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  1. Article ; Online: Unraveling the Complexities of Mast Cells in Health and Disease.

    Firinu, Davide

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: As we draw the curtain on this Special Issue dedicated to the intricate roles of mast cells (MCs) in health and disease, we reflect on the insights garnered from the array of research articles featured within the published papers of ... ...

    Abstract As we draw the curtain on this Special Issue dedicated to the intricate roles of mast cells (MCs) in health and disease, we reflect on the insights garnered from the array of research articles featured within the published papers of the
    MeSH term(s) Mast Cells
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073791
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  2. Article: Current Understanding of the Immune Response after COVID-19 Vaccination.

    Ning, Shunbin / Firinu, Davide

    Vaccines

    2024  Volume 12, Issue 3

    Abstract: The global vaccination campaign against SARS-CoV-2, the virus responsible for COVID-19, has been a monumental endeavor, marked by unprecedented collaboration between scientific researchers and pharmaceutical companies [ ... ]. ...

    Abstract The global vaccination campaign against SARS-CoV-2, the virus responsible for COVID-19, has been a monumental endeavor, marked by unprecedented collaboration between scientific researchers and pharmaceutical companies [...].
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12030250
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  3. Article ; Online: A promising new treatment for SAPHO syndrome that deserves further studies.

    Firinu, Davide

    The British journal of dermatology

    2018  Volume 179, Issue 4, Page(s) 823

    MeSH term(s) Acquired Hyperostosis Syndrome ; Humans ; Thalidomide/analogs & derivatives
    Chemical Substances Thalidomide (4Z8R6ORS6L) ; apremilast (UP7QBP99PN)
    Language English
    Publishing date 2018-10-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.16771
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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.23: Show issues Location:
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  4. Article ; Online: SARS-CoV-2 vaccination in primary antibody deficiencies: an overview on efficacy, immunogenicity, durability of immune response and safety.

    Cusa, Gabriella / Sardella, Germano / Garzi, Giulia / Firinu, Davide / Milito, Cinzia

    Current opinion in allergy and clinical immunology

    2023  Volume 24, Issue 1, Page(s) 37–43

    Abstract: Purpose of review: This review aims to summarize the current best knowledge on the efficacy of COVID-19 vaccination in vulnerable patients affected by primary antibody deficiencies (PADs), both in patients previously infected and vaccine-immunized, ... ...

    Abstract Purpose of review: This review aims to summarize the current best knowledge on the efficacy of COVID-19 vaccination in vulnerable patients affected by primary antibody deficiencies (PADs), both in patients previously infected and vaccine-immunized, focusing also on the durability, on the need for multiple booster doses and on the safety of anti-SARS-CoV-2 vaccines.
    Recent findings: Patients vaccinated for SARS-CoV2 have variable humoral response, still showing a tendency towards an increase in antibody titers, with factors such as booster doses, previous infections, age and specific genetic mutations influencing the outcome. Long-lasting cellular responses to SARS-CoV-2 vaccination instead, mostly of the T-cell type, have been observed. Overall, the duration of protection given by vaccinations is sufficient and increased upon further simulations. Furthermore, the safety profile in PID patients is excellent, with most adverse events being transient and mild and no major adverse event reported.
    Summary: Several studies have emphasized the benefit of vaccinating patients with PADs against the SARS-CoV-2 virus and the necessity of administering booster doses. This review, by gathering the most recent and significant data from the scientific literature, could be helpful in clinical practice in the management of disease prevention in patients affected by primary immunodeficiency and also serve as inspiration for further in-depth clinical research.
    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Immunity ; Primary Immunodeficiency Diseases ; RNA, Viral ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; RNA, Viral
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000955
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Multimodal, open-source big data analysis in asthma: A novel approach to inform public health programming.

    Gangemi, Sebastiano / Tonacci, Alessandro / Costanzo, Giulia / Firinu, Davide / Del Giacco, Stefano

    The World Allergy Organization journal

    2023  Volume 16, Issue 4, Page(s) 100764

    Abstract: Asthma is a chronic respiratory disease affecting over 358 million people worldwide; for this reason analysing big data on asthma from different countries could give a more detailed picture of current disease burden. We aim to investigate the ... ...

