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Article: On the Late Accident by Lightning in the West-End Park, Glasgow, on the Afternoon of Sunday, 29th May, 1859.

Fleming, Joseph

2018 Volume 7, Issue 27, Page(s) 257–263

Language	English
Publishing date	2018-11-14
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	414084-9
ISSN	0367-4800
ISSN	0367-4800
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Article ; Online: Repeated familiarisation with hypohydration attenuates the performance decrement caused by hypohydration during treadmill running.

Fleming, Joseph / James, Lewis J

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

2014 Volume 39, Issue 2, Page(s) 124–129

Abstract: This study examined the effect of repeated familiarisation to hypohydration on hypohydrated exercise performance. After familiarisation with the exercise protocol, 10 recreationally active males completed a euhydrated (EU-pre) and hypohydrated (HYPO-pre) ...

Abstract	This study examined the effect of repeated familiarisation to hypohydration on hypohydrated exercise performance. After familiarisation with the exercise protocol, 10 recreationally active males completed a euhydrated (EU-pre) and hypohydrated (HYPO-pre) trial, which involved a 45-min steady state run at 75% peak oxygen uptake (45SS) followed by a 5-km time trial (TT). Euhydration and hypohydration were induced by manipulating fluid intake in the 24-h pre-exercise and during the 45SS. Subjects then completed 4 habituation sessions that involved replication of the HYPO-pre trial, except they completed 60 min of running at 75% peak oxygen uptake and no TT. Subjects then replicated the euhydrated (EU-post) and hypohydrated (HYPO-post) trials. Body mass loss pre-TT was 0.2 (0.2)% (EU-pre), 2.4 (0.3)% (HYPO-pre), 0.1 (0.1)% (EU-post), and 2.4 (0.3)% (HYPO-post). TT performance was 5.8 (2.4)% slower during the HYPO-pre trial (1459 (250) s) than during the EU-pre trial (1381 (237) s) (p < 0.01), but only 1.2 (1.6)% slower during the HYPO-post trial (1381 (200) s) than during the EU-post trial (1366 (211) s) (p = 0.064). TT performance was not different between EU-pre and EU-post trials, but was 5.1 (2.3)% faster during the HYPO-post trial than the HYPO-pre trial (p < 0.01). Heart rate was greater during HYPO trials than EU trials (p < 0.001), whilst rating of perceived exertion (RPE) response was similar to TT time and was lower in the HYPO-post trial than the HYPO-pre trial (p < 0.01). In conclusion, hypohydration impaired 5-km running performance in subjects unfamiliar with the hypohydration protocol, but 4 familiarisation sessions designed to habituate subjects with the hypohydration protocol attenuated the performance decrement, seemingly via an attenuation of RPE during hypohydrated exercise.
MeSH term(s)	Athletic Performance/physiology ; Dehydration/physiopathology ; Exercise Test ; Humans ; Male ; Running/physiology ; Young Adult
Language	English
Publishing date	2014-02
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2013-0044
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Article: Repeated familiarisation with hypohydration attenuates the performance decrement caused by hypohydration during treadmill running

