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  1. Article: Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of

    Ferhat, Allain-Thibeault / Verpy, Elisabeth / Biton, Anne / Forget, Benoît / De Chaumont, Fabrice / Mueller, Florian / Le Sourd, Anne-Marie / Coqueran, Sabrina / Schmitt, Julien / Rochefort, Christelle / Rondi-Reig, Laure / Leboucher, Aziliz / Boland, Anne / Fin, Bertrand / Deleuze, Jean-François / Boeckers, Tobias M / Ey, Elodie / Bourgeron, Thomas

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1139118

    Abstract: Autism is characterized by atypical social communication and stereotyped behaviors. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are detected in 1-2% of patients with autism and intellectual disability, but the mechanisms ... ...

    Abstract Autism is characterized by atypical social communication and stereotyped behaviors. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are detected in 1-2% of patients with autism and intellectual disability, but the mechanisms underpinning the symptoms remain largely unknown. Here, we characterized the behavior of
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1139118
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  2. Article: Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia.

    Ghaleb, Youmna / Elbitar, Sandy / Philippi, Anne / El Khoury, Petra / Azar, Yara / Andrianirina, Miangaly / Loste, Alexia / Abou-Khalil, Yara / Nicolas, Gaël / Le Borgne, Marie / Moulin, Philippe / Di-Filippo, Mathilde / Charrière, Sybil / Farnier, Michel / Yelnick, Cécile / Carreau, Valérie / Ferrières, Jean / Lecerf, Jean-Michel / Derksen, Alexa /
    Bernard, Geneviève / Gauthier, Marie-Soleil / Coulombe, Benoit / Lütjohann, Dieter / Fin, Bertrand / Boland, Anne / Olaso, Robert / Deleuze, Jean-François / Rabès, Jean-Pierre / Boileau, Catherine / Abifadel, Marianne / Varret, Mathilde

    Metabolites

    2022  Volume 12, Issue 3

    Abstract: Autosomal Dominant Hypercholesterolemia (ADH) is a genetic disorder caused by pathogenic variants ... ...

    Abstract Autosomal Dominant Hypercholesterolemia (ADH) is a genetic disorder caused by pathogenic variants in
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12030262
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  3. Article ; Online: Performance comparison of three DNA extraction kits on human whole-exome data from formalin-fixed paraffin-embedded normal and tumor samples.

    Bonnet, Eric / Moutet, Marie-Laure / Baulard, Céline / Bacq-Daian, Delphine / Sandron, Florian / Mesrob, Lilia / Fin, Bertrand / Delépine, Marc / Palomares, Marie-Ange / Jubin, Claire / Blanché, Hélène / Meyer, Vincent / Boland, Anne / Olaso, Robert / Deleuze, Jean-François

    PloS one

    2018  Volume 13, Issue 4, Page(s) e0195471

    Abstract: Next-generation sequencing (NGS) studies are becoming routinely used for the detection of novel and clinically actionable DNA variants at a pangenomic scale. Such analyses are now used in the clinical practice to enable precision medicine. Formalin-fixed ...

    Abstract Next-generation sequencing (NGS) studies are becoming routinely used for the detection of novel and clinically actionable DNA variants at a pangenomic scale. Such analyses are now used in the clinical practice to enable precision medicine. Formalin-fixed paraffin-embedded (FFPE) tissues are still one of the most abundant source of cancer clinical specimen, unfortunately this method of preparation is known to degrade DNA and therefore compromise subsequent analysis. Some studies have reported that variant detection can be performed on FFPE samples sequenced with NGS techniques, but few or none have done an in-depth coverage analysis and compared the influence of different state-of-the-art FFPE DNA extraction kits on the quality of the variant calling. Here, we generated 42 human whole-exome sequencing data sets from fresh-frozen (FF) and FFPE samples. These samples include normal and tumor tissues from two different organs (liver and colon), that we extracted with three different FFPE extraction kits (QIAamp DNA FFPE Tissue kit and GeneRead DNA FFPE kit from Qiagen, Maxwell™ RSC DNA FFPE Kit from Promega). We determined the rate of concordance of called variants between matched FF and FFPE samples on all common variants (representing at least 86% of the total number of variants for SNVs). The concordance rate is very high between all matched FF / FFPE pairs, with equivalent values for the three kits we analyzed. On the other hand, when looking at the difference between the total number of variants in FF and FFPE, we find a significant variation for the three different FFPE DNA extraction kits. Coverage analysis shows that FFPE samples have less good indicators than FF samples, yet the coverage quality remains above accepted thresholds. We detect limited but statistically significant variations in coverage indicator values between the three FFPE extraction kits. Globally, the GeneRead and QIAamp kits have better variant calling and coverage indicators than the Maxwell kit on the samples used in this study, although this kit performs better on some indicators and has advantages in terms of practical usage. Taken together, our results confirm the potential of FFPE samples analysis for clinical genomic studies, but also indicate that the choice of a FFPE DNA extraction kit should be done with careful testing and analysis beforehand in order to maximize the accuracy of the results.
    MeSH term(s) Colon/metabolism ; Colonic Neoplasms/metabolism ; Computational Biology ; Cryopreservation ; DNA/analysis ; DNA/isolation & purification ; DNA, Neoplasm/analysis ; DNA, Neoplasm/isolation & purification ; Fixatives ; Formaldehyde ; Humans ; INDEL Mutation ; Liver/metabolism ; Liver Neoplasms/metabolism ; Paraffin Embedding ; Polymorphism, Single Nucleotide ; Tissue Fixation ; Whole Exome Sequencing
    Chemical Substances DNA, Neoplasm ; Fixatives ; Formaldehyde (1HG84L3525) ; DNA (9007-49-2)
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0195471
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  4. Article ; Online: Accelerated genome sequencing with controlled costs for infants in intensive care units: a feasibility study in a French hospital network.

