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  1. Book ; Online: The Molecular and Cellular Basis of Retinal Diseases

    Pittler, Steven J. / Fliesler, Steven J.

    2020  

    Keywords Research & information: general ; Biology, life sciences
    Size 1 electronic resource (334 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044061
    ISBN 9783039366552 ; 3039366556
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The subretinal drusenoid deposit (SDD) of age-related macular degeneration (AMD) may have a specific and strong association with high-risk vascular diseases (HRVDs).

    Fliesler, Steven J

    Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

    2024  Volume 13, Issue 1, Page(s) 100035

    MeSH term(s) Humans ; Macular Degeneration ; Fluorescein Angiography ; Vascular Diseases/complications ; Tomography, Optical Coherence
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2756329-7
    ISSN 2162-0989 ; 2162-0989
    ISSN (online) 2162-0989
    ISSN 2162-0989
    DOI 10.1016/j.apjo.2024.100035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Signal transduction in the retina

    Fliesler, Steven J.

    (Methods in signal transduction series)

    2008  

    Author's details ed. by Steven J. Fliesler
    Series title Methods in signal transduction series
    Keywords Retina / physiology ; Phototransduction / physiology ; Rods (Retina) / physiology ; Vertebrates ; Retina/Cytology ; Cellular signal transduction
    Subject code 573.88364
    Language English
    Size XXI, 432 S. : Ill., graph. Darst., 24cm
    Publisher CRC Press
    Publishing place Boca Raton, Fla. u.a.
    Publishing country United States
    Document type Book
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT015273838
    ISBN 0-8493-7315-8 ; 978-0-8493-7315-2
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Cells Special Issue: "The Molecular and Cellular Basis of Retinal Diseases".

    Pittler, Steven J / Fliesler, Steven J

    Cells

    2023  Volume 12, Issue 15

    Abstract: The recent success in the treatment of hereditary retinal disease caused by defects in the RPE65 gene and the FDA approval of this treatment has established the importance of the study of animal models and the translational impact of these research ... ...

    Abstract The recent success in the treatment of hereditary retinal disease caused by defects in the RPE65 gene and the FDA approval of this treatment has established the importance of the study of animal models and the translational impact of these research findings [...].
    MeSH term(s) Animals ; Retina ; Retinal Degeneration/genetics ; Retinal Degeneration/therapy ; Retinitis Pigmentosa/genetics
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12151933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In Memoriam: G. Stephen (Steve) Tint, PhD (1935-2022).

    Fliesler, Steven J / Steiner, Robert D

    Journal of lipid research

    2023  Volume 64, Issue 8, Page(s) 100421

    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2023.100421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bottlenecks in the Investigation of Retinal Sterol Homeostasis.

    Ramachandra Rao, Sriganesh / Fliesler, Steven J

    Biomolecules

    2024  Volume 14, Issue 3

    Abstract: Sterol homeostasis in mammalian cells and tissues involves balancing three fundamental processes: de novo sterol biosynthesis; sterol import (e.g., from blood-borne lipoproteins); and sterol export. In complex tissues, composed of multiple different cell ...

    Abstract Sterol homeostasis in mammalian cells and tissues involves balancing three fundamental processes: de novo sterol biosynthesis; sterol import (e.g., from blood-borne lipoproteins); and sterol export. In complex tissues, composed of multiple different cell types (such as the retina), import and export also may involve intratissue, intercellular sterol exchange. Disruption of any of these processes can result in pathologies that impact the normal structure and function of the retina. Here, we provide a brief overview of what is known currently about sterol homeostasis in the vertebrate retina and offer a proposed path for future experimental work to further our understanding of these processes, with relevance to the development of novel therapeutic interventions for human diseases involving defective sterol homeostasis.
    MeSH term(s) Animals ; Humans ; Cholesterol/metabolism ; Retina/metabolism ; Sterols/metabolism ; Homeostasis ; Biological Transport ; Mammals/metabolism
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Sterols
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14030341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Introduction to the Thematic Review Series: Seeing 2020: lipids and lipid-soluble molecules in the eye.

    Fliesler, Steven J

    Journal of lipid research

    2020  Volume 62, Page(s) 100007

    MeSH term(s) Lipid Metabolism
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2020.100007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: EDITOR'S PERSPECTIVE: On the verge of translation: Combined cholesterol-antioxidant supplementation as a potential therapeutic intervention for Smith-Lemli-Opitz syndrome.

    Fliesler, Steven J

    Experimental eye research

    2020  Volume 202, Page(s) 108390

    MeSH term(s) Antioxidants/therapeutic use ; Dehydrocholesterols/therapeutic use ; Dietary Supplements ; Drug Therapy, Combination ; Humans ; Provitamins/therapeutic use ; Smith-Lemli-Opitz Syndrome/drug therapy ; Treatment Outcome
    Chemical Substances Antioxidants ; Dehydrocholesterols ; Provitamins
    Language English
    Publishing date 2020-12-08
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2020.108390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reassessing the suitability of ARPE-19 cells as a valid model of native RPE biology.

    Pfeffer, Bruce A / Fliesler, Steven J

    Experimental eye research

    2022  Volume 219, Page(s) 109046

    MeSH term(s) Biology ; Cell Line ; Cells, Cultured ; Retinal Pigment Epithelium
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Editorial
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2022.109046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Sterols and oxysterols

    Fliesler, Steven J.

    chemistry, biology, and pathobiology

    2002  

    Author's details ed.: Steven J. Fliesler
    Language English
    Size 200 S. : Ill., graph. Darst.
    Publisher Research Signpost
    Publishing place India
    Publishing country India
    Document type Book
    HBZ-ID HT013878770
    ISBN 81-7736-069-8 ; 978-81-7736-069-1
    Database Catalogue ZB MED Medicine, Health

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