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Book ; Thesis: Positronen-Emissions-Tomographische Langzeitmessung der Aktivierung von Mikroglia nach Herz-Kreislauf-Stillstand im In-vivo-Modell

Finke, Simon-Richard / Annecke, Thorsten / Endepols, Heike

2020

Institution	Universitätsklinikum Köln / Klinik für Anästhesiologie und Operative Intensivmedizin
Author's details	vorgelegt von Simon-Richard Finke ; 1. Gutachter: Universitätsprofessor Dr. med. Th. Annecke, 2. Gutachterin: Professorin Dr. rer. nat. H. Endepols ; aus der Klinik für Anästhesiologie und Operative Intensivmedizin der Universität zu Köln
Subject code	610
Language	German
Size	103 Seiten, Illustrationen
Publishing place	Köln
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität zu Köln, 2020
HBZ-ID	HT020659300
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Education of schoolchildren in cardiopulmonary resuscitation - overview of the current literature.

Schroeder, Daniel C / Finke, Simon-Richard / Grübl, Tobias / Jänig, Christoph W / Böttiger, Bernd W

Current opinion in critical care

2023 Volume 29, Issue 6, Page(s) 616–620

Abstract: Purpose of review: Recognition of cardiac arrest and initiation of cardiopulmonary resuscitation (CPR) can be learned and adequately replicated by schoolchildren. Regular instruction of schoolchildren in CPR is therefore a core element to increase low ... ...

Abstract	Purpose of review: Recognition of cardiac arrest and initiation of cardiopulmonary resuscitation (CPR) can be learned and adequately replicated by schoolchildren. Regular instruction of schoolchildren in CPR is therefore a core element to increase low bystander CPR rates. Thereby, schoolchildren CPR training evolved as own scientific field within the last decade. Aim was to describe current evidence in terms of epidemiology, teaching approaches and political aspects. Recent findings: Schoolchildren demonstrate a high motivation to be trained in CPR. Teaching approaches that combine theoretical and practical learning sessions guarantee a sustainable learning effect. Schoolchildren can adequately perform chest compressions and mouth-to-mouth ventilation from the age of 12 years. Use of digital media is a highly promising teaching approach. CPR training conducted by teachers from the own school is effective and guarantees continuous development of CPR skills. Integration of schoolchildren CPR training into school curricula is the foundation for a sustainable increase of lay resuscitation rates in the population. Scientific and political promotion of schoolchildren CPR training is needed to sensitize the population and move bystander CPR in the social focus. Summary: While bystander CPR rates are low in Europe comprehensive establishment of schoolchildren CPR training may sustainably increase survival after cardiac arrest.
MeSH term(s)	Humans ; Child ; Cardiopulmonary Resuscitation ; Internet ; Out-of-Hospital Cardiac Arrest/therapy ; Schools ; Europe
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1235629-3
ISSN	1531-7072 ; 1070-5295
ISSN (online)	1531-7072
ISSN	1070-5295
DOI	10.1097/MCC.0000000000001111
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Article ; Online: Comparing Simulation Training of Bronchoscopy-Guided Percutaneous Dilatational Tracheostomy Using Conventional Versus 3D Printed Simulators (TRAC-Sim Study).

Wegner, Moritz / Dusse, Fabian / Beeser, Finnard / Leister, Nicolas / Lefarth, Marian / Finke, Simon-Richard / Böttiger, Bernd W / Dorweiler, Bernhard / Stoll, Sandra Emily

Journal of intensive care medicine

2024 , Page(s) 8850666241232918

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	632828-3
ISSN	1525-1489 ; 0885-0666
ISSN (online)	1525-1489
ISSN	0885-0666
DOI	10.1177/08850666241232918
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Zs.A 2158: Show issues

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Article ; Online: Comparing suction rates of novel DuCanto catheter against Yankauer and standard suction catheter using liquids of different viscosity-a technical simulation.