    Denommé-Pichon, Anne-Sophie / Vitobello, Antonio / Olaso, Robert / Ziegler, Alban / Jeanne, Médéric / Tran Mau-Them, Frédéric / Couturier, Victor / Racine, Caroline / Isidor, Bertrand / Poë, Charlotte / Jouan, Thibaud / Boland, Anne / Fin, Bertrand / Bacq-Daian, Delphine / Besse, Céline / Garde, Aurore / Prost, Adeline / Garret, Philippine / Tisserant, Émilie /
    Delanne, Julian / Nambot, Sophie / Juven, Aurélien / Gorce, Magali / Nizon, Mathilde / Vincent, Marie / Moutton, Sébastien / Fradin, Mélanie / Lavillaureix, Alinoë / Rollier, Paul / Capri, Yline / Van-Gils, Julien / Busa, Tiffany / Sigaudy, Sabine / Pasquier, Laurent / Barth, Magalie / Bruel, Ange-Line / Flamant, Cyril / Prouteau, Clément / Bonneau, Dominique / Toutain, Annick / Chantegret, Corinne / Callier, Patrick / Philippe, Christophe / Duffourd, Yannis / Deleuze, Jean-François / Sorlin, Arthur / Faivre, Laurence / Thauvin-Robinet, Christel

    European journal of human genetics : EJHG

    2021  Volume 30, Issue 5, Page(s) 567–576

    Abstract: Obtaining a rapid etiological diagnosis for infants with early-onset rare diseases remains a major challenge. These diseases often have a severe presentation and unknown prognosis, and the genetic causes are very heterogeneous. In a French hospital ... ...

    Abstract Obtaining a rapid etiological diagnosis for infants with early-onset rare diseases remains a major challenge. These diseases often have a severe presentation and unknown prognosis, and the genetic causes are very heterogeneous. In a French hospital network, we assessed the feasibility of performing accelerated trio-genome sequencing (GS) with limited additional costs by integrating urgent requests into the routine workflow. In addition to evaluating our capacity for such an approach, this prospective multicentre pilot study was designed to identify pitfalls encountered during its implementation. Over 14 months, we included newborns and infants hospitalized in neonatal or paediatric intensive care units with probable genetic disease and in urgent need for etiological diagnosis to guide medical care. The duration of each step and the pitfalls were recorded. We analysed any deviation from the planned schedule and identified obstacles. Trio-GS was performed for 37 individuals, leading to a molecular diagnosis in 18/37 (49%), and 21/37 (57%) after reanalysis. Corrective measures and protocol adaptations resulted in a median duration of 42 days from blood sampling to report. Accelerated trio-GS is undeniably valuable for individuals in an urgent care context. Such a circuit should coexist with a rapid or ultra-rapid circuit, which, although more expensive, can be used in particularly urgent cases. The drop in GS costs should result in its generalized use for diagnostic purposes and lead to a reduction of the costs of rapid GS.
    MeSH term(s) Child ; Feasibility Studies ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units ; Pilot Projects ; Prospective Studies
    Language English
    Publishing date 2021-11-15
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-021-00998-4
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  5. Article ; Online: The Comoros Show the Earliest Austronesian Gene Flow into the Swahili Corridor.

    Brucato, Nicolas / Fernandes, Veronica / Mazières, Stéphane / Kusuma, Pradiptajati / Cox, Murray P / Ng'ang'a, Joseph Wainaina / Omar, Mohammed / Simeone-Senelle, Marie-Claude / Frassati, Coralie / Alshamali, Farida / Fin, Bertrand / Boland, Anne / Deleuze, Jean-Francois / Stoneking, Mark / Adelaar, Alexander / Crowther, Alison / Boivin, Nicole / Pereira, Luisa / Bailly, Pascal /
    Chiaroni, Jacques / Ricaut, François-Xavier

    American journal of human genetics

    2017  Volume 102, Issue 1, Page(s) 58–68

    Abstract: At the dawn of the second millennium, the expansion of the Indian Ocean trading network aligned with the emergence of an outward-oriented community along the East African coast to create a cosmopolitan cultural and trading zone known as the Swahili ... ...

    Abstract At the dawn of the second millennium, the expansion of the Indian Ocean trading network aligned with the emergence of an outward-oriented community along the East African coast to create a cosmopolitan cultural and trading zone known as the Swahili Corridor. On the basis of analyses of new genome-wide genotyping data and uniparental data in 276 individuals from coastal Kenya and the Comoros islands, along with large-scale genetic datasets from the Indian Ocean rim, we reconstruct historical population dynamics to show that the Swahili Corridor is largely an eastern Bantu genetic continuum. Limited gene flows from the Middle East can be seen in Swahili and Comorian populations at dates corresponding to historically documented contacts. However, the main admixture event in southern insular populations, particularly Comorian and Malagasy groups, occurred with individuals from Island Southeast Asia as early as the 8
    MeSH term(s) Asia ; Australia ; Comoros ; Gene Flow ; Genetic Variation ; Genetics, Population ; Humans ; Kenya ; Polymorphism, Single Nucleotide/genetics
    Language English
    Publishing date 2017-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1016/j.ajhg.2017.11.011
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    Zs.A 107: Show issues Location:
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  6. Article ; Online: New insights into the genetic etiology of Alzheimer's disease and related dementias.

