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  1. Book ; Thesis: Charakterisierung funktioneller Domänen der antiviralen MxA-GTPase

    Flohr, Felