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Article ; Online: Haemophilus influenzae

Finlay, Liam / Cvetkovic, Anna / Chagla, Zain

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

2020 Volume 5, Issue 1, Page(s) 44–48

Abstract: Necrotizing fasciitis of an extremity due ... ...

Abstract	Necrotizing fasciitis of an extremity due to
Language	English
Publishing date	2020-03-04
Publishing country	Canada
Document type	Case Reports
ISSN	2371-0888
ISSN (online)	2371-0888
DOI	10.3138/jammi.2019-0022
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Article ; Online: Assessing the safety profile of voriconazole use in suspected COVID-19-associated pulmonary aspergillosis-a two-centre observational study.

Costa-Pinto, Rahul / Klink, Sarah / Rotherham, Hannah / Perera, Padeepa / Finlay, Liam / Urbancic, Karen / Vaz, Karl / Trubiano, Jason / Bellomo, Rinaldo

Medical mycology

2023 Volume 61, Issue 6

Abstract: The decision to use voriconazole for suspected COVID-19-associated pulmonary aspergillosis (CAPA) is based on clinical judgement weighed against concerns about its potential toxicity. We assessed the safety profile of voriconazole for patients with ... ...

Abstract	The decision to use voriconazole for suspected COVID-19-associated pulmonary aspergillosis (CAPA) is based on clinical judgement weighed against concerns about its potential toxicity. We assessed the safety profile of voriconazole for patients with suspected CAPA by conducting a retrospective study of patients across two intensive care units. We compared changes in any liver enzymes or bilirubin and any new or increasing corrected QT interval (QTc) prolongation following voriconazole use to patient baseline to indicate possible drug effect. In total, 48 patients with presumed CAPA treated with voriconazole were identified. Voriconazole therapy was administered for a median of 8 days (interquartile range [IQR] 5-22) and the median level was 1.86 mg/L (IQR 1.22-2.94). At baseline, 2% of patients had a hepatocellular injury profile, 54% had a cholestatic injury profile, and 21% had a mixed injury profile. There were no statistically significant changes in liver function tests over the first 7 days after voriconazole initiation. At day 28, there was a significant increase in alkaline phospahte only (81-122 U/L, P = 0.006), driven by changes in patients with baseline cholestatic injury. In contrast, patients with baseline hepatocellular or mixed injury had a significant decrease in alanine transaminase and aspartate transaminase. Baseline QTc was 437 ms and remained unchanged after 7 days of voriconazole therapy even after sensitivity analysis for concomitantly administered QT prolonging agents. Therefore, at the doses used in this study, we did not detect evidence of significant liver or cardiac toxicity related to voriconazole use. Such information can be used to assist clinicians in the decision to initiate such treatment.
MeSH term(s)	Animals ; Voriconazole/adverse effects ; Antifungal Agents/adverse effects ; Retrospective Studies ; Triazoles/adverse effects ; COVID-19/veterinary ; Pulmonary Aspergillosis/drug therapy ; Pulmonary Aspergillosis/veterinary
Chemical Substances	Voriconazole (JFU09I87TR) ; Antifungal Agents ; Triazoles
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Observational Study, Veterinary ; Journal Article
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1093/mmy/myad054
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Article: Neutrophil kinetics and function after major trauma: A systematic review.

Finlay, Liam Db / Conway Morris, Andrew / Deane, Adam M / Wood, Alexander Jt

World journal of critical care medicine

2021 Volume 10, Issue 5, Page(s) 260–277

Abstract: Background: Immune dysfunction following major traumatic injury is complex and strongly associated with significant morbidity and mortality through the development of multiple organ dysfunction syndrome (MODS), persistent inflammation, immunosuppression, ...