Finke, Simon-Richard / Schroeder, Daniel C / Ecker, Hannes / Böttiger, Bernd W / Herff, Holger / Wetsch, Wolfgang A

BMC anesthesiology

2022 Volume 22, Issue 1, Page(s) 285

Abstract: Purpose: Aspiration is a feared complication that may occur during airway management, and can significantly contribute to morbidity and mortality. Availability of a suctioning device with a suction catheter capable of clearing the airway is mandatory ... ...

Abstract	Purpose: Aspiration is a feared complication that may occur during airway management, and can significantly contribute to morbidity and mortality. Availability of a suctioning device with a suction catheter capable of clearing the airway is mandatory for airway management. However, suction performance may be significantly different amongst different suction catheters. The aim of this study was to compare suction rates of a standard 14 Ch suction catheter (SC), a Yankauer catheter (Y) and a DuCanto catheter (DC) using 4 fluids with different viscosity. Methods: In this simulation trial, 4 preparations with standardized viscosity were prepared using a Xanthane-based medical fluid thickener. Lowest viscosity was achieved using tap water without thickener, syrup-like viscosity was achieved by adding 10 g per liter tap water, honey-like viscosity was achieved by adding 20 g per liter, and a pudding-like viscosity was achieved by adding 30 g of thickening powder per liter tap water. Each preparation was suctioned for 15 s with the three different suctioning devices. Measurements were repeated four times. The amount of removed preparation by suctioning was measured using a tared scale. Results: Suction rates for water were 580 ± 34 mg for SC, 888 ± 5 mg for Y and 1087 ± 15 for DC; for syrup-like viscosity it was 383 ± 34(SC) vs. 661 ± 64(Y) vs. 935 ± 42(DC); for honey-like viscosity it was 191 ± 21(SC) vs. 426 ± 34(Y) vs. 590 ± 68(DC); and for pudding-like viscosity 74 ± 13(SC) vs. 164 ± 6(Y) vs. 211 ± 8(DC). Conclusion: Suctioning liquids of different viscosity, the new DuCanto catheter was more effective than the Yankauer catheter that was more effective than a standard suctioning catheter. The relative superiority of the DuCanto was highest in fluids with high viscosity.
MeSH term(s)	Catheterization ; Catheters ; Suction ; Viscosity ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2022-09-10
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-022-01830-2
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Article ; Online: Apneic laryngeal oxygenation during elective fiberoptic intubation - a technical simulation.

Schroeder, Daniel C / Wetsch, Wolfgang A / Finke, Simon-Richard / Dusse, Fabian / Böttiger, Bernd W / Herff, Holger

BMC anesthesiology

2020 Volume 20, Issue 1, Page(s) 300

Abstract: Background: Sedation during elective fiberoptic intubation for difficult airway can cause respiratory depression, apnea and periods of desaturation. During apneic episodes, hypoxemia can be prevented by insufflation of oxygen in the deep laryngeal space. ...

Abstract	Background: Sedation during elective fiberoptic intubation for difficult airway can cause respiratory depression, apnea and periods of desaturation. During apneic episodes, hypoxemia can be prevented by insufflation of oxygen in the deep laryngeal space. The aim of this study was to evaluate an oropharyngeal oxygenation device (OOD) designed for deep laryngeal insufflation during fiberoptic intubation. Methods: The OOD is split in the front to form a path for the bronchoscope. An external lumen delivers oxygen in the deep laryngeal space. In this experimental study, air application (as control group), oxygen application via nasal prongs, oxygen application via the OOD, and oxygen application via the working channel of a bronchoscope were compared in a technical simulation. In a preoxygenated test lung of a manikin, decrease of the oxygen saturation was measured over 20 min for each method. Results: Oxygen saturation in the test lung dropped from 97 ± 1% (baseline in all groups) to 58 ± 3% in the control-group (p < 0.001 compared to all other groups) and to 78 ± 1% in the nasal prong group (p < 0.001 compared to all other groups). Oxygen saturation remained at 95 ± 2% in both the OOD group and the bronchoscopy group (p = 0.451 between those two groups). Conclusion: Simulating apneic laryngeal oxygenation in a preoxygenated manikin, both oxygen insufflation via the OOD and the bronchoscope kept oxygen saturation in the test lung at 95% over 20 min. Both methods significantly were more effective than oxygen insufflation via nasal prongs.
MeSH term(s)	Apnea/therapy ; Elective Surgical Procedures ; Equipment Design ; Fiber Optic Technology ; Hypoxia/prevention & control ; Insufflation/instrumentation ; Insufflation/methods ; Intubation, Intratracheal/methods ; Larynx ; Manikins ; Oxygen/administration & dosage ; Oxygen Inhalation Therapy/instrumentation ; Oxygen Inhalation Therapy/methods
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2020-12-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2253
ISSN (online)	1471-2253
DOI	10.1186/s12871-020-01216-2
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Article ; Online: A special oropharyngeal oxygenation device to facilitate apneic oxygenation in comparison to high flow oxygenation devices.

Wetsch, Wolfgang A / Schroeder, Daniel C / Finke, Simon-Richard / Sander, David / Ecker, Hannes / Böttiger, Bernd W / Herff, Holger

Medical gas research

2021 Volume 12, Issue 1, Page(s) 28–31

Abstract: Oxygen application and apneic oxygenation may reduce the risk of hypoxemia due to apnea during awake fiberoptic intubation or failed endotracheal intubation. High flow devices are recommended, but their effect compared to moderate deep oropharyngeal ... ...

Abstract	Oxygen application and apneic oxygenation may reduce the risk of hypoxemia due to apnea during awake fiberoptic intubation or failed endotracheal intubation. High flow devices are recommended, but their effect compared to moderate deep oropharyngeal oxygen application is unknown. Designed as an experimental manikin trial, we made a comparison between oxygen application via nasal prongs at 10 L/min (control group), applying oxygen via oropharyngeal oxygenation device (at 10 L/min), oxygen application via high flow nasal oxygen with 20 L/min and 90% oxygen (20 L/90% group), oxygen application via high flow nasal oxygen with 60 L/min and 45% oxygen (60 L/45% group), and oxygen application via sealed face mask with a special adapter to allow for fiberoptic entering of the airway. We preoxygenated the lung of a manikin and measured the decrease in oxygen level during the following 20 minutes for each way of oxygen application. Oxygen levels fell from 97 ± 1% at baseline to 75 ± 1% in control group, and to 86 ± 1% in oropharyngeal oxygenation device group. In the high flow nasal oxygen group, oxygen level dropped to 72 ± 1% in the 20 L/90% group and to 44 ± 1% in the 60 L/45% group. Oxygen level remained at 98 ± 0% in the face mask group. In conclusion, in this manikin simulation study of apneic oxygenation, oxygen insufflation using a sealed face mask kept oxygen levels in the test lung at 98% over 20 minutes, oral oxygenation device led to oxygen levels at 86%, whereas all other methods resulted in the decrease of oxygen levels below 75%.
MeSH term(s)	Apnea/therapy ; Humans ; Intubation, Intratracheal ; Lung ; Manikins ; Oxygen Inhalation Therapy ; Respiration, Artificial
Language	English
Publishing date	2021-09-02
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2616230-1
ISSN	2045-9912 ; 2045-9912
ISSN (online)	2045-9912
ISSN	2045-9912
DOI	10.4103/2045-9912.323536
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Article: Notfallmedizinische Aspekte bei Laufveranstaltungen.

Finke, Simon-Richard / Jänig, Christoph / Deschler, Andreas / Hanske, Jan / Herff, Holger / Hinkelbein, Jochen / Böttiger, Bernd W / Schmidbauer, W / Schroeder, Daniel C

Notfall & rettungsmedizin

2021 Volume 26, Issue 3, Page(s) 189–198

Abstract: Background: The number of short- and long-distance running events in Germany is increasing. Running as a popular sport is practiced by a large number of people of different ages, risk groups, and degrees of professionalism, which results in a wide range ...

