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  1. Article: Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review.

    Leisegang, Kristian / Finelli, Renata

    Arab journal of urology

    2021  Volume 19, Issue 3, Page(s) 323–339

    Abstract: ... ...

    Abstract Objectives
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2631788-6
    ISSN 2090-598X
    ISSN 2090-598X
    DOI 10.1080/2090598X.2021.1926753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Effect of Aqueous

    Leisegang, Kristian / Finelli, Renata / Henkel, Ralf / Zenoaga-Barbăroșie, Cătălina

    Frontiers in bioscience (Landmark edition)

    2023  Volume 28, Issue 9, Page(s) 213

    Abstract: Background: Extractions of : Methods: Human chorionic gonadotrophin-stimulated TM3 Leydig cells were exposed for 24 h to (a) TNF-α (0.1, 1, 10, 100 ng/mL), (b) : Results: TNF-α exposure decreased cell viability, increased cytotoxicity, and caspase ...

    Abstract Background: Extractions of
    Methods: Human chorionic gonadotrophin-stimulated TM3 Leydig cells were exposed for 24 h to (a) TNF-α (0.1, 1, 10, 100 ng/mL), (b)
    Results: TNF-α exposure decreased cell viability, increased cytotoxicity, and caspase 3/7, with no significant effect on intracellular superoxide in TM3 Leydig cells. When
    Conclusions: In our TM3 Leydig cell model,
    MeSH term(s) Male ; Humans ; Leydig Cells/physiology ; Tumor Necrosis Factor-alpha/pharmacology ; Superoxides ; Caspase 3 ; Testosterone/pharmacology
    Chemical Substances Tumor Necrosis Factor-alpha ; Superoxides (11062-77-4) ; Caspase 3 (EC 3.4.22.-) ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2023-10-05
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2809213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review.

    Leisegang, Kristian / Opuwari, Chinyerum Sylvia / Moichela, Faith / Finelli, Renata

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 9

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Male ; Premature Ejaculation/drug therapy ; Acupuncture Therapy ; Databases, Factual ; Dietary Supplements ; Exercise
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59091607
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  4. Article ; Online: Polymorphic Rearrangements of Human Chromosome 9 and Male Infertility: New Evidence and Impact on Spermatogenesis.

    Mottola, Filomena / Santonastaso, Marianna / Ronga, Valentina / Finelli, Renata / Rocco, Lucia

    Biomolecules

    2023  Volume 13, Issue 5

    Abstract: Chromosomal polymorphisms are structural variations in chromosomes that define the genomic variance of a species. These alterations are recurrent in the general population, and some of them appear to be more recurrent in the infertile population. Human ... ...

    Abstract Chromosomal polymorphisms are structural variations in chromosomes that define the genomic variance of a species. These alterations are recurrent in the general population, and some of them appear to be more recurrent in the infertile population. Human chromosome 9 is highly heteromorphic, and how its rearrangement affects male fertility remains to be fully investigated. In this study, we aimed to investigate the association between the polymorphic rearrangements of chromosome 9 and male infertility via an Italian cohort of male infertile patients. Cytogenetic analysis was carried out, along with Y microdeletion screening, semen analysis, fluorescence in situ hybridization, and TUNEL assays using spermatic cells. Chromosome 9 rearrangements were observed in six patients: three of them showed a pericentric inversion, while the others showed a polymorphic heterochromatin variant 9qh. Of these, four patients exhibited oligozoospermia associated with teratozoospermia, along with a percentage of aneuploidy in the sperm of above 9%, in particular, an increase in XY disomy. Additionally, high values for sperm DNA fragmentation (≥30%) were observed in two patients. None of them had microdeletions to the AZF loci on chromosome Y. Our results suggest that polymorphic rearrangements of chromosome 9 might be associated with abnormalities in sperm quality due to incorrect spermatogenesis regulation.
    MeSH term(s) Humans ; Male ; In Situ Hybridization, Fluorescence ; Semen ; Infertility, Male/genetics ; Spermatozoa/physiology ; Spermatogenesis/genetics ; Chromosomes, Human ; Chromosomes, Human, Pair 9
    Language English
    Publishing date 2023-04-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13050729
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  5. Article: Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction.

    Finelli, Renata / Moreira, Bruno P / Alves, Marco G / Agarwal, Ashok

    Advances in experimental medicine and biology

    2022  Volume 1358, Page(s) 77–113

    Abstract: Semen analysis is the cornerstone in the investigation of fertility status of male partner. However, more advanced tests have emerged including the analysis of sperm chromatin integrity and DNA damage as markers of semen quality. This is of particular ... ...

