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  1. Book ; Online ; E-Book: Laboratory animal anaesthesia

    Flecknell, Paul A.

    2016  

    Author's details Paul Flecknell
    Keywords Anesthesia / veterinary ; Animals, Laboratory
    Subject code 636.089796
    Language English
    Size 1 Online-Ressource (xxvii, 322 Seiten), Illustrationen
    Edition Fourth edition
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Note Previous edition: 2009
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019179719
    ISBN 978-0-12-800578-1 ; 9780128000366 ; 0-12-800578-5 ; 0128000368
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Laboratory animal anaesthesia

    Flecknell, Paul A.

    2009  

    Author's details Paul Flecknell
    Keywords Versuchstiere ; Anästhesie
    Subject Laboratoriumstiere ; Labortiere
    Language English
    Size XXIV, 300 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016006900
    ISBN 978-0-12-369376-1 ; 0-12-369376-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 3460 order for loan Magazin

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  3. Book: Experimental and surgical technique in the rat

    Waynforth, H. Bryan / Flecknell, Paul A.

    2004  

    Author's details H. B. Waynforth ; P. A. Flecknell
    Keywords Surgical Procedures, Operative ; Rats ; Chirurgie ; Ratte
    Subject Laborratte ; Surgery
    Language English
    Size XVII, 382 S. : Ill., graph. Darst.
    Edition 2. ed., repr.
    Publisher Elsevier, Academic Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014714426
    ISBN 0-12-738851-6 ; 978-0-12-738851-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 2219 order for loan Magazin

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  4. Book: Laboratory animal anaesthesia

    Flecknell, Paul A.

    an introduction for research workers and technicians

    1987  

    Author's details P. A. Flecknell
    Keywords Anesthesia ; Animals, Laboratory ; Versuchstiere ; Anästhesie
    Subject Laboratoriumstiere ; Labortiere
    Language English
    Size XIV, 156 S. : graph. Darst.
    Publisher Acad. Pr
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003244715
    ISBN 0-12-260360-5 ; 978-0-12-260360-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 A 621 order for loan Magazin

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  5. Article ; Online: A cervical mass in a laboratory rhesus macaque (Macaca mulatta): Suspicion of air sacculitis.

    Bertrand, Henri G M J / Flecknell, Paul A

    Journal of medical primatology

    2020  Volume 50, Issue 1, Page(s) 79–81

    Abstract: A 13-year-old rhesus macaque presented a cervical swelling associated with sudden deterioration of its condition. This mass was surgically removed, and its histopathological examination revealed a stratified squamous epithelium. This appearance has been ... ...

    Abstract A 13-year-old rhesus macaque presented a cervical swelling associated with sudden deterioration of its condition. This mass was surgically removed, and its histopathological examination revealed a stratified squamous epithelium. This appearance has been reported in some case of air sacculitis in others non-human primate species.
    MeSH term(s) Animals ; Macaca mulatta ; Male ; Monkey Diseases/diagnostic imaging ; Monkey Diseases/pathology ; Monkey Diseases/surgery ; Pneumonia/diagnostic imaging ; Pneumonia/pathology ; Pneumonia/surgery ; Pneumonia/veterinary ; Treatment Outcome
    Language English
    Publishing date 2020-11-10
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 121206-0
    ISSN 1600-0684 ; 0047-2565
    ISSN (online) 1600-0684
    ISSN 0047-2565
    DOI 10.1111/jmp.12502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 819: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Negative mood affects the expression of negative but not positive emotions in mice.

    Clarkson, Jasmine M / Leach, Matthew C / Flecknell, Paul A / Rowe, Candy

    Proceedings. Biological sciences

    2020  Volume 287, Issue 1933, Page(s) 20201636

    Abstract: Whether and to what extent animals experience emotions is crucial for understanding their decisions and behaviour, and underpins a range of scientific fields, including animal behaviour, neuroscience, evolutionary biology and animal welfare science. ... ...

    Abstract Whether and to what extent animals experience emotions is crucial for understanding their decisions and behaviour, and underpins a range of scientific fields, including animal behaviour, neuroscience, evolutionary biology and animal welfare science. However, research has predominantly focused on alleviating negative emotions in animals, with the expression of positive emotions left largely unexplored. Therefore, little is known about positive emotions in animals and how their expression is mediated. We used tail handling to induce a negative mood in laboratory mice and found that while being more anxious and depressed increased their expression of a discrete negative emotion (disappointment), meaning that they were less resilient to negative events, their capacity to express a discrete positive emotion (elation) was unaffected relative to control mice. Therefore, we show not only that mice have discrete positive emotions, but that they do so regardless of their current mood state. Our findings are the first to suggest that the expression of discrete positive and negative emotions in animals is not equally affected by long-term mood state. Our results also demonstrate that repeated negative events can have a cumulative effect to reduce resilience in laboratory animals, which has significant implications for animal welfare.
    MeSH term(s) Affect ; Animals ; Anxiety ; Behavior, Animal ; Emotions ; Mice/physiology
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2020.1636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1364: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Do mice have a pain face?

    Flecknell, Paul A

    Nature methods

    2010  Volume 7, Issue 6, Page(s) 437–438

    MeSH term(s) Animals ; Facial Expression ; Mice ; Pain Measurement/methods
    Language English
    Publishing date 2010-05-27
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/nmeth0610-437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6022: Show issues Location:
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  8. Article: Evaluating Pain and Analgesia Effectiveness Following Routine Castration in Rabbits Using Behavior and Facial Expressions.

