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  1. Article: A New Method of Running the Suspension Dental-Engine by the Electric Current.

    Fletcher, T A

    International dental journal (Philadelphia, Pa.)

    2023  Volume 12, Issue 11, Page(s) 762–763

    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 1069-0441
    ISSN 1069-0441
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  2. Article: Violence in the workplace: new perspectives in forensic mental health services in the USA.

    Fletcher, T A / Brakel, S J / Cavanaugh, J L

    The British journal of psychiatry : the journal of mental science

    1999  Volume 176, Page(s) 339–344

    Abstract: Background: This paper reviews current research on workplace violence in the USA and offers suggestions concerning the roles that mental health professionals with forensic expertise can play in this expanding field.: Aims: To clarify the role of the ... ...

    Abstract Background: This paper reviews current research on workplace violence in the USA and offers suggestions concerning the roles that mental health professionals with forensic expertise can play in this expanding field.
    Aims: To clarify the role of the mental health professional in evaluating issues related to workplace violence.
    Method: Manual and computer literature searches were performed.
    Results: The incidence of reported workplace violence is on the rise and can be devastating beyond the immediate injury. Forensically oriented mental health professionals can assist companies by providing pre-employment screenings, fitness-for-duty evaluations and threat assessment by using the results of current research on potentially violent individuals.
    Conclusions: With the growing interest in workplace violence come many opportunities for mental health professionals to assist companies in assessment, intervention and prevention.
    MeSH term(s) Forensic Psychiatry ; Humans ; Mental Health Services/organization & administration ; Personnel Selection ; Professional Practice ; Research Design ; United States ; Violence/prevention & control ; Violence/statistics & numerical data ; Workplace
    Language English
    Publishing date 1999-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.176.4.339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multivariate analysis of MLH1 c.1664T>C (p.Leu555Pro) mismatch repair gene variant demonstrates its pathogenicity.

    Farrell, M P / Hughes, D J / Drost, M / Wallace, A J / Cummins, R J / Fletcher, T A / Meany, M A / Kay, E W / de Wind, N / Power, D G / Andrews, E J / Green, A J / Gallagher, D J

    Familial cancer

    2013  Volume 12, Issue 4, Page(s) 741–747

    Abstract: Genetic testing of an Irish kindred identified an exonic nucleotide substitution c.1664T>C (p.Leu555Pro) in the MLH1 mismatch repair (MMR) gene. This previously unreported variant is classified as a "variant of uncertain significance" (VUS). ... ...

    Abstract Genetic testing of an Irish kindred identified an exonic nucleotide substitution c.1664T>C (p.Leu555Pro) in the MLH1 mismatch repair (MMR) gene. This previously unreported variant is classified as a "variant of uncertain significance" (VUS). Immunohistochemical (IHC) analysis and microsatellite instability (MSI) studies, genetic testing, a literature and online MMR mutation database review, in silico phenotype prediction tools, and an in vitro MMR activity assay were used to study the clinical significance of this variant. The MLH1 c.1664T>C (p.Leu555Pro) VUS co-segregated with three cases of classic Lynch syndrome-associated malignancies over two generations, with consistent loss of MLH1 and PMS2 protein expression on IHC, and evidence of the MSI-High mutator phenotype. The leucine at position 555 is well conserved across a number of species, and this novel variant has not been reported as a normal polymorphism in the general population. In silico and in vitro analyses suggest that this variant may have a deleterious effect on the MLH1 protein and abrogate MMR activity. Evidence from clinical, histological, immunohistochemical, and molecular genetic data suggests that MLH1 c.1664T>C (p.Leu555Pro) is likely to be the pathogenic cause of Lynch syndrome in this family.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Adult ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; DNA Mismatch Repair/genetics ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Follow-Up Studies ; Humans ; Immunoenzyme Techniques ; Male ; Microsatellite Instability ; Middle Aged ; Mismatch Repair Endonuclease PMS2 ; Multivariate Analysis ; MutL Protein Homolog 1 ; Mutation/genetics ; Neoplasm Staging ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Pedigree ; Phenotype ; Prognosis ; Young Adult
    Chemical Substances Adaptor Proteins, Signal Transducing ; DNA-Binding Proteins ; MLH1 protein, human ; Nuclear Proteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; PMS2 protein, human (EC 3.6.1.-) ; Mismatch Repair Endonuclease PMS2 (EC 3.6.1.3) ; MutL Protein Homolog 1 (EC 3.6.1.3) ; DNA Repair Enzymes (EC 6.5.1.-)
    Language English
    Publishing date 2013-05-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1502496-9
    ISSN 1573-7292 ; 1389-9600
    ISSN (online) 1573-7292
    ISSN 1389-9600
    DOI 10.1007/s10689-013-9652-9
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    Zs.A 6099: Show issues Location:
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  4. Article: Auditory working memory in HIV-1 infection.

    Martin, E M / Sullivan, T S / Reed, R A / Fletcher, T A / Pitrak, D L / Weddington, W / Harrow, M

    Journal of the International Neuropsychological Society : JINS

    2001  Volume 7, Issue 1, Page(s) 20–26

    Abstract: We evaluated auditory working memory in 41 HIV-seropositive (HIV+) and 37 HIV-seronegative (HIV-) male drug users, employing a modified version of the Letter-Number Span Task developed by Gold and colleagues. We added a control condition to the standard ... ...

    Abstract We evaluated auditory working memory in 41 HIV-seropositive (HIV+) and 37 HIV-seronegative (HIV-) male drug users, employing a modified version of the Letter-Number Span Task developed by Gold and colleagues. We added a control condition to the standard task in order to evaluate more directly the contribution of the processing component to the working memory deficits with the effects of storage demands minimized. HIV+ subjects performed significantly more poorly compared to controls on an index of working memory processing derived from raw scores obtained under the two testing conditions. These findings are consistent with our previous reports that HIV-related working memory deficits are evident across multiple informational domains; further, the deficit appears to involve multiple-component functions of working memory. Converging findings from recent working memory studies and from primate and neuroimaging investigations suggest that functional abnormalities of prefrontal cortex should receive greater emphasis in models of neurocognitive aspects of HIV-1 infection, which have typically emphasized "subcortical" deficits.
    MeSH term(s) AIDS Dementia Complex/complications ; AIDS Dementia Complex/physiopathology ; AIDS Dementia Complex/psychology ; Auditory Perception/physiology ; Depression/etiology ; HIV Seropositivity/complications ; HIV-1 ; Humans ; Male ; Memory Disorders/diagnosis ; Memory Disorders/etiology ; Middle Aged ; Neuropsychological Tests ; Prefrontal Cortex/physiopathology ; Substance-Related Disorders/complications
    Language English
    Publishing date 2001-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1230632-0
    ISSN 1469-7661 ; 1355-6177
    ISSN (online) 1469-7661
    ISSN 1355-6177
    DOI 10.1017/s1355617701711022
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  5. Article: Cerebral vasospasm; clinical and experimental evidence.

    POOL, J L / JACOBSON, S / FLETCHER, T A

    Journal of the American Medical Association

    1958  Volume 167, Issue 13, Page(s) 1599–1601

    MeSH term(s) Brain/blood supply ; Cardiovascular System ; Humans ; Vasospasm, Intracranial
    Language English
    Publishing date 1958-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0002-9955 ; 0254-9077 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0002-9955 ; 0254-9077 ; 0098-7484
    DOI 10.1001/jama.1958.02990300025005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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