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  1. AU="Flanagan, T L"
  2. AU=Davila Eduardo
  3. AU="Miroli, Augusto"
  4. AU="Stahl, B"
  5. AU="Dehari, Hironari"
  6. AU="Pinheiro, Silviane Bezerra"
  7. AU="Jamal Al Deen Alkoteesh"
  8. AU="Chen, Dingqiang"
  9. AU="Jeremy C. Ganz"
  10. AU="Lee, Ta-Sheng"
  11. AU="Shi, Jin-Ming"
  12. AU=Kristoffersen K B
  13. AU=Du Chao
  14. AU="Anton I. Skaro"

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  1. Artikel: Determination of N',N'-anhydrobis(beta-hydroxyethyl)-biguanide hydrochloride in urine.

    FLANAGAN, T L / HORIKAWA, E K / VAN LOON, E J

    Analytical biochemistry

    2003  Band 2, Seite(n) 231–236

    Mesh-Begriff(e) Amidines/urine ; Biguanides ; Body Fluids ; Humans ; Salts
    Chemische Substanzen Amidines ; Biguanides ; Salts
    Sprache Englisch
    Erscheinungsdatum 2003-04-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/s0003-2697(61)80005-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Khellin III. Polarographic determination of Khellin in Serum.

    BURKE, M M / FLANAGAN, T L / YOUNG, R L / BAILEY, S D / HEMING, A E

    Journal of the American Pharmaceutical Association. American Pharmaceutical Association

    2004  Band 41, Heft 7, Seite(n) 379–382

    Mesh-Begriff(e) Humans ; Khellin/blood ; Polarography
    Chemische Substanzen Khellin (5G117T0TJZ)
    Sprache Englisch
    Erscheinungsdatum 2004-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    DOI 10.1002/jps.3030410713
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Possible utilization of polyelectrolytes in enhancing drug absorption.

    HIGUCHI, T / KURAMOTO, R / KENNON, L / FLANAGAN, T L / POLK, A

    Journal of the American Pharmaceutical Association. American Pharmaceutical Association

    2003  Band 43, Heft 11, Seite(n) 646–651

    Mesh-Begriff(e) Electrolytes ; Humans ; Pharmaceutical Preparations
    Chemische Substanzen Electrolytes ; Pharmaceutical Preparations
    Sprache Englisch
    Erscheinungsdatum 2003-08-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    DOI 10.1002/jps.3030431104
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Determination of fluoride ion in femurs of rats receiving organic fluoride.

    HORIKAWA, E K / STEELMAN, R / FLANAGAN, T L / VAN LOON, E J

    Journal of medicinal and pharmaceutical chemistry

    2003  Band 2, Seite(n) 541–551

    Mesh-Begriff(e) Animals ; Femur/chemistry ; Fluorides/chemistry ; Fluorine ; Phosphates ; Rats
    Chemische Substanzen Phosphates ; fluorophosphate (15181-43-8) ; Fluorine (284SYP0193) ; Fluorides (Q80VPU408O)
    Sprache Englisch
    Erscheinungsdatum 2003-10-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 218132-0
    ISSN 0095-9065
    ISSN 0095-9065
    DOI 10.1021/jm50012a005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Spectrophotometric method for the determination of chlorpromazine and chlorpromazine sulphoxide in biological fluids.

    FLANAGAN, T L / LIN, T H / NOVICK, W J / RONDISH, I M / BOCHER, C A / VAN LOON, E J

    Journal of medicinal and pharmaceutical chemistry

    2003  Band 1, Seite(n) 263–273

    Mesh-Begriff(e) Body Fluids ; Chlorpromazine/chemistry ; Feces ; Spectrophotometry
    Chemische Substanzen opromazine (016U10PN9N) ; Chlorpromazine (U42B7VYA4P)
    Sprache Englisch
    Erscheinungsdatum 2003-10-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 218132-0
    ISSN 0095-9065
    ISSN 0095-9065
    DOI 10.1021/jm50004a005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: A safe approach to the treatment of iliac artery aneurysms. Aortobifemoral bypass grafting with exclusion of the aneurysm.

    Schroeder, R A / Flanagan, T L / Kron, I L / Tribble, C G

    The American surgeon

    1991  Band 57, Heft 10, Seite(n) 624–626

    Abstract: Aneurysms of the iliac arterial system are often difficult to approach surgically. Aortobifemoral (ABF) bypass grafting with exclusion of the aneurysms can be used as an alternative to the usually recommended approach of endoaneurysmorrhaphy. Fourteen ... ...

    Abstract Aneurysms of the iliac arterial system are often difficult to approach surgically. Aortobifemoral (ABF) bypass grafting with exclusion of the aneurysms can be used as an alternative to the usually recommended approach of endoaneurysmorrhaphy. Fourteen patients with iliac artery aneurysms treated by ABF are compared to 16 patients treated by direct repair to compare the incidence of complications related to decreased pelvic blood flow or to the presence of the excluded iliac artery aneurysm. There were no differences between the two groups. Therefore, it is concluded that ABF is a reasonable alternative in the treatment of iliac artery aneurysms.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Anastomosis, Surgical ; Aneurysm/mortality ; Aneurysm/surgery ; Female ; Humans ; Iliac Artery ; Male ; Postoperative Complications ; Regional Blood Flow ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 1991-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Mechanism of remote myocardial ischaemia after coronary occlusion in open chest dogs.

    Gascho, J A / Flanagan, T L / Jennings, C F / Beller, G A

    Cardiovascular research

    1988  Band 22, Heft 6, Seite(n) 398–406

    Abstract: To determine whether or not the fall in coronary perfusion pressure after coronary occlusion is the cause of remote myocardial ischaemia, regional myocardial blood flow was measured using radiolabelled microspheres before and after left anterior ... ...

    Abstract To determine whether or not the fall in coronary perfusion pressure after coronary occlusion is the cause of remote myocardial ischaemia, regional myocardial blood flow was measured using radiolabelled microspheres before and after left anterior descending (LAD) occlusion in the presence of a left circumflex artery stenosis in 22 anaesthetised dogs. Aortic pressure was maintained constant at the time of left anterior descending artery occlusion in 13 dogs (group 1) and proximal left circumflex artery pressure was held constant by a servocontrolled pump in nine dogs with a carotid artery-left circumflex artery shunt (group 2). Despite the maintenance of constant mean aortic pressure in group 1, remote posterior bed mean(SEM) endocardial flow fell from 0.69(0.05) to 0.43(0.07) ml.min-1.g-1 (p less than 0.05). In the dogs in which left atrial pressure rose to less than or equal to 9 mmHg after left anterior descending artery occlusion, remote bed endocardial flow did not fall significantly (0.66(0.07) to 0.56(0.11) ml.min-1.g-1; NS). In contrast, remote bed endocardial flow fell from 0.73(0.07) to 0.28(0.06) ml.min-1.g-1 (p less than 0.0001) after left anterior descending artery occlusion in the dogs in which left atrial pressure rose to greater than 9 mmHg. The fall in remote bed endocardial flow was prevented in group 2 dogs by maintaining proximal left circumflex artery pressure constant (0.95(0.08) to 0.86(0.09) ml.min-1.g-1; NS). An important mechanism for the development of remote myocardial ischaemia appears to be the fall in proximal coronary perfusion pressure at the time of coronary occlusion.
    Mesh-Begriff(e) Animals ; Blood Pressure ; Constriction ; Coronary Circulation ; Coronary Disease/etiology ; Coronary Disease/physiopathology ; Coronary Vessels/physiopathology ; Disease Models, Animal ; Dogs ; Heart Rate
    Sprache Englisch
    Erscheinungsdatum 1988-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/22.6.398
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Activation of the renin angiotensin system in short aortic cross-clamp times.

    George, J E / Joob, A W / Flanagan, T L / Kron, I L

    Current surgery

    1988  Band 45, Heft 1, Seite(n) 7–9

    Mesh-Begriff(e) Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Aorta, Thoracic/surgery ; Constriction ; Dogs ; Enalapril/analogs & derivatives ; Enalapril/pharmacology ; Enalaprilat ; Renal Circulation/drug effects ; Renin-Angiotensin System/drug effects ; Time Factors
    Chemische Substanzen Angiotensin-Converting Enzyme Inhibitors ; Enalapril (69PN84IO1A) ; Enalaprilat (GV0O7ES0R3)
    Sprache Englisch
    Erscheinungsdatum 1988-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 428044-1
    ISSN 0149-7944
    ISSN 0149-7944
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Myocardial thallium-201 kinetics and regional flow alterations with 3 hours of coronary occlusion and either rapid reperfusion through a totally patent vessel or slow reperfusion through a critical stenosis.

    Granato, J E / Watson, D D / Flanagan, T L / Beller, G A

    Journal of the American College of Cardiology

    1987  Band 9, Heft 1, Seite(n) 109–118

    Abstract: Myocardial thallium-201 kinetics and regional blood flow alterations were examined in a canine model using 3 hours of coronary occlusion and different methods of reperfusion. Group I comprised 10 dogs undergoing a 3 hour left anterior descending artery ... ...

