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  1. Article: Non-O1/Non-O139

    Zhang, Quantao / Alter, Thomas / Fleischmann, Susanne

    Microorganisms

    2024  Volume 12, Issue 4

    Abstract: In recent years, the number of foodborne infections with non-O1 and non- ... ...

    Abstract In recent years, the number of foodborne infections with non-O1 and non-O139
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12040818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Ursachen, begünstigende Faktoren, Auswirkungen und Prophylaxe von Feuchtigkeit und Schimmelpilzbildung in Wohnräumen

    Fleischmann, Sabine

    2003  

    Author's details von Sabine Fleischmann
    Language German
    Size 116 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2003
    HBZ-ID HT013751875
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: German coasts harbor non-O1/non-O139 Vibrio cholerae with clinical virulence gene profiles.

    Zhang, Quantao / Alter, Thomas / Strauch, Eckhard / Eichhorn, Inga / Borowiak, Maria / Deneke, Carlus / Fleischmann, Susanne

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2024  Volume 120, Page(s) 105587

    Abstract: Non-O1/non-O139 Vibrio cholerae (NOVC) are ubiquitous in aquatic ecosystems. In rare cases, they can cause intestinal and extra-intestinal infections in human. This ability is associated with various virulence factors. The presence of NOVC in German ... ...

    Abstract Non-O1/non-O139 Vibrio cholerae (NOVC) are ubiquitous in aquatic ecosystems. In rare cases, they can cause intestinal and extra-intestinal infections in human. This ability is associated with various virulence factors. The presence of NOVC in German North Sea and Baltic Sea was observed in previous studies. However, data on virulence characteristics are still scarce. Therefore, this work aimed to investigating the virulence potential of NOVC isolated in these two regions. In total, 31 NOVC strains were collected and subjected to whole genome sequencing. In silico analysis of the pathogenic potential was performed based on the detection of genes involved in colonization and virulence. Phenotypic assays, including biofilm formation, mobility and human serum resistance assays were applied for validation. Associated toxin genes (hlyA, rtxA, chxA and stn), pathogenicity islands (Vibrio pathogenicity island 2 (VPI-II) and Vibrio seventh pathogenicity island 2 (VSP-II)) and secretion systems (Type II, III and VI secretion system) were observed. A maximum likelihood analysis from shared core genes revealed a close relationship between clinical NOVCs published in NCBI and environmental strains from this study. NOVC strains are more mobile at 37 °C than at 25 °C, and 68% of the NOVC strains could form strong biofilms at both temperatures. All tested strains were able to lyse erythrocytes from both human and sheep blood. Additionally, one strain could survive up to 60% and seven strains up to 40% human serum at 37 °C. Overall, the genetic virulence profile as well as the phenotypic virulence characteristics of the investigated NOVC from the German North Sea and Baltic Sea suggest potential human pathogenicity.
    MeSH term(s) Virulence Factors/genetics ; Humans ; Virulence/genetics ; Vibrio cholerae non-O1/genetics ; Vibrio cholerae non-O1/pathogenicity ; Vibrio cholerae non-O1/isolation & purification ; Germany ; Genomic Islands/genetics ; Biofilms/growth & development ; Phylogeny ; North Sea ; Vibrio cholerae/genetics ; Vibrio cholerae/pathogenicity ; Vibrio cholerae/classification ; Cholera/microbiology ; Animals ; Whole Genome Sequencing
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2024-03-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2024.105587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Molekulargenetische Untersuchungen auf FRAXA und FRAXE

    Fleischmann, Silvia

    1997  

    Author's details vorgelegt von Silvia Fleischmann
    Language German
    Size 82 S. : Ill.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1998
    HBZ-ID HT009124329
    Database Catalogue ZB MED Medicine, Health

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  5. Article: Cramp and salt balance.

    FLEISCHMANN, S

    Lancet (London, England)

    2009  Volume 2, Issue 6474, Page(s) 492

    MeSH term(s) Humans ; Muscle Cramp
    Language English
    Publishing date 2009-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(47)90518-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Zur Toxizität der Verschwelungsprodukte aus Polyurethan-Schäumen und ihre Auswirkungen auf den Organismus

    Fleischmann, Siegfried

    (tierexperimentelle Untersuchungen)

    1993  

    Author's details vorgelegt von Siegfried Fleischmann
    Language German
    Size 84 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Diss., 1993
    HBZ-ID HT006235958
    Database Catalogue ZB MED Medicine, Health

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  7. Book ; Online: Evidenzbasiertes Markenmanagement

    Fleischmann, Sophie

    Preis-Qualitäts-Positionierung und Social Media Analytics

    (Beiträge zur empirischen Marketing- und Vertriebsforschung)

    2016  

    Abstract: Text 4. Umschlagseite Sophie Fleischmann trägt mit diesem Buch zu einer Entmystifizierung des Markenmanagements bei. Vor dem Hintergrund mangelnder Fundierung widmet sich die Autorin mit umfangreichen Empirien zwei zentralen Entscheidungsfeldern des ... ...

