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  1. Article: New Approaches to Multifrequency Sp Stacking Tested in the Anatolian Region

    Hua, J. / Fischer, K. M. / Wu, M. / Blom, N. A.

    Journal of geophysical research. 2020 Nov., v. 125, no. 11

    2020  

    Abstract: This study presents an improved approach to common‐conversion point stacking of converted body waves that incorporates scattering kernels, accurate and efficient measurement of stack uncertainties, and an alternative method for estimating free surface ... ...

    Abstract This study presents an improved approach to common‐conversion point stacking of converted body waves that incorporates scattering kernels, accurate and efficient measurement of stack uncertainties, and an alternative method for estimating free surface seismic velocities. To better separate waveforms into the P and SV components to calculate receiver functions, we developed an alternative method to measure near‐surface compressional and shear wave velocities from particle motions. To more accurately reflect converted phase scattering kernels in the common‐conversion point stack, we defined new weighting functions to project receiver function amplitudes only to locations where sensitivities to horizontal discontinuities are high. To better quantify stack uncertainties, we derived an expression for the standard deviation of the stack amplitude that is more efficient than bootstrapping and can be used for any problem requiring the standard deviation of a weighted average. We tested these improved methods on Sp phase data from the Anatolian region, using multiple band‐pass filters to image velocity gradients of varying depth extents. Common conversion point stacks of 23,787 Sp receiver functions demonstrate that the new weighting functions produce clearer and more continuous mantle phases, compared to previous approaches. The stacks reveal a positive velocity gradient at 80–150 km depth that is consistent with the base of an asthenospheric low‐velocity layer. This feature is particularly strong in stacks of longer period data, indicating it represents a gradual velocity gradient. At shorter periods, a lithosphere‐asthenosphere boundary phase is observed at 60–90 km depth, marking the top of the low‐velocity layer.
    Keywords Turkey (country) ; geophysics ; research ; standard deviation
    Language English
    Dates of publication 2020-11
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2020JB020313
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Cascading Hazards in a Migrating Forearc‐Arc System: Earthquake and Eruption Triggering in Nicaragua

    Higgins, M. / La Femina, P. C. / Saballos, A. J. / Ouertani, S. / Fischer, K. M. / Geirsson, H. / Strauch, W. / Mattioli, G. / Malservisi, R.

    Journal of Geophysical Research: Solid Earth. 2022 Dec., v. 127, no. 12 p.e2022JB024899-

    2022  

    Abstract: Strain partitioning in oblique convergent margins results in margin‐parallel shear in the overriding plate. Margin‐parallel shear is often accommodated by margin‐parallel strike‐slip faults proximal to active volcanic arcs. Along the Nicaraguan segment ... ...

    Abstract Strain partitioning in oblique convergent margins results in margin‐parallel shear in the overriding plate. Margin‐parallel shear is often accommodated by margin‐parallel strike‐slip faults proximal to active volcanic arcs. Along the Nicaraguan segment of the Central American Forearc (CAFA) in the Cocos‐Caribbean plate convergent margin, there are no well‐expressed right‐lateral faults that accommodate CA‐CAFA relative motion. Instead, historical earthquakes and mapped fault orientations indicate that the ∼12 mm/yr of dextral motion is accommodated on arc‐normal, left‐lateral faults (i.e., bookshelf faults). We investigate three upper‐plate earthquakes; the 10 April 2014 (Mw 6.1), 15 September 2016 (Mw 5.7), and 28 September 2016 (Mw 5.5), using Global Position System co‐seismic displacements and relocated earthquake aftershocks. Our analyses of the three earthquakes indicate that the 10 April 2014 earthquake ruptured an unmapped margin‐parallel right‐lateral fault in Lago Xolotlán (Managua) and the September 2016 earthquakes ruptured arc‐normal, left‐lateral and oblique‐slip faults. These earthquakes represent a triggered sequence whereby the 10 April 2014 earthquake promoted failure of the faults that ruptured in September 2016 by imparting a static Coulomb stress change (ΔCFS) of 0.02–0.07 MPa. Likewise, the 15 September 2016, earthquake additionally promoted failure (ΔCFS of 0.08–0.1 MPa) on sub‐parallel faults that ruptured in two subsequent earthquakes. We also present an instance of magma‐tectonic interaction whereby the 10 April 2014 earthquake dilated (10s of μStrain) the shallow magmatic system of Momotombo Volcano, which led to magma injection, ascent, and eruption on 1 December 2015, after ∼100 years of quiescence.
    Keywords earthquakes ; geophysics ; global positioning systems ; research ; Nicaragua
    Language English
    Dates of publication 2022-12
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ISSN 2169-9313
    DOI 10.1029/2022JB024899
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Expanded (CAG)n, (CGG)n and (GAA)n trinucleotide repeat microsatellites, and mutant purine synthesis and pigmentation genes cause schizophrenia and autism.

