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  1. Book ; Online ; Thesis: Das Druckgeschwür als krankheitsmodifizierender Faktor nach akuter Rückenmarksverletzung

    Finkenstaedt, Felix [Verfasser]

    2022  

    Author's details Felix Finkenstaedt
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Long-term functional outcome in patients with acquired infections after acute spinal cord injury.

    Kopp, Marcel A / Watzlawick, Ralf / Martus, Peter / Failli, Vieri / Finkenstaedt, Felix W / Chen, Yuying / DeVivo, Michael J / Dirnagl, Ulrich / Schwab, Jan M

    Neurology

    2017  Volume 88, Issue 9, Page(s) 892–900

    Abstract: Objective: To investigate whether prevalent hospital-acquired pneumonia and wound infection affect the clinical long-term outcome after acute traumatic spinal cord injury (SCI).: Methods: This was a longitudinal cohort study within the prospective ... ...

    Abstract Objective: To investigate whether prevalent hospital-acquired pneumonia and wound infection affect the clinical long-term outcome after acute traumatic spinal cord injury (SCI).
    Methods: This was a longitudinal cohort study within the prospective multicenter National Spinal Cord Injury Database (Birmingham, Alabama). We screened datasets of 3,834 patients enrolled in 20 trial centers from 1995 to 2005 followed up until 2016. Eligibility criteria were cervical SCI and American Spinal Cord Injury Association impairment scale A, B, and C. Pneumonia or postoperative wound infections (Pn/Wi) acquired during acute medical care/inpatient rehabilitation were analyzed for their association with changes in the motor items of the Functional Independence Measure (FIM
    Results: A total of 1,203 patients met the eligibility criteria. During hospitalization, 564 patients (47%) developed Pn/Wi (pneumonia n = 540; postoperative wound infection n = 11; pneumonia and postoperative wound infection n = 13). Adjusted linear mixed models after multiple imputation revealed that Pn/Wi are significantly associated with lower gain in FIM
    Conclusion: Hospital-acquired Pn/Wi are predictive of propagated disability and mortality after SCI. Pn/Wi qualify as a potent and targetable outcome-modifying factor. Pn/Wi prevention constitutes a viable strategy to protect functional recovery and reduce mortality. Pn/Wi can be considered as rehabilitation confounders in clinical trials.
    MeSH term(s) Adult ; Cross Infection/complications ; Cross Infection/diagnosis ; Cross Infection/mortality ; Databases, Factual ; Disability Evaluation ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Pneumonia/complications ; Pneumonia/diagnosis ; Pneumonia/mortality ; Prevalence ; Prognosis ; Prospective Studies ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/diagnosis ; Spinal Cord Injuries/mortality ; Spinal Cord Injuries/therapy ; Surgical Wound Infection/complications ; Surgical Wound Infection/diagnosis ; Surgical Wound Infection/mortality ; Time Factors ; Treatment Outcome ; United States ; Young Adult
    Language English
    Publishing date 2017-01-27
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000003652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level.

    Brommer, Benedikt / Engel, Odilo / Kopp, Marcel A / Watzlawick, Ralf / Müller, Susanne / Prüss, Harald / Chen, Yuying / DeVivo, Michael J / Finkenstaedt, Felix W / Dirnagl, Ulrich / Liebscher, Thomas / Meisel, Andreas / Schwab, Jan M

    Brain : a journal of neurology

    2016  Volume 139, Issue Pt 3, Page(s) 692–707

    Abstract: Pneumonia is the leading cause of death after acute spinal cord injury and is associated with poor neurological outcome. In contrast to the current understanding, attributing enhanced infection susceptibility solely to the patient's environment and motor ...

