LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Fleischmann, Wim A"
  2. AU="Tran, Thanh"

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: A severe case of Plasmodium falciparum malaria in a traveler returning from Kazakhstan, a malaria-free country.

    Velavan, Thirumalaisamy P / Fleischmann, Wim A / Kremsner, Peter G

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 143, Page(s) 107026

    Abstract: Following a 2-week trip to Kazakhstan, a 42-year-old woman presented at the emergency department in Germany with fever, headache, nausea, and neurological symptoms. An infection with Plasmodium falciparum was rapidly diagnosed. The patient was ... ...

    Abstract Following a 2-week trip to Kazakhstan, a 42-year-old woman presented at the emergency department in Germany with fever, headache, nausea, and neurological symptoms. An infection with Plasmodium falciparum was rapidly diagnosed. The patient was immediately treated with intravenous artesunate and transferred to an intensive care unit. The initial parasite density was as high as 30% infected erythrocytes with 845,880 parasites/µL. Since Kazakhstan was declared malaria-free in 2012, molecular testing for Plasmodium has been initiated to identify a possible origin. Genotyping of the msp-1 gene and microsatellite markers showed that the parasites are of African origin, with two different alleles indicating a polyclonal infection. After a hospitalization of 10 days, the patient was discharged in good health. Overall, our results emphasize that malaria must be on the list of differential diagnoses for patients with fever of unknown origin, even if they come from countries where malaria does not commonly occur.
    MeSH term(s) Humans ; Malaria, Falciparum/diagnosis ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Female ; Adult ; Plasmodium falciparum/genetics ; Plasmodium falciparum/isolation & purification ; Antimalarials/therapeutic use ; Kazakhstan ; Travel ; Artesunate/therapeutic use ; Genotype ; Artemisinins/therapeutic use ; Merozoite Surface Protein 1/genetics ; Germany
    Chemical Substances Antimalarials ; Artesunate (60W3249T9M) ; Artemisinins ; Merozoite Surface Protein 1
    Language English
    Publishing date 2024-04-05
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107026
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: In Vitro

    Fleischmann, Wim A / Greenwood-Quaintance, Kerryl E / Patel, Robin

    Antimicrobial agents and chemotherapy

    2020  Volume 64, Issue 2

    Abstract: The worldwide spread of multidrug- ... ...

    Abstract The worldwide spread of multidrug-resistant
    MeSH term(s) Amikacin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial/drug effects ; Gentamicins/pharmacology ; Gram-Negative Aerobic Bacteria/drug effects ; Gram-Negative Aerobic Bacteria/enzymology ; Microbial Sensitivity Tests ; Sisomicin/analogs & derivatives ; Sisomicin/pharmacology ; Tobramycin/pharmacology ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; Gentamicins ; Amikacin (84319SGC3C) ; beta-Lactamases (EC 3.5.2.6) ; plazomicin (LYO9XZ250J) ; Tobramycin (VZ8RRZ51VK) ; Sisomicin (X55XSL74YQ)
    Language English
    Publishing date 2020-01-27
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01711-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Markers of prolonged hospitalisation in severe dengue.

    Recker, Mario / Fleischmann, Wim A / Nghia, Trinh Huu / Truong, Nguyen Van / Nam, Le Van / Duc Anh, Do / Song, Le Huu / The, Nguyen Trong / Anh, Chu Xuan / Hoang, Nguyen Viet / My Truong, Nhat / Toan, Nguyen Linh / Kremsner, Peter G / Velavan, Thirumalaisamy P

    PLoS neglected tropical diseases

    2024  Volume 18, Issue 1, Page(s) e0011922

    Abstract: Background: Dengue is one of the most common diseases in the tropics and subtropics. Whilst mortality is a rare event when adequate supportive care can be provided, a large number of patients get hospitalised with dengue every year that places a heavy ... ...

    Abstract Background: Dengue is one of the most common diseases in the tropics and subtropics. Whilst mortality is a rare event when adequate supportive care can be provided, a large number of patients get hospitalised with dengue every year that places a heavy burden on local health systems. A better understanding of the support required at the time of hospitalisation is therefore of critical importance for healthcare planning, especially when resources are limited during major outbreaks.
    Methods: Here we performed a retrospective analysis of clinical data from over 1500 individuals hospitalised with dengue in Vietnam between 2017 and 2019. Using a broad panel of potential biomarkers, we sought to evaluate robust predictors of prolonged hospitalisation periods.
    Results: Our analyses revealed a lead-time bias, whereby early admission to hospital correlates with longer hospital stays - irrespective of disease severity. Importantly, taking into account the symptom duration prior to hospitalisation significantly affects observed associations between hospitalisation length and previously reported risk markers of prolonged stays, which themselves showed marked inter-annual variations. Once corrected for symptom duration, age, temperature at admission and elevated neutrophil-to-lymphocyte ratio were found predictive of longer hospitalisation periods.
    Conclusion: This study demonstrates that the time since dengue symptom onset is one of the most significant predictors for the length of hospital stays, independent of the assigned severity score. Pre-hospital symptom durations need to be accounted for to evaluate clinically relevant biomarkers of dengue hospitalisation trajectories.
    MeSH term(s) Humans ; Severe Dengue/diagnosis ; Severe Dengue/epidemiology ; Retrospective Studies ; Hospitalization ; Length of Stay ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011922
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top