    Bellenguez, Céline / Küçükali, Fahri / Jansen, Iris E / Kleineidam, Luca / Moreno-Grau, Sonia / Amin, Najaf / Naj, Adam C / Campos-Martin, Rafael / Grenier-Boley, Benjamin / Andrade, Victor / Holmans, Peter A / Boland, Anne / Damotte, Vincent / van der Lee, Sven J / Costa, Marcos R / Kuulasmaa, Teemu / Yang, Qiong / de Rojas, Itziar / Bis, Joshua C /
    Yaqub, Amber / Prokic, Ivana / Chapuis, Julien / Ahmad, Shahzad / Giedraitis, Vilmantas / Aarsland, Dag / Garcia-Gonzalez, Pablo / Abdelnour, Carla / Alarcón-Martín, Emilio / Alcolea, Daniel / Alegret, Montserrat / Alvarez, Ignacio / Álvarez, Victoria / Armstrong, Nicola J / Tsolaki, Anthoula / Antúnez, Carmen / Appollonio, Ildebrando / Arcaro, Marina / Archetti, Silvana / Pastor, Alfonso Arias / Arosio, Beatrice / Athanasiu, Lavinia / Bailly, Henri / Banaj, Nerisa / Baquero, Miquel / Barral, Sandra / Beiser, Alexa / Pastor, Ana Belén / Below, Jennifer E / Benchek, Penelope / Benussi, Luisa / Berr, Claudine / Besse, Céline / Bessi, Valentina / Binetti, Giuliano / Bizarro, Alessandra / Blesa, Rafael / Boada, Mercè / Boerwinkle, Eric / Borroni, Barbara / Boschi, Silvia / Bossù, Paola / Bråthen, Geir / Bressler, Jan / Bresner, Catherine / Brodaty, Henry / Brookes, Keeley J / Brusco, Luis Ignacio / Buiza-Rueda, Dolores / Bûrger, Katharina / Burholt, Vanessa / Bush, William S / Calero, Miguel / Cantwell, Laura B / Chene, Geneviève / Chung, Jaeyoon / Cuccaro, Michael L / Carracedo, Ángel / Cecchetti, Roberta / Cervera-Carles, Laura / Charbonnier, Camille / Chen, Hung-Hsin / Chillotti, Caterina / Ciccone, Simona / Claassen, Jurgen A H R / Clark, Christopher / Conti, Elisa / Corma-Gómez, Anaïs / Costantini, Emanuele / Custodero, Carlo / Daian, Delphine / Dalmasso, Maria Carolina / Daniele, Antonio / Dardiotis, Efthimios / Dartigues, Jean-François / de Deyn, Peter Paul / de Paiva Lopes, Katia / de Witte, Lot D / Debette, Stéphanie / Deckert, Jürgen / Del Ser, Teodoro / Denning, Nicola / DeStefano, Anita / Dichgans, Martin / Diehl-Schmid, Janine / Diez-Fairen, Mónica / Rossi, Paolo Dionigi / Djurovic, Srdjan / Duron, Emmanuelle / Düzel, Emrah / Dufouil, Carole / Eiriksdottir, Gudny / Engelborghs, Sebastiaan / Escott-Price, Valentina / Espinosa, Ana / Ewers, Michael / Faber, Kelley M / Fabrizio, Tagliavini / Nielsen, Sune Fallgaard / Fardo, David W / Farotti, Lucia / Fenoglio, Chiara / Fernández-Fuertes, Marta / Ferrari, Raffaele / Ferreira, Catarina B / Ferri, Evelyn / Fin, Bertrand / Fischer, Peter / Fladby, Tormod / Fließbach, Klaus / Fongang, Bernard / Fornage, Myriam / Fortea, Juan / Foroud, Tatiana M / Fostinelli, Silvia / Fox, Nick C / Franco-Macías, Emlio / Bullido, María J / Frank-García, Ana / Froelich, Lutz / Fulton-Howard, Brian / Galimberti, Daniela / García-Alberca, Jose Maria / García-González, Pablo / Garcia-Madrona, Sebastian / Garcia-Ribas, Guillermo / Ghidoni, Roberta / Giegling, Ina / Giorgio, Giaccone / Goate, Alison M / Goldhardt, Oliver / Gomez-Fonseca, Duber / González-Pérez, Antonio / Graff, Caroline / Grande, Giulia / Green, Emma / Grimmer, Timo / Grünblatt, Edna / Grunin, Michelle / Gudnason, Vilmundur / Guetta-Baranes, Tamar / Haapasalo, Annakaisa / Hadjigeorgiou, Georgios / Haines, Jonathan L / Hamilton-Nelson, Kara L / Hampel, Harald / Hanon, Olivier / Hardy, John / Hartmann, Annette M / Hausner, Lucrezia / Harwood, Janet / Heilmann-Heimbach, Stefanie / Helisalmi, Seppo / Heneka, Michael T / Hernández, Isabel / Herrmann, Martin J / Hoffmann, Per / Holmes, Clive / Holstege, Henne / Vilas, Raquel Huerto / Hulsman, Marc / Humphrey, Jack / Biessels, Geert Jan / Jian, Xueqiu / Johansson, Charlotte / Jun, Gyungah R / Kastumata, Yuriko / Kauwe, John / Kehoe, Patrick G / Kilander, Lena / Ståhlbom, Anne Kinhult / Kivipelto, Miia / Koivisto, Anne / Kornhuber, Johannes / Kosmidis, Mary H / Kukull, Walter A / Kuksa, Pavel P / Kunkle, Brian W / Kuzma, Amanda B / Lage, Carmen / Laukka, Erika J / Launer, Lenore / Lauria, Alessandra / Lee, Chien-Yueh / Lehtisalo, Jenni / Lerch, Ondrej / Lleó, Alberto / Longstreth, William / Lopez, Oscar / de Munain, Adolfo Lopez / Love, Seth / Löwemark, Malin / Luckcuck, Lauren / Lunetta, Kathryn L / Ma, Yiyi / Macías, Juan / MacLeod, Catherine A / Maier, Wolfgang / Mangialasche, Francesca / Spallazzi, Marco / Marquié, Marta / Marshall, Rachel / Martin, Eden R / Montes, Angel Martín / Rodríguez, Carmen Martínez / Masullo, Carlo / Mayeux, Richard / Mead, Simon / Mecocci, Patrizia / Medina, Miguel / Meggy, Alun / Mehrabian, Shima / Mendoza, Silvia / Menéndez-González, Manuel / Mir, Pablo / Moebus, Susanne / Mol, Merel / Molina-Porcel, Laura / Montrreal, Laura / Morelli, Laura / Moreno, Fermin / Morgan, Kevin / Mosley, Thomas / Nöthen, Markus M / Muchnik, Carolina / Mukherjee, Shubhabrata / Nacmias, Benedetta / Ngandu, Tiia / Nicolas, Gael / Nordestgaard, Børge G / Olaso, Robert / Orellana, Adelina / Orsini, Michela / Ortega, Gemma / Padovani, Alessandro / Paolo, Caffarra / Papenberg, Goran / Parnetti, Lucilla / Pasquier, Florence / Pastor, Pau / Peloso, Gina / Pérez-Cordón, Alba / Pérez-Tur, Jordi / Pericard, Pierre / Peters, Oliver / Pijnenburg, Yolande A L / Pineda, Juan A / Piñol-Ripoll, Gerard / Pisanu, Claudia / Polak, Thomas / Popp, Julius / Posthuma, Danielle / Priller, Josef / Puerta, Raquel / Quenez, Olivier / Quintela, Inés / Thomassen, Jesper Qvist / Rábano, Alberto / Rainero, Innocenzo / Rajabli, Farid / Ramakers, Inez / Real, Luis M / Reinders, Marcel J T / Reitz, Christiane / Reyes-Dumeyer, Dolly / Ridge, Perry / Riedel-Heller, Steffi / Riederer, Peter / Roberto, Natalia / Rodriguez-Rodriguez, Eloy / Rongve, Arvid / Allende, Irene Rosas / Rosende-Roca, Maitée / Royo, Jose Luis / Rubino, Elisa / Rujescu, Dan / Sáez, María Eugenia / Sakka, Paraskevi / Saltvedt, Ingvild / Sanabria, Ángela / Sánchez-Arjona, María Bernal / Sanchez-Garcia, Florentino / Juan, Pascual Sánchez / Sánchez-Valle, Raquel / Sando, Sigrid B / Sarnowski, Chloé / Satizabal, Claudia L / Scamosci, Michela / Scarmeas, Nikolaos / Scarpini, Elio / Scheltens, Philip / Scherbaum, Norbert / Scherer, Martin / Schmid, Matthias / Schneider, Anja / Schott, Jonathan M / Selbæk, Geir / Seripa, Davide / Serrano, Manuel / Sha, Jin / Shadrin, Alexey A / Skrobot, Olivia / Slifer, Susan / Snijders, Gijsje J L / Soininen, Hilkka / Solfrizzi, Vincenzo / Solomon, Alina / Song, Yeunjoo / Sorbi, Sandro / Sotolongo-Grau, Oscar / Spalletta, Gianfranco / Spottke, Annika / Squassina, Alessio / Stordal, Eystein / Tartan, Juan Pablo / Tárraga, Lluís / Tesí, Niccolo / Thalamuthu, Anbupalam / Thomas, Tegos / Tosto, Giuseppe / Traykov, Latchezar / Tremolizzo, Lucio / Tybjærg-Hansen, Anne / Uitterlinden, Andre / Ullgren, Abbe / Ulstein, Ingun / Valero, Sergi / Valladares, Otto / Broeckhoven, Christine Van / Vance, Jeffery / Vardarajan, Badri N / van der Lugt, Aad / Dongen, Jasper Van / van Rooij, Jeroen / van Swieten, John / Vandenberghe, Rik / Verhey, Frans / Vidal, Jean-Sébastien / Vogelgsang, Jonathan / Vyhnalek, Martin / Wagner, Michael / Wallon, David / Wang, Li-San / Wang, Ruiqi / Weinhold, Leonie / Wiltfang, Jens / Windle, Gill / Woods, Bob / Yannakoulia, Mary / Zare, Habil / Zhao, Yi / Zhang, Xiaoling / Zhu, Congcong / Zulaica, Miren / Farrer, Lindsay A / Psaty, Bruce M / Ghanbari, Mohsen / Raj, Towfique / Sachdev, Perminder / Mather, Karen / Jessen, Frank / Ikram, M Arfan / de Mendonça, Alexandre / Hort, Jakub / Tsolaki, Magda / Pericak-Vance, Margaret A / Amouyel, Philippe / Williams, Julie / Frikke-Schmidt, Ruth / Clarimon, Jordi / Deleuze, Jean-François / Rossi, Giacomina / Seshadri, Sudha / Andreassen, Ole A / Ingelsson, Martin / Hiltunen, Mikko / Sleegers, Kristel / Schellenberg, Gerard D / van Duijn, Cornelia M / Sims, Rebecca / van der Flier, Wiesje M / Ruiz, Agustín / Ramirez, Alfredo / Lambert, Jean-Charles