Fleming, Joseph / Lewis J. James

Applied Physiology, Nutrition, and Metabolism. 2013 July 26, v. 39, no. 2

2013

Abstract	This study examined the effect of repeated familiarisation to hypohydration on hypohydrated exercise performance. After familiarisation with the exercise protocol, 10 recreationally active males completed a euhydrated (EU-pre) and hypohydrated (HYPO-pre) trial, which involved a 45-min steady state run at 75% peak oxygen uptake (45SS) followed by a 5-km time trial (TT). Euhydration and hypohydration were induced by manipulating fluid intake in the 24-h pre-exercise and during the 45SS. Subjects then completed 4 habituation sessions that involved replication of the HYPO-pre trial, except they completed 60 min of running at 75% peak oxygen uptake and no TT. Subjects then replicated the euhydrated (EU-post) and hypohydrated (HYPO-post) trials. Body mass loss pre-TT was 0.2 (0.2)% (EU-pre), 2.4 (0.3)% (HYPO-pre), 0.1 (0.1)% (EU-post), and 2.4 (0.3)% (HYPO-post). TT performance was 5.8 (2.4)% slower during the HYPO-pre trial (1459 (250) s) than during the EU-pre trial (1381 (237) s) (p < 0.01), but only 1.2 (1.6)% slower during the HYPO-post trial (1381 (200) s) than during the EU-post trial (1366 (211) s) (p = 0.064). TT performance was not different between EU-pre and EU-post trials, but was 5.1 (2.3)% faster during the HYPO-post trial than the HYPO-pre trial (p < 0.01). Heart rate was greater during HYPO trials than EU trials (p < 0.001), whilst rating of perceived exertion (RPE) response was similar to TT time and was lower in the HYPO-post trial than the HYPO-pre trial (p < 0.01). In conclusion, hypohydration impaired 5-km running performance in subjects unfamiliar with the hypohydration protocol, but 4 familiarisation sessions designed to habituate subjects with the hypohydration protocol attenuated the performance decrement, seemingly via an attenuation of RPE during hypohydrated exercise.
Keywords	euhydration ; exercise ; heart rate ; males ; metabolism ; nutrition ; oxygen
Language	English
Dates of publication	2013-0726
Size	p. 124-129.
Publishing place	NRC Research Press
Document type	Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2013-0044
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Article ; Online: Health Toll From Open Flame and Cigarette-Started Fires on Flame-Retardant Furniture in Massachusetts, 2003-2016.

Rodgers, Kathryn M / Swetschinski, Lucien R / Dodson, Robin E / Alpert, Hillel R / Fleming, Joseph M / Rudel, Ruthann A

American journal of public health

2019 Volume 109, Issue 9, Page(s) 1205–1211

Abstract: Objectives. ...

Abstract	Objectives.
MeSH term(s)	Burns/etiology ; Burns/mortality ; Fires/statistics & numerical data ; Flame Retardants ; Humans ; Interior Design and Furnishings/statistics & numerical data ; Massachusetts/epidemiology ; Risk Assessment ; Tobacco Products
Chemical Substances	Flame Retardants
Language	English
Publishing date	2019-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2019.305157
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Article: Hitching a ride: Seed accrual rates on different types of vehicles

Rew, Lisa J / Balbach, Harold E / Brummer, Tyler J / Fleming, Joseph D / Larson, Christian D / Pollnac, Fredric W / Taper, Mark L / Taylor, Kimberley T

Journal of environmental management. 2018 Jan. 15, v. 206

2018

Abstract: Human activities, from resource extraction to recreation, are increasing global connectivity, especially to less-disturbed and previously inaccessible places. Such activities necessitate road networks and vehicles. Vehicles can transport reproductive ... ...

Abstract	Human activities, from resource extraction to recreation, are increasing global connectivity, especially to less-disturbed and previously inaccessible places. Such activities necessitate road networks and vehicles. Vehicles can transport reproductive plant propagules long distances, thereby increasing the risk of invasive plant species transport and dispersal. Subsequent invasions by less desirable species have significant implications for the future of threatened species and habitats. The goal of this study was to understand vehicle seed accrual by different vehicle types and under different driving conditions, and to evaluate different mitigation strategies. Using studies and experiments at four sites in the western USA we addressed three questions: How many seeds and species accumulate and are transported on vehicles? Does this differ with vehicle type, driving surface, surface conditions, and season? What is our ability to mitigate seed dispersal risk by cleaning vehicles? Our results demonstrated that vehicles accrue plant propagules, and driving surface, surface conditions, and season affect the rate of accrual: on- and off-trail summer seed accrual on all-terrain vehicles was 13 and 3508 seeds km−1, respectively, and was higher in the fall than in the summer. Early season seed accrual on 4-wheel drive vehicles averaged 7 and 36 seeds km−1 on paved and unpaved roads respectively, under dry conditions. Furthermore, seed accrual on unpaved roads differed by vehicle type, with tracked vehicles accruing more than small and large 4-wheel drives; and small 4-wheel drives more than large. Rates were dramatically increased under wet surface conditions. Vehicles indiscriminately accrue a wide diversity of seeds (different life histories, forms and seed lengths); total richness, richness of annuals, biennials, forbs and shrubs, and seed length didn't differ among vehicle types, or additional seed bank samples. Our evaluation of portable vehicle wash units showed that approximately 80% of soil and seed was removed from dirty vehicles. This suggests that interception programs to reduce vehicular seed transportation risk are feasible and should be developed for areas of high conservation value, or where the spread of invasive species is of special concern.
Keywords	all-terrain vehicles ; annuals ; autumn ; biennials ; cleaning ; forbs ; habitats ; humans ; invasive species ; life history ; recreation ; risk ; roads ; seed dispersal ; seeds ; shrubs ; soil ; summer ; threatened species ; Western United States
Language	English
Dates of publication	2018-0115
Size	p. 547-555.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2017.10.060
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Article ; Online: Hitching a ride: Seed accrual rates on different types of vehicles.

