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  1. Article ; Online: Challenges of artificial intelligence in precision oncology: public-private partnerships including national health agencies as an asset to make it happen.

    Luu, V P / Fiorini, M / Combes, S / Quemeneur, E / Bonneville, M / Bousquet, P J

    Annals of oncology : official journal of the European Society for Medical Oncology

    2023  Volume 35, Issue 2, Page(s) 154–158

    MeSH term(s) Humans ; Neoplasms/diagnosis ; Neoplasms/therapy ; Public-Private Sector Partnerships ; Artificial Intelligence ; Precision Medicine ; Medical Oncology
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Editorial
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2023.09.3106
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2862: Show issues Location:
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  2. Article ; Online: COVID-19: Black Swan or clumsy use?

    Fiorini, Marcello / LA Gioia, Antonio

    Journal of preventive medicine and hygiene

    2021  Volume 62, Issue 1, Page(s) E7–E9

    Abstract: Black Swan" is an unexpected and catastrophic event characterized by three conditions: the anomalous and exceptional value, the extreme impact, and predictability a posteriori. On many sides - by politicians, commentators, scientists - there have been ... ...

    Abstract "Black Swan" is an unexpected and catastrophic event characterized by three conditions: the anomalous and exceptional value, the extreme impact, and predictability a posteriori. On many sides - by politicians, commentators, scientists - there have been attempts to give the COVID-19 pandemic event the meaning of Black Swan. In reality, one should wonder if the Black Swan was not, instead (or even), the way the epidemic was handled. In Italy, an unreasonable use of a two-step protocol - IgM/IgG anti-COVID followed by RT-PCR in the serologically positive only has caused considerable uncertainty, particularly relevant in measures for maintenance or readmission to work of health personnel. This protocol could be affected by serious uncertainties arising from the analytical limitations of the tests used. To quantify this defect, we evaluated the analytical specifications of serological tests under different prevalence conditions. In conclusion, although laboratory diagnostics represent a useful tool, it can only be used for epidemiological purposes and not to provide healthy pass.
    MeSH term(s) Antibodies, Viral/blood ; COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Humans ; Italy ; Mass Screening/methods ; Mass Screening/standards ; Pandemics ; SARS-CoV-2/isolation & purification
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-04-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1102926-2
    ISSN 2421-4248 ; 1121-2233
    ISSN (online) 2421-4248
    ISSN 1121-2233
    DOI 10.15167/2421-4248/jpmh2021.62.1.1829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Analysis of microplastics in commercial vegetable edible oils from Italy and Spain.

    Battaglini, Elena / Miralles, Pablo / Lotti, Nadia / Soccio, Michelina / Fiorini, Maurizio / Coscollà, Clara

    Food chemistry

    2024  Volume 443, Page(s) 138567

    Abstract: In this work, assessment of microplastics (MPs) in commercial vegetable edible oils from Italy and Spain, including extra-virgin olive oil, olive oil, sunflower oil, and mixed seed oil, has been conducted for the first time. The method was based on ... ...

    Abstract In this work, assessment of microplastics (MPs) in commercial vegetable edible oils from Italy and Spain, including extra-virgin olive oil, olive oil, sunflower oil, and mixed seed oil, has been conducted for the first time. The method was based on sample dilution with ethanol:n-hexane (1:3, v/v), homogenization, vacuum filtration on macroporous silicon filters with 5 μm pore diameter to collect MPs, and automatic µ-FTIR spectroscopy for MPs detection and characterization. In the analysis of oil samples, a mean MPs abundance of 1140 ± 350 MPs/L was found. Observed MPs were characterized, being most of them fragments (81.2 %), with particle sizes < 100 µm (77.5 %), and mainly composed of polyethylene (50.3 %) and polypropylene (28.7 %), among others. Statistical analysis revealed that there were not significant differences (p-value > 0.05) in the abundance of MPs between oil samples or types.
    MeSH term(s) Plant Oils/chemistry ; Vegetables ; Microplastics ; Plastics ; Spain ; Olive Oil/chemistry ; Italy
    Chemical Substances Plant Oils ; Microplastics ; Plastics ; Olive Oil
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.138567
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  4. Article ; Online: When dysplasia deceives instrumental results: Pseudo monocytosis on the sysmex XN haematological analyser and DI-60 digital morphology system: Cases report and literature review.

