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  1. Article ; Online: Validity and Reliability of the Reflux Sign Assessment-10 (RSA-10).

    Lechien, Jérôme R / De Marrez, Lisa G / Finck, Camille / Saussez, Sven

    The Laryngoscope

    2024  

    Abstract: Objective: To develop and validate the Reflux Sign Assessment-10 (RSA-10) for documenting the physical findings of laryngopharyngeal reflux disease (LPRD).: Methods: Patients with LPRD at the hypopharyngeal-esophageal multichannel intraluminal ... ...

    Abstract Objective: To develop and validate the Reflux Sign Assessment-10 (RSA-10) for documenting the physical findings of laryngopharyngeal reflux disease (LPRD).
    Methods: Patients with LPRD at the hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring and asymptomatic individuals were consecutively recruited from two European hospitals. Three experienced otolaryngologists rated RSA-10 in patients and controls for assessing internal validity. RSA-10 was rated within a 7-day period to assess test-retest reliability. Internal consistency was measured using Cronbach's α in patients and controls. Convergent validity was evaluated through a correlation analysis between RSA-10 and Reflux Finding Score (RFS). Interrater reliability was evaluated by comparing the RSA-10 evaluations of the three otolaryngologists through Fleiss kappa. Pre- to posttreatment change of RSA-10 was evaluated to assess responsiveness to change. The RSA-10 thresholds were examined by receiver operating characteristic analysis.
    Results: Fifty-five patients completed the pre- to posttreatment evaluations from January 2020 to December 2023. A total of 115 asymptomatic individuals completed the study. RSA-10 reported high internal consistency reliability (α = 0.822) and test-retest reliability (r
    Conclusion: The RSA-10 is a reliable and valid clinical instrument for documenting the most prevalent laryngeal and extra-laryngeal findings associated with LPRD.
    Level of evidence: 3 Laryngoscope, 2024.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31420
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  2. Article: Case report: Successive ipsilateral and contralateral laryngeal nerve palsy as probable manifestation of neuroborreliosis.

    Finck, Camille / Gambron, Tersia / Benchimol, Lionel / Camby, Severine / Morsomme, Dominique

    Heliyon

    2023  Volume 9, Issue 10, Page(s) e20869

    Abstract: Neuroborreliosis is part of advanced stage of Lyme disease and often characterized by damage to the cranial and/or peripheral nerves. Involvement of one or both recurrent nerves is rare. Diagnosis is often difficult and based on a set of clinical ... ...

    Abstract Neuroborreliosis is part of advanced stage of Lyme disease and often characterized by damage to the cranial and/or peripheral nerves. Involvement of one or both recurrent nerves is rare. Diagnosis is often difficult and based on a set of clinical manifestations, biological arguments, and cerebrospinal fluid (CSF) analysis. A 70-year-old man was referred to our Voice Clinic with a 3-month history of dysphonia caused by right vocal fold paralysis (VFP) without any cutaneous symptoms of tick bite or erythema migrans in the previous weeks and normal initial radiological examination (neck and thorax CT). Methylprednisolone had already been prescribed but without any clinical improvement. Late biological investigation 3 months after initial symptoms of VFP showed high IgG (93 U/mL; reference <10 U/mL) against
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e20869
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  3. Article ; Online: In Reference to A 10-Year Study of the Etiopathogenesis of Cysts With a Study of Seromucinous Glands in Vocal Folds.

    Lechien, Jerome R / Finck, Camille

    The Laryngoscope

    2019  Volume 130, Issue 6, Page(s) E397–E398

    MeSH term(s) Cysts ; Humans ; Laryngeal Diseases ; Vocal Cords
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28381
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  4. Article ; Online: Laryngeal hereditary hemorrhagic telangiectasia.

    Lechien, Jérôme R / Finck, Camille

    Ear, nose, & throat journal

    2018  Volume 97, Issue 12, Page(s) 388

    MeSH term(s) Adult ; Dysphonia/etiology ; Hemoptysis/etiology ; Humans ; Laryngeal Diseases/diagnostic imaging ; Laryngeal Diseases/surgery ; Male ; Singing ; Telangiectasia, Hereditary Hemorrhagic/diagnostic imaging ; Telangiectasia, Hereditary Hemorrhagic/surgery
    Language English
    Publishing date 2018-12-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/014556131809701203
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  5. Article ; Online: Lewis-Sumner Syndrome Manifesting as Unilateral Vocal Fold Paresis and Laryngeal Fasciculations.

