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  1. Article ; Online: Environmental Medicine: Exploring the Pollutome for Solutions to Chronic Diseases.

    Fine, Anne Marie / Patrick, Lyn

    Physical medicine and rehabilitation clinics of North America

    2022  Volume 33, Issue 3, Page(s) 719–732

    Abstract: Environmental toxicant exposure, according to many researchers in the field, is the leading cause of chronic disease and premature death globally. For the purposes of this review, we will use obesity and type 2 diabetes as examples of toxicant-induced ... ...

    Abstract Environmental toxicant exposure, according to many researchers in the field, is the leading cause of chronic disease and premature death globally. For the purposes of this review, we will use obesity and type 2 diabetes as examples of toxicant-induced chronic diseases. Endocrine Disrupting chemicals (EDCs) such as phthalates and bisphenols, per- and polyfluoroalkyl substances (PFAS), and persistent organic pollutants (POPs) have been linked to increased risk for obesity and type 2 diabetes in both animal and large epidemiologic studies. These two conditions are well-documented examples of evidence for mechanisms of both adipose metabolism disruption and pancreatic cell dysfunction. The implications for health care directives to both identify, prevent, and treat these exposures are reviewed.
    MeSH term(s) Animals ; Chronic Disease ; Diabetes Mellitus, Type 2 ; Endocrine Disruptors/toxicity ; Environmental Medicine ; Humans ; Obesity/chemically induced
    Chemical Substances Endocrine Disruptors
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196791-2
    ISSN 1558-1381 ; 1047-9651
    ISSN (online) 1558-1381
    ISSN 1047-9651
    DOI 10.1016/j.pmr.2022.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA).

    Vom Saal, Frederick S / Antoniou, Michael / Belcher, Scott M / Bergman, Ake / Bhandari, Ramji K / Birnbaum, Linda S / Cohen, Aly / Collins, Terrence J / Demeneix, Barbara / Fine, Anne Marie / Flaws, Jodi A / Gayrard, Veronique / Goodson, William H / Gore, Andrea C / Heindel, Jerrold J / Hunt, Patricia A / Iguchi, Taisen / Kassotis, Christopher D / Kortenkamp, Andreas /
    Mesnage, Robin / Muncke, Jane / Myers, John Peterson / Nadal, Angel / Newbold, Retha R / Padmanabhan, Vasantha / Palanza, Paola / Palma, Zandra / Parmigiani, Stefano / Patrick, Lyn / Prins, Gail S / Rosenfeld, Cheryl S / Skakkebaek, Niels E / Sonnenschein, Carlos / Soto, Ana M / Swan, Shanna H / Taylor, Julia A / Toutain, Pierre-Louis / von Hippel, Frank A / Welshons, Wade V / Zalko, Daniel / Zoeller, R Thomas

    Environmental health perspectives

    2024  Volume 132, Issue 4, Page(s) 45001

    Abstract: Background: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to : Objectives: We identify the flaws in the assumptions that the German BfR, as well as the ... ...

    Abstract Background: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to
    Objectives: We identify the flaws in the assumptions that the German BfR, as well as the FDA, have used to justify maintaining the TDI for BPA at levels above what a vast amount of academic research shows to cause harm. We argue that regulatory agencies need to incorporate 21st century science into chemical hazard identifications using the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) nonguideline academic studies in a collaborative government-academic program model.
    Discussion: We strongly endorse EFSA's revised TDI for BPA and support the European Commission's (EC) apparent acceptance of this updated BPA risk assessment. We discuss challenges to current chemical risk assessment assumptions about EDCs that need to be addressed by regulatory agencies to, in our opinion, become truly protective of public health. Addressing these challenges will hopefully result in BPA, and eventually other structurally similar bisphenols (called regrettable substitutions) for which there are known adverse effects, being eliminated from all food-related and many other uses in the EU and elsewhere. https://doi.org/10.1289/EHP13812.
    MeSH term(s) Humans ; Benzhydryl Compounds ; Food Safety ; No-Observed-Adverse-Effect Level ; Phenols ; Systematic Reviews as Topic
    Chemical Substances Benzhydryl Compounds ; bisphenol A (MLT3645I99) ; Phenols
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP13812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 379: Show issues

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