    Fischer, K M

    Medical hypotheses

    1998  Volume 51, Issue 3, Page(s) 223–233

    Abstract: Unstable (CAG)n trinucleotide repeat microsatellites are hypothesized to cause schizophrenia. The (CAG)n microsatellite of dominant spinal cerebellar ataxia type 1 (SCA1) is a candidate schizophrenia gene. Autism results from expansions of (CGG)n and ( ... ...

    Abstract Unstable (CAG)n trinucleotide repeat microsatellites are hypothesized to cause schizophrenia. The (CAG)n microsatellite of dominant spinal cerebellar ataxia type 1 (SCA1) is a candidate schizophrenia gene. Autism results from expansions of (CGG)n and (GAA)n trinucleotide repeat stretches at fragile X syndrome (FRAXA), and the recessive Friedreich's ataxia (FA). Dominant ataxia genes may cause schizophrenia and recessive ataxia genes may cause autism. Syndromes with autism show purine synthesis defects (PSDs) and/or pigmentation defects (PDs). Autism is caused by very lengthy expansions of (CAG)n, (CGG)n and (GAA)n repeats, while schizophrenia results from much smaller (CAG)n and (CGG)n repeat expansions.
    MeSH term(s) Animals ; Autistic Disorder/genetics ; Fragile X Syndrome/genetics ; Friedreich Ataxia/genetics ; Genes, Dominant ; Humans ; Models, Genetic ; Pigmentation/genetics ; Purines/biosynthesis ; Schizophrenia/genetics ; Trinucleotide Repeat Expansion/genetics
    Chemical Substances Purines
    Language English
    Publishing date 1998-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/s0306-9877(98)90080-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Parkinson's disease, amyotrophic lateral sclerosis and spinal muscular atrophy are caused by an unstable (CAG)n trinucleotide repeat microsatellite.

    Fischer, K M

    Medical hypotheses

    1997  Volume 49, Issue 4, Page(s) 337–345

    MeSH term(s) Age of Onset ; Amyotrophic Lateral Sclerosis/epidemiology ; Amyotrophic Lateral Sclerosis/genetics ; Animals ; Genetic Linkage ; Humans ; Meiosis/genetics ; Muscular Atrophy, Spinal/epidemiology ; Muscular Atrophy, Spinal/genetics ; Parkinson Disease/epidemiology ; Parkinson Disease/genetics ; Trinucleotide Repeat Expansion
    Language English
    Publishing date 1997-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/s0306-9877(97)90200-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Etiology of (CAG)n triplet repeat neurodegenerative diseases such as Huntington's disease is connected to stimulation of glutamate receptors.

    Fischer, K M

    Medical hypotheses

    1997  Volume 48, Issue 5, Page(s) 393–398

    Abstract: Chronic neurodegenerative diseases with expanded, genetically unstable (CAG)n triplet repeats include Huntington's disease. It is hypothesized that pathology results from excessive stimulation of glutamate receptors by glutamine. ...

    Abstract Chronic neurodegenerative diseases with expanded, genetically unstable (CAG)n triplet repeats include Huntington's disease. It is hypothesized that pathology results from excessive stimulation of glutamate receptors by glutamine.
    MeSH term(s) Autoimmunity ; Cerebrovascular Disorders/metabolism ; Epilepsy/metabolism ; Glutamic Acid/metabolism ; Humans ; Huntington Disease/etiology ; Huntington Disease/genetics ; Huntington Disease/metabolism ; Minisatellite Repeats ; Models, Biological ; Nerve Degeneration/genetics ; Nerve Degeneration/physiology ; Receptors, Glutamate/metabolism ; Trinucleotide Repeats
    Chemical Substances Receptors, Glutamate ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 1997-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/s0306-9877(97)90034-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Die Seele ist transpersonal. Beiträge zur Transpersonalen Psychotherapie

    Fischer, Karl Maximilian (Ed.)

    2007  

    Abstract: Ansätze der transpersonalen Psychotherapie werden beschrieben. - Inhalt: (1) B. Fischer und K. M. Fischer: Am Tor zu den Weiten der Seele. Schritte zu einer transpersonalen und spirituellen Psychotherapie im psychotherapeutischen Alltag. (2) M. Rief: " ... ...

