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  1. Article: Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation.

    Feng, Xiaogang / Andersson, Tilde / Gschwend, Julia / Flüchter, Pascal / Berest, Ivan / Muff, Julian L / Carchidi, Daniele / Lechner, Antonie / de Tenorio, Jeshua C / Brander, Nina / Boehm, Ulrich / Klose, Christoph S N / Artis, David / Leinders-Zufall, Trese / Zufall, Frank / Schneider, Christoph

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The tuft cell-ILC2 circuit orchestrates rapid type 2 responses upon detecting microbe-derived succinate and luminal helminths. Our findings delineate key mechanistic steps, involving IP3R2 engagement and ... ...

    Abstract The tuft cell-ILC2 circuit orchestrates rapid type 2 responses upon detecting microbe-derived succinate and luminal helminths. Our findings delineate key mechanistic steps, involving IP3R2 engagement and Ca
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.04.583299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Voluntary exercise does not always suppress lung cancer progression.

    Leimbacher, Aurelia C / Villiger, Philipp / Desboeufs, Nina / Aboouf, Mostafa A / Nanni, Monica / Armbruster, Julia / Ademi, Hyrije / Flüchter, Pascal / Ruetten, Maja / Gantenbein, Felix / Haider, Thomas J / Gassmann, Max / Thiersch, Markus

    iScience

    2023  Volume 26, Issue 8, Page(s) 107298

    Abstract: Physical exercise can lower lung cancer incidence. However, its effect on lung cancer progression is less understood. Studies on exercising mice have shown decreased ectopic lung cancer growth through the secretion of interleukin-6 from muscles and the ... ...

    Abstract Physical exercise can lower lung cancer incidence. However, its effect on lung cancer progression is less understood. Studies on exercising mice have shown decreased ectopic lung cancer growth through the secretion of interleukin-6 from muscles and the recruitment of natural killer (NK) cells to tumors. We asked if exercise suppresses lung cancer in an orthotopic model also. Single-housed C57Bl/6 male mice in cages with running wheels were tail vein-injected with LLC1.1 lung cancer cells, and lung tumor nodules were analyzed. Exercise did not affect lung cancer. Therefore, we also tested the effect of exercise on a subcutaneous LLC1 tumor and a tail vein-injected B16F10 melanoma model. Except for one case of excessive exercise, tumor progression was not influenced. Moderately exercising mice did not increase IL-6 or recruit NK cells to the tumor. Our data suggest that the exercise dose may dictate how efficiently the immune system is stimulated and controls tumor progression.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling.

    Chiaranunt, Pailin / Burrows, Kyle / Ngai, Louis / Tai, Siu Ling / Cao, Eric Y / Liang, Helen / Hamidzada, Homaira / Wong, Anthony / Gschwend, Julia / Flüchter, Pascal / Kuypers, Meggie / Despot, Tijana / Momen, Abdul / Lim, Sung Min / Mallevaey, Thierry / Schneider, Christoph / Conway, Tyrrell / Imamura, Hiromi / Epelman, Slava /
    Mortha, Arthur

    Science immunology

    2023  Volume 8, Issue 86, Page(s) eabq4573

    Abstract: Maintaining macrophage (MΦ) heterogeneity is critical to ensure intestinal tissue homeostasis and host defense. The gut microbiota and host factors are thought to synergistically guide intestinal MΦ development, although the exact nature, regulation, and ...

    Abstract Maintaining macrophage (MΦ) heterogeneity is critical to ensure intestinal tissue homeostasis and host defense. The gut microbiota and host factors are thought to synergistically guide intestinal MΦ development, although the exact nature, regulation, and location of such collaboration remain unclear. Here, we report that microbial biochemical energy metabolism promotes colony-stimulating factor 2 (CSF2) production by group 3 innate lymphoid cells (ILC3s) within solitary isolated lymphoid tissues (SILTs) in a cell-extrinsic, NLRP3/P2X7R-dependent fashion in the steady state. Tissue-infiltrating monocytes accumulating around SILTs followed a spatially constrained, distinct developmental trajectory into SILT-associated MΦs (SAMs). CSF2 regulated the mitochondrial membrane potential and reactive oxygen species production of SAMs and contributed to the antimicrobial defense against enteric bacterial infections. Collectively, these findings identify SILTs and CSF2-producing ILC3s as a microanatomic niche for intestinal MΦ development and functional programming fueled by the integration of commensal microbial energy metabolism.
    MeSH term(s) Immunity, Innate ; Lymphocytes/metabolism ; Intestines ; Lymphoid Tissue ; Macrophages
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abq4573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control.