    Abstract Asthma is a chronic respiratory disease affecting over 358 million people worldwide; for this reason analysing big data on asthma from different countries could give a more detailed picture of current disease burden. We aim to investigate the correlations between asthma and key socio-demographic parameters from different world databases. We found a direct correlation with the gross domestic product (GDP) per capita and its nominal counterpart, with wealthiest countries seen to have the highest prevalence of asthma, as also confirmed by a similar correlation with the human development index (HDI). A positive correlation was also seen between asthma prevalence and a number of socio-cultural data being representative of a good life quality index and prevalent in more developed and wealthier countries. Concerning medical data, an inverse relationship was seen between asthma prevalence and helminthiasis. Those data indicate a higher prevalence for asthma in more developed countries, where socio-economic status is higher and also the access to medical care is more ubiquitous. The approach used in our study highlighted the role of medical literacy and access to healthcare facilities in the correct diagnosis of asthma and vice versa. Our data appear to be suitable in terms of a health programming approach because of the high burden of disease worldwide.
    Language English
    Publishing date 2023-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2023.100764
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  6. Article: Impact of Menopause in Patients with Multiple Sclerosis: Current Perspectives.

    Lorefice, Lorena / D'Alterio, Maurizio Nicola / Firinu, Davide / Fenu, Giuseppe / Cocco, Eleonora

    International journal of women's health

    2023  Volume 15, Page(s) 103–109

    Abstract: Given the aging population, with a peak age-specific prevalence that is shifting beyond the age of 50, several women currently living with MS are very close to menopause. Menopause is usually characterized by several specific symptoms with adverse ... ...

    Abstract Given the aging population, with a peak age-specific prevalence that is shifting beyond the age of 50, several women currently living with MS are very close to menopause. Menopause is usually characterized by several specific symptoms with adverse impacts on different aspects of a woman's quality of life, such as fatigue, and cognitive, mood and bladder disorders, which overlap with symptoms of MS. Generally, after this biological transition, women with MS appear to be subject to less inflammatory activity. However, several studies have reported an increase of disability accumulation after menopause, suggesting that it is a turning point to a more progressive phase of the disease. This may be attributable to the hormonal and immunological changes associated with menopause, with several effects on neuroinflammation and neurodegeneration increasing due to the immunosenescence of aging. This review summarizes the hormonal and immunological changes associated with menopause, detailing the effects on MS symptoms, outcomes, and the aging process. Furthermore, possible interventions to improve patients' quality of life are evaluated. In fact, it is increasingly necessary to improve the global management of MS women, as well as their lives, at this multifaceted turning point.
    Language English
    Publishing date 2023-01-25
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508161-5
    ISSN 1179-1411
    ISSN 1179-1411
    DOI 10.2147/IJWH.S334719
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  7. Article ; Online: Is hereditary angioedema related to an increased risk of atherosclerosis?

    Bassareo, Pier Paolo / Firinu, Davide / Del Giacco, Stefano

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2019  Volume 122, Issue 2, Page(s) 228–229

    MeSH term(s) Angioedema ; Angioedemas, Hereditary ; Atherosclerosis ; Complement C1 Inhibitor Protein ; Humans ; Vasodilation
    Chemical Substances Complement C1 Inhibitor Protein
    Language English
    Publishing date 2019-01-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2018.11.006
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.136: Show issues Location:
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  8. Article ; Online: Humoral responses to wild type and ancient BA.1 SARS-CoV-2 variant after heterologous priming vaccination with ChAdOx1 nCoV-19 and BNT162b2 booster dose.

    Sanna, Giuseppina / Marongiu, Alessandra / Firinu, Davide / Piras, Cristina / Palmas, Vanessa / Galdiero, Massimiliano / Atzori, Luigi / Caria, Paola / Campagna, Marcello / Perra, Andrea / Costanzo, Giulia / Coghe, Ferdinando / Littera, Roberto / Chessa, Luchino / Manzin, Aldo

    Clinical and experimental medicine

    2024  Volume 24, Issue 1, Page(s) 12

    Abstract: Several countries have recommended a booster dose of Pfizer BNT162b2 vaccine for subjects under the age of 60, who have already received the first dose of ChAdOx1. This is due to several ChAdOx1 vaccine-associated adverse vascular events and ... ...

