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  1. Book: Melanoma

    Bastian, Boris Christoph / Fisher, David E.

    2019  

    Author's details David E. Fisher, Boris C. Bastian editors
    Language English
    Size xxii, 828 Seiten
    Publisher Springer
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT020170911
    ISBN 978-1-4614-7148-6 ; 9781461471462 ; 9781461471479 ; 1-4614-7148-6 ; 146147146X ; 1461471478
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 1293 available for loan (reading room) Lesesaal EG

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  2. Book: Advances in melanoma

    Fisher, David E.

    (Hematology oncology clincis of North America ; 23,3)

    2009  

    Author's details guest ed. David E. Fisher
    Series title Hematology oncology clincis of North America ; 23,3
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size XIV S., S. 384 - 631 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015977723
    ISBN 1-4377-0488-3 ; 978-1-4377-0488-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1077 -23,3- verfügbar in Königswinter Königswinter

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  3. Article ; Online: mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic.

    Xu, Ziyang / Fisher, David E

    Frontiers in immunology

    2023  Volume 14, Page(s) 1155728

    Abstract: The advent of mRNA vaccines represents a significant advance in the field of vaccinology. While several vaccine approaches (mRNA, DNA, recombinant protein, and viral-vectored vaccines) had been investigated at the start of the COVID-19 pandemic, mRNA ... ...

    Abstract The advent of mRNA vaccines represents a significant advance in the field of vaccinology. While several vaccine approaches (mRNA, DNA, recombinant protein, and viral-vectored vaccines) had been investigated at the start of the COVID-19 pandemic, mRNA vaccines quickly gained popularity due to superior immunogenicity at a low dose, strong safety/tolerability profiles, and the possibility of rapid vaccine mass manufacturing and deployment to rural regions. In addition to inducing protective neutralizing antibody responses, mRNA vaccines can also elicit high-magnitude cytotoxic T-cell responses comparable to natural viral infections; thereby, drawing significant interest from cancer immunotherapy experts. This mini-review will highlight key developmental milestones and lessons we have learned from mRNA vaccines during the COVID-19 pandemic, with a specific emphasis on clinical trial data gathered so far for mRNA vaccines against melanoma and other forms of cancer.
    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines ; SARS-CoV-2 ; RNA, Messenger/genetics ; Pandemics/prevention & control ; Antibodies, Neutralizing ; Antibodies, Viral ; Viral Vaccines ; Melanoma
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; Antibodies, Neutralizing ; Antibodies, Viral ; Viral Vaccines
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1155728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MAPK-Activating Gene Fusions in Congenital Nevi.

    Flesher, Jessica L / Fisher, David E

    The Journal of investigative dermatology

    2023  Volume 144, Issue 3, Page(s) 446–448

    MeSH term(s) Humans ; Skin Neoplasms/genetics ; Skin Neoplasms/congenital ; Nevus, Pigmented/genetics ; Nevus, Pigmented/congenital ; Gene Fusion
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.07.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Dual Targeting with EZH2 Inhibitor and STING Agonist to Treat Melanoma.

    Emran, Abdullah Al / Fisher, David E

    The Journal of investigative dermatology

    2022  Volume 142, Issue 4, Page(s) 1004–1006

    Abstract: The immunotherapy era has ushered in enormous promise for cancer, largely led by progress in melanoma management. However a significant fraction of melanoma patients suffers early progression or relapse due to treatment resistance. Immunologically cold ... ...

    Abstract The immunotherapy era has ushered in enormous promise for cancer, largely led by progress in melanoma management. However a significant fraction of melanoma patients suffers early progression or relapse due to treatment resistance. Immunologically cold tumors are often refractory to immunotherapies and are associated with a lack of interferon signalling and antigen presentation. In their new article, Xu et al. (2022) demonstrate that the epigenetic modifier enhancer of zeste homolog 2 (EZH2) regulates expression of the innate immune signalling factor STING and that dual targeting of EZH2 and STING induces interferon signalling, major histocompatibility complex expression and synergistically reduces tumor growth in a preclinical model. Strategies such as this stand to improve therapeutic opportunities for otherwise refractory tumor contexts.
    MeSH term(s) Enhancer of Zeste Homolog 2 Protein/metabolism ; Humans ; Immunotherapy ; Interferons ; Melanoma/pathology ; Neoplasm Recurrence, Local
    Chemical Substances Interferons (9008-11-1) ; EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43)
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.09.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Complex Interplay between Nevi and Melanoma: Risk Factors and Precursors.

    Shreberk-Hassidim, Rony / Ostrowski, Stephen M / Fisher, David E

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: One effort to combat the rising incidence of malignant melanoma is focused on early detection by the clinical and dermoscopic screening of melanocytic nevi. However, the interaction between nevi, which are congenital or acquired benign melanocytic ... ...

    Abstract One effort to combat the rising incidence of malignant melanoma is focused on early detection by the clinical and dermoscopic screening of melanocytic nevi. However, the interaction between nevi, which are congenital or acquired benign melanocytic proliferations, and melanoma is still enigmatic. On the one hand, the majority of melanomas are thought to form de novo, as only a third of primary melanomas are associated with a histologically identifiable nevus precursor. On the other hand, an increased number of melanocytic nevi is a strong risk factor for developing melanoma, including melanomas that do not derive from nevi. The formation of nevi is modulated by diverse factors, including pigmentation, genetic risk factors, and environmental sun exposure. While the molecular alterations that occur during the progression of a nevus to melanoma have been well characterized, many unanswered questions remain surrounding the process of nevus to melanoma evolution. In this review, we discuss clinical, histological, molecular, and genetic factors that influence nevus formation and progression to melanoma.
    MeSH term(s) Humans ; Melanoma/pathology ; Skin Neoplasms/pathology ; Nevus/pathology ; Nevus, Pigmented ; Risk Factors ; Nevus, Epithelioid and Spindle Cell
    Language English
    Publishing date 2023-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Epitope Spreading and the Efficacy of Immune Checkpoint Inhibition in Cancer.