Rew, Lisa J / Brummer, Tyler J / Pollnac, Fredric W / Larson, Christian D / Taylor, Kimberley T / Taper, Mark L / Fleming, Joseph D / Balbach, Harold E

Journal of environmental management

2017 Volume 206, Page(s) 547–555

Abstract	Human activities, from resource extraction to recreation, are increasing global connectivity, especially to less-disturbed and previously inaccessible places. Such activities necessitate road networks and vehicles. Vehicles can transport reproductive plant propagules long distances, thereby increasing the risk of invasive plant species transport and dispersal. Subsequent invasions by less desirable species have significant implications for the future of threatened species and habitats. The goal of this study was to understand vehicle seed accrual by different vehicle types and under different driving conditions, and to evaluate different mitigation strategies. Using studies and experiments at four sites in the western USA we addressed three questions: How many seeds and species accumulate and are transported on vehicles? Does this differ with vehicle type, driving surface, surface conditions, and season? What is our ability to mitigate seed dispersal risk by cleaning vehicles? Our results demonstrated that vehicles accrue plant propagules, and driving surface, surface conditions, and season affect the rate of accrual: on- and off-trail summer seed accrual on all-terrain vehicles was 13 and 3508 seeds km
MeSH term(s)	Ecosystem ; Humans ; Plants ; Recreation ; Seeds ; Soil
Chemical Substances	Soil
Language	English
Publishing date	2017-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2017.10.060
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Article ; Online: Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma.

Christudoss, Pamela / Selvakumar, R / Fleming, Joseph J / Gopalakrishnan, Ganesh

Indian journal of urology : IJU : journal of the Urological Society of India

2011 Volume 27, Issue 1, Page(s) 14–18

Abstract: Objectives: The exact cause of benign prostatic hyperplasia (BPH) and prostatic carcinoma is unknown. Changes in the level of the trace element zinc (Zn) are known to be associated with the functioning of different organs (breast, colon, stomach, liver, ...

Abstract	Objectives: The exact cause of benign prostatic hyperplasia (BPH) and prostatic carcinoma is unknown. Changes in the level of the trace element zinc (Zn) are known to be associated with the functioning of different organs (breast, colon, stomach, liver, kidney, prostate, and muscle). This study is aimed at estimating and comparing the zinc levels in the prostate tissue, plasma, and urine obtained from patients diagnosed with BPH or prostatic carcinoma. Materials and methods: The prostate tissue zinc, plasma zinc, and urine zinc/creatinine ratio in BPH, prostate cancer, and normal subjects were measured by atomic absorption spectrophotometry. Results: In prostate carcinoma, the mean tissue zinc was decreased by 83% as compared to normal tissue and in BPH, there was a 61% decrease in mean tissue zinc as compared to normal tissues. Both these values were statistically significant. The plasma zinc in prostate cancer patients showed a 27% decrease (P < 0.01) as compared to controls and 18% decrease (P < 0.01) as compared to BPH. The urine zinc/creatinine (ratio) was significantly increased to 53% in prostate cancer patients, and a 20% significant increase was observed in BPH as compared to normal subjects. Conclusions: It is evident from this study that BPH or prostate carcinoma may be associated with a reduction in the levels of tissue zinc, plasma zinc, and an increase in urine zinc/creatinine.
Language	English
Publishing date	2011-06-26
Publishing country	India
Document type	Journal Article
ZDB-ID	639268-4
ISSN	1998-3824 ; 0970-1591
ISSN (online)	1998-3824
ISSN	0970-1591
DOI	10.4103/0970-1591.78405
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Article ; Online: NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.

