Article ; Online: Chronic, episodic nicotine exposure alters GABAergic synaptic transmission to hypoglossal motor neurons and genioglossus muscle function at a critical developmental age.
2022 Volume 128, Issue 6, Page(s) 1483–1500
Abstract: Regulation of GABAergic signaling through nicotinic acetylcholine receptor (nAChR) activation is critical for neuronal development. Here, we test the hypothesis that chronic episodic developmental nicotine exposure (eDNE) disrupts GABAergic signaling, ... ...
| Abstract | Regulation of GABAergic signaling through nicotinic acetylcholine receptor (nAChR) activation is critical for neuronal development. Here, we test the hypothesis that chronic episodic developmental nicotine exposure (eDNE) disrupts GABAergic signaling, leading to dysfunction of hypoglossal motor neurons (XIIMNs), which innervate the tongue muscles. We studied control and eDNE pups at two developmentally vulnerable age ranges: postnatal days (P)1-5 and P10-12. The amplitude and frequency of spontaneous and miniature inhibitory postsynaptic currents (sIPSCs, mIPSCs) at baseline were not altered by eDNE at either age. In contrast, eDNE increased GABA |
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| MeSH term(s) | Humans ; Rats ; Animals ; Infant, Newborn ; Nicotine/pharmacology ; Muscimol/pharmacology ; Animals, Newborn ; Rats, Sprague-Dawley ; Synaptic Transmission/physiology ; Motor Neurons/physiology ; Tongue ; Muscles | |||||
| Chemical Substances | Nicotine (6M3C89ZY6R) ; Muscimol (2763-96-4) | |||||
| Language | English | |||||
| Publishing date | 2022-11-09 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural | |||||
| ZDB-ID | 80161-6 | |||||
| ISSN | 1522-1598 ; 0022-3077 | |||||
| ISSN (online) | 1522-1598 | |||||
| ISSN | 0022-3077 | |||||
| DOI | 10.1152/jn.00397.2022 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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