    Abstract Several countries have recommended a booster dose of Pfizer BNT162b2 vaccine for subjects under the age of 60, who have already received the first dose of ChAdOx1. This is due to several ChAdOx1 vaccine-associated adverse vascular events and thrombocytopenia. Neutralization assay and quantitative IgG anti-SARS-CoV-2 Spike antibody (anti-S-IgG) were conducted to investigate the long-term responses to vaccine treatment in a cohort of Sardinian participants, who have received heterologous Prime-Boost Vaccination via ChAdOx1 vector vaccine and a booster dose via BNT162b2. The obtained results were compared with those of a cohort of healthcare workers (HCW) who received homologous BNT162b2 (BNT/BNT/BNT) vaccination. One month (T2) and five months after the second and before the third dose (T3), anti-spike antibody or neutralizing titers in the subjects vaccinated with ChAdOx1-S/BNT162b2 were significantly higher than those who experienced the ChAdOx1-S/ChAdOx1-S or BNT162b2/BNT162b2 schedule. These results suggest that a ChAdOx1-S/BNT162b2 regimen provides a more robust antibody response than either of the homologous regimens. However, the anti-spike antibodies or neutralizing titers after the third injection (mRNA vaccine) of ChAdOx1-S as a second dose and BNT162b2 were not statistically different. Homologous and heterologous vaccination provided a strong antibody response. Neutralizing activities were also described against the Omicron BA.1 variant in a sub-group (40) representative of the three vaccination regimens among our cohort.
    MeSH term(s) Humans ; BNT162 Vaccine ; ChAdOx1 nCoV-19 ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Vaccination ; Antibodies, Viral ; Immunoglobulin G
    Chemical Substances BNT162 Vaccine ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2024-01-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-023-01276-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5481: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: COVID-19 Clinical Features and Outcome in Italian Patients Treated with Biological Drugs Targeting Type 2 Inflammation.

    Sambugaro, Giada / Brambilla, Elena / Costanzo, Giulia / Bonato, Vera / Ledda, Andrea Giovanni / Del Giacco, Stefano / Scarpa, Riccardo / Rattazzi, Marcello / Favero, Elisabetta / Cinetto, Francesco / Firinu, Davide

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: This is a multicentric investigation involving two Italian centers that examined the clinical course of COVID-19 in patients receiving biological therapy targeting type 2 inflammation and those not receiving biologicals. Since the beginning of the COVID- ... ...

    Abstract This is a multicentric investigation involving two Italian centers that examined the clinical course of COVID-19 in patients receiving biological therapy targeting type 2 inflammation and those not receiving biologicals. Since the beginning of the COVID-19 pandemic, the management of respiratory and allergic disorders and the potential impact of biological therapy in the most severe forms has been a point of uncertainty. Our multicentric investigation aimed to compare the clinical course of COVID-19 and the impact of vaccination in an Italian cohort of patients with atopic disorders caused by a type 2 inflammation, such as eosinophilic asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), atopic dermatitis (AD), and chronic spontaneous urticaria (CSU). A questionnaire was given to patients coming to our outpatient clinic for the first evaluation or follow-up visit, asking for the clinical characteristics of the infection, the ongoing therapy during the infection, any relevant change, and the patient's vaccination status. We enrolled 132 atopic patients from two Italian centers; 62 patients were on biological therapy at the time of infection (omalizumab 31%, mepolizumab 26%, benralizumab 19%, and dupilumab 24%). The median age was 56 (IQR 22.8) for patients on biologicals and 48 (IQR 26.5) for those not on biologicals (
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14030378
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  10. Article: The Stability of Social and Behavioral Rhythms and Unexpected Low Rate of Relevant Depressive Symptoms in Old Adults during the COVID-19 Pandemic.

    Sancassiani, Federica / Cossu, Giulia / Cantone, Elisa / Romano, Ferdinando / Perra, Alessandra / Urban, Antonio / Pinna, Samantha / Del Giacco, Stefano / Littera, Roberto / Firinu, Davide / Chessa, Luchino / Tramontano, Enzo / Nardi, Antonio Egidio / Carta, Mauro Giovanni

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13072005
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