    Abstract Pneumonia is the leading cause of death after acute spinal cord injury and is associated with poor neurological outcome. In contrast to the current understanding, attributing enhanced infection susceptibility solely to the patient's environment and motor dysfunction, we investigate whether a secondary functional neurogenic immune deficiency (spinal cord injury-induced immune deficiency syndrome, SCI-IDS) may account for the enhanced infection susceptibility. We applied a clinically relevant model of experimental induced pneumonia to investigate whether the systemic SCI-IDS is functional sufficient to cause pneumonia dependent on spinal cord injury lesion level and investigated whether findings are mirrored in a large prospective cohort study after human spinal cord injury. In a mouse model of inducible pneumonia, high thoracic lesions that interrupt sympathetic innervation to major immune organs, but not low thoracic lesions, significantly increased bacterial load in lungs. The ability to clear the bacterial load from the lung remained preserved in sham animals. Propagated immune susceptibility depended on injury of central pre-ganglionic but not peripheral postganglionic sympathetic innervation to the spleen. Thoracic spinal cord injury level was confirmed as an independent increased risk factor of pneumonia in patients after motor complete spinal cord injury (odds ratio = 1.35, P < 0.001) independently from mechanical ventilation and preserved sensory function by multiple regression analysis. We present evidence that spinal cord injury directly causes increased risk for bacterial infection in mice as well as in patients. Besides obvious motor and sensory paralysis, spinal cord injury also induces a functional SCI-IDS ('immune paralysis'), sufficient to propagate clinically relevant infection in an injury level dependent manner.
    MeSH term(s) Animals ; Disease Susceptibility ; Immunologic Deficiency Syndromes/etiology ; Immunologic Deficiency Syndromes/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/pathology ; Thoracic Vertebrae/injuries ; Thoracic Vertebrae/pathology
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awv375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Presentation abstracts.

    Rice, Laura / Sung, JongHun / Keane, Kathleen / Peterson, Elizabeth / Sosnoff, Jacob / Farkas, Gary / Swartz, Ann / Strath, Scott / Gorgey, Ashraf / Berg, Arthur / Gater, David / Dyson-Hudson, Trevor / Malanga, Gerard / Cherian, Chris / Michalec, Monica / Kirshblum, Steven / Miller, Carrie / Garlanger, Kristin / Kortes, Sam /
    Schnorenberg, Alyssa / Slavens, Brooke / Lee, Kenneth / Potter-Baker, Kelsey / Frost, Frederick / Plow, Ela / Solinsky, Ryan / Wilson, Catherine / Henry, Carrie Ann / Lombard, Alexander / Maher, Matthew / Weir, Joseph / Saeed, Sana / Cirnigliaro, Christopher / Specht, Adam / Garbarini, Erica / Augustine, Jonathan / Forrest, Gail / Bauman, William / Wecht, Jill / Hearn, Jasmine / Razvi, Imaduddin S / Sikka, Seema / Callender, Librada / Bennett, Monica / Robertson, Keston / Driver, Simon / Kline-Quiroz, Cristina / Donovan, Jayne / Botticello, Amanda / Arnold, Dannae / Latham, Nancy / Houlihan, Bethlyn / Bickmore, Timothy / Trinh, Ha / Shamekhi, Ameneh / Ellis, Teresa / LaVela, Sherri L / Burkhart, Elizabeth / Kale, Ibuola / Bombardier, Charles / Snoxell, Ellen / Knezevic, Steven / Hong, EunKyoung / Asselin, Pierre / Kornfeld, Stephen / Gorman, Peter / Spungen, Ann / Castillo, Camilo / Cleveland, Christine / Gabet, Joelle / Harrington, Amanda / Arenth, Patricia / Dolbow, David / Luther, Stephen / Finch, Dezon / Bouayad, Lina / Kopp, Marcel / Watzlawick, Ralf / Martus, Peter / Failli, Vieri / Finkenstaedt, Felix / Chen, Yuying / DeVivo, Michael / Dirnagl, Ulrich / Schwab, Jan / LiMonta, James / Santiago, Tiffany / Wu, Yu-Kuang / Harel, Noam / Monden, Kimberley / Trost, Zina / Nguyen, Nguyen / Morse, Leslie / Boals, Adriel / Wenzel, Lisa / Silveira, Stephanie / Hughes, Rosemary / Nosek, Margaret / LeDoux, Tracey / Taylor, Heather / Diaz, Lauren / Robinson-Whelen, Susan / Garshick, Eric / Betz, Kendra / Krause, James / Cao, Yue / Li, Chao / Hon, Beverly / Khong, Cria-May / Dirlikov, Ben / Shem, Kazuko / Charlifue, Susan / Song, Shawn / Burns, Stephen

    The journal of spinal cord medicine

    2018  Volume 41, Issue 5, Page(s) 599–622

    Language English
    Publishing date 2018-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1223949-5
    ISSN 2045-7723 ; 1079-0268
    ISSN (online) 2045-7723
    ISSN 1079-0268
    DOI 10.1080/10790268.2018.1498262
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