Abstract	Background: Immune dysfunction following major traumatic injury is complex and strongly associated with significant morbidity and mortality through the development of multiple organ dysfunction syndrome (MODS), persistent inflammation, immunosuppression, and catabolism syndrome and sepsis. Neutrophils are thought to be a pivotal mediator in the development of immune dysfunction. Aim: To provide a review with a systematic approach of the recent literature describing neutrophil kinetics and functional changes after major trauma in humans and discuss hypotheses as to the mechanisms of the observed neutrophil dysfunction in this setting. Methods: Medline, Embase and PubMed were searched on January 15, 2021. Papers were screened by two reviewers and those included had their reference list hand searched for additional papers of interest. Inclusion criteria were adults > 18 years old, with an injury severity score > 12 requiring admission to an intensive care unit. Papers that analysed major trauma patients as a subgroup were included. Results: Of 107 papers screened, 48 were included in the review. Data were heterogeneous and most studies had a moderate to significant risk of bias owing to their observational nature and small sample sizes. Key findings included a persistently elevated neutrophil count, stereotyped alterations in cell-surface markers of activation, and the elaboration of heterogeneous and immunosuppressive populations of cells in the circulation. Some of these changes correlate with clinical outcomes such as MODS and secondary infection. Neutrophil phenotype remains a promising avenue for the development of predictive markers for immune dysfunction. Conclusion: Understanding of neutrophil phenotypes after traumatic injury is expanding. A greater emphasis on incorporating functional and clinically significant markers, greater uniformity in study design and assessment of extravasated neutrophils may facilitate risk stratification in patients affected by major trauma.
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article
ISSN	2220-3141
ISSN	2220-3141
DOI	10.5492/wjccm.v10.i5.260
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Article: Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age

Keith, Dove / Finlay, Liam / Butler, Judy / Gómez, Luis / Smith, Eric / Moreau, Régis / Hagen, Tory

Biochemical and biophysical research communications. 2014 July 18, v. 450

2014

Abstract: It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Because ... ...

Abstract	It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Because our lab has shown that lipoic acid (LA) improves lipid homeostasis in aged animals, we hypothesized that LA affects the circadian clock to achieve these results. We fed 24month old male F344 rats a diet supplemented with 0.2% (w/w) LA for 2weeks prior to sacrifice and quantified hepatic circadian clock protein levels and clock-controlled lipid metabolic enzymes. LA treatment caused a significant phase-shift in the expression patterns of the circadian clock proteins Period (Per) 2, Brain and Muscle Arnt-Like1 (BMAL1), and Reverse Erythroblastosis virus (Rev-erb) β without altering the amplitude of protein levels during the light phase of the day. LA also significantly altered the oscillatory patterns of clock-controlled proteins associated with lipid metabolism. The level of peroxisome proliferator-activated receptor (PPAR) α was significantly increased and acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) were both significantly reduced, suggesting that the LA-supplemented aged animals are in a catabolic state. We conclude that LA remediates some of the dyslipidemic processes associated with advanced age, and this mechanism may be at least partially through entrainment of circadian clocks.
Keywords	acetyl-CoA carboxylase ; animals ; brain ; circadian rhythm ; diet ; elderly ; fatty-acid synthase ; homeostasis ; hyperlipidemia ; lipid metabolism ; lipids ; lipoic acid ; males ; metabolic syndrome ; muscles ; peroxisome proliferator-activated receptors ; viruses
Language	English
Dates of publication	2014-0718
Size	p. 324-329.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2014.05.112
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Article ; Online: Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age.

Keith, Dove / Finlay, Liam / Butler, Judy / Gómez, Luis / Smith, Eric / Moreau, Régis / Hagen, Tory

Biochemical and biophysical research communications

2014 Volume 450, Issue 1, Page(s) 324–329

Abstract	It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Because our lab has shown that lipoic acid (LA) improves lipid homeostasis in aged animals, we hypothesized that LA affects the circadian clock to achieve these results. We fed 24 month old male F344 rats a diet supplemented with 0.2% (w/w) LA for 2 weeks prior to sacrifice and quantified hepatic circadian clock protein levels and clock-controlled lipid metabolic enzymes. LA treatment caused a significant phase-shift in the expression patterns of the circadian clock proteins Period (Per) 2, Brain and Muscle Arnt-Like1 (BMAL1), and Reverse Erythroblastosis virus (Rev-erb) β without altering the amplitude of protein levels during the light phase of the day. LA also significantly altered the oscillatory patterns of clock-controlled proteins associated with lipid metabolism. The level of peroxisome proliferator-activated receptor (PPAR) α was significantly increased and acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) were both significantly reduced, suggesting that the LA-supplemented aged animals are in a catabolic state. We conclude that LA remediates some of the dyslipidemic processes associated with advanced age, and this mechanism may be at least partially through entrainment of circadian clocks.
MeSH term(s)	Administration, Oral ; Aging/physiology ; Animals ; CLOCK Proteins/metabolism ; Circadian Clocks/physiology ; Feedback, Physiological/drug effects ; Feedback, Physiological/physiology ; Lipid Metabolism/drug effects ; Lipid Metabolism/physiology ; Male ; Rats ; Rats, Inbred F344 ; Thioctic Acid/administration & dosage
Chemical Substances	Thioctic Acid (73Y7P0K73Y) ; CLOCK Proteins (EC 2.3.1.48)
Language	English
Publishing date	2014-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2014.05.112
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Article ; Online: Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.

