Medicine, a classical type of adjuvant made of DNA oligonucleotide containing CpG motifs, which has already been used in humans, is shown to boost humoral immunity primarily by acting on monocyte-derived dendritic cells. This study provides novel insight on the mode of action of adjuvant targeting Toll-like receptors.
MeSH term(s)	Adjuvants, Immunologic/pharmacology ; Animals ; Cell Differentiation ; Dendritic Cells/immunology ; Oligodeoxyribonucleotides/pharmacology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/physiology
Chemical Substances	Adjuvants, Immunologic ; CPG-oligonucleotide ; Oligodeoxyribonucleotides
Language	English
Publishing date	2014-05-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2467145-9
ISSN	1757-4684 ; 1757-4676
ISSN (online)	1757-4684
ISSN	1757-4676
DOI	10.1002/emmm.201404015
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