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  1. Article ; Online: Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions.

    Amormino, Carola / Russo, Emanuela / Tedeschi, Valentina / Fiorillo, Maria Teresa / Paiardini, Alessandro / Spallotta, Francesco / Rosanò, Laura / Tuosto, Loretta / Kunkl, Martina

    Frontiers in immunology

    2024  Volume 15, Page(s) 1365074

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    MeSH term(s) Humans ; Superantigens ; CD28 Antigens ; Caco-2 Cells ; Enterotoxins ; Cytokines
    Chemical Substances enterotoxin B, staphylococcal (39424-53-8) ; Superantigens ; CD28 Antigens ; Enterotoxins ; Cytokines
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1365074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation.

    Mattorre, Benedetta / Tedeschi, Valentina / Paldino, Giorgia / Fiorillo, Maria Teresa / Paladini, Fabiana / Sorrentino, Rosa

    Frontiers in immunology

    2022  Volume 13, Page(s) 1002375

    Abstract: The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum (ERAP1 and ...

    Abstract The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum (ERAP1 and ERAP2), or in the endosomes (IRAP). However, other novel and distinct functions are emerging. Here, we focus specifically on ERAP2. This gene has a peculiar evolutionary history, being absent in rodents and undergoing in humans to a balanced selection of two haplotypes, one of which not expressing the full length ERAP2. These observations suggest that its role in antigen presentation is not essential. An additional, less investigated role is in the regulation of the Renin Angiotensin System (RAS). ERAP1 and ERAP2 cleave Angiotensin II (Ang II) into Ang III and IV, which counteract the action of Ang II whereas IRAP is itself the receptor for Ang IV. We have recently reported that macrophages, independently from the haplotype, express and release a N-terminus ERAP2 "short" form which directly binds IRAP and the two molecules are co-expressed in the endosomes and on the cell membrane. This new evidence suggests that the maintenance of the ERAP2 gene in humans could be due to its activity in the regulation of the RAS system, possibly as an Ang IV agonist. Its role in the immune-mediated diseases as well as in disorders more specifically related to an imbalance of the RAS system, including hypertension, pre-eclampsia but also viral infections such as COVID-19, is discussed here.
    MeSH term(s) Aminopeptidases ; Angiotensin II/metabolism ; Antigen Presentation ; COVID-19 ; Humans ; Insulin/metabolism ; Minor Histocompatibility Antigens/genetics ; Minor Histocompatibility Antigens/metabolism ; Renin-Angiotensin System/genetics ; Zinc
    Chemical Substances Insulin ; Minor Histocompatibility Antigens ; Angiotensin II (11128-99-7) ; Aminopeptidases (EC 3.4.11.-) ; ERAP1 protein, human (EC 3.4.11.-) ; ERAP2 protein, human (EC 3.4.11.-) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1002375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Astrocytes and Inflammatory T Helper Cells: A Dangerous Liaison in Multiple Sclerosis.

    Kunkl, Martina / Amormino, Carola / Tedeschi, Valentina / Fiorillo, Maria Teresa / Tuosto, Loretta

    Frontiers in immunology

    2022  Volume 13, Page(s) 824411

    Abstract: Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly inflammatory T helper (Th) cell subsets. Once recruited within the CNS, ... ...

    Abstract Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly inflammatory T helper (Th) cell subsets. Once recruited within the CNS, inflammatory Th cells produce several inflammatory cytokines and chemokines that activate resident glial cells, thus contributing to the breakdown of blood-brain barrier (BBB), demyelination and axonal loss. Astrocytes are recognized as key players of MS immunopathology, which respond to Th cell-defining cytokines by acquiring a reactive phenotype that amplify neuroinflammation into the CNS and contribute to MS progression. In this review, we summarize current knowledge of the astrocytic changes and behaviour in both MS and experimental autoimmune encephalomyelitis (EAE), and the contribution of pathogenic Th1, Th17 and Th1-like Th17 cell subsets, and CD8
    MeSH term(s) Animals ; Astrocytes/physiology ; CD8-Positive T-Lymphocytes/immunology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/physiopathology ; Humans ; Inflammation/immunology ; Multiple Sclerosis/immunology ; Multiple Sclerosis/physiopathology ; T-Lymphocytes, Helper-Inducer/classification ; T-Lymphocytes, Helper-Inducer/immunology
    Language English
    Publishing date 2022-02-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.824411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Corrigendum: Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells.

    Kunkl, Martina / Amormino, Carola / Spallotta, Francesco / Caristi, Silvana / Fiorillo, Maria Teresa / Paiardini, Alessandro / Kaempfer, Raymond / Tuosto, Loretta

    Frontiers in immunology

    2023  Volume 14, Page(s) 1273921

    Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1170821.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2023.1170821.].
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1273921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells.

    Kunkl, Martina / Amormino, Carola / Spallotta, Francesco / Caristi, Silvana / Fiorillo, Maria Teresa / Paiardini, Alessandro / Kaempfer, Raymond / Tuosto, Loretta

    Frontiers in immunology

    2023  Volume 14, Page(s) 1170821

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureu
    MeSH term(s) Superantigens ; CD28 Antigens ; Artificial Intelligence ; Staphylococcus/metabolism ; Antigen-Presenting Cells/metabolism ; Receptors, Antigen, T-Cell
    Chemical Substances Superantigens ; CD28 Antigens ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1170821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Human Papillomavirus and Oral Lesions: What is the Best Diagnostic Method?

