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  1. Book ; Online: The Origin and Early Evolution of Life: Prebiotic Chemistry of Biomolecules

    Fiore, Michele

    2019  

    Abstract: Studying the origin of life is one of man's greatest achievements over the last sixty years. The fields of interest encompassed by this quest are multiple and interdisciplinary: chemistry, physics, biology, biochemistry, mathematics, geology but also ... ...

    Abstract Studying the origin of life is one of man's greatest achievements over the last sixty years. The fields of interest encompassed by this quest are multiple and interdisciplinary: chemistry, physics, biology, biochemistry, mathematics, geology but also statistics, atmospheric science, meteorology, oceanography, and astrophysics. Recent scientific discoveries, such as water on Mars and the existence of super-Earths with atmospheres similar to primordial Earth, have pushed researchers to simulate prebiotic conditions in explaining the abiotic formation of molecules essential to life. This collection of articles offers an overview of recent discoveries in the field of prebiotic chemistry of biomolecules, their formation and selection, and the evolution of complex chemical systems
    Keywords Science (General) ; Chemistry
    Size 1 electronic resource (288 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020324060
    ISBN 9783039216062 ; 9783039216079 ; 3039216066 ; 3039216074
    DOI 10.3390/books978-3-03921-607-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: The Origin and Early Evolution of Life

    Fiore, Michele / Altamura, Emiliano

    Prebiotic Systems Chemistry Perspective

    2022  

    Keywords Research & information: general ; Biology, life sciences ; origin of life ; peptidyl-transferase center ; pseudo-symmetry ; proto-ribosome ; SymR ; emergence of biological systems ; RNA ligation ; dimerization ; standard genetic codes ; codon assignment ; tRNA ; aminoacyl-tRNA synthetase classes ; thiophene ; acetylene ; transition metal sulfides ; hydrothermal conditions ; early metabolism ; origin-of-life ; prebiotic chemistry ; protein-monosaccharide recognition ; protein-monosaccharide interactions ; FRET analysis ; glycocodon theory ; glucose oxidase ; Mars ; prebiotic chemical evolution ; early Earth ; astrobiology ; CHNOPS ; transition elements ; sample return ; exoplanets ; complex organic molecules ; astrochemistry ; interstellar medium ; molecular ices ; solid state ; protoplanetary disks ; star forming regions ; comets ; vesicles ; division ; urea-urease enzymatic reaction ; bending modulus ; budding ; ADE theory ; dynamic kinetic stability ; cognition ; chemical evolution ; systems chemistry ; metabolism ; network expansion simulation ; temperature ; thermodynamics ; protocell ; compartment ; solid interface ; lipid ; polymerization ; cyclic nucleotides ; autocatalytic set ; osmotic pressure ; cell division ; lipid membrane ; bistable reaction system ; template-directed RNA synthesis ; origin of genetic code ; time order of canonical amino acids ; proto-metabolism ; chirogenesis ; quartz ; amino acids ; radiation damage ; GC×GC-TOFMS ; origins of life ; prebiotic membranes ; protoamphiphiles ; metal ions ; hot springs ; N-acyl amino acid ; analogue conditions ; viroids ; ribozyviruses ; primordial replicators ; ribozymes ; bilayer structure ; molecular dynamics ; aggregation process ; selection ; evolution ; Fenton chemistry ; reduced phosphorus ; pyrophosphate ; chemical complexity ; minerals ; schreibersite ; olivine ; serpentinite ; ulexite ; n/a
    Language 0|e
    Size 1 electronic resource (320 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021617519
    ISBN 9783036544694 ; 3036544690
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Highlighting New Perspectives on Musculoskeletal Infections.

    Fiore, Michele / Sambri, Andrea

    Microorganisms

    2024  Volume 12, Issue 1

    Abstract: The treatment of musculoskeletal and prosthetic joint infections represents a considerable challenge for patients, healthcare providers, and the healthcare system because of the high number of treatment failures and the significant economic burden [ ... ]. ...

    Abstract The treatment of musculoskeletal and prosthetic joint infections represents a considerable challenge for patients, healthcare providers, and the healthcare system because of the high number of treatment failures and the significant economic burden [...].
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12010226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In Regard to Parikh et al.

    Cellini, Francesco / Fiore, Michele

    International journal of radiation oncology, biology, physics

    2024  Volume 119, Issue 1, Page(s) 308–309

    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Letter
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2024.01.211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: The Impact of Education and Culture on Poverty Reduction: Evidence from Panel Data of European Countries.

    Spada, A / Fiore, M / Galati, A

    Social indicators research

    2023  , Page(s) 1–14

    Abstract: The 2030 Agenda has among its key objectives the poverty eradication through increasing the level of education. A good level of education and investment in culture of a country is in fact necessary to guarantee a sustainable economy, in which coexists ... ...

    Abstract The 2030 Agenda has among its key objectives the poverty eradication through increasing the level of education. A good level of education and investment in culture of a country is in fact necessary to guarantee a sustainable economy, in which coexists satisfactory levels of quality of life and an equitable distribution of income. There is a lack of studies in particular on the relations between some significant dimensions, such as education, culture and poverty, considering time lags for the measurement of impacts. Therefore, this study aims to fill this gap by focusing on the relationship between education, culture and poverty based on a panel of data from 34 European countries, over a 5-year period, 2015-2019. For this purpose, after applying principal component analysis to avoid multicollinearity problems, the authors applied three different approaches: pooled-ordinary least squares model, fixed effect model and random effect model. Fixed-effects estimator was selected as the optimal and most appropriate model. The results highlight that increasing education and culture levels in these countries reduce poverty. This opens space to new research paths and policy strategies that can start from this connection to implement concrete actions aimed at widening and improving educational and cultural offer.
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018687-3
    ISSN 1573-0921 ; 0303-8300
    ISSN (online) 1573-0921
    ISSN 0303-8300
    DOI 10.1007/s11205-023-03155-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Semantic Analysis of Normalisation by Evaluation for Typed Lambda Calculus

    Fiore, Marcelo

    2022  

    Abstract: This paper studies normalisation by evaluation for typed lambda calculus from a categorical and algebraic viewpoint. The first part of the paper analyses the lambda definability result of Jung and Tiuryn via Kripke logical relations and shows how it can ... ...

    Abstract This paper studies normalisation by evaluation for typed lambda calculus from a categorical and algebraic viewpoint. The first part of the paper analyses the lambda definability result of Jung and Tiuryn via Kripke logical relations and shows how it can be adapted to unify definability and normalisation, yielding an extensional normalisation result. In the second part of the paper the analysis is refined further by considering intensional Kripke relations (in the form of Artin glueing) and shown to provide a function for normalising terms, casting normalisation by evaluation in the context of categorical glueing. The technical development includes an algebraic treatment of the syntax and semantics of the typed lambda calculus that allows the definition of the normalisation function to be given within a simply typed metatheory. A normalisation-by-evaluation program in a dependently-typed functional programming language is synthesised.

    Comment: This is a slight revision, with an implementation, of the full version, with proofs, of February 2003 for the extended abstract with the same title published in the Proceedings of the 4th ACM SIGPLAN International Conference on Principles and Practice of Declarative Programming (PPDP) in October 2002
    Keywords Computer Science - Logic in Computer Science ; Mathematics - Category Theory ; 03B40 ; 03B38 ; 68N18 ; F.3.2 ; F.4.1
    Subject code 005
    Publishing date 2022-07-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Letter: the emergence of multi-drug resistant spontaneous bacterial peritonitis: a new challenge for the hepatologist?

    Fiore, M

    Alimentary pharmacology & therapeutics

    2016  Volume 43, Issue 8, Page(s) 944–945

    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Letter
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.13539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The Origin and Early Evolution of Life: Prebiotic Chemistry.

    Fiore, Michele

    Life (Basel, Switzerland)

    2019  Volume 9, Issue 3

    Abstract: Microfossil evidence indicates that cellular life on Earth emerged during the Paleoarchean era be-tween 3 [ ... ]. ...

    Abstract Microfossil evidence indicates that cellular life on Earth emerged during the Paleoarchean era be-tween 3 [...].
    Language English
    Publishing date 2019-09-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life9030073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Climate change and human health: Last call to arms for us.

    Corrente, Antonio / Pace, Maria Caterina / Fiore, Marco

    World journal of clinical cases

    2024  Volume 12, Issue 11, Page(s) 1870–1874

    Abstract: Climate change, now the foremost global health hazard, poses multifaceted challenges to human health. This editorial elucidates the extensive impact of climate change on health, emphasising the increasing burden of diseases and the exacerbation of health ...

    Abstract Climate change, now the foremost global health hazard, poses multifaceted challenges to human health. This editorial elucidates the extensive impact of climate change on health, emphasising the increasing burden of diseases and the exacerbation of health disparities. It highlights the critical role of the healthcare sector, particularly anaesthesia, in both contributing to and mitigating climate change. It is a call to action for the medical community to recognise and respond to the health challenges posed by climate change.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Editorial
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v12.i11.1870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions.

    Fiore, Michele

    Organic & biomolecular chemistry

    2018  Volume 16, Issue 17, Page(s) 3068–3086

    Abstract: Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways. n-Alkyl phosphates and their derivatives have been recognized as amphiphilic molecules for nearly two centuries. In the last 50 years, n-alkyl phosphate ... ...

    Abstract Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways. n-Alkyl phosphates and their derivatives have been recognized as amphiphilic molecules for nearly two centuries. In the last 50 years, n-alkyl phosphate derivatives such as di-alkyl phosphates, mono-alkyl phosphatidyl ethanol amines and mono-alkyl phosphocholines have become predominant compounds with applications in different areas, from food chemistry to life science. The aim of this review is to summarize the most relevant progress made in the field of the synthesis of these molecules and to provide a concise perspective on the use of these amphiphiles as possible prebiotic membrane constituents. The first part of the review is dedicated to the analysis of the most relevant syntheses carried out in recent years with respect to those reported from the second half of the nineteenth century. The second part is dedicated to a description of the latest reports on prebiotic synthesis of mono-alkyl phosphates. In this part, the authors did not report the phosphorylation of other relevant biomolecules, such as nucleosides, which have been excellently reviewed elsewere.
    MeSH term(s) Alkanes/chemical synthesis ; Alkanes/chemistry ; Alkylation ; Chemistry Techniques, Synthetic/methods ; Membranes, Artificial ; Origin of Life ; Phosphates/chemical synthesis ; Phosphates/chemistry ; Phosphatidic Acids/chemical synthesis ; Phosphatidic Acids/chemistry ; Phospholipids/chemical synthesis ; Phospholipids/chemistry ; Phosphorylation
    Chemical Substances Alkanes ; Membranes, Artificial ; Phosphates ; Phosphatidic Acids ; Phospholipids
    Language English
    Publishing date 2018-04-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c8ob00469b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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