    Lechien, Jérôme R / Finck, Camille

    Journal of voice : official journal of the Voice Foundation

    2017  Volume 32, Issue 3, Page(s) 356–358

    Abstract: Lewis-Sumner syndrome (LSS) is a rare disease characterized by asymmetrical and multifocal mononeuropathy commonly located in the upper limbs. Some rare cases affecting cranial nerve have been described, but LSS is unknown to affect especially laryngeal ... ...

    Abstract Lewis-Sumner syndrome (LSS) is a rare disease characterized by asymmetrical and multifocal mononeuropathy commonly located in the upper limbs. Some rare cases affecting cranial nerve have been described, but LSS is unknown to affect especially laryngeal nerves. This paper presents the first case of unilateral vocal fold paresis caused by an LSS in a 59-year-old man complaining of dysphonia, breathy voice, and vocal fatigue. Epidemiology, clinical features, diagnosis, and treatment will be described.
    MeSH term(s) Dysphonia/diagnosis ; Dysphonia/etiology ; Dysphonia/physiopathology ; Fasciculation ; Humans ; Laryngeal Nerves/physiopathology ; Male ; Middle Aged ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/complications ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/physiopathology ; Vocal Cord Paralysis/diagnosis ; Vocal Cord Paralysis/etiology ; Vocal Cord Paralysis/physiopathology ; Vocal Cords/physiopathology ; Voice Quality
    Language English
    Publishing date 2017-08-03
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2017.05.020
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  6. Article ; Online: Validation of the Acoustic Voice Quality Index, Version 03.01, in French.

    Pommée, Timothy / Maryn, Youri / Finck, Camille / Morsomme, Dominique

    Journal of voice : official journal of the Voice Foundation

    2018  Volume 34, Issue 4, Page(s) 646.e11–646.e26

    Abstract: Objectives: The Acoustic Voice Quality Index (AVQI), version 03.01, is a tool for quantitative assessment of the overall severity of dysphonia. It is based on the recordings of a sustained vowel and part of a text read aloud. For the Dutch sample, 34 ... ...

    Abstract Objectives: The Acoustic Voice Quality Index (AVQI), version 03.01, is a tool for quantitative assessment of the overall severity of dysphonia. It is based on the recordings of a sustained vowel and part of a text read aloud. For the Dutch sample, 34 syllables must be read aloud to balance the duration of the two tasks. The first part of this study thus aimed to determine how many syllables of a commonly used text in the French-speaking part of Belgium should be used to achieve the same balance. The psychometric qualities of the AVQI have been confirmed by numerous publications in various languages. However, its validation in French relies on a small cohort of patients, who were not native French speakers. Furthermore, version 03.01 of the AVQI has not yet been validated at all on French samples. Hence, the main aim of this study was to assess the criterion-related concurrent validity and diagnostic accuracy of the AVQI 03.01 applied to a sample of native French speakers.
    Methods: For the first part of this study, the optimal part of the text to be used for the AVQI was identified, taking into account both its phonemic contents and its time balance with the sustained vowel. For the validation study, 90 recordings from the University Hospital of Liège's ENT caseload database were used, as well as 30 new recordings of normophonic individuals, composing a control group. Four judges assessed the recordings using the G parameter of the GRBAS scale. Once the intra- and inter-rater reliability of the perceptual ratings was confirmed, the AVQI 03.01's criterion validity was assessed on the French sample. The diagnostic accuracy of the AVQI 03.01 in French was measured, and the cut-off score allowing for the greatest diagnostic precision determined.
    Results: The most appropriate syllable number of the text to be read aloud was found to be 27, in order to balance the time analyzed for both the sustained vowel and the continuous speech. Regarding the validation study, intra-rater reliability was substantial for each of the four vocologists (κ
    Conclusions: This study confirms the external validity of the AVQI 03.01 when applied on a French 27-syllable sample. The AVQI 03.01 is a robust, ecologically valid objective measure of overall voice quality. The cut-off score to be used is 2.33. However, clinicians should be cautious when the AVQI score is lower than 2.33. The AVQI 03.01 does not yield a sufficiently low negative likelihood ratio to be sure that this score indeed indicates normophonia. Also, taking into account the limitations regarding the perceptual judgements used in this study, a replication study should be carried out in order to confirm the cut-off score.
    MeSH term(s) Acoustics ; Adult ; Aged ; Aged, 80 and over ; Dysphonia/diagnosis ; Dysphonia/physiopathology ; Female ; Humans ; Language ; Male ; Middle Aged ; Observer Variation ; Predictive Value of Tests ; Psychometrics ; Reproducibility of Results ; Severity of Illness Index ; Sound Spectrography ; Speech Acoustics ; Speech Production Measurement ; Voice Quality ; Young Adult
    Language English
    Publishing date 2018-12-28
    Publishing country United States
    Document type Journal Article ; Validation Study
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2018.12.008
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  7. Article ; Online: The Acoustic Voice Quality Index, Version 03.01, in French and the Voice Handicap Index.

