Article ; Online: Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus.
2024 Volume 15, Page(s) 1328820
Abstract: Introduction: Bluetongue virus (BTV) is an arthropod-borne : Methods: In this study, the role of cell-mediated immunity and specific T-cell subsets in BTV pathogenesis, clinical outcome, viral dynamics, immune protection, and onwards transmission to ... ...
| Abstract | Introduction: Bluetongue virus (BTV) is an arthropod-borne Methods: In this study, the role of cell-mediated immunity and specific T-cell subsets in BTV pathogenesis, clinical outcome, viral dynamics, immune protection, and onwards transmission to a susceptible Results: The absence of cytotoxic CD8 Discussion: This study identifies a diverse repertoire of T-cell functions during BTV infection in sheep, particularly in inducing specific anti-viral immune responses and disease manifestation, and will support more effective vaccination strategies. |
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| MeSH term(s) | Sheep ; Animals ; Livestock ; Viremia ; Arboviruses ; CD8-Positive T-Lymphocytes ; Ruminants ; T-Lymphocyte Subsets ; Bluetongue virus ; Bluetongue/prevention & control ; Ceratopogonidae/physiology |
| Language | English |
| Publishing date | 2024-01-31 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2024.1328820 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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