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  1. Article ; Online: Flurofamide Prevention and Treatment of

    Fleming, Derek / Patel, Robin

    Microbiology spectrum

    2022  Volume 10, Issue 5, Page(s) e0192722

    Abstract: Hyperammonemia (HA) syndrome caused by respiratory infection with ammonia ( ... ...

    Abstract Hyperammonemia (HA) syndrome caused by respiratory infection with ammonia (NH
    MeSH term(s) Mice ; Animals ; Ureaplasma ; Hyperammonemia/drug therapy ; Hyperammonemia/prevention & control ; Hyperammonemia/complications ; Urease/pharmacology ; Ammonia/pharmacology ; Ureaplasma Infections/complications ; Ureaplasma Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Urea/pharmacology
    Chemical Substances flurofamide (599XHU06GH) ; Urease (EC 3.5.1.5) ; Ammonia (7664-41-7) ; Anti-Bacterial Agents ; Urea (8W8T17847W)
    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01927-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reducing long acting antipsychotic injection dosage frequency: A pilot study in a community mental health team.

    Fleming, D / Raynsford, J / Hosalli, P

    Journal of mental health (Abingdon, England)

    2020  Volume 30, Issue 1, Page(s) 129–133

    Abstract: Background: Antipsychotic long acting injections (LAI) allow a range of dosage intervals to be administered. Short intervals can be inconvenient for patients and staff. There are few clinical reasons for using them yet this is common practice.: Aims: ...

    Abstract Background: Antipsychotic long acting injections (LAI) allow a range of dosage intervals to be administered. Short intervals can be inconvenient for patients and staff. There are few clinical reasons for using them yet this is common practice.
    Aims: This study aimed to examine the feasibility of reducing LAI frequency with service user consent.
    Methods: The study took place in a community mental health team in the north of England. A specialist mental health pharmacist reviewed records of all service users on LAI and drew up an action plan. Each service user then met with the consultant psychiatrist for medication review.
    Result: Nineteen out of thirty service users on LAI had intervals less than the maximum licensed. The frequency was reduced in eight cases. After 6 months follow-up, there was no deterioration in symptoms. In nine cases, antipsychotic doses were also reduced as a result of the review.
    Conclusion: Where a service user is prescribed a LAI with a short dosage interval consideration should be given to increase the interval. This can free up service user and staff time. A medication focused review can also lead to other benefits such as dosage reduction.
    MeSH term(s) Antipsychotic Agents/therapeutic use ; Delayed-Action Preparations ; Humans ; Injections ; Mental Health ; Pilot Projects
    Chemical Substances Antipsychotic Agents ; Delayed-Action Preparations
    Language English
    Publishing date 2020-01-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1145439-8
    ISSN 1360-0567 ; 0963-8237
    ISSN (online) 1360-0567
    ISSN 0963-8237
    DOI 10.1080/09638237.2020.1714003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3695: Show issues Location:
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  3. Article: Evaluation of Treatment of Methicillin-Resistant

    Islam Anoy, Md Monzurul / Kim, Won-Jun / Gelston, Suzanne / Fleming, Derek / Patel, Robin / Beyenal, Haluk

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Chronic wound infections can be difficult to treat and may lead to impaired healing and worsened patient outcomes. Novel treatment strategies are needed. This study evaluated effects of intermittently produced ... ...

    Abstract Chronic wound infections can be difficult to treat and may lead to impaired healing and worsened patient outcomes. Novel treatment strategies are needed. This study evaluated effects of intermittently produced H
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.22.586337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Contribution of Uremia to

    Fleming, Derek / Cunningham, Scott A / Patel, Robin

    Microbiology spectrum

    2022  Volume 10, Issue 1, Page(s) e0194221

    Abstract: Lung transplant recipients (LTRs) are vulnerable to hyperammonemia syndrome (HS) in the early postoperative period, a condition typically unresponsive to nonantibiotic interventions. HS in LTRs is strongly correlated with Ureaplasma infection of the ... ...