    Ruiz-Serrano, Amalia / Monné Rodríguez, Josep M / Günter, Julia / Sherman, Samantha P M / Jucht, Agnieszka E / Fluechter, Pascal / Volkova, Yulia L / Pfundstein, Svende / Pellegrini, Giovanni / Wagner, Carsten A / Schneider, Christoph / Wenger, Roland H / Scholz, Carsten C

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2021  Volume 35, Issue 12, Page(s) e22039

    Abstract: OTUB1 is one of the most highly expressed deubiquitinases, counter-regulating the two most abundant ubiquitin chain types. OTUB1 expression is linked to the development and progression of lung cancer and idiopathic pulmonary fibrosis in humans. However, ... ...

    Abstract OTUB1 is one of the most highly expressed deubiquitinases, counter-regulating the two most abundant ubiquitin chain types. OTUB1 expression is linked to the development and progression of lung cancer and idiopathic pulmonary fibrosis in humans. However, the physiological function of OTUB1 is unknown. Here, we show that constitutive whole-body Otub1 deletion in mice leads to perinatal lethality by asphyxiation. Analysis of (single-cell) RNA sequencing and proteome data demonstrated that OTUB1 is expressed in all lung cell types with a particularly high expression during late-stage lung development (E16.5, E18.5). At E18.5, the lungs of animals with Otub1 deletion presented with increased cell proliferation that decreased saccular air space and prevented inhalation. Flow cytometry-based analysis of E18.5 lung tissue revealed that Otub1 deletion increased proliferation of major lung parenchymal and mesenchymal/other non-hematopoietic cell types. Adult mice with conditional whole-body Otub1 deletion (wbOtub1
    MeSH term(s) Animals ; Cell Proliferation ; Cysteine Endopeptidases/physiology ; Female ; Homeostasis ; Hyperventilation/etiology ; Hyperventilation/pathology ; Lung Diseases/etiology ; Lung Diseases/metabolism ; Lung Diseases/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/pathology ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances mTOR protein, mouse (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Cysteine Endopeptidases (EC 3.4.22.-) ; Otub1 protein, mouse (EC 3.4.22.-)
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202100346R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 296: Show issues

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  5. Article: Plasma citrulline correlates with basolateral amino acid transporter LAT4 expression in human small intestine

    Maric, Stefano / Flüchter, Pascal / Guglielmetti, Laura Chiara / Staerkle, Ralph Fabian / Sasse, Tom / Restin, Tanja / Schneider, Christoph / Holland-Cunz, Stefan Gerhard / Crenn, Pascal / Vuille-dit-Bille, Raphael Nicolas

    Clinical nutrition. 2020 Oct. 01,

    2020  

    Abstract: Plasma citrulline, a non-protein amino acid, is a biochemical marker of small intestine enterocyte mass in humans. Indeed, citrulline is highly correlated with residual bowel length in patients with short bowel syndrome. It is known to be synthesised in ... ...

    Abstract Plasma citrulline, a non-protein amino acid, is a biochemical marker of small intestine enterocyte mass in humans. Indeed, citrulline is highly correlated with residual bowel length in patients with short bowel syndrome. It is known to be synthesised in epithelial cells of the small intestine from other amino acids (precursors). Citrulline is then released into systemic circulation and interconverted into arginine in kidneys. If plasma citrulline concentration depends on abundance of intestinal amino acid transporters is not known. The aim of the present study was to explore whether plasma citrulline concentration correlates with the expression of intestinal amino acid transporters. Furthermore, we assessed if arginine in urine correlates with plasma citrulline.Duodenal samples, blood plasma and urine were collected from 43 subjects undergoing routine gastroduodenoscopy. mRNA expression of seven basolateral membrane amino acid transporters/transporter subunits were assessed by real-time PCR. Plasma and urine amino acid concentrations of citrulline, its precursors and other amino acids were analysed using High Performance Liquid Chromatography measurements. Amino acid transporter mRNA expression was correlated with blood plasma and urine levels of citrulline and its precursors using Spearman's rank correlation. Likewise, urine arginine was correlated with plasma citrulline.Plasma citrulline correlated with the mRNA expression of basolateral amino acid transporter LAT4 (Spearman's r = 0.467, p = 0.028) in small intestine. None of the other basolateral membrane transporters/transporter subunits assessed correlated with plasma citrulline. Plasma citrulline correlated with urinary arginine, (Spearman's r = 0.419, p = 0.017), but not with urinary citrulline or other proteinogenic amino acids in the urine.In this study, we showed for the first time that small intestinal basolateral LAT4 expression correlates with plasma citrulline concentration. This finding indicates that LAT4 has an important function in mediating citrulline efflux from enterocytes. Furthermore, urine arginine correlated with plasma citrulline, indicating arginine in the urine as possible additional marker for small intestine enterocyte mass. Finally, basolateral LAT4 expression along the human small intestine was shown for the first time.
    Keywords amino acid composition ; amino acid transporters ; arginine ; blood plasma ; citrulline ; clinical nutrition ; correlation ; digestive system diseases ; enterocytes ; gene expression ; high performance liquid chromatography ; humans ; kidneys ; length ; mass ; patients ; quantitative polymerase chain reaction ; sampling ; small intestine ; urine
    Language English
    Dates of publication 2020-1001
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light ; Pre-press version
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2020.10.003
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Plasma citrulline correlates with basolateral amino acid transporter LAT4 expression in human small intestine.