    Miller, Amy L / Clarkson, Jasmine M / Quigley, Caroline / Neville, Vikki / Krall, Caroline / Geijer-Simpson, Annika / Flecknell, Paul A / Leach, Matthew C

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 782486

    Abstract: Prevention of pain in rabbits is a priority for both welfare and validity of scientific data. We aimed to determine if the rabbit grimace scale (RbtGS) could be used as a viable, rapid assessment tool in two breeds of rabbit, Dutch belted (DB) and New ... ...

    Abstract Prevention of pain in rabbits is a priority for both welfare and validity of scientific data. We aimed to determine if the rabbit grimace scale (RbtGS) could be used as a viable, rapid assessment tool in two breeds of rabbit, Dutch belted (DB) and New Zealand white (NZW), following orchidectomy, as an adjunct to behavioral analysis. All animals received analgesia. Rabbits were filmed and their behavior was recorded at multiple time points pre- and post-orchidectomy. Observers then scored specific pain associated behaviors for analysis. Time matched footage was also scored using the rabbit grimace scale (RbtGS). Following surgery, rabbits showed significant increases in the duration spent displaying key pain associated behaviors at 1 and 5 h post-surgery. DB rabbits that received low dose meloxicam (0.2 mg/kg) showed significantly more pain behaviors at 1 and 5 h post-surgery compared to those administered a combination of higher dose meloxicam (0.6 mg/kg) and a lidocaine/bupivacaine local infusion. DB rabbits showed an increase in RbtGS score at both 1 and 5 h post-surgery. In the NZW rabbits, an increase in RbtGS score was only observed at 1 h post-surgery. Using behavioral analysis as the gold standard for comparison, the RbtGS was an effective means of determining when rabbits are painful following orchidectomy. Higher dose meloxicam (0.6 mg/kg) combined with local anesthetic was a more effective method of reducing pain, compared to lower dose meloxicam (0.2 mg/kg) alone.
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.782486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The use of desflurane for neurosurgical procedures in rhesus macaque ( Macaca mulatta).

    Bertrand, Henri Gmj / Sandersen, Charlotte / Flecknell, Paul A

    Laboratory animals

    2017  Volume 52, Issue 3, Page(s) 292–299

    Abstract: Volatile agents are widely used to anaesthetise laboratory non-human primates as they allow a rapid induction and recovery as well as an easy adjustment of the anaesthesia plan. Desflurane is currently the volatile agent with the lowest solubility in ... ...

    Abstract Volatile agents are widely used to anaesthetise laboratory non-human primates as they allow a rapid induction and recovery as well as an easy adjustment of the anaesthesia plan. Desflurane is currently the volatile agent with the lowest solubility in blood, and hence enables the most rapid onset of anaesthesia and most rapid recovery. This study aimed to investigate the suitability of desflurane for maintenance of general anaesthesia in rhesus macaques undergoing elective experimental neurosurgery. Fourteen primates (five males and nine females) were sedated with ketamine (10 mg kg
    MeSH term(s) Anesthetics, Inhalation/adverse effects ; Animals ; Female ; Isoflurane/adverse effects ; Isoflurane/analogs & derivatives ; Macaca mulatta/surgery ; Male ; Methyl Ethers/adverse effects ; Neurosurgical Procedures/methods
    Chemical Substances Anesthetics, Inhalation ; Methyl Ethers ; sevoflurane (38LVP0K73A) ; desflurane (CRS35BZ94Q) ; Isoflurane (CYS9AKD70P)
    Language English
    Publishing date 2017-11-13
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 391008-8
    ISSN 1758-1117 ; 0023-6772
    ISSN (online) 1758-1117
    ISSN 0023-6772
    DOI 10.1177/0023677217740169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1951: Show issues Location:
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  10. Article ; Online: MRI-guided stereotaxic brain surgery in the infant and adult common marmoset.

    Mundinano, Inaki-Carril / Flecknell, Paul A / Bourne, James A

    Nature protocols

    2016  Volume 11, Issue 7, Page(s) 1299–1308

    Abstract: In the past decade, the New World common marmoset (Callithrix jacchus) has taken a seminal position in neurobiological research, fueled in part by its smooth cortical sheet, which allows cortical areas to be easily accessed by current technologies on the ...

    Abstract In the past decade, the New World common marmoset (Callithrix jacchus) has taken a seminal position in neurobiological research, fueled in part by its smooth cortical sheet, which allows cortical areas to be easily accessed by current technologies on the dorsal surface of the brain. In this protocol, we describe a method for the precision placement of agents (e.g., tracers or neurotoxins) into small brain regions of the infant and adult marmoset, using an MRI-guided approach. This strategy uses a protocol for prolonged anesthesia without the need for intubation that we have recently developed, alongside appropriate analgesia and monitoring. The protocol can be readily adapted to be used together with advanced research techniques, such as two-photon microscopy and optical imaging. Including a 5-d postoperative care plan, this protocol takes 7 d to complete. The protocol requires a team of personnel experienced in marmoset care and handling, and small-animal neurosurgery; an assistant for monitoring the animal and assisting with anesthesia; and an MRI technician.
    MeSH term(s) Animals ; Animals, Newborn ; Brain/diagnostic imaging ; Brain/surgery ; Callithrix ; Magnetic Resonance Imaging/methods ; Models, Animal ; Neurosurgical Procedures/methods ; Surgery, Computer-Assisted/methods
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/nprot.2016.076
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