    Pommée, Timothy / Maryn, Youri / Finck, Camille / Morsomme, Dominique

    Journal of voice : official journal of the Voice Foundation

    2018  Volume 34, Issue 4, Page(s) 646.e1–646.e10

    Abstract: Objectives: The Acoustic Voice Quality Index (AVQI), version 03.01, is a tool for quantitative assessment of the overall severity of dysphonia. Its computation includes six acoustic parameters, which are all analyzed with Praat freeware. It is based on ... ...

    Abstract Objectives: The Acoustic Voice Quality Index (AVQI), version 03.01, is a tool for quantitative assessment of the overall severity of dysphonia. Its computation includes six acoustic parameters, which are all analyzed with Praat freeware. It is based on recordings of a sustained vowel and part of a text read aloud. The psychometric qualities of this tool in various languages, including French, have been confirmed by numerous publications. However, studies investigating the correlation between tools for objective vocal assessment and voice-related quality of life show inconsistent results. Hence, the aim of this study was to contribute to the debate on measuring the correlations between the AVQI 03.01 score computed on French samples and the Voice Handicap Index (VHI).
    Methods: Data from 78 patients were used; they were collected during initial vocal assessment and stored in the ear, nose, and throat caseload database of the University Hospital of Liège. The Spearman rank-order correlations (r
    Results: The Spearman correlation between AVQI 03.01 score and total VHI score, controlling for age, was moderate (r
    Conclusions: Although AVQI 03.01 scores were moderately correlated with the VHI total score and subscores, they measure two different things. The AVQI 03.01 assesses overall voice quality in terms of acoustic parameters, whereas the VHI assesses the multidetermined impact on the patient's everyday life. Both results should thus be taken into account, as part of a comprehensive vocal assessment.
    MeSH term(s) Acoustics ; Adult ; Aged ; Aged, 80 and over ; Cost of Illness ; Disability Evaluation ; Dysphonia/diagnosis ; Dysphonia/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Phonation ; Predictive Value of Tests ; Quality of Life ; Reproducibility of Results ; Severity of Illness Index ; Speech Production Measurement ; Surveys and Questionnaires ; Voice Quality ; Young Adult
    Language English
    Publishing date 2018-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2018.11.017
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  8. Article ; Online: Description of patients consulting the voice clinic regarding gender, age, occupational status, and diagnosis.

    Remacle, Angélique / Petitfils, Cloé / Finck, Camille / Morsomme, Dominique

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2017  Volume 274, Issue 3, Page(s) 1567–1576

    Abstract: The purpose of this paper was to describe the gender, age, occupational status, and diagnosis of dysphonic patients. We retrospectively analyzed the medical records of 1079 patients examined at the Voice clinic of the University hospital of Liège in ... ...

    Abstract The purpose of this paper was to describe the gender, age, occupational status, and diagnosis of dysphonic patients. We retrospectively analyzed the medical records of 1079 patients examined at the Voice clinic of the University hospital of Liège in French-speaking Belgium. Overall, seven out of ten patients who attended the voice clinic for dysphonia were females. The patients' ages ranged from 4 to 93 (mean = 43.5). Females predominantly consulted at the age of 54 and males at the age of 9. Regarding the occupational status, workers represented more than half of our patients (53 %), while 11.2 % were unemployed, 15.4 % were students, and 19.9 % were retired. Regarding the diagnoses of the 1079 patients, nodules were the most common pathologies (n = 182, 16.9 % of the patients), prevailing in females (n = 142, 18.8 % of the females), and encountered in 16.8 % of the workers and 42.8 % of the students consulting the voice clinic. Following nodules, laryngeal mobility disorders were diagnosed in 16.4 % of the patients (n = 177), mainly females (n = 115), and was the most frequent diagnosis in retirees (n = 75, 34.9 %). The majority of the patients consulting the voice clinic for dysphonia were adult females, in their workforce, diagnosed with vocal nodules. The identification of the patients' characteristics and diagnoses is important to develop treatments and prevention of dysphonia, estimate their costs, and allow comparisons across referral centers.
    MeSH term(s) Adult ; Age Factors ; Belgium/epidemiology ; Dysphonia/diagnosis ; Dysphonia/epidemiology ; Dysphonia/etiology ; Employment/statistics & numerical data ; Female ; Humans ; Laryngeal Diseases/complications ; Laryngeal Diseases/diagnosis ; Laryngeal Diseases/epidemiology ; Male ; Retrospective Studies ; Sex Factors ; Speech Production Measurement/methods ; Voice Disorders/complications ; Voice Disorders/diagnosis ; Voice Disorders/epidemiology ; Voice Quality
    Language English
    Publishing date 2017-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-016-4332-7
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  9. Article ; Online: Laryngopharyngeal Reflux as Causative Factor of Vocal Fold Nodules.