    Title translation The soul is transpersonal. Contributions to transpersonal psychotherapy
    Abstract Ansätze der transpersonalen Psychotherapie werden beschrieben. - Inhalt: (1) B. Fischer und K. M. Fischer: Am Tor zu den Weiten der Seele. Schritte zu einer transpersonalen und spirituellen Psychotherapie im psychotherapeutischen Alltag. (2) M. Rief: "Nah ist das Land, das sie das Leben nennen". Transpersonal/spirituell orientierte Psychotherapie und Meditation. (3) S. Essen: Therapie als Prozess des Überschreitens. Sinn und Zweck der Dualität ist die Liebe. Das Personale und das Transpersonale in der systemischen Therapie und die Spiritualität systemischen Denkens. (4) Sylvester Walch: Holotropes Atmen zwischen Therapie und Spiritualität. Heilung und Öffnung durch veränderte Bewusstseinszustände. (5) R. Lasser: Qualität und Struktur in gewöhnlichen und außergewöhnlichen Bewusstseinszuständen. (5) H. Piron: Psychosynthese. (6) H. Piron: Transpersonale Verhaltenstherapie. (6) A. Maurer: Über den Körper die Seele berühren. Integrative Gestalt Message (IGM) & IGM-Körpertherapie. (7) A. Reiter: Die "verletzte Seele". Psychotraumatologie aus transpersonaler Sicht.
    Keywords Bewusstseinszustände ; Consciousness States ; Psychotherapeutic Processes ; Psychotherapeutic Techniques ; Psychotherapeutische Prozesse ; Psychotherapeutische Techniken ; Psychotherapie ; Psychotherapy ; Spirituality ; Spiritualität ; Transpersonal Psychology ; Transpersonale Psychologie
    Language German
    Size 305 S.
    Publisher Edition pro mente
    Publishing place Linz
    Document type Book
    ISBN 978-3-901409-86-8 ; 3-901409-86-6
    Database PSYNDEX

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  7. Article ; Online: Radiographic monitoring of the distal insertion of the calcaneofibular ligament in anatomical reconstructions of ankle instabilities: A preliminary cadaveric study.

    Best, R / Mauch, F / Fischer, K M / Rueth, J / Brueggemann, G P

    Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

    2015  Volume 21, Issue 4, Page(s) 245–249

    Abstract: Background: The purpose of the study therefore was to determine radiographic landmarks that support the identification of the insertion site of the distal calcaneofibular ligament (CFL) in anatomic ankle ligament reconstructions.: Methods: In 10 ... ...

    Abstract Background: The purpose of the study therefore was to determine radiographic landmarks that support the identification of the insertion site of the distal calcaneofibular ligament (CFL) in anatomic ankle ligament reconstructions.
    Methods: In 10 lower limb cadaver specimens the midpoint of the distal CFL insertion was dissected and marked with a nail inserted orthogonally. On a standardized lateral radiograph in neutral ankle position a horizontal tangent was aligned to the deepest visible concavity of the tarsal sinus and one vertical tangent to the farthest posterior convexity of the talus. Additionally, a line was drawn from the radiographically marked distal CFL to the fibular insertion of the CFL to determine the CFL-fibular angle.
    Results: In relation to the radiographic tangents intersection the mean deviation of the depicted CFL nails was 2.2mm [SD ± 1.1 mm] leading to an angular, circular to slightly oval 6 mm insertion. The scatter-plot of the marked positions convened along a line from the supposed fibular CFL insertion to the intersection in all cases. The mean CFL-fibular angle was 131.7° [SD ± 3.16°].
    Conclusions: Determining a virtual intersection between a horizontal tangent aligned to the deepest visible concavity of the tarsal sinus and one vertical tangent aligned to the farthest posterior convexity of the talus on a standardized lateral radiograph in neutral ankle position supports an anatomic insertion of the distal calcaneofibular ligament most probably.
    MeSH term(s) Aged, 80 and over ; Ankle Joint/diagnostic imaging ; Ankle Joint/surgery ; Cadaver ; Female ; Humans ; Joint Instability/diagnostic imaging ; Joint Instability/surgery ; Lateral Ligament, Ankle/diagnostic imaging ; Lateral Ligament, Ankle/surgery ; Male ; Radiography ; Reconstructive Surgical Procedures/methods
    Language English
    Publishing date 2015-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 1424533-4
    ISSN 1460-9584 ; 1268-7731
    ISSN (online) 1460-9584
    ISSN 1268-7731
    DOI 10.1016/j.fas.2015.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Genes for Prader Willi syndrome/Angelman syndrome and fragile X syndrome are homologous, with genetic imprinting and unstable trinucleotide repeats causing mental retardation, autism and aggression.