    Abstract Lung transplant recipients (LTRs) are vulnerable to hyperammonemia syndrome (HS) in the early postoperative period, a condition typically unresponsive to nonantibiotic interventions. HS in LTRs is strongly correlated with Ureaplasma infection of the respiratory tract, although it is not well understood what makes LTRs preferentially susceptible to HS compared to other immunocompromised hosts. Ureaplasma species harbor highly active ureases, and postoperative LTRs commonly experience uremia. We hypothesized that uremia could be a potentiating comorbidity, providing increased substrate for ureaplasmal ureases. Using a novel dialyzed flow system, the ammonia-producing capacities of four isolates of Ureaplasma parvum and six isolates of Ureaplasma urealyticum in media formulations relating to normal and uremic host conditions were tested. For all isolates, growth under simulated uremic conditions resulted in increased ammonia production over 24 h, despite similar endpoint bacterial quantities. Further, transcripts of
    MeSH term(s) Ammonia/metabolism ; Animals ; Humans ; Hyperammonemia/complications ; Hyperammonemia/microbiology ; Immunocompromised Host ; Lung ; Lung Transplantation ; Mice ; Transplant Recipients ; Ureaplasma ; Ureaplasma urealyticum/isolation & purification ; Uremia/complications ; Uremia/microbiology ; Urinary Tract
    Chemical Substances Ammonia (7664-41-7)
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01942-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tribal alchemy: turning lesser into better, together.

    Fleming, Dave

    Oncology nursing forum

    2014  Volume 41, Issue 2, Page(s) 209–211

    MeSH term(s) Alchemy ; History, Medieval ; Humans ; Imagination ; Leadership ; Oncology Nursing ; Symbolism
    Language English
    Publishing date 2014-03-01
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 604886-9
    ISSN 1538-0688 ; 0190-535X ; 1538-0688
    ISSN (online) 1538-0688 ; 0190-535X
    ISSN 1538-0688
    DOI 10.1188/14.ONF.209-211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1818: Show issues Location:
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    Zs.MO 414: Show issues

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  6. Article ; Online: Spatiotemporal analysis of out-of-hospital cardiac arrest in the City of Los Angeles, 2011-2019.

    Fleming, Douglas / Owens, Ann / Eckstein, Marc / Sanko, Stephen

    Resuscitation

    2021  Volume 165, Page(s) 110–118

    Abstract: Objective: The goal of this analysis is to spatiotemporally identify and categorize areas in a large urban city according to Out-of-Hospital Cardiac Arrest (OHCA) rates and No Bystander CPR (NBCPR) risk levels.: Study area and participants: The study ...

    Abstract Objective: The goal of this analysis is to spatiotemporally identify and categorize areas in a large urban city according to Out-of-Hospital Cardiac Arrest (OHCA) rates and No Bystander CPR (NBCPR) risk levels.
    Study area and participants: The study comprised all cardiac arrests within the administrative geographic boundary of the City of Los Angeles. The final sample included 15,904 cases that were geolocated within 985 census tracts.
    Main outcomes and measures: The primary outcome was stratification of census tracts into risk levels of OHCA and NBCPR by observed spatiotemporal patterns.
    Results: Of 985 census tracts in the analytical sample, 182 census tracts (18.5%) were identified as having higher risk of OHCA and NBCPR. This assessment resulted in 129 census tracts in Tier 3 (moderate risk), 36 in Tier 2 (moderate-high risk), and 17 in Tier 1 (highest risk). Census tracts in Tiers 2 and 3 had higher amounts incident OHCA, while those in tier 1 had more OHCA events with NBCPR. These areas were largely contiguous and located in the Central and South areas of Los Angeles.
    Conclusions: Using a novel three-tiered neighborhood risk classification tool, specific neighborhoods have been identified in the second largest city in the U.S. with consistently high or accelerating rates of OHCA and low bystander CPR. Further study of bystander response and community-based public health campaigns are needed in these communities.
    MeSH term(s) Cardiopulmonary Resuscitation ; Cities ; Emergency Medical Services ; Humans ; Los Angeles/epidemiology ; Out-of-Hospital Cardiac Arrest/epidemiology ; Spatio-Temporal Analysis
    Language English
    Publishing date 2021-06-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2021.05.013
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    Zs.A 1048: Show issues Location:
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  7. Article: DUAL ACTION ELECTROCHEMICAL BANDAGE OPERATED by a PROGRAMMABLE MULTIMODAL WEARABLE POTENTIOSTAT.