    Author's details von Sophie Fleischmann
    Series title Beiträge zur empirischen Marketing- und Vertriebsforschung
    Abstract Text 4. Umschlagseite Sophie Fleischmann trägt mit diesem Buch zu einer Entmystifizierung des Markenmanagements bei. Vor dem Hintergrund mangelnder Fundierung widmet sich die Autorin mit umfangreichen Empirien zwei zentralen Entscheidungsfeldern des Markenmanagements: Der Markenstrategie und der Markenkontrolle. Im Rahmen der Markenstrategie liegt der Fokus auf der Preis-Qualitäts-Positionierung. Es werden systematisch Nachweise in Bezug auf die Kategorisierungsprozesse der Konsumenten hinsichtlich Preis und Qualität erbracht und eine Verknüpfung der Positionierung mit dem Unternehmenserfolg vorgenommen. Im Bereich der Markenkontrolle werden Messmethoden durch Hinzunahme von Daten aus sozialen Medien weiterentwickelt. Konkret wird untersucht, inwieweit sich Markenindikatoren anhand von öffentlich verfügbaren Daten sozialer Medien approximieren lassen. Auf diese Weise werden die Diskrepanzen zwischen Online- und Offline-Marktforschung und somit die Grenzen einer Marktforschungsautomatisierung aufgezeigt. Der Inhalt Gestaltung, Wahrnehmung und Implikationen der Preis-Qualitäts-Positionierung Approximation von Markenindikatoren durch Social Media Analytics Die Zielgruppen Dozenten und Studenten der Betriebswirtschaftslehre mit den Schwerpunkten Marketing und Management Fach- und Führungskräfte mit diesen Schwerpunkten Die Autorin Dr. Sophie Fleischmann promovierte bei der Forschergruppe Marketing & Vertrieb von Prof. Dr. Martin Klarmann am Karlsruher Institut für Technologie
    Keywords Business ; Management ; Marketing
    Language German
    Size Online-Ressource (XVI, 187 S. 14 Abb), online resource
    Edition 1. Aufl. 2016
    Publisher Springer Fachmedien Wiesbaden
    Publishing place Wiesbaden ;s.l
    Document type Book ; Online
    ISBN 9783658119973 ; 9783658119980 ; 3658119977 ; 3658119985
    DOI 10.1007/978-3-658-11998-0
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online: Die Agrarkrisis von 1845 - 1855 mit besonderer Berücksichtigung von Baden

    Fleischmann, Sigmund

    2016  

    Author's details vorgelegt von Sigmund Fleischmann (Lehramtspraktikant)
    Language German
    Size 1 Online-Ressource (108 Seiten)
    Publisher ZBW
    Publishing place Kiel ; Hamburg
    Document type Book ; Online
    Database ECONomics Information System

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  9. Article: How to Evaluate Non-Growing Cells-Current Strategies for Determining Antimicrobial Resistance of VBNC Bacteria.

    Fleischmann, Susanne / Robben, Christian / Alter, Thomas / Rossmanith, Peter / Mester, Patrick

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Thanks to the achievements in sanitation, hygiene practices, and antibiotics, we have considerably improved in our ongoing battle against pathogenic bacteria. However, with our increasing knowledge about the complex bacterial lifestyles and cycles and ... ...

    Abstract Thanks to the achievements in sanitation, hygiene practices, and antibiotics, we have considerably improved in our ongoing battle against pathogenic bacteria. However, with our increasing knowledge about the complex bacterial lifestyles and cycles and their plethora of defense mechanisms, it is clear that the fight is far from over. One of these resistance mechanisms that has received increasing attention is the ability to enter a dormancy state termed viable but non-culturable (VBNC). Bacteria that enter the VBNC state, either through unfavorable environmental conditions or through potentially lethal stress, lose their ability to grow on standard enrichment media, but show a drastically increased tolerance against antimicrobials including antibiotics. The inability to utilize traditional culture-based methods represents a considerable experimental hurdle to investigate their increased antimicrobial resistance and impedes the development and evaluation of effective treatments or interventions against bacteria in the VBNC state. Although experimental approaches were developed to detect and quantify VBNCs, only a few have been utilized for antimicrobial resistance screening and this review aims to provide an overview of possible methodological approaches.
    Language English
    Publishing date 2021-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10020115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Silencing

    Wang, Yidong / Sun, Weizhao / Fleischmann, Sonja / Millar, Jocelyn G / Ruther, Joachim / Verhulst, Eveline C

    Proceedings. Biological sciences

    2022  Volume 289, Issue 1967, Page(s) 20212002

    Abstract: Doublesex (Dsx) has a conserved function in controlling sexual morphological differences in insects, but our knowledge of its role in regulating sexual behaviour is primarily limited ... ...

    Abstract Doublesex (Dsx) has a conserved function in controlling sexual morphological differences in insects, but our knowledge of its role in regulating sexual behaviour is primarily limited to
    MeSH term(s) Animals ; Courtship ; Female ; Feminization ; Humans ; Hydrocarbons/metabolism ; Male ; Pheromones/metabolism ; Sex Attractants/metabolism ; Sexual Behavior, Animal/physiology ; Wasps/genetics
    Chemical Substances Hydrocarbons ; Pheromones ; Sex Attractants
    Language English
    Publishing date 2022-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2021.2002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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