    Fischer, K M

    Medical hypotheses

    1996  Volume 47, Issue 4, Page(s) 289–298

    Abstract: Genes for Prader Willi syndrome/Angelman syndrome are homologous to genes for fragile X syndrome. Genetic imprinting and expanded trinucleotide repeats cause mental retardation, autism and aggression. ...

    Abstract Genes for Prader Willi syndrome/Angelman syndrome are homologous to genes for fragile X syndrome. Genetic imprinting and expanded trinucleotide repeats cause mental retardation, autism and aggression.
    MeSH term(s) Aggression ; Angelman Syndrome/genetics ; Animals ; Autistic Disorder/genetics ; Chromosome Mapping ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 15 ; Fragile X Syndrome/genetics ; Genomic Imprinting ; Humans ; Intellectual Disability/genetics ; Models, Genetic ; Prader-Willi Syndrome/genetics ; Trinucleotide Repeats
    Language English
    Publishing date 1996-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/s0306-9877(96)90069-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Transgenic domestic animals provide an animal model for rheumatoid arthritis.

    Fischer, K M

    Medical hypotheses

    1992  Volume 38, Issue 3, Page(s) 240–243

    Abstract: Production of transgenic domestic animals by microinjection of egg nuclei has permitted the introduction of exogenous genes into the transgenic animal. Pursell et al (1) report severe synovitis, cardiomegaly, dermatitis, renal disease and gastric ulcers ... ...

    Abstract Production of transgenic domestic animals by microinjection of egg nuclei has permitted the introduction of exogenous genes into the transgenic animal. Pursell et al (1) report severe synovitis, cardiomegaly, dermatitis, renal disease and gastric ulcers in pigs with an expressed bovine growth hormone transgene. I have hypothesized that rheumatoid arthritis (RA) is a disease with initial symptoms to the gamete (2, 3). This hypothesis is supported by data showing a reduced rate of RA in women using oral contraceptives (4, 5) and remission of RA in pregnancy (6). RA in animals resulting from trauma to the gamete would be consistent with this hypothesis. This paper hypothesizes that some of the pathology associated with genetic engineering of livestock can be attributed to a rheumatoid arthritis-like spectrum of symptoms. This systemic reaction could be sufficiently similar to human RA to permit the transgenic pig to serve as an animal model of the disease.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/physiopathology ; Arthritis, Rheumatoid/prevention & control ; Contraceptives, Oral ; Disease Models, Animal ; Female ; Humans
    Chemical Substances Contraceptives, Oral
    Language English
    Publishing date 1992-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/0306-9877(92)90102-i
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Hypothesis: tobacco use is a risk factor in rheumatoid arthritis.

    Fischer, K M

    Medical hypotheses

    1991  Volume 34, Issue 2, Page(s) 116–117

    Abstract: Rheumatoid arthritis (RA) has been described in 3000-5000 year-old skeletal remains from North America by Rothschild, Turner and DeLuca (1). RA was first described unambiguously in Europeans in 1800 (1). Tobacco was introduced into Europe from the New ... ...

    Abstract Rheumatoid arthritis (RA) has been described in 3000-5000 year-old skeletal remains from North America by Rothschild, Turner and DeLuca (1). RA was first described unambiguously in Europeans in 1800 (1). Tobacco was introduced into Europe from the New World in the 1600s, and Rothschild, Turner and DeLuca include tobacco among variables that could be responsible for the appearance of RA in Europe. Primary and secondary exposure to tobacco smoke could be etiological, along with other causal variables. Tokuhata found cigarette smoking correlated with reduced fertility in women (2). I have hypothesized that RA is a disease with initial symptoms to the gamete and gonad (3). The hypothesis predicts a significant positive correlation between primary and secondary exposure to smoking and RA.
    MeSH term(s) Arthritis, Rheumatoid/etiology ; Female ; Humans ; Male ; Ovulation ; Risk Factors ; Sex Characteristics ; Smoking/adverse effects ; Tobacco Smoke Pollution/adverse effects
    Chemical Substances Tobacco Smoke Pollution
    Language English
    Publishing date 1991-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/0306-9877(91)90177-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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