    Bozyel, Ibrahim / Fleming, Derek / Kim, Won-Jun / Rosen, Peter F / Gelston, Suzanne / Ozdemir, Dilara / Ay, Suat U / Patel, Robin / Beyenal, Haluk

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Electrochemical bandages (e-bandages) can be applied to biofilm-infected wounds to generate reactive oxygen species, such as hypochlorous acid (HOCl) or hydrogen peroxide ( ... ...

    Abstract Electrochemical bandages (e-bandages) can be applied to biofilm-infected wounds to generate reactive oxygen species, such as hypochlorous acid (HOCl) or hydrogen peroxide (H
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.22.586346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Consequences of Biofilm Dispersal on the Host.

    Fleming, Derek / Rumbaugh, Kendra

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 10738

    Abstract: Chronic infections are often associated with the presence of a biofilm, a community of microorganisms coexisting within a protective matrix of extracellular polymeric substance. Living within a biofilm can make resident microbes significantly more ... ...

    Abstract Chronic infections are often associated with the presence of a biofilm, a community of microorganisms coexisting within a protective matrix of extracellular polymeric substance. Living within a biofilm can make resident microbes significantly more tolerant to antibiotics in comparison to planktonic, free-floating cells. Thus, agents that can degrade biofilms are being pursued for clinical applications. While biofilm degrading and dispersing agents may represent attractive adjunctive therapies for biofilm-associated chronic infections, very little is known about how the host responds to the sudden dispersal of biofilm cells. In this study, we found that large-scale, in vivo dispersal of motile biofilm bacteria by glycoside hydrolases caused lethal septicemia in the absence of antibiotic therapy in a mouse wound model. However, when administered prudently, biofilm degrading enzymes had the potential to potentiate the efficacy of antibiotics and help resolve biofilm-associated wound infections.
    MeSH term(s) Animals ; Anti-Bacterial Agents/administration & dosage ; Biofilms/drug effects ; Biofilms/growth & development ; Disease Models, Animal ; Drug Therapy, Combination/adverse effects ; Drug Therapy, Combination/methods ; Glycoside Hydrolases/administration & dosage ; Glycoside Hydrolases/adverse effects ; Humans ; Mice ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/immunology ; Pseudomonas aeruginosa/pathogenicity ; Sepsis/chemically induced ; Sepsis/immunology ; Sepsis/mortality ; Skin/injuries ; Skin/microbiology ; Wound Infection/drug therapy ; Wound Infection/immunology ; Wound Infection/microbiology
    Chemical Substances Anti-Bacterial Agents ; Glycoside Hydrolases (EC 3.2.1.-)
    Language English
    Publishing date 2018-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-29121-2
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  9. Book: William H. Welch and the rise of modern medicine

    Fleming, Donald

    (A Johns Hopkins paperback)

    1987  

    Series title A Johns Hopkins paperback
    Keywords History of Medicine, 19th Cent. / United States ; History of Medicine, 20th Cent. / United States ; Physicians / biography
    Size VI, 232 S.
    Edition Reprint.
    Publisher Johns Hopkins Univ. Press
    Publishing place Baltimore
    Publishing country United States
    Document type Book
    HBZ-ID HT003960042
    ISBN 0-8018-3389-2 ; 978-0-8018-3389-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1991 B 1679 order for loan Magazin

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  10. Article ; Online: Kenneth William Cross: an appreciation.

    Fleming, Douglas

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2011  Volume 61, Issue 592, Page(s) 683

    MeSH term(s) History, 20th Century ; History, 21st Century ; Statistics as Topic/history ; United Kingdom
    Language English
    Publishing date 2011-11-06
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp11X606681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 576: Show issues Location:
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    Zs.MO 100: Show issues

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