    Liu, W Robert / Fisher, David E

    International journal of oncology research

    2021  Volume 4, Issue 1

    Abstract: Therapeutic antibodies that target immune checkpoints have revolutionized cancer therapy. While these checkpoints restrain T cell activation in response to antigen engagement, checkpoint inhibitors de-repress such tumor-associated T cells, and have ... ...

    Abstract Therapeutic antibodies that target immune checkpoints have revolutionized cancer therapy. While these checkpoints restrain T cell activation in response to antigen engagement, checkpoint inhibitors de-repress such tumor-associated T cells, and have generated major clinical responses in multiple tumor types. Nonetheless, the vast majority of cancers remain resistant to this therapeutic approach as currently deployed, either through intrinsic or acquired resistance mechanisms. One key question involves the identity of the tumor targets which effector T cells recognize. Tumor-specific mutant epitopes (often called neoantigens) represent a favored example, whose recognition has been demonstrated in certain contexts. While potentially helpful in identifying likely therapeutic opportunities (such as cancers harboring DNA repair defects), numerous cancers are relatively deficient in neoantigen loads. This commentary discusses the prospect that a phenomenon of "epitope spreading" may occur in certain high mutation contexts, giving rise to T cell responses against non-mutated/wild-type lineage proteins. Recent evidence is also discussed that suggests this mechanism may be exploited to purposely trigger epitope spreading and induce systemic tumor eradication in neoantigen-deficient cancers.
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Journal Article
    ISSN 2643-4563
    ISSN (online) 2643-4563
    DOI 10.23937/2643-4563/1710029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: G9a: An Emerging Epigenetic Target for Melanoma Therapy.

    Flesher, Jessica L / Fisher, David E

    Epigenomes

    2021  Volume 5, Issue 4

    Abstract: Epigenetic regulation is a crucial component of DNA maintenance and cellular identity. As our understanding of the vast array of proteins that contribute to chromatin accessibility has advanced, the role of epigenetic remodelers in disease has become ... ...

    Abstract Epigenetic regulation is a crucial component of DNA maintenance and cellular identity. As our understanding of the vast array of proteins that contribute to chromatin accessibility has advanced, the role of epigenetic remodelers in disease has become more apparent. G9a is a histone methyltransferase that contributes to immune cell differentiation and function, neuronal development, and has been implicated in diseases, including cancer. In melanoma, recurrent mutations and amplifications of G9a have led to its identification as a therapeutic target. The pathways that are regulated by G9a provide an insight into relevant biomarkers for patient stratification. Future work is aided by the breadth of literature on G9a function during normal differentiation and development, along with similarities to EZH2, another histone methyltransferase that forms a synthetic lethal relationship with members of the SWI/SNF complex in certain cancers. Here, we review the literature on G9a, its role in melanoma, and lessons from EZH2 inhibitor studies.
    Language English
    Publishing date 2021-10-12
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2075-4655
    ISSN (online) 2075-4655
    DOI 10.3390/epigenomes5040023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Melanocyte Lineage Factor miR-211 Promotes BRAF

    Ostrowski, Stephen M / Fisher, David E

    The Journal of investigative dermatology

    2021  Volume 141, Issue 2, Page(s) 250–252

    Abstract: Resistance to targeted therapy and immunotherapy remains a major obstacle in improving care for patients with advanced melanoma. MicroRNAs play important roles in regulating gene networks involved in disease progression and resistance to therapy in ... ...

    Abstract Resistance to targeted therapy and immunotherapy remains a major obstacle in improving care for patients with advanced melanoma. MicroRNAs play important roles in regulating gene networks involved in disease progression and resistance to therapy in cancers such as melanoma. MicroRNA miR-211 contributes to melanocyte and melanoma biology and has been implicated in targeted therapy resistance. Lee et al. (2020) report a novel mechanism by which miR-211 promotes resistance to BRAF
    MeSH term(s) Drug Resistance, Neoplasm ; Humans ; MAP Kinase Signaling System/physiology ; Melanoma/drug therapy ; MicroRNAs/physiology ; Mitogen-Activated Protein Kinase 7/physiology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; TRPM Cation Channels/physiology
    Chemical Substances MIRN211 microRNA, human ; MicroRNAs ; Protein Kinase Inhibitors ; TRPM Cation Channels ; TRPM1 protein, human ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase 7 (EC 2.7.11.24)
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2020.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: The role of MiT/TFE family members in autophagy regulation.

    Theodosakis, Nicholas / Pagan, Angel D / Fisher, David E

    Current topics in biochemical research

    2022  Volume 22, Page(s) 151–159

    Abstract: The MiT/TFE family of proteins are important regulators of a number of metabolic processes. One of their most important roles is activating the autophagy pathway in the setting of nutrient deprivation or buildup of toxic metabolites. Their proper and ... ...

    Abstract The MiT/TFE family of proteins are important regulators of a number of metabolic processes. One of their most important roles is activating the autophagy pathway in the setting of nutrient deprivation or buildup of toxic metabolites. Their proper and improper functioning in this role has been linked to several types of disease, including cancer and multiple forms of neurodegeneration. In this review we will briefly outline what is known about individual family members' roles in regulating autophagy across a variety of contexts.
    Language English
    Publishing date 2022-05-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2055368-7
    ISSN 0972-4583
    ISSN 0972-4583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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