    Nature genetics

    2022  Volume 54, Issue 4, Page(s) 412–436

    Abstract: Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association ... ...

    Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
    MeSH term(s) Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Cognitive Dysfunction/psychology ; Genome-Wide Association Study ; Humans ; tau Proteins/genetics
    Chemical Substances tau Proteins
    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-022-01024-z
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  7. Article ; Online: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

    Kunkle, Brian W / Grenier-Boley, Benjamin / Sims, Rebecca / Bis, Joshua C / Damotte, Vincent / Naj, Adam C / Boland, Anne / Vronskaya, Maria / van der Lee, Sven J / Amlie-Wolf, Alexandre / Bellenguez, Céline / Frizatti, Aura / Chouraki, Vincent / Martin, Eden R / Sleegers, Kristel / Badarinarayan, Nandini / Jakobsdottir, Johanna / Hamilton-Nelson, Kara L / Moreno-Grau, Sonia /
    Olaso, Robert / Raybould, Rachel / Chen, Yuning / Kuzma, Amanda B / Hiltunen, Mikko / Morgan, Taniesha / Ahmad, Shahzad / Vardarajan, Badri N / Epelbaum, Jacques / Hoffmann, Per / Boada, Merce / Beecham, Gary W / Garnier, Jean-Guillaume / Harold, Denise / Fitzpatrick, Annette L / Valladares, Otto / Moutet, Marie-Laure / Gerrish, Amy / Smith, Albert V / Qu, Liming / Bacq, Delphine / Denning, Nicola / Jian, Xueqiu / Zhao, Yi / Del Zompo, Maria / Fox, Nick C / Choi, Seung-Hoan / Mateo, Ignacio / Hughes, Joseph T / Adams, Hieab H / Malamon, John / Sanchez-Garcia, Florentino / Patel, Yogen / Brody, Jennifer A / Dombroski, Beth A / Naranjo, Maria Candida Deniz / Daniilidou, Makrina / Eiriksdottir, Gudny / Mukherjee, Shubhabrata / Wallon, David / Uphill, James / Aspelund, Thor / Cantwell, Laura B / Garzia, Fabienne / Galimberti, Daniela / Hofer, Edith / Butkiewicz, Mariusz / Fin, Bertrand / Scarpini, Elio / Sarnowski, Chloe / Bush, Will S / Meslage, Stéphane / Kornhuber, Johannes / White, Charles C / Song, Yuenjoo / Barber, Robert C / Engelborghs, Sebastiaan / Sordon, Sabrina / Voijnovic, Dina / Adams, Perrie M / Vandenberghe, Rik / Mayhaus, Manuel / Cupples, L Adrienne / Albert, Marilyn S / De Deyn, Peter P / Gu, Wei / Himali, Jayanadra J / Beekly, Duane / Squassina, Alessio / Hartmann, Annette M / Orellana, Adelina / Blacker, Deborah / Rodriguez-Rodriguez, Eloy / Lovestone, Simon / Garcia, Melissa E / Doody, Rachelle S / Munoz-Fernadez, Carmen / Sussams, Rebecca / Lin, Honghuang / Fairchild, Thomas J / Benito, Yolanda A / Holmes, Clive / Karamujić-Čomić, Hata / Frosch, Matthew P / Thonberg, Hakan / Maier, Wolfgang / Roshchupkin, Gennady / Ghetti, Bernardino / Giedraitis, Vilmantas / Kawalia, Amit / Li, Shuo / Huebinger, Ryan M / Kilander, Lena / Moebus, Susanne / Hernández, Isabel / Kamboh, M Ilyas / Brundin, RoseMarie / Turton, James / Yang, Qiong / Katz, Mindy J / Concari, Letizia / Lord, Jenny / Beiser, Alexa S / Keene, C Dirk / Helisalmi, Seppo / Kloszewska, Iwona / Kukull, Walter A / Koivisto, Anne Maria / Lynch, Aoibhinn / Tarraga, Lluís / Larson, Eric B / Haapasalo, Annakaisa / Lawlor, Brian / Mosley, Thomas H / Lipton, Richard B / Solfrizzi, Vincenzo / Gill, Michael / Longstreth, W T / Montine, Thomas J / Frisardi, Vincenza / Diez-Fairen, Monica / Rivadeneira, Fernando / Petersen, Ronald C / Deramecourt, Vincent / Alvarez, Ignacio / Salani, Francesca / Ciaramella, Antonio / Boerwinkle, Eric / Reiman, Eric M / Fievet, Nathalie / Rotter, Jerome I / Reisch, Joan S / Hanon, Olivier / Cupidi, Chiara / Andre Uitterlinden, A G / Royall, Donald R / Dufouil, Carole / Maletta, Raffaele Giovanni / de Rojas, Itziar / Sano, Mary / Brice, Alexis / Cecchetti, Roberta / George-Hyslop, Peter St / Ritchie, Karen / Tsolaki, Magda / Tsuang, Debby W / Dubois, Bruno / Craig, David / Wu, Chuang-Kuo / Soininen, Hilkka / Avramidou, Despoina / Albin, Roger L / Fratiglioni, Laura / Germanou, Antonia / Apostolova, Liana G / Keller, Lina / Koutroumani, Maria / Arnold, Steven E / Panza, Francesco / Gkatzima, Olymbia / Asthana, Sanjay / Hannequin, Didier / Whitehead, Patrice / Atwood, Craig S / Caffarra, Paolo / Hampel, Harald / Quintela, Inés / Carracedo, Ángel / Lannfelt, Lars / Rubinsztein, David C / Barnes, Lisa L / Pasquier, Florence / Frölich, Lutz / Barral, Sandra / McGuinness, Bernadette / Beach, Thomas G / Johnston, Janet A / Becker, James T / Passmore, Peter / Bigio, Eileen H / Schott, Jonathan M / Bird, Thomas D / Warren, Jason D / Boeve, Bradley F / Lupton, Michelle K / Bowen, James D / Proitsi, Petra / Boxer, Adam / Powell, John F / Burke, James R / Kauwe, John S K / Burns, Jeffrey M / Mancuso, Michelangelo / Buxbaum, Joseph D / Bonuccelli, Ubaldo / Cairns, Nigel J / McQuillin, Andrew / Cao, Chuanhai / Livingston, Gill / Carlson, Chris S / Bass, Nicholas J / Carlsson, Cynthia M / Hardy, John / Carney, Regina M / Bras, Jose / Carrasquillo, Minerva M / Guerreiro, Rita / Allen, Mariet / Chui, Helena C / Fisher, Elizabeth / Masullo, Carlo / Crocco, Elizabeth A / DeCarli, Charles / Bisceglio, Gina / Dick, Malcolm / Ma, Li / Duara, Ranjan / Graff-Radford, Neill R / Evans, Denis A / Hodges, Angela / Faber, Kelley M / Scherer, Martin / Fallon, Kenneth B / Riemenschneider, Matthias / Fardo, David W / Heun, Reinhard / Farlow, Martin R / Kölsch, Heike / Ferris, Steven / Leber, Markus / Foroud, Tatiana M / Heuser, Isabella / Galasko, Douglas R / Giegling, Ina / Gearing, Marla / Hüll, Michael / Geschwind, Daniel H / Gilbert, John R / Morris, John / Green, Robert C / Mayo, Kevin / Growdon, John H / Feulner, Thomas / Hamilton, Ronald L / Harrell, Lindy E / Drichel, Dmitriy / Honig, Lawrence S / Cushion, Thomas D / Huentelman, Matthew J / Hollingworth, Paul / Hulette, Christine M / Hyman, Bradley T / Marshall, Rachel / Jarvik, Gail P / Meggy, Alun / Abner, Erin / Menzies, Georgina E / Jin, Lee-Way / Leonenko, Ganna / Real, Luis M / Jun, Gyungah R / Baldwin, Clinton T / Grozeva, Detelina / Karydas, Anna / Russo, Giancarlo / Kaye, Jeffrey A / Kim, Ronald / Jessen, Frank / Kowall, Neil W / Vellas, Bruno / Kramer, Joel H / Vardy, Emma / LaFerla, Frank M / Jöckel, Karl-Heinz / Lah, James J / Dichgans, Martin / Leverenz, James B / Mann, David / Levey, Allan I / Pickering-Brown, Stuart / Lieberman, Andrew P / Klopp, Norman / Lunetta, Kathryn L / Wichmann, H-Erich / Lyketsos, Constantine G / Morgan, Kevin / Marson, Daniel C / Brown, Kristelle / Martiniuk, Frank / Medway, Christopher / Mash, Deborah C / Nöthen, Markus M / Masliah, Eliezer / Hooper, Nigel M / McCormick, Wayne C / Daniele, Antonio / McCurry, Susan M / Bayer, Anthony / McDavid, Andrew N / Gallacher, John / McKee, Ann C / van den Bussche, Hendrik / Mesulam, Marsel / Brayne, Carol / Miller, Bruce L / Riedel-Heller, Steffi / Miller, Carol A / Miller, Joshua W / Al-Chalabi, Ammar / Morris, John C / Shaw, Christopher E / Myers, Amanda J / Wiltfang, Jens / O'Bryant, Sid / Olichney, John M / Alvarez, Victoria / Parisi, Joseph E / Singleton, Andrew B / Paulson, Henry L / Collinge, John / Perry, William R / Mead, Simon / Peskind, Elaine / Cribbs, David H / Rossor, Martin / Pierce, Aimee / Ryan, Natalie S / Poon, Wayne W / Nacmias, Benedetta / Potter, Huntington / Sorbi, Sandro / Quinn, Joseph F / Sacchinelli, Eleonora / Raj, Ashok / Spalletta, Gianfranco / Raskind, Murray / Caltagirone, Carlo / Bossù, Paola / Orfei, Maria Donata / Reisberg, Barry / Clarke, Robert / Reitz, Christiane / Smith, A David / Ringman, John M / Warden, Donald / Roberson, Erik D / Wilcock, Gordon / Rogaeva, Ekaterina / Bruni, Amalia Cecilia / Rosen, Howard J / Gallo, Maura / Rosenberg, Roger N / Ben-Shlomo, Yoav / Sager, Mark A / Mecocci, Patrizia / Saykin, Andrew J / Pastor, Pau / Cuccaro, Michael L / Vance, Jeffery M / Schneider, Julie A / Schneider, Lori S / Slifer, Susan / Seeley, William W / Smith, Amanda G / Sonnen, Joshua A / Spina, Salvatore / Stern, Robert A / Swerdlow, Russell H / Tang, Mitchell / Tanzi, Rudolph E / Trojanowski, John Q / Troncoso, Juan C / Van Deerlin, Vivianna M / Van Eldik, Linda J / Vinters, Harry V / Vonsattel, Jean Paul / Weintraub, Sandra / Welsh-Bohmer, Kathleen A / Wilhelmsen, Kirk C / Williamson, Jennifer / Wingo, Thomas S / Woltjer, Randall L / Wright, Clinton B / Yu, Chang-En / Yu, Lei / Saba, Yasaman / Pilotto, Alberto / Bullido, Maria J / Peters, Oliver / Crane, Paul K / Bennett, David / Bosco, Paola / Coto, Eliecer / Boccardi, Virginia / De Jager, Phil L / Lleo, Alberto / Warner, Nick / Lopez, Oscar L / Ingelsson, Martin / Deloukas, Panagiotis / Cruchaga, Carlos / Graff, Caroline / Gwilliam, Rhian / Fornage, Myriam / Goate, Alison M / Sanchez-Juan, Pascual / Kehoe, Patrick G / Amin, Najaf / Ertekin-Taner, Nilifur / Berr, Claudine / Debette, Stéphanie / Love, Seth / Launer, Lenore J / Younkin, Steven G / Dartigues, Jean-Francois / Corcoran, Chris / Ikram, M Arfan / Dickson, Dennis W / Nicolas, Gael / Campion, Dominique / Tschanz, JoAnn / Schmidt, Helena / Hakonarson, Hakon / Clarimon, Jordi / Munger, Ron / Schmidt, Reinhold / Farrer, Lindsay A / Van Broeckhoven, Christine / C O'Donovan, Michael / DeStefano, Anita L / Jones, Lesley / Haines, Jonathan L / Deleuze, Jean-Francois / Owen, Michael J / Gudnason, Vilmundur / Mayeux, Richard / Escott-Price, Valentina / Psaty, Bruce M / Ramirez, Alfredo / Wang, Li-San / Ruiz, Agustin / van Duijn, Cornelia M / Holmans, Peter A / Seshadri, Sudha / Williams, Julie / Amouyel, Phillippe / Schellenberg, Gerard D / Lambert, Jean-Charles / Pericak-Vance, Margaret A