    Abstract Myocardial thallium-201 kinetics and regional blood flow alterations were examined in a canine model using 3 hours of coronary occlusion and different methods of reperfusion. Group I comprised 10 dogs undergoing a 3 hour left anterior descending artery occlusion and no reperfusion. Group II comprised seven dogs undergoing 3 hours of left anterior descending artery occlusion and rapid reperfusion through a totally patent vessel. Group III comprised 10 dogs undergoing 3 hours of left anterior descending artery occlusion and slow reperfusion through a residual stenosis. All dogs received 1.5 mCi of thallium-201 after 40 minutes of coronary occlusion. During occlusion and 2 hours of reperfusion, serial hemodynamic, blood flow and myocardial thallium-201 activity measurements were made. The relative thallium-201 gradient (normal zone minus ischemic zone activity when initial normal activity is expressed as 100%) during left anterior descending coronary occlusion was similar in all groups. Group I, 87 +/- 3%; Group II, 78 +/- 6%; Group III, 83 +/- 6% (p = NS). After 2 hours of either method of reperfusion, the final relative gradient had decreased to a similar level (Group II, 51 +/- 9%; Group III, 42 +/- 6%). These values were not significantly different from the final relative thallium-201 gradient seen in dogs undergoing a sustained 3 hour occlusion (Group I, 55 +/- 5%). After 2 hours of reperfusion, both methods of reflow were associated with similar degrees of "no reflow." Transmural flows in the central ischemic zone were 89 +/- 10% of normal in Group II and 71 +/- 6% of normal in Group III after reperfusion, with both flows substantially higher than the relative thallium-201 activities in these dogs. Infarct size (percent of left ventricle) determined with triphenyltetrazolium chloride was similar in all groups (Group I, 24 +/- 4%; Group II, 29 +/- 4%; Group III, 25 +/- 4%). Thus, in this experimental canine model, 3 hours of coronary occlusion followed by either rapid reperfusion through a totally patent vessel or slow reperfusion through a critical stenosis resulted in little delayed thallium-201 redistribution or myocardial salvage as assessed histologically, despite significant recovery of regional flow.
    Mesh-Begriff(e) Animals ; Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/therapy ; Coronary Circulation ; Coronary Disease/diagnostic imaging ; Coronary Disease/therapy ; Dogs ; Heart/diagnostic imaging ; Kinetics ; Radioisotopes ; Radionuclide Imaging ; Thallium ; Time Factors ; Vascular Patency
    Chemische Substanzen Radioisotopes ; Thallium (AD84R52XLF)
    Sprache Englisch
    Erscheinungsdatum 1987-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/s0735-1097(87)80089-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Effects of in vivo cyclosporine administration on endothelium-dependent responses in isolated vascular rings.

    Chan, B B / Kern, J A / Flanagan, T L / Kron, I L / Tribble, C G

    Circulation

    1992  Band 86, Heft 5 Suppl, Seite(n) II295–9

    Abstract: Background: Although in vitro studies suggest that cyclosporine (CSA) reduces endothelium-dependent relaxation (EDR), controversy still remains regarding the effects of in vivo CSA treatment. The lack of correlation between CSA dosages and therapeutic ... ...

    Abstract Background: Although in vitro studies suggest that cyclosporine (CSA) reduces endothelium-dependent relaxation (EDR), controversy still remains regarding the effects of in vivo CSA treatment. The lack of correlation between CSA dosages and therapeutic efficacy has led to an increased emphasis on the monitoring of CSA blood levels in clinical immunosuppression. We therefore studied the effects of in vivo administration to rats of a therapeutic level of CSA on endothelium-dependent vascular reactivity using isolated vascular rings obtained from these animals.
    Methods and results: Thoracic aorta vascular rings from adult Sprague-Dawley rats treated with subcutaneous injections of CSA (5 mg/kg/day) for 7 and 21 days were suspended in Krebs buffer containing indomethacin and tested for EDR to methacholine (1 x 10(-7) to 5 x 10(-5) M) and for endothelium-independent relaxation (EIR) to nitroprusside (5 x 10(-6) M). Mean whole blood CSA trough levels were 978 +/- 287 and 2,865 +/- 379 ng/ml for the 7- and 21-day groups, respectively. No differences were noted in both EDR and EIR between untreated control rats and the treated groups. Maximal EDR (mean +/- SEM) was 83 +/- 3%, 79 +/- 2%, and 81 +/- 3% for control rats and 7- and 21-day treatment groups, respectively. Relative developed tension (grams) to 5 x 10(-6) M phenylephrine was significantly (p < 0.05) increased in the CSA-treated groups (1.03 +/- 0.01 and 1.08 +/- 0.01 g at 7 and 21 days, respectively, versus 0.73 +/- 0.01 g (p = NS) for untreated controls). Minimal endothelial disruption was evident on scanning electron microscopy in the CSA-treated animals.
    Conclusions: We conclude that CSA-induced vascular dysfunction may be in part a result of an increased sensitivity to direct vasoconstriction rather than of an attenuation of endothelium-dependent relaxation.
    Mesh-Begriff(e) Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/physiology ; Cyclosporine/blood ; Cyclosporine/pharmacology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiology ; Microscopy, Electron, Scanning ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/physiology ; Rats ; Rats, Sprague-Dawley ; Vasoconstriction/drug effects
    Chemische Substanzen Cyclosporine (83HN0GTJ6D)
    Sprache Englisch
    Erscheinungsdatum 1992-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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