Fleming, Joseph D / Pavesi, Giulio / Benatti, Paolo / Imbriano, Carol / Mantovani, Roberto / Struhl, Kevin

Genome research

2013 Volume 23, Issue 8, Page(s) 1195–1209

Abstract: NF-Y, a trimeric transcription factor (TF) composed of two histone-like subunits (NF-YB and NF-YC) and a sequence-specific subunit (NF-YA), binds to the CCAAT motif, a common promoter element. Genome-wide mapping reveals 5000-15,000 NF-Y binding sites ... ...

Abstract	NF-Y, a trimeric transcription factor (TF) composed of two histone-like subunits (NF-YB and NF-YC) and a sequence-specific subunit (NF-YA), binds to the CCAAT motif, a common promoter element. Genome-wide mapping reveals 5000-15,000 NF-Y binding sites depending on the cell type, with the NF-YA and NF-YB subunits binding asymmetrically with respect to the CCAAT motif. Despite being characterized as a proximal promoter TF, only 25% of NF-Y sites map to promoters. A comparable number of NF-Y sites are located at enhancers, many of which are tissue specific, and nearly half of the NF-Y sites are in select subclasses of HERV LTR repeats. Unlike most TFs, NF-Y can access its target DNA motif in inactive (nonmodified) or polycomb-repressed chromatin domains. Unexpectedly, NF-Y extensively colocalizes with FOS in all genomic contexts, and this often occurs in the absence of JUN and the AP-1 motif. NF-Y also coassociates with a select cluster of growth-controlling and oncogenic TFs, consistent with the abundance of CCAAT motifs in the promoters of genes overexpressed in cancer. Interestingly, NF-Y and several growth-controlling TFs bind in a stereo-specific manner, suggesting a mechanism for cooperative action at promoters and enhancers. Our results indicate that NF-Y is not merely a commonly used proximal promoter TF, but rather performs a more diverse set of biological functions, many of which are likely to involve coassociation with FOS.
MeSH term(s)	Base Sequence ; Binding Sites ; CCAAT-Binding Factor/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Consensus Sequence ; Enhancer Elements, Genetic ; Gene Expression Regulation ; Gene Ontology ; Genome, Human ; HeLa Cells ; Humans ; K562 Cells ; Molecular Sequence Annotation ; Organ Specificity ; Promoter Regions, Genetic ; Protein Binding ; Protein Transport ; Proto-Oncogene Proteins c-fos/metabolism ; Terminal Repeat Sequences ; Transcription Factors/metabolism ; Transcription Initiation Site
Chemical Substances	CCAAT-Binding Factor ; Chromatin ; NFYA protein, human ; NFYB protein, human ; Proto-Oncogene Proteins c-fos ; Transcription Factors
Language	English
Publishing date	2013-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1284872-4
ISSN	1549-5469 ; 1088-9051 ; 1054-9803
ISSN (online)	1549-5469
ISSN	1088-9051 ; 1054-9803
DOI	10.1101/gr.148080.112
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Article: Intracorneal ring segments for iatrogenic keratectasia after laser in situ keratomileusis or photorefractive keratectomy.

Lovisolo, Carlo F / Fleming, Joseph F

Journal of refractive surgery (Thorofare, N.J. : 1995)

2002 Volume 18, Issue 5, Page(s) 535–541

Abstract: Purpose: Intrastromal corneal ring segments (Intacs) were inserted in four eyes with iatrogenic keratectasia, 12 to 44 months after laser in situ keratomileusis (LASIK) in two patients and photorefractive keratectomy (PRK) in two patients, in order to ... ...