    Nature genetics

    2019  Volume 51, Issue 3, Page(s) 414–430

    Abstract: Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We ... ...

    Abstract Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10
    MeSH term(s) Aged ; Alzheimer Disease/genetics ; Amyloid beta-Peptides/genetics ; Case-Control Studies ; Female ; Genetic Loci/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Testing/methods ; Genome-Wide Association Study/methods ; Haplotypes/genetics ; Humans ; Immunity/genetics ; Lipid Metabolism/genetics ; Lipids/genetics ; Male ; tau Proteins/genetics
    Chemical Substances Amyloid beta-Peptides ; Lipids ; tau Proteins
    Language English
    Publishing date 2019-02-28
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-019-0358-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

    Kunkle, Brian W / Grenier-Boley, Benjamin / Sims, Rebecca / Bis, Joshua C / Damotte, Vincent / Naj, Adam C / Boland, Anne / Vronskaya, Maria / van der Lee, Sven J / Amlie-Wolf, Alexandre / Bellenguez, Céline / Frizatti, Aura / Chouraki, Vincent / Martin, Eden R / Sleegers, Kristel / Badarinarayan, Nandini / Jakobsdottir, Johanna / Hamilton-Nelson, Kara L / Moreno-Grau, Sonia /
    Olaso, Robert / Raybould, Rachel / Chen, Yuning / Kuzma, Amanda B / Hiltunen, Mikko / Morgan, Taniesha / Ahmad, Shahzad / Vardarajan, Badri N / Epelbaum, Jacques / Hoffmann, Per / Boada, Merce / Beecham, Gary W / Garnier, Jean-Guillaume / Harold, Denise / Fitzpatrick, Annette L / Valladares, Otto / Moutet, Marie-Laure / Gerrish, Amy / Smith, Albert V / Qu, Liming / Bacq, Delphine / Denning, Nicola / Jian, Xueqiu / Zhao, Yi / Del Zompo, Maria / Fox, Nick C / Choi, Seung-Hoan / Mateo, Ignacio / Hughes, Joseph T / Adams, Hieab H / Malamon, John / Sanchez-Garcia, Florentino / Patel, Yogen / Brody, Jennifer A / Dombroski, Beth A / Naranjo, Maria Candida Deniz / Daniilidou, Makrina / Eiriksdottir, Gudny / Mukherjee, Shubhabrata / Wallon, David / Uphill, James / Aspelund, Thor / Cantwell, Laura B / Garzia, Fabienne / Galimberti, Daniela / Hofer, Edith / Butkiewicz, Mariusz / Fin, Bertrand / Scarpini, Elio / Sarnowski, Chloe / Bush, Will S / Meslage, Stéphane / Kornhuber, Johannes / White, Charles C / Song, Yuenjoo / Barber, Robert C / Engelborghs, Sebastiaan / Sordon, Sabrina / Voijnovic, Dina / Adams, Perrie M / Vandenberghe, Rik / Mayhaus, Manuel / Cupples, L Adrienne / Albert, Marilyn S / De Deyn, Peter P / Gu, Wei / Himali, Jayanadra J / Beekly, Duane / Squassina, Alessio / Hartmann, Annette M / Orellana, Adelina / Blacker, Deborah / Rodriguez-Rodriguez, Eloy / Lovestone, Simon / Garcia, Melissa E / Doody, Rachelle S / Munoz-Fernadez, Carmen / Sussams, Rebecca / Lin, Honghuang / Fairchild, Thomas J / Benito, Yolanda A / Holmes, Clive / Karamujić-Čomić, Hata / Frosch, Matthew P / Thonberg, Hakan / Maier, Wolfgang / Roshchupkin, Gennady / Ghetti, Bernardino / Giedraitis, Vilmantas / Kawalia, Amit / Li, Shuo / Huebinger, Ryan M / Kilander, Lena / Moebus, Susanne / Hernández, Isabel / Kamboh, M Ilyas / Brundin, RoseMarie / Turton, James / Yang, Qiong / Katz, Mindy J / Concari, Letizia / Lord, Jenny / Beiser, Alexa S / Keene, C Dirk / Helisalmi, Seppo / Kloszewska, Iwona / Kukull, Walter A / Koivisto, Anne Maria / Lynch, Aoibhinn / Tarraga, Lluís / Larson, Eric B / Haapasalo, Annakaisa / Lawlor, Brian / Mosley, Thomas H / Lipton, Richard B / Solfrizzi, Vincenzo / Gill, Michael / Longstreth, W T / Montine, Thomas J / Frisardi, Vincenza / Diez-Fairen, Monica / Rivadeneira, Fernando / Petersen, Ronald C / Deramecourt, Vincent / Alvarez, Ignacio / Salani, Francesca / Ciaramella, Antonio / Boerwinkle, Eric / Reiman, Eric M / Fievet, Nathalie / Rotter, Jerome I / Reisch, Joan S / Hanon, Olivier / Cupidi, Chiara / Uitterlinden, A G Andre / Royall, Donald R / Dufouil, Carole / Maletta, Raffaele Giovanni / de Rojas, Itziar / Sano, Mary / Brice, Alexis / Cecchetti, Roberta / George-Hyslop, Peter St / Ritchie, Karen / Tsolaki, Magda / Tsuang, Debby W / Dubois, Bruno / Craig, David / Wu, Chuang-Kuo / Soininen, Hilkka / Avramidou, Despoina / Albin, Roger L / Fratiglioni, Laura / Germanou, Antonia / Apostolova, Liana G / Keller, Lina / Koutroumani, Maria / Arnold, Steven E / Panza, Francesco / Gkatzima, Olymbia / Asthana, Sanjay / Hannequin, Didier / Whitehead, Patrice / Atwood, Craig S / Caffarra, Paolo / Hampel, Harald / Quintela, Inés / Carracedo, Ángel / Lannfelt, Lars / Rubinsztein, David C / Barnes, Lisa L / Pasquier, Florence / Frölich, Lutz / Barral, Sandra / McGuinness, Bernadette / Beach, Thomas G / Johnston, Janet A / Becker, James T / Passmore, Peter / Bigio, Eileen H / Schott, Jonathan M / Bird, Thomas D / Warren, Jason D / Boeve, Bradley F / Lupton, Michelle K / Bowen, James D / Proitsi, Petra / Boxer, Adam / Powell, John F / Burke, James R / Kauwe, John S K / Burns, Jeffrey M / Mancuso, Michelangelo / Buxbaum, Joseph D / Bonuccelli, Ubaldo / Cairns, Nigel J / McQuillin, Andrew / Cao, Chuanhai / Livingston, Gill / Carlson, Chris