Article ; Online: Contribution of S100A4-expressing fibroblasts to anti-SSA/Ro-associated atrioventricular nodal calcification and soluble S100A4 as a biomarker of clinical severity.
2023 Volume 14, Page(s) 1114808
Abstract: Background: Fibrosis and dystrophic calcification disrupting conduction tissue architecture are histopathological lesions characterizing cardiac manifestations of neonatal lupus (cardiac-NL) associated with maternal anti-SSA/Ro antibodies.: Objectives! ...
| Abstract | Background: Fibrosis and dystrophic calcification disrupting conduction tissue architecture are histopathological lesions characterizing cardiac manifestations of neonatal lupus (cardiac-NL) associated with maternal anti-SSA/Ro antibodies. Objectives: Increased appreciation of heterogeneity in fibroblasts encourages re-examination of existing models with the consideration of multiple fibroblast subtypes (and their unique functional differences) in mind. This study addressed fibroblast heterogeneity by examining expression of α-Smooth Muscle Actin (myofibroblasts) and of S100 Calcium-Binding Protein A4 (S100A4). Methods: Using a previously established model of rheumatic scarring/fibrosis Results: S100A4 immunostaining was observed in 4 cardiac-NL hearts with positional identity in the conduction system at regions of dystrophic calcification but not fibrotic zones, the latter containing only myofibroblasts. Conclusions: These findings position the S100A4 |
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| MeSH term(s) | Infant, Newborn ; Humans ; Heart Block/etiology ; Heart Block/pathology ; Heart ; Biomarkers ; Calcinosis ; Fibrosis ; Fibroblasts/metabolism ; S100 Calcium-Binding Protein A4/metabolism |
| Chemical Substances | Biomarkers ; S100A4 protein, human (142662-27-9) ; S100 Calcium-Binding Protein A4 |
| Language | English |
| Publishing date | 2023-04-06 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2023.1114808 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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