Smith, Eric J / Shay, Kate P / Thomas, Nicholas O / Butler, Judy A / Finlay, Liam F / Hagen, Tory M

Free radical biology & medicine

2015 Volume 89, Page(s) 1184–1191

Abstract: Nrf2 regulates the expression of numerous anti-oxidant, anti-inflammatory, and metabolic genes. We observed that, paradoxically, Nrf2 protein levels decline in the livers of aged rats despite the inflammatory environment evident in that organ. To examine ...

Abstract	Nrf2 regulates the expression of numerous anti-oxidant, anti-inflammatory, and metabolic genes. We observed that, paradoxically, Nrf2 protein levels decline in the livers of aged rats despite the inflammatory environment evident in that organ. To examine the cause(s) of this loss, we investigated the age-related changes in Nrf2 protein homeostasis and activation in cultured hepatocytes from young (4-6 months) and old (24-28 months) Fischer 344 rats. While no age-dependent change in Nrf2 mRNA levels was observed (p>0.05), Nrf2 protein content, and the basal and anetholetrithione (A3T)-induced expression of Nrf2-dependent genes were attenuated with age. Conversely, overexpression of Nrf2 in cells from old animals reinstated gene induction. Treatment with A3T, along with bortezomib to inhibit degradation of existing protein, caused Nrf2 to accumulate significantly in cells from young animals (p<0.05), but not old, indicating a lack of new Nrf2 synthesis. We hypothesized that the loss of Nrf2 protein synthesis with age may partly stem from an age-related increase in microRNA inhibition of Nrf2 translation. Microarray analysis revealed that six microRNAs significantly increase >2-fold with age (p<0.05). One of these, miRNA-146a, is predicted to bind Nrf2 mRNA. Transfection of hepatocytes from young rats with a miRNA-146a mimic caused a 55% attenuation of Nrf2 translation that paralleled the age-related loss of Nrf2. Overall, these results provide novel insights for the age-related decline in Nrf2 and identify new targets to maintain Nrf2-dependent detoxification with age.
MeSH term(s)	Aging/physiology ; Animals ; Cells, Cultured ; Hepatocytes/cytology ; Hepatocytes/metabolism ; Homeostasis/genetics ; Male ; MicroRNAs/genetics ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Protein Biosynthesis/genetics ; RNA, Messenger/genetics ; Rats ; Rats, Inbred F344 ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction
Chemical Substances	MIRN146 microRNA, rat ; MicroRNAs ; NF-E2-Related Factor 2 ; RNA, Messenger
Language	English
Publishing date	2015-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2015.11.003
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Article: Analysis of the retrovirus capsid interdomain linker region.

Arvidson, Brian / Seeds, Joshua / Webb, Mike / Finlay, Liam / Barklis, Eric

Virology

2003 Volume 308, Issue 1, Page(s) 166–177

Abstract: In structural studies, the retrovirus capsid interdomain linker region has been shown as a flexible connector between the CA N-terminal domain and its C-terminal domain. To analyze the function of the linker region, we have examined the effects of three ... ...

Abstract	In structural studies, the retrovirus capsid interdomain linker region has been shown as a flexible connector between the CA N-terminal domain and its C-terminal domain. To analyze the function of the linker region, we have examined the effects of three Moloney murine leukemia virus (M-MuLV) capsid linker mutations/variations in vivo, in the context of the full-length M-MuLV structural precursor protein (PrGag). Two mutations, A1SP and A5SP, respectively, inserted three and seven additional codons within the linker region to test the effects of increased linker lengths. The third variant, HIV/Mo, represented a chimeric HIV-1/M-MuLV PrGag protein, fused at the linker region. When expressed in cells, the three variants reduced the efficiency of virus particle assembly, with PrGag proteins and particles accumulating at the cellular plasma membranes. Although PrGag recognition of viral RNA was not impaired, the capsid linker variant particles were abnormal, with decreased stabilities, anomalous densities, and aberrant multiple lobed and tubular morphologies. Additionally, rather than crosslinking as PrGag dimers, particle-associated A1SP, A5SP, and HIV/Mo proteins showed an increased propensity to crosslink as trimers. Our results suggest that a wild-type retrovirus capsid linker region is required for the proper alignment of capsid protein domains.
MeSH term(s)	3T3 Cells ; Amino Acid Sequence ; Animals ; COS Cells ; Capsid/chemistry ; Capsid Proteins/genetics ; Cell Line ; Cell Membrane/metabolism ; Codon ; Gene Products, gag/genetics ; Gene Products, gag/metabolism ; Genetic Variation ; HIV-1/chemistry ; HIV-1/genetics ; Humans ; Mice ; Molecular Sequence Data ; Moloney murine leukemia virus/chemistry ; Moloney murine leukemia virus/genetics ; Moloney murine leukemia virus/physiology ; Mutagenesis, Insertional ; Protein Precursors/genetics ; Protein Precursors/metabolism ; Recombination, Genetic ; Sequence Alignment ; Virus Replication
Chemical Substances	Capsid Proteins ; Codon ; Gene Products, gag ; Protein Precursors
Language	English
Publishing date	2003-03-30
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/s0042-6822(02)00142-3
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Article ; Online: Seasonality and vertical structure of microbial communities in an ocean gyre.