    Abstract Semen analysis is the cornerstone in the investigation of fertility status of male partner. However, more advanced tests have emerged including the analysis of sperm chromatin integrity and DNA damage as markers of semen quality. This is of particular interest, as preserving the genetic information is essential to achieve a successful reproductive event. Moreover, the presence of unrepaired DNA lesions can affect cellular functions, resulting in the onset of pathological conditions associated with male infertility, and the transmission of diseases to the offspring. Hence, in this chapter, we aim to review the main factors leading to sperm DNA damage, along with the different types of damage which can occur. Furthermore, molecular mechanisms involved in DNA repair during spermatogenesis or after fertilization of the oocyte are described, and the laboratory techniques currently used in diagnostics and research, for the analysis of sperm DNA damage are also presented. Finally, the impact of sperm DNA damage on reproductive outcomes such as fertilization and pregnancy rates will be discussed with a focus on animal and human studies, along with the identification of new markers of sperm chromatin integrity.
    MeSH term(s) Animals ; Biomarkers ; Chromatin/genetics ; DNA Damage/genetics ; Female ; Humans ; Male ; Pregnancy ; Semen Analysis/methods ; Spermatogenesis/genetics ; Spermatozoa/pathology
    Chemical Substances Biomarkers ; Chromatin
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-89340-8_5
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  6. Article ; Online: Eurycoma longifolia

    Leisegang, Kristian / Finelli, Renata / Sikka, Suresh C / Panner Selvam, Manesh Kumar

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 8

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Eurycoma ; Humans ; Hypogonadism/drug therapy ; Male ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plants, Medicinal ; Testosterone/therapeutic use
    Chemical Substances Plant Extracts ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Systematic Review ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58081047
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  7. Article ; Online: The efficacy of Zingiber officinale on dyslipidaemia, blood pressure, and inflammation as cardiovascular risk factors: A systematic review.

    Daniels, Chelsea Courtney / Isaacs, Zaiyaan / Finelli, Renata / Leisegang, Kristian

    Clinical nutrition ESPEN

    2022  Volume 51, Page(s) 72–82

    Abstract: Background & aims: Hypertension, dyslipidaemia, and chronic inflammation contribute to the development of cardiovascular disease (CVD). Zingiber officinale has been suggested to reduce these CVD risk factors; however, the clinical evidence remains ... ...

    Abstract Background & aims: Hypertension, dyslipidaemia, and chronic inflammation contribute to the development of cardiovascular disease (CVD). Zingiber officinale has been suggested to reduce these CVD risk factors; however, the clinical evidence remains unclear. This systematic review aims to analyse the effect of Z. officinale as a sole intervention on these risk factors.
    Methods: In this PRISMA-based systematic review, we included randomised clinical trials from PubMed, Scopus and Cochrane Database of Systematic Reviews (July 2020) analysing triglycerides, low- and high-density lipoprotein (LDL, HDL), total cholesterol, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin 1, 6, 10, systolic and/or diastolic blood pressure as outcomes. Quality of studies was evaluated by JADAD and the Cochrane risk-of-bias tools.
    Results: A total of 24 studies were included, mostly (79.2%) showing low risk of bias. These were based on obesity and cardio-metabolic derangements (33.3%), type 2 diabetes mellitus (37.5%), and miscellaneous conditions (29.2%). While total cholesterol and triglycerides levels mostly improved after Z. officinale, results were inconsistent for other blood lipids markers. Inflammatory markers (CRP, TNF-α) were more consistently reduced by Z. officinale, while only 3 studies reported a non-significant reduction of blood pressure.
    Conclusions: Although there remains a paucity of studies, Z. officinale may be beneficial for improving dyslipidaemia and inflammation.
    MeSH term(s) Blood Pressure ; C-Reactive Protein ; Cardiovascular Diseases/prevention & control ; Cholesterol ; Diabetes Mellitus, Type 2 ; Dyslipidemias/drug therapy ; Zingiber officinale ; Humans ; Inflammation/drug therapy ; Interleukin-1 ; Lipids ; Lipoproteins, HDL ; Triglycerides ; Tumor Necrosis Factor-alpha
    Chemical Substances Interleukin-1 ; Lipids ; Lipoproteins, HDL ; Triglycerides ; Tumor Necrosis Factor-alpha ; C-Reactive Protein (9007-41-4) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-09-03
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2022.08.031
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  8. Article: Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele.

    Finelli, Renata / Leisegang, Kristian / Kandil, Hussein / Agarwal, Ashok

    The world journal of men's health

    2021  Volume 40, Issue 1, Page(s) 87–103

    Abstract: Oxidative stress is a condition due to an imbalance between the concentrations of oxidants and antioxidants, and it is a well-recognized contributor in several male infertility conditions. Varicocele, a common vascular condition, may cause male ... ...