    Lechien, Jerome R / Saussez, Sven / Harmegnies, Bernard / Finck, Camille

    Journal of voice : official journal of the Voice Foundation

    2018  Volume 34, Issue 1, Page(s) 150–151

    MeSH term(s) Humans ; Laryngeal Diseases ; Laryngopharyngeal Reflux ; Pepsin A ; Polyps ; Vocal Cords
    Chemical Substances Pepsin A (EC 3.4.23.1)
    Language English
    Publishing date 2018-08-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2018.06.006
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  10. Article ; Online: Saliva Pepsin Concentration of Laryngopharyngeal Reflux Patients Is Influenced by Meals Consumed Before the Samples.

    Lechien, Jerome R / Bobin, Francois / Muls, Vinciane / Horoi, Mihaela / Thill, Marie-Paule / Dequanter, Didier / Finck, Camille / Rodriguez, Alexandra / Saussez, Sven

    The Laryngoscope

    2020  Volume 131, Issue 2, Page(s) 350–359

    Abstract: Objectives/hypothesis: To assess the impact of diet on the saliva pepsin concentration of patients with laryngopharyngeal reflux (LPR).: Study design: Non-controlled Prospective Study.: Methods: Patients with positive LPR regarding hypopharyngeal- ... ...

    Abstract Objectives/hypothesis: To assess the impact of diet on the saliva pepsin concentration of patients with laryngopharyngeal reflux (LPR).
    Study design: Non-controlled Prospective Study.
    Methods: Patients with positive LPR regarding hypopharyngeal-esophageal impedance-pH monitoring (HEMII-pH) were enrolled from three European Hospitals. Patients collected three saliva samples, respectively, in the morning (fasting), and 1 to 2 hour after lunch and dinner. Patients carefully detailed foods and beverages consumed during meals and before the pepsin samples. The 3-month treatment was based on the association of diet, proton pump inhibitors, alginate, or magaldrate regarding the HEMII-pH characteristics. Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were used for assessing the pre- to posttreatment clinical evolution. The Refluxogenic Diet Score and the Refluxogenic Score of a Dish (RESDI) were used to assess the refluxogenic potential of foods and beverages. The relationship between saliva pepsin concentration, HEMII-pH, RESDI, RSS, and RSA was investigated through multiple linear regression.
    Results: Forty-two patients were included. The saliva pepsin concentration of the 24-hour period of testing was significantly associated with foods and beverages consumed during the testing period and the evening dinner (r
    Conclusions: Foods and beverages may significantly impact the saliva pepsin concentration of patients with LPR. Patients with high-level saliva pepsin in the morning had lower therapeutic response compared with those with low-level saliva pepsin.
    Level of evidence: 4 Laryngoscope, 131:350-359, 2021.
    MeSH term(s) Adult ; Aged ; Diet/adverse effects ; Diet/statistics & numerical data ; Diet Surveys ; Electric Impedance ; Esophageal pH Monitoring ; Female ; Humans ; Laryngopharyngeal Reflux/drug therapy ; Laryngopharyngeal Reflux/metabolism ; Male ; Meals/physiology ; Middle Aged ; Pepsin A/metabolism ; Prospective Studies ; Proton Pump Inhibitors/therapeutic use ; Saliva/chemistry ; Severity of Illness Index ; Young Adult
    Chemical Substances Proton Pump Inhibitors ; Pepsin A (EC 3.4.23.1)
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28756
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