Treusch, Alexander H / Vergin, Kevin L / Finlay, Liam A / Donatz, Michael G / Burton, Robert M / Carlson, Craig A / Giovannoni, Stephen J

The ISME journal

2009 Volume 3, Issue 10, Page(s) 1148–1163

Abstract: Vertical, seasonal and geographical patterns in ocean microbial communities have been observed in many studies, but the resolution of community dynamics has been limited by the scope of data sets, which are seldom up to the task of illuminating the ... ...

Abstract	Vertical, seasonal and geographical patterns in ocean microbial communities have been observed in many studies, but the resolution of community dynamics has been limited by the scope of data sets, which are seldom up to the task of illuminating the highly structured and rhythmic patterns of change found in ocean ecosystems. We studied vertical and temporal patterns in the microbial community composition in a set of 412 samples collected from the upper 300 m of the water column in the northwestern Sargasso Sea, on cruises between 1991 and 2004. The region sampled spans the extent of deep winter mixing and the transition between the euphotic and the upper mesopelagic zones, where most carbon fixation and reoxidation occurs. A bioinformatic pipeline was developed to de-noise, normalize and align terminal restriction fragment length polymorphism (T-RFLP) data from three restriction enzymes and link T-RFLP peaks to microbial clades. Non-metric multidimensional scaling statistics resolved three microbial communities with distinctive composition during seasonal stratification: a surface community in the region of lowest nutrients, a deep chlorophyll maximum community and an upper mesopelagic community. A fourth microbial community was associated with annual spring blooms of eukaryotic phytoplankton that occur in the northwestern Sargasso Sea as a consequence of winter convective mixing that entrains nutrients to the surface. Many bacterial clades bloomed in seasonal patterns that shifted with the progression of stratification. These richly detailed patterns of community change suggest that highly specialized adaptations and interactions govern the success of microbial populations in the oligotrophic ocean.
MeSH term(s)	Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Biodiversity ; Cluster Analysis ; DNA Fingerprinting/methods ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; DNA, Ribosomal/chemistry ; DNA, Ribosomal/genetics ; Molecular Sequence Data ; Oceans and Seas ; Phylogeny ; Polymorphism, Restriction Fragment Length ; RNA, Ribosomal, 16S/genetics ; Seasons ; Seawater/microbiology ; Sequence Analysis, DNA
Chemical Substances	DNA, Bacterial ; DNA, Ribosomal ; RNA, Ribosomal, 16S
Language	English
Publishing date	2009-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2406536-5
ISSN	1751-7370 ; 1751-7362
ISSN (online)	1751-7370
ISSN	1751-7362
DOI	10.1038/ismej.2009.60
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Article: (R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria

Monette, Jeffrey S / Gómez, Luis A / Moreau, Régis F / Dunn, Kevin C / Butler, Judy A / Finlay, Liam A / Michels, Alexander J / Shay, Kate Petersen / Smith, Eric J / Hagen, Tory M

Pharmacological research. 2011 Jan., v. 63, no. 1

2011

Abstract: Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics, we ... ...

Abstract	Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics, we hypothesized that mitochondrial decay stems partly from an age-related ceramidosis that heretofore has not been recognized for the heart. Intact mitochondria or their purified inner membranes (IMM) were isolated from young (4–6mo) and old (26–28mo) rats and analyzed for ceramides by LC–MS/MS. Results showed that ceramide levels increased by 32% with age and three ceramide isoforms, found primarily in the IMM (e.g. C16-, C18-, and C24:1-ceramide), caused this increase. The ceramidosis may stem from enhanced hydrolysis of sphingomyelin, as neutral sphingomyelinase (nSMase) activity doubled with age but with no attendant change in ceramidase activity. Because (R)-α-lipoic acid (LA) improves many parameters of cardiac mitochondrial decay in aging and lowers ceramide levels in vascular endothelial cells, we hypothesized that LA may limit cardiac ceramidosis and thereby improve mitochondrial function. Feeding LA [0.2%, w/w] to old rats for two weeks prior to mitochondrial isolation reversed the age-associated decline in glutathione levels and concomitantly improved Complex IV activity. This improvement was associated with lower nSMase activity and a remediation in mitochondrial ceramide levels. In summary, LA treatment lowers ceramide levels to that seen in young rat heart mitochondria and restores Complex IV activity which otherwise declines with age.
Keywords	acid treatment ; apoptosis ; ceramides ; electron transport chain ; endothelial cells ; glutathione ; heart ; hydrolysis ; inflammation ; mitochondria ; rats ; reactive oxygen species ; remediation ; sphingomyelins
Language	English
Dates of publication	2011-01
Size	p. 23-29.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1043-6618
DOI	10.1016/j.phrs.2010.09.007
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Article ; Online: R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.

Finlay, Liam A / Michels, Alex J / Butler, Judy A / Smith, Eric J / Monette, Jeffrey S / Moreau, Régis F / Petersen, Shay Kate / Frei, Balz / Hagen, Tory M

American journal of physiology. Regulatory, integrative and comparative physiology

2011 Volume 302, Issue 5, Page(s) R587–97

Abstract: To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 mo) and old (24 mo) male Fischer 344 rats a diet with or without 0.2% (wt/wt) R-α-lipoic acid (LA) for 2 wk. Total RNA isolated from liver tissue ... ...

Abstract	To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 mo) and old (24 mo) male Fischer 344 rats a diet with or without 0.2% (wt/wt) R-α-lipoic acid (LA) for 2 wk. Total RNA isolated from liver tissue was analyzed by Affymetrix microarray to examine changes in transcriptional profiles. Results showed elevated proinflammatory gene expression in the aging liver and evidence for increased immune cell activation and tissue remodeling, together representing 45% of the age-related transcriptome changes. In addition, age-related increases in transcripts of genes related to fatty acid, triglyceride, and cholesterol synthesis, including acetyl-CoA carboxylase-β (Acacb) and fatty acid synthase (Fasn), were observed. Supplementation of old animals with LA did not reverse the necroinflammatory phenotype but, intriguingly, altered the expression of genes governing circadian rhythm. Most notably, Arntl, Npas2, and Per changed in a coordinated manner with respect to rhythmic transcription. LA further caused a decrease in transcripts of several bile acid and lipid synthesis genes, including Acacb and Fasn, which are regulated by first-order clock transcription factors. Similar effects of LA supplementation on bile acid and lipid synthesis genes were observed in young animals. Transcript changes of lipid metabolism genes were corroborated by a decrease in FASN and ACC protein levels. We conclude that advanced age is associated with a necroinflammatory phenotype and increased lipid synthesis, while chronic LA supplementation influences hepatic genes associated with lipid and energy metabolism and circadian rhythm, regardless of age.
MeSH term(s)	ARNTL Transcription Factors/genetics ; ARNTL Transcription Factors/metabolism ; Aging/drug effects ; Aging/metabolism ; Animals ; Circadian Rhythm/drug effects ; Circadian Rhythm/genetics ; Circadian Rhythm Signaling Peptides and Proteins/genetics ; Circadian Rhythm Signaling Peptides and Proteins/metabolism ; Dietary Supplements ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Gene Expression/drug effects ; Gene Expression/physiology ; Gene Expression Profiling ; Hepatitis/genetics ; Hepatitis/metabolism ; Hepatitis/prevention & control ; Lipid Metabolism/drug effects ; Lipid Metabolism/physiology ; Liver/drug effects ; Liver/metabolism ; Male ; Models, Animal ; Period Circadian Proteins/genetics ; Period Circadian Proteins/metabolism ; Rats ; Rats, Inbred F344 ; Thioctic Acid/administration & dosage ; Thioctic Acid/pharmacology ; Thioctic Acid/therapeutic use
Chemical Substances	ARNTL Transcription Factors ; Circadian Rhythm Signaling Peptides and Proteins ; Npas2 protein, rat ; Per2 protein, rat ; Period Circadian Proteins ; Thioctic Acid (73Y7P0K73Y)
Language	English
Publishing date	2011-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00393.2011
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