Abstract	Purpose: Intrastromal corneal ring segments (Intacs) were inserted in four eyes with iatrogenic keratectasia, 12 to 44 months after laser in situ keratomileusis (LASIK) in two patients and photorefractive keratectomy (PRK) in two patients, in order to avoid penetrating keratoplasty and to improve quality of vision. Methods: A modified asymmetrical Intacs micro-thin prescription inserts implantation technique was used in three eyes where a 1.0-mm temporal incision and a superior-inferior dissection were performed. A thicker segment was implanted in the lower stromal channel and a thinner one was placed in the superior channel. In the fourth eye, because of the severity of the corneal bulging after PRK, two 5.0-mm optical zone symmetrical Ferrara Ring segments were implanted. Results: Ten months after surgery, all eyes experienced a significant improvement of uncorrected and best spectacle-corrected visual acuity. The topographical indices showed an overall surface regularization with increased corneal uniformity and potential corneal visual acuity. No intraoperative or postoperative complications occurred. Conclusions: Asymmetrical or symmetrical corneal ring segment implantation in eyes with keratectasia after LASIK or PRK resulted in safe, fairly predictable corneal regularization, with significant improvement of aided and unaided vision. In the short term, these techniques seem to be helpful in reducing the progression of corneal ectasia after excimer laser surgery, delaying or avoiding the need of penetrating keratoplasty.
MeSH term(s)	Adult ; Cornea/pathology ; Corneal Stroma/surgery ; Corneal Topography ; Dilatation, Pathologic ; Female ; Humans ; Iatrogenic Disease ; Keratoconus/etiology ; Keratoconus/surgery ; Keratomileusis, Laser In Situ/adverse effects ; Lasers, Excimer ; Male ; Photorefractive Keratectomy/adverse effects ; Polymethyl Methacrylate ; Prostheses and Implants ; Prosthesis Implantation/methods ; Refraction, Ocular ; Reoperation ; Visual Acuity
Chemical Substances	Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2002-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	1081-597X
ISSN	1081-597X
DOI	10.3928/1081-597X-20020901-08
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Article: STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer.

Fleming, Joseph D / Giresi, Paul G / Lindahl-Allen, Marianne / Krall, Elsa B / Lieb, Jason D / Struhl, Kevin

Epigenetics & chromatin

2015 Volume 8, Page(s) 7

Abstract: Background: Transient induction of the Src oncoprotein in a non-transformed breast cell line can initiate an epigenetic switch to a cancer cell via a positive feedback loop that involves activation of the signal transducer and activator of transcription ...

Abstract	Background: Transient induction of the Src oncoprotein in a non-transformed breast cell line can initiate an epigenetic switch to a cancer cell via a positive feedback loop that involves activation of the signal transducer and activator of transcription 3 protein (STAT3) and NF-κB transcription factors. Results: We show that during the transformation process, nucleosome-depleted regions (defined by formaldehyde-assisted isolation of regulatory elements (FAIRE)) are largely unchanged and that both before and during transformation, STAT3 binds almost exclusively to previously open chromatin regions. Roughly, a third of the transformation-inducible genes require STAT3 for the induction. STAT3 and NF-κB appear to drive the regulation of different gene sets during the transformation process. Interestingly, STAT3 directly regulates the expression of NFKB1, which encodes a subunit of NF-κB, and IL6, a cytokine that stimulates STAT3 activity. Lastly, many STAT3 binding sites are also bound by FOS and the expression of several AP-1 factors is altered during transformation in a STAT3-dependent manner, suggesting that STAT3 may cooperate with AP-1 proteins. Conclusions: These observations uncover additional complexities to the inflammatory feedback loop that are likely to contribute to the epigenetic switch. In addition, gene expression changes during transformation, whether driven by pre-existing or induced transcription factors, occur largely through pre-existing nucleosome-depleted regions.
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article
ZDB-ID	2462129-8
ISSN	1756-8935
ISSN	1756-8935
DOI	10.1186/1756-8935-8-7
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