    Abstract Oxidative stress is a condition due to an imbalance between the concentrations of oxidants and antioxidants, and it is a well-recognized contributor in several male infertility conditions. Varicocele, a common vascular condition, may cause male infertility due to hyperthermia, hypoxia and/or exposure to toxic adrenal and renal metabolites. In this review, the mechanisms by which oxidative stress can affect cellular integrity and functions are described, along with molecular markers of cellular oxidative damage, and the most commonly performed techniques for their detection in seminal fluid. Moreover, we focus on the role of oxidative stress in the pathophysiology of varicocele based on recently published evidence from omics based studies, such as proteomics and genomics. Finally, we discuss strategies for the management of oxidative stress and the clinical guidelines for testing oxidative stress-related sperm DNA fragmentation in this group of patients.
    Language English
    Publishing date 2021-10-13
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2719786-4
    ISSN 2287-4690 ; 2287-4208
    ISSN (online) 2287-4690
    ISSN 2287-4208
    DOI 10.5534/wjmh.210153
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  9. Article ; Online: Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review.

    Finelli, Renata / Mottola, Filomena / Agarwal, Ashok

    International journal of environmental research and public health

    2021  Volume 19, Issue 1

    Abstract: Alcohol abuse disorder is a serious condition, implicating more than 15 million people aged 12 years and older in 2019 in the United States. Ethanol (or ethyl alcohol) is mainly oxidized in the liver, resulting in the synthesis of acetaldehyde and ... ...

    Abstract Alcohol abuse disorder is a serious condition, implicating more than 15 million people aged 12 years and older in 2019 in the United States. Ethanol (or ethyl alcohol) is mainly oxidized in the liver, resulting in the synthesis of acetaldehyde and acetate, which are toxic and carcinogenic metabolites, as well as in the generation of a reductive cellular environment. Moreover, ethanol can interact with lipids, generating fatty acid ethyl esters and phosphatidylethanol, which interfere with physiological cellular pathways. This narrative review summarizes the impact of excessive alcohol consumption on male fertility by describing its metabolism and how ethanol consumption may induce cellular damage. Furthermore, the impact of alcohol consumption on hormonal regulation, semen quality, and genetic and epigenetic regulations is discussed based on evidence from animal and human studies, focusing on the consequences on the offspring. Finally, the limitations of the current evidence are discussed. Our review highlights the association between chronic alcohol consumption and poor semen quality, mainly due to the development of oxidative stress, as well as its genotoxic impact on hormonal regulation and DNA integrity, affecting the offspring's health. New landscapes of investigation are proposed for the identification of molecular markers for alcohol-associated infertility, with a focus on advanced OMICS-based approaches applied to the analysis of semen samples.
    MeSH term(s) Acetaldehyde ; Alcohol Drinking/adverse effects ; Animals ; Ethanol/toxicity ; Fertility ; Humans ; Male ; Semen Analysis
    Chemical Substances Ethanol (3K9958V90M) ; Acetaldehyde (GO1N1ZPR3B)
    Language English
    Publishing date 2021-12-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19010328
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  10. Article ; Online: Beyond conventional sperm parameters: the role of sperm DNA fragmentation in male infertility.

    Farkouh, Ala'a / Finelli, Renata / Agarwal, Ashok

    Minerva endocrinology

    2021  Volume 47, Issue 1, Page(s) 23–37

    Abstract: Infertility is a condition that widely affects couples all over the world. In this regard, sperm DNA fragmentation can lead to harmful reproductive consequences, including male infertility and poor outcomes after assisted reproductive techniques. The ... ...

    Abstract Infertility is a condition that widely affects couples all over the world. In this regard, sperm DNA fragmentation can lead to harmful reproductive consequences, including male infertility and poor outcomes after assisted reproductive techniques. The investigation of sperm DNA fragmentation in male infertility diagnostics has constantly increased over time, becoming more common in clinical practice with the recent publication of several guidelines regarding its testing. This narrative review aims to provide a comprehensive overview of the pathogenesis and causes of sperm DNA fragmentation, as well as the assays which are commonly performed for testing. Moreover, we discuss the most recently published evidence regarding the use of sperm DNA fragmentation testing in clinical practice, highlighting the implications of high sperm DNA fragmentation rate on human reproduction, and the therapeutic approaches for the clinical management of infertile patients. Our review confirms a significant harmful impact of sperm DNA fragmentation on reproduction and points out several interventions which can be applied in clinics to reduce sperm DNA fragmentation and improve reproductive outcomes. Sperm DNA fragmentation has been shown to adversely impact male fertility potential. As high sperm DNA fragmentation levels have been associated with poor reproductive outcomes, its testing may significantly help clinicians in defining the best therapeutic strategy for infertile patients.
    MeSH term(s) DNA Fragmentation ; Humans ; Infertility, Male/diagnosis ; Male ; Reproduction ; Reproductive Techniques, Assisted ; Spermatozoa/pathology
    Language English
    Publishing date 2021-12-09
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.21.03623-X
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