Title translation	Medical emergencies during running events.
Abstract	Background: The number of short- and long-distance running events in Germany is increasing. Running as a popular sport is practiced by a large number of people of different ages, risk groups, and degrees of professionalism, which results in a wide range of medical emergencies. Objective: The present article elucidates incidence, pathophysiology and therapy of relevant emergencies during running events. Aim was the optimization of work processes of emergency personnel. Materials and methods: A literature search was conducted in PubMed. Results: Exercise-associated muscle cramps, gastrointestinal symptoms, collapse, compartment syndrome, and tendinopathy are common clinical manifestations. Cardiac arrest and sudden cardiac death are rare events. Consciousness and seizures are major complications. Disseminated intravascular coagulation, exercise-associated hyponatremia, heat stroke, rhabdomyolysis, and thromboembolism are associated with high morbidity and mortality. Substances increasing pain resilience as well as performance-enhancing substances are popular among amateur and professional runners and are associated with a high incidence of side effects. Conclusion: General symptoms including vomiting, fever, collapse, muscle-pain, nausea and weakness are the leading symptoms during running events. A careful anamnesis is important for targeted clinical therapy. Symptom control is the main task. Fluid management the most challenging task for healthcare providers in the prehospital setting.
Language	German
Publishing date	2021-12-02
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1424737-9
ISSN	1436-0578 ; 1434-6222
ISSN (online)	1436-0578
ISSN	1434-6222
DOI	10.1007/s10049-021-00959-w
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Article ; Online: KIDS SAVE LIVES: Basic Life Support Education for Schoolchildren: A Narrative Review and Scientific Statement From the International Liaison Committee on Resuscitation.

Schroeder, Daniel C / Semeraro, Federico / Greif, Robert / Bray, Janet / Morley, Peter / Parr, Michael / Kondo Nakagawa, Naomi / Iwami, Taku / Finke, Simon-Richard / Malta Hansen, Carolina / Lockey, Andrew / Del Rios, Marina / Bhanji, Farhan / Sasson, Comilla / Schexnayder, Stephen M / Scquizzato, Tommaso / Wetsch, Wolfgang A / Böttiger, Bernd W

Resuscitation

2023 Volume 188, Page(s) 109772

Abstract: Background: Basic life support education for schoolchildren has become a key initiative to increase bystander cardiopulmonary resuscitation rates. Our objective was to review the existing literature on teaching schoolchildren basic life support to ... ...

Abstract	Background: Basic life support education for schoolchildren has become a key initiative to increase bystander cardiopulmonary resuscitation rates. Our objective was to review the existing literature on teaching schoolchildren basic life support to identify the best practices to provide basic life support training in schoolchildren. Methods: After topics and subgroups were defined, a comprehensive literature search was conducted. Systematic reviews and controlled and uncontrolled prospective and retrospective studies containing data on students <20 years of age were included. Results: Schoolchildren are highly motivated to learn basic life support. The CHECK-CALL-COMPRESS algorithm is recommended for all schoolchildren. Regular training in basic life support regardless of age consolidates long-term skills. Young children from 4 years of age are able to assess the first links in the chain of survival. By 10 to 12 years of age, effective chest compression depths and ventilation volumes can be achieved on training manikins. A combination of theoretical and practical training is recommended. Schoolteachers serve as effective basic life support instructors. Schoolchildren also serve as multipliers by passing on basic life support skills to others. The use of age-appropriate social media tools for teaching is a promising approach for schoolchildren of all ages. Conclusions: Schoolchildren basic life support training has the potential to educate whole generations to respond to cardiac arrest and to increase survival after out-of-hospital cardiac arrest. Comprehensive legislation, curricula, and scientific assessment are crucial to further develop the education of schoolchildren in basic life support.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Retrospective Studies ; Prospective Studies ; Cardiopulmonary Resuscitation/education ; Educational Status ; Out-of-Hospital Cardiac Arrest/therapy
Language	English
Publishing date	2023-05-17
Publishing country	Ireland
Document type	Review ; Journal Article
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2023.109772
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Article ; Online: KIDS SAVE LIVES: Basic Life Support Education for Schoolchildren: A Narrative Review and Scientific Statement From the International Liaison Committee on Resuscitation.