    La Gioia, Antonio / Basile, Manuela / Fiorini, Fabiana / Fiorini, Marcello

    International journal of laboratory hematology

    2023  Volume 45, Issue 6, Page(s) 987–989

    MeSH term(s) Humans ; Leukocyte Count ; Leukocytes ; Leukocytosis
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Review ; Case Reports ; Letter
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.14125
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    Zs.A 1499: Show issues Location:
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  5. Article ; Online: Platelet Satellitism: Just a Laboratory Curiosity? A Case Report of Platelet Satellitism with Multilineage Involvement.

    La Gioia, Antonio / Fiorini, Fabiana / Fiorini, Marcello

    Annals of laboratory medicine

    2022  Volume 42, Issue 5, Page(s) 606–608

    MeSH term(s) Blood Platelets ; Hematologic Tests ; Humans ; Laboratories
    Language English
    Publishing date 2022-04-22
    Publishing country Korea (South)
    Document type Case Reports ; Letter
    ZDB-ID 2677441-0
    ISSN 2234-3814 ; 2234-3814
    ISSN (online) 2234-3814
    ISSN 2234-3814
    DOI 10.3343/alm.2022.42.5.606
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  6. Article ; Online: Analytical performance of free testosterone calculated by direct immunoluminometric method compared with the Vermeulen equation: results from a clinical series.

    Dalmiglio, Cristina / Bombardieri, Alessio / Mattii, Elisa / Sestini, Fausta / Fioravanti, Carla / Castagna, Maria Grazia / Fiorini, Marcello / Dotta, Francesco / Cantara, Silvia

    Hormones (Athens, Greece)

    2024  

    Abstract: Introduction: Testosterone (T) is a hormone that is crucial for primary and secondary sexual development in both males and females. Free testosterone (FT) represents the biologically active form of T, and its measurement is of great importance in ... ...

    Abstract Introduction: Testosterone (T) is a hormone that is crucial for primary and secondary sexual development in both males and females. Free testosterone (FT) represents the biologically active form of T, and its measurement is of great importance in clinical practice. While application of either equilibrium dialysis or ultrafiltration is considered to be the gold standard for FT assessment, these methods are expensive and not widely accessible. As an alternative, the Vermeulen formula is a commonly utilized calculated method.
    Methods: This clinical study, including 190 consecutive patients, was carried out to compare FT levels obtained through direct immunoluminometric assay and the Vermeulen formula. The comparison was performed using Passing-Bablok and Deming regression as well as the Bland-Altman plot. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were assessed.
    Results: The calculated method employing the Vermeulen formula was considered the gold standard. Passing-Bablok regression indicated a good agreement between the two methods, with slopes close to 1 for the whole series. Although the Bland-Altman plot demonstrated overall agreement, a potential proportional bias was observed in females. Deming regression confirmed excellent agreement and reliable estimates. Sensitivity and specificity analysis revealed that the direct method had a sensitivity of 75.0% and a specificity of 93.4% in all patients. However, sensitivity improved to 81.0% in males and dropped to 18.2% in females likely due to the low number of true positive cases.
    Conclusion: The direct method exhibited comparable performance to the calculated method, but caution should be exercised when interpreting results, particularly in females. Further studies are necessary to validate its sensitivity and specificity in larger series.
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2075912-5
    ISSN 2520-8721 ; 1109-3099
    ISSN (online) 2520-8721
    ISSN 1109-3099
    DOI 10.1007/s42000-023-00522-x
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    Zs.A 5613: Show issues Location:
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  7. Article ; Online: Enhanced expression of the autophagosomal marker LC3-II in detergent-resistant protein lysates from a CLN3 patient's post-mortem brain.

    Pezzini, Francesco / Fiorini, Michele / Doccini, Stefano / Santorelli, Filippo Maria / Zanusso, Gianluigi / Simonati, Alessandro

    Biochimica et biophysica acta. Molecular basis of disease

    2023  Volume 1869, Issue 6, Page(s) 166756

    Abstract: Neuronal Ceroido Lipofuscinoses (NCL) are inherited, neurodegenerative disorders associated with lysosomal storage. • Impaired autophagy plays a pathogenetic role in several NCL forms, including CLN3 disease, but study on human brains are lacking. • In ...

