LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 642

Search options

  1. Book ; Thesis: Evaluation of FGFR1-4 as therapeutic targets in neuroblastoma

    Henkel, Elisabeth / Fischer, Matthias / Odenthal, Margarete

    2021  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Elisabeth Henkel, geb. Arnz ; 1. Gutachter: Universitätsprofessor Dr. med. M. Fischer, 2. Gutachterin: Professorin Dr. rer. nat. M. Odenthal ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language English ; German
    Size 70 Blätter, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT020871377
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 D 179 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Thesis: Observation after surgery for low grade glioma

    Jansen, Elena Maria / Grau, Stefan / Fischer, Matthias

    long-term outcome in the light of the 2016 WHO classification

    2021  

    Institution Universitätsklinikum Köln / Klinik für Allgemeine Neurochirurgie
    Author's details vorgelegt von Elena Maria Jansen ; 1. Gutachterin oder Gutachter: Privatdozent Dr. med. S.J. Grau, 2. Gutachterin oder Gutachter: Universitätsprofessor Dr. med. M. Fischer ; aus dem Zentrum für Neurochirurgie der Universität zu Köln, Klinik für Allgemeine Neurochirurgie
    Subject code 610
    Language German ; English
    Size 26 Blätter, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache
    HBZ-ID HT021178090
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 D 696 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Thesis: ALK als potenzielles Zielmolekül im Neuroblastom

    Tekampe, Christine / Fischer, Matthias / Büttner, Roland

    In-vitro-Testung des ALK-Inhibitors LDK378 (Ceritinib) an Neuroblastomzelllinien

    2021  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Christine Tekampe geb. Stindt ; 1. Gutachter: Universitätsprofessor Dr. med. M. Fischer, 2. Gutachter: Universitätsprofessor Dr. med. R. H. Büttner ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language German
    Size 83 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Open Access
    HBZ-ID HT021296968
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 192 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book ; Online ; Thesis: ALK als potenzielles Zielmolekül im Neuroblastom

    Tekampe, Christine / Fischer, Matthias / Büttner, Roland

    In-vitro-Testung des ALK-Inhibitors LDK378 (Ceritinib) an Neuroblastomzelllinien

    2021  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Christine Tekampe geb. Stindt ; 1. Gutachter: Universitätsprofessor Dr. med. M. Fischer, 2. Gutachter: Universitätsprofessor Dr. med. R. H. Büttner ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language German
    Size 1 Online-Ressource (83 Seiten), Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2021
    Note Open Access
    HBZ-ID HT021207750
    DOI 10.4126/FRL01-006431266
    Database Repository for Life Sciences

    Full text online

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book: Letzte Hilfe

    Bollig, Georg / Famos, Rita / Fischer, Matthias / Niedermann, Eva / Rüegger, Heinz

    schwerkranke und sterbende Menschen begleiten

    2020  

    Institution Evangelisch-Reformierte Landeskirche des Kantons Zürich
    Author's details Georg Bollig, Rita Famos, Matthias Fischer, Eva Niedermann, Heinz Rüegger
    Language German
    Size 80 Seiten, 20 cm x 12.5 cm
    Edition Schweizer Ausgabe
    Publisher Theologischer Verlag Zürich
    Publishing place Zürich
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020526812
    ISBN 978-3-290-18338-7 ; 3-290-18338-6
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 12486 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Thesis: Prävalenz und klinische Relevanz des Alternative Lengthening of Telomeres (ALT) Phänotyps in Neuroblastomen

    Walter, Esther Megumi / Fischer, Matthias / Friedrichs, Nicolaus

    2020  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Esther Megumi Walter ; 1. Gutachter: Universitätsprofessor Dr. med. M. Fischer, 2. Gutachter: Professor Dr. med. N. Friedrichs ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language German
    Size 70 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    HBZ-ID HT020671423
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 964 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Audio / Video ; Online: Vegan, vegetarisch und Novel Food

    Fischer, Matthias

    das Ende von Lebensmittelinfektionen?

    2023  

    Keywords Text ; ddc:610 ; Zoonosen
    Language German
    Publishing date 2023-05-11
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Book ; Thesis: Prävalenz und klinische Bedeutung von TERT-Translokationen beim Neuroblastom

    Sand, Frederik / Fischer, Matthias / Schweiger, Michal-Ruth

    2019  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Frederik Sand ; 1. Berichterstatter: Universitätsprofessor Dr. med. M. Fischer, 2. Berichterstatterin: Universitätsprofessorin Dr. rer. nat. Dr. med. M.R. Schweiger ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language German
    Size 78 Seiten, Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2019
    HBZ-ID HT020022209
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 525 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Thesis: Novel insights into the pathogenesis and improved outcome prediction of neuroblastoma by gene expression profiling analyses

    Fischer, Matthias

    = Neue Erkenntnisse zur Pathogenese und verbesserte Risikoabschätzung des Neuroblastoms durch Analysen von Genexpressionsprofilen

    2007  

    Title variant Neue Erkenntnisse zur Pathogenese und verbesserte Risikoabschätzung des Neuroblastoms durch Analysen von Genexpressionsprofilen
    Author's details vorgelegt von Matthias Fischer
    Language German
    Size 55 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Habil.-Schr., 2007
    HBZ-ID HT015278557
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 E 1722 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: On minimising tumoural growth under treatment resistance.

    Fischer, Matthias M / Blüthgen, Nils

    Journal of theoretical biology

    2023  Volume 579, Page(s) 111716

    Abstract: Drug resistance is a major challenge for curative cancer treatment, representing the main reason of death in patients. Evolutionary biology suggests pauses between treatment rounds as a way to delay or even avoid resistance emergence. Indeed, this ... ...

    Abstract Drug resistance is a major challenge for curative cancer treatment, representing the main reason of death in patients. Evolutionary biology suggests pauses between treatment rounds as a way to delay or even avoid resistance emergence. Indeed, this approach has already shown promising preclinical and early clinical results, and stimulated the development of mathematical models for finding optimal treatment protocols. Due to their complexity, however, these models do not lend themself to a rigorous mathematical analysis, hence so far clinical recommendations generally relied on numerical simulations and ad-hoc heuristics. Here, we derive two mathematical models describing tumour growth under genetic and epigenetic treatment resistance, respectively, which are simple enough for a complete analytical investigation. First, we find key differences in response to treatment protocols between the two modes of resistance. Second, we identify the optimal treatment protocol which leads to the largest possible tumour shrinkage rate. Third, we fit the "epigenetic model" to previously published xenograft experiment data, finding excellent agreement, underscoring the biological validity of our approach. Finally, we use the fitted model to calculate the optimal treatment protocol for this specific experiment, which we demonstrate to cause curative treatment, making it superior to previous approaches which generally aimed at stabilising tumour burden. Overall, our approach underscores the usefulness of simple mathematical models and their analytical examination, and we anticipate our findings to guide future preclinical and, ultimately, clinical research in optimising treatment regimes.
    MeSH term(s) Humans ; Undertreatment ; Neoplasms/pathology ; Models, Theoretical ; Biological Evolution
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2972-5
    ISSN 1095-8541 ; 0022-5193
    ISSN (online) 1095-8541
    ISSN 0022-5193
    DOI 10.1016/j.jtbi.2023.111716
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 923: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top