Circulation

2023 Volume 147, Issue 24, Page(s) 1854–1868

Abstract	Background: Basic life support education for schoolchildren has become a key initiative to increase bystander cardiopulmonary resuscitation rates. Our objective was to review the existing literature on teaching schoolchildren basic life support to identify the best practices to provide basic life support training in schoolchildren. Methods: After topics and subgroups were defined, a comprehensive literature search was conducted. Systematic reviews and controlled and uncontrolled prospective and retrospective studies containing data on students <20 years of age were included. Results: Schoolchildren are highly motivated to learn basic life support. The CHECK-CALL-COMPRESS algorithm is recommended for all schoolchildren. Regular training in basic life support regardless of age consolidates long-term skills. Young children from 4 years of age are able to assess the first links in the chain of survival. By 10 to 12 years of age, effective chest compression depths and ventilation volumes can be achieved on training manikins. A combination of theoretical and practical training is recommended. Schoolteachers serve as effective basic life support instructors. Schoolchildren also serve as multipliers by passing on basic life support skills to others. The use of age-appropriate social media tools for teaching is a promising approach for schoolchildren of all ages. Conclusions: Schoolchildren basic life support training has the potential to educate whole generations to respond to cardiac arrest and to increase survival after out-of-hospital cardiac arrest. Comprehensive legislation, curricula, and scientific assessment are crucial to further develop the education of schoolchildren in basic life support.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Retrospective Studies ; Prospective Studies ; Cardiopulmonary Resuscitation/education ; Educational Status ; Out-of-Hospital Cardiac Arrest
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIR.0000000000001128
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Article ; Online: First-time evaluation of ascending compared to rectangular transthoracic defibrillation waveforms in modelled out-of-hospital cardiac arrest.

Neumann, Tobias / Finke, Simon-Richard / Henninger, Maja / Lemke, Sebastian / Hoepfner, Ben / Steven, Daniel / Maul, Alexandra C / Schroeder, Daniel C / Annecke, Thorsten

Resuscitation plus

2020 Volume 1-2, Page(s) 100006

Abstract: Aim of the study: Prognosis in out-of-hospital cardiac arrest (OHCA) depends on cardiopulmonary resuscitation (CPR) duration. Therefore, the optimal biphasic defibrillation waveform shows high conversion rates besides low energy. Matthew Fishler ... ...

Abstract	Aim of the study: Prognosis in out-of-hospital cardiac arrest (OHCA) depends on cardiopulmonary resuscitation (CPR) duration. Therefore, the optimal biphasic defibrillation waveform shows high conversion rates besides low energy. Matthew Fishler theoretically predicted it to be truncated ascending exponential. We realised a prototypic defibrillator and compared ascending with conventional rectangular waveforms in modelled OHCA and CPR. Methods: Approved by the authorities, 57 healthy swine (Landrace × Piétrain) were randomised to ASCDefib ( Results: Under our model-specific conditions, VF was initially terminated by 13/80 ascending waveforms and 13/79 rectangular waveforms and persistent return of spontaneous circulation was achieved in 8/26 (ASCDefib) vs. 10/26 (CONVDefib) animals. Mean current rather than waveform design was predictive for defibrillation success in a generalised linear model. Conclusion: Contrary to theoretical assumptions, transthoracic biphasic defibrillation with ascending waveforms is not superior to rectangular waveforms in modelled OHCA. We advocate defibrillation dosage to be guided by current, that has proven its predictive value again. Institutional protocol number: 84-02.04.2017.A176.
Language	English
Publishing date	2020-06-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2020.100006
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