    Maric, Stefano / Flüchter, Pascal / Guglielmetti, Laura Chiara / Staerkle, Ralph Fabian / Sasse, Tom / Restin, Tanja / Schneider, Christoph / Holland-Cunz, Stefan Gerhard / Crenn, Pascal / Vuille-Dit-Bille, Raphael Nicolas

    Clinical nutrition (Edinburgh, Scotland)

    2020  Volume 40, Issue 4, Page(s) 2244–2251

    Abstract: Background & aims: Plasma citrulline, a non-protein amino acid, is a biochemical marker of small intestine enterocyte mass in humans. Indeed, citrulline is highly correlated with residual bowel length in patients with short bowel syndrome. It is known ... ...

    Abstract Background & aims: Plasma citrulline, a non-protein amino acid, is a biochemical marker of small intestine enterocyte mass in humans. Indeed, citrulline is highly correlated with residual bowel length in patients with short bowel syndrome. It is known to be synthesised in epithelial cells of the small intestine from other amino acids (precursors). Citrulline is then released into systemic circulation and interconverted into arginine in kidneys. If plasma citrulline concentration depends on abundance of intestinal amino acid transporters is not known. The aim of the present study was to explore whether plasma citrulline concentration correlates with the expression of intestinal amino acid transporters. Furthermore, we assessed if arginine in urine correlates with plasma citrulline.
    Methods: Duodenal samples, blood plasma and urine were collected from 43 subjects undergoing routine gastroduodenoscopy. mRNA expression of seven basolateral membrane amino acid transporters/transporter subunits were assessed by real-time PCR. Plasma and urine amino acid concentrations of citrulline, its precursors and other amino acids were analysed using High Performance Liquid Chromatography measurements. Amino acid transporter mRNA expression was correlated with blood plasma and urine levels of citrulline and its precursors using Spearman's rank correlation. Likewise, urine arginine was correlated with plasma citrulline.
    Results: Plasma citrulline correlated with the mRNA expression of basolateral amino acid transporter LAT4 (Spearman's r = 0.467, p = 0.028) in small intestine. None of the other basolateral membrane transporters/transporter subunits assessed correlated with plasma citrulline. Plasma citrulline correlated with urinary arginine, (Spearman's r = 0.419, p = 0.017), but not with urinary citrulline or other proteinogenic amino acids in the urine.
    Conclusions: In this study, we showed for the first time that small intestinal basolateral LAT4 expression correlates with plasma citrulline concentration. This finding indicates that LAT4 has an important function in mediating citrulline efflux from enterocytes. Furthermore, urine arginine correlated with plasma citrulline, indicating arginine in the urine as possible additional marker for small intestine enterocyte mass. Finally, basolateral LAT4 expression along the human small intestine was shown for the first time.
    MeSH term(s) Adult ; Aged ; Arginine/urine ; Body Mass Index ; Citrulline/blood ; Enterocytes/metabolism ; Female ; Gene Expression ; Humans ; Intestine, Small/metabolism ; Male ; Middle Aged ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Young Adult
    Chemical Substances RNA, Messenger ; Citrulline (29VT07BGDA) ; Arginine (94ZLA3W45F)
    Keywords covid19
    Language English
    Publishing date 2020-10-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2020.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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