S / Bass, Nicholas J / Carlsson, Cynthia M / Hardy, John / Carney, Regina M / Bras, Jose / Carrasquillo, Minerva M / Guerreiro, Rita / Allen, Mariet / Chui, Helena C / Fisher, Elizabeth / Masullo, Carlo / Crocco, Elizabeth A / DeCarli, Charles / Bisceglio, Gina / Dick, Malcolm / Ma, Li / Duara, Ranjan / Graff-Radford, Neill R / Evans, Denis A / Hodges, Angela / Faber, Kelley M / Scherer, Martin / Fallon, Kenneth B / Riemenschneider, Matthias / Fardo, David W / Heun, Reinhard / Farlow, Martin R / Kölsch, Heike / Ferris, Steven / Leber, Markus / Foroud, Tatiana M / Heuser, Isabella / Galasko, Douglas R / Giegling, Ina / Gearing, Marla / Hüll, Michael / Geschwind, Daniel H / Gilbert, John R / Morris, John / Green, Robert C / Mayo, Kevin / Growdon, John H / Feulner, Thomas / Hamilton, Ronald L / Harrell, Lindy E / Drichel, Dmitriy / Honig, Lawrence S / Cushion, Thomas D / Huentelman, Matthew J / Hollingworth, Paul / Hulette, Christine M / Hyman, Bradley T / Marshall, Rachel / Jarvik, Gail P / Meggy, Alun / Abner, Erin / Menzies, Georgina E / Jin, Lee-Way / Leonenko, Ganna / Real, Luis M / Jun, Gyungah R / Baldwin, Clinton T / Grozeva, Detelina / Karydas, Anna / Russo, Giancarlo / Kaye, Jeffrey A / Kim, Ronald / Jessen, Frank / Kowall, Neil W / Vellas, Bruno / Kramer, Joel H / Vardy, Emma / LaFerla, Frank M / Jöckel, Karl-Heinz / Lah, James J / Dichgans, Martin / Leverenz, James B / Mann, David / Levey, Allan I / Pickering-Brown, Stuart / Lieberman, Andrew P / Klopp, Norman / Lunetta, Kathryn L / Wichmann, H-Erich / Lyketsos, Constantine G / Morgan, Kevin / Marson, Daniel C / Brown, Kristelle / Martiniuk, Frank / Medway, Christopher / Mash, Deborah C / Nöthen, Markus M / Masliah, Eliezer / Hooper, Nigel M / McCormick, Wayne C / Daniele, Antonio / McCurry, Susan M / Bayer, Anthony / McDavid, Andrew N / Gallacher, John / McKee, Ann C / van den Bussche, Hendrik / Mesulam, Marsel / Brayne, Carol / Miller, Bruce L / Riedel-Heller, Steffi / Miller, Carol A / Miller, Joshua W / Al-Chalabi, Ammar / Morris, John C / Shaw, Christopher E / Myers, Amanda J / Wiltfang, Jens / O'Bryant, Sid / Olichney, John M / Alvarez, Victoria / Parisi, Joseph E / Singleton, Andrew B / Paulson, Henry L / Collinge, John / Perry, William R / Mead, Simon / Peskind, Elaine / Cribbs, David H / Rossor, Martin / Pierce, Aimee / Ryan, Natalie S / Poon, Wayne W / Nacmias, Benedetta / Potter, Huntington / Sorbi, Sandro / Quinn, Joseph F / Sacchinelli, Eleonora / Raj, Ashok / Spalletta, Gianfranco / Raskind, Murray / Caltagirone, Carlo / Bossù, Paola / Orfei, Maria Donata / Reisberg, Barry / Clarke, Robert / Reitz, Christiane / Smith, A David / Ringman, John M / Warden, Donald / Roberson, Erik D / Wilcock, Gordon / Rogaeva, Ekaterina / Bruni, Amalia Cecilia / Rosen, Howard J / Gallo, Maura / Rosenberg, Roger N / Ben-Shlomo, Yoav / Sager, Mark A / Mecocci, Patrizia / Saykin, Andrew J / Pastor, Pau / Cuccaro, Michael L / Vance, Jeffery M / Schneider, Julie A / Schneider, Lori S / Slifer, Susan / Seeley, William W / Smith, Amanda G / Sonnen, Joshua A / Spina, Salvatore / Stern, Robert A / Swerdlow, Russell H / Tang, Mitchell / Tanzi, Rudolph E / Trojanowski, John Q / Troncoso, Juan C / Van Deerlin, Vivianna M / Van Eldik, Linda J / Vinters, Harry V / Vonsattel, Jean Paul / Weintraub, Sandra / Welsh-Bohmer, Kathleen A / Wilhelmsen, Kirk C / Williamson, Jennifer / Wingo, Thomas S / Woltjer, Randall L / Wright, Clinton B / Yu, Chang-En / Yu, Lei / Saba, Yasaman / Pilotto, Alberto / Bullido, Maria J / Peters, Oliver / Crane, Paul K / Bennett, David / Bosco, Paola / Coto, Eliecer / Boccardi, Virginia / De Jager, Phil L / Lleo, Alberto / Warner, Nick / Lopez, Oscar L / Ingelsson, Martin / Deloukas, Panagiotis / Cruchaga, Carlos / Graff, Caroline / Gwilliam, Rhian / Fornage, Myriam / Goate, Alison M / Sanchez-Juan, Pascual / Kehoe, Patrick G / Amin, Najaf / Ertekin-Taner, Nilifur / Berr, Claudine / Debette, Stéphanie / Love, Seth / Launer, Lenore J / Younkin, Steven G / Dartigues, Jean-Francois / Corcoran, Chris / Ikram, M Arfan / Dickson, Dennis W / Nicolas, Gael / Campion, Dominique / Tschanz, JoAnn / Schmidt, Helena / Hakonarson, Hakon / Clarimon, Jordi / Munger, Ron / Schmidt, Reinhold / Farrer, Lindsay A / Van Broeckhoven, Christine / O'Donovan, Michael C / DeStefano, Anita L / Jones, Lesley / Haines, Jonathan L / Deleuze, Jean-Francois / Owen, Michael J / Gudnason, Vilmundur / Mayeux, Richard / Escott-Price, Valentina / Psaty, Bruce M / Ramirez, Alfredo / Wang, Li-San / Ruiz, Agustin / van Duijn, Cornelia M / Holmans, Peter A / Seshadri, Sudha / Williams, Julie / Amouyel, Phillippe / Schellenberg, Gerard D / Lambert, Jean-Charles / Pericak-Vance, Margaret A

    Nature genetics

    2019  Volume 51, Issue 9, Page(s) 1423–1424

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2019-10-25
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-019-0495-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

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