    Abstract • Neuronal Ceroido Lipofuscinoses (NCL) are inherited, neurodegenerative disorders associated with lysosomal storage. • Impaired autophagy plays a pathogenetic role in several NCL forms, including CLN3 disease, but study on human brains are lacking. • In post-mortem brain samples of a CLN3 patient the LC3-I to LC3-II shift was consistent with activated autophagy. However, the autophagic process seemed to be ineffective due to the presence of lysosomal storage markers. • After fractionation with buffers of increasing detergent-denaturing strength, a peculiar solubility pattern of LC3-II was observed in CLN3 patient's samples, suggesting a different lipid composition of the membranes where LC3-II is stacked.
    MeSH term(s) Humans ; Detergents/pharmacology ; Membrane Glycoproteins/metabolism ; Neuronal Ceroid-Lipofuscinoses/metabolism ; Molecular Chaperones/metabolism ; Lysosomal Storage Diseases/pathology ; Brain/metabolism
    Chemical Substances Detergents ; Membrane Glycoproteins ; Molecular Chaperones ; CLN3 protein, human
    Language English
    Publishing date 2023-05-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2023.166756
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    Uc I Zs.247: Show issues Location:
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  8. Article: The effect of home computer use on children’s cognitive and non-cognitive skills

    Fiorini, M

    Economics of education review Vol. 29, No. 1 , p. 55-72

    2010  Volume 29, Issue 1, Page(s) 55–72

    Author's details M. Fiorini
    Language English
    Size graph. Darst.
    Publisher Elsevier Science
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 865180-2
    ISSN 0272-7757
    Database ECONomics Information System

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  9. Article ; Online: Pseudo-erythroblastosis on Sysmex XN hematology analyzers: a clue to Candida sepsis. Case report and literature review.

    La Gioia, Antonio / Basile, Manuela / Fiorini, Fabiana / Andreoli, Elisabetta / Salamone, Domenico / Fiorini, Marcello

    Clinical chemistry and laboratory medicine

    2022  Volume 60, Issue 9, Page(s) e210–e212

    MeSH term(s) Candida ; Candidiasis ; Hematology ; Humans ; Reproducibility of Results ; Sepsis/diagnosis
    Language English
    Publishing date 2022-06-23
    Publishing country Germany
    Document type Case Reports ; Letter ; Review
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2022-0486
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
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  10. Article ; Online: Identification and quantification of tire wear particles by employing different cross-validation techniques: FTIR-ATR Micro-FTIR, Pyr-GC/MS, and SEM.

    Rosso, Beatrice / Gregoris, Elena / Litti, Lucio / Zorzi, Federico / Fiorini, Maurizio / Bravo, Barbara / Barbante, Carlo / Gambaro, Andrea / Corami, Fabiana

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 326, Page(s) 121511

    Abstract: Tire wear particles (TWPs) are one of the environment's most important emission sources of microplastics. In this work, chemical identification of these particles was carried out in highway stormwater runoff through cross-validation techniques for the ... ...

    Abstract Tire wear particles (TWPs) are one of the environment's most important emission sources of microplastics. In this work, chemical identification of these particles was carried out in highway stormwater runoff through cross-validation techniques for the first time. Optimization of a pre-treatment method (i.e., extraction and purification) was provided to extract TWPs, avoiding their degradation and denaturation, to prevent getting low recognizable identification and consequently underestimates in the quantification. Specific markers were used for TWPs identification comparing real stormwater samples and reference materials via FTIR-ATR, Micro-FTIR, and Pyrolysis-gas-chromatography-mass spectrometry (Pyr-GC/MS). Quantification of TWPs was carried out via Micro-FTIR (microscopic counting); the abundance ranged from 220,371 ± 651 TWPs/L to 358,915 ± 831 TWPs/L, while the higher mass was 39,6 ± 9 mg TWPs/L and the lowest 31,0 ± 8 mg TWPs/L. Most of the TWPs analyzed were less than 100 μm in size. The sizes were also confirmed using a scanning electron microscope (SEM), including the presence of potential nano TWPs in the samples. Elemental analysis via SEM supported that a complex mixture of heterogeneous composition characterizes these particles by agglomerating organic and inorganic particles that could derive from brake and road wear, road pavement, road dust, asphalts, and construction road work. Due to the analytical lack of knowledge about TWPs chemical identification and quantification in scientific literature, this study significantly contributes to providing a novel pre-treatment and analytical methodology for these emerging contaminants in highway stormwater runoff. The results of this study highlight the uttermost necessity to employ cross-validation techniques, i.e., FTIR-ATR, Micro-FTIR, Pyr-GC/MS, and SEM for the TWPs identification and quantification in the real environmental samples.
    MeSH term(s) Plastics ; Environmental Monitoring/methods ; Pyrolysis ; Spectroscopy, Fourier Transform Infrared ; Dust/analysis
    Chemical Substances Plastics ; Dust
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121511
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