Article ; Online: Significance of the Percentage of Gleason Pattern 4 at Prostate Biopsy in Predicting Adverse Pathology on Radical Prostatectomy: Application in Active Surveillance.
American journal of clinical pathology
2023 Volume 160, Issue 1, Page(s) 35–40
Abstract: Objectives: To determine the prognostic significance of the maximum allowable percentage of Gleason pattern 4 (GP4) at prostate biopsy compared with adverse pathology observed at radical prostatectomy (RP) to expand active surveillance eligibility among ...
Abstract | Objectives: To determine the prognostic significance of the maximum allowable percentage of Gleason pattern 4 (GP4) at prostate biopsy compared with adverse pathology observed at radical prostatectomy (RP) to expand active surveillance eligibility among a cohort with intermediate risk of prostate cancer. Methods: A retrospective study of patients with grade group (GG) 1 or 2 prostate cancer on prostate biopsy with subsequent RP was performed at our institution. A Fisher exact test was used to understand the relationship among GP4 subgroups (0%, ≤5%, 6%-10%, and 11%-49%) assigned at biopsy and adverse pathologic findings at RP. Additional analyses comparing the GP4 ≤5% cohort's prebiopsy prostate-specific antigen (PSA) level and GP4 length with adverse pathology at RP were also performed. Results: No statistically significant difference in adverse pathology at RP was observed between the active surveillance-eligible control (GP4 0%) and the GP4 ≤5% subgroup. In total, 68.9% of the GP4 ≤5% cohort showed favorable pathologic outcomes. A separate analysis of the GP4 ≤5% subgroup revealed that neither prebiopsy serum PSA levels nor GP4 length showed statistical correlation with adverse pathology at RP. Conclusions: Active surveillance may be a reasonable option for management of patients in the GP4 ≤5% group until long-term follow-up data become available. |
---|---|
MeSH term(s) | Male ; Humans ; Prostate/surgery ; Prostate/pathology ; Prostate-Specific Antigen ; Retrospective Studies ; Watchful Waiting ; Biopsy ; Prostatectomy ; Prostatic Neoplasms/pathology ; Neoplasm Grading |
Chemical Substances | Prostate-Specific Antigen (EC 3.4.21.77) ; GP 4 (81746-15-8) |
Language | English |
Publishing date | 2023-03-10 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2944-0 |
ISSN | 1943-7722 ; 0002-9173 |
ISSN (online) | 1943-7722 |
ISSN | 0002-9173 |
DOI | 10.1093/ajcp/aqad005 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Ud II Zs.91: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.