    Fiorillo, Luca / Cervino, Gabriele / Surace, Giovanni / Fiorillo, Maria Teresa / Meto, Agron / Cicciu, Marco

    The Journal of craniofacial surgery

    2021  Volume 33, Issue 3, Page(s) e279–e281

    Abstract: Abstract: Oropharyngeal squamous cell carcinoma is the most common neoplasm of head and neck cancers related to the presence of human papillomavirus (HPV). in the dental, maxillofacial and ENT fields, the finding of mediated HPV lesions is quite common. ...

    Abstract Abstract: Oropharyngeal squamous cell carcinoma is the most common neoplasm of head and neck cancers related to the presence of human papillomavirus (HPV). in the dental, maxillofacial and ENT fields, the finding of mediated HPV lesions is quite common. The diagnostic techniques currently available are different and can be more or less invasive depending on the type of lesion and the need for the clinician. In this study, two clinical cases subjected to a double diagnostic technique were considered in order to exclude any possible risk of false negatives. The polymerase chain reaction (PCR) technique showed a lower sensitivity or in any case dictated by a limited number of HPV strains analyzed. Histological examination nowadays turns out to be the best diagnostic method despite requiring a surgical phase.
    MeSH term(s) Alphapapillomavirus ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; DNA, Viral/analysis ; Head and Neck Neoplasms ; Humans ; Oropharyngeal Neoplasms/diagnosis ; Papillomaviridae/genetics ; Papillomavirus Infections/diagnosis
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000008113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3761: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 175: Show issues

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  7. Article: The Double Game Played by Th17 Cells in Infection: Host Defense and Immunopathology.

    Paroli, Marino / Caccavale, Rosalba / Fiorillo, Maria Teresa / Spadea, Luca / Gumina, Stefano / Candela, Vittorio / Paroli, Maria Pia

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 12

    Abstract: T-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an essential role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 cells by their ability to produce members of the interleukin-17 (IL-17) ... ...

    Abstract T-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an essential role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 cells by their ability to produce members of the interleukin-17 (IL-17) family, namely IL-17A and IL-17F. IL-17 in turn induces several target cells to synthesize and release cytokines, chemokines, and metalloproteinases, thereby amplifying the inflammatory cascade. Th17 cells reside predominantly in the lamina propria of the mucosa. Their main physiological function is to maintain the integrity of the mucosal barrier against the aggression of infectious agents. However, in an appropriate inflammatory microenvironment, Th17 cells can transform into immunopathogenic cells, giving rise to inflammatory and autoimmune diseases. This review aims to analyze the complex mechanisms through which the interaction between Th17 and pathogens can be on the one hand favorable to the host by protecting it from infectious agents, and on the other hand harmful, potentially generating autoimmune reactions and tissue damage.
    Language English
    Publishing date 2022-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11121547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CD8

    Tedeschi, Valentina / Paldino, Giorgia / Kunkl, Martina / Paroli, Marino / Sorrentino, Rosa / Tuosto, Loretta / Fiorillo, Maria Teresa

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Autoimmune Diseases ; CD28 Antigens ; CD8-Positive T-Lymphocytes ; COVID-19 ; Cellular Senescence ; HIV Infections/drug therapy ; Humans ; Neoplasms ; SARS-CoV-2 ; Tumor Microenvironment ; Virus Diseases
    Chemical Substances CD28 Antigens
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity.

    Amormino, Carola / Tedeschi, Valentina / Paldino, Giorgia / Arcieri, Stefano / Fiorillo, Maria Teresa / Paiardini, Alessandro / Tuosto, Loretta / Kunkl, Martina

    Cells

    2022  Volume 11, Issue 16

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disease occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C and the toxic shock syndrome, together with the preferential expansion ... ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disease occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C and the toxic shock syndrome, together with the preferential expansion of T cells with a T-cell receptor variable β chain (TCRVβ) skewing, suggested a superantigen theory of MIS-C. For instance, recent in silico modelling evidenced the presence of a highly conserved motif within SARS-CoV-2 spike protein similar in structure to the superantigenic fragment of staphylococcal enterotoxin B (SEB). However, experimental data on the superantigenic activity of the SARS-CoV-2 spike have not yet been provided. Here, we assessed the superantigenic activity of the SARS-CoV-2 spike by analysing inflammatory cytokine production in both Jurkat cells and the peripheral blood CD4
    MeSH term(s) COVID-19/complications ; Child ; Humans ; Receptors, Antigen, T-Cell, alpha-beta ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Superantigens ; Systemic Inflammatory Response Syndrome
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta ; Spike Glycoprotein, Coronavirus ; Superantigens ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-08-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11162526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial: Ankylosing Spondylitis and Related Immune-Mediated Disorders.

    Fiorillo, Maria Teresa / Haroon, Nigil / Ciccia, Francesco / Breban, Maxime

    Frontiers in immunology

    2019  Volume 10, Page(s) 1232

    MeSH term(s) Disease Management ; Disease Susceptibility ; Humans ; Immune System Diseases/diagnosis ; Immune System Diseases/etiology ; Immune System Diseases/metabolism ; Immune System Diseases/therapy ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/etiology ; Spondylitis, Ankylosing/metabolism ; Spondylitis, Ankylosing/therapy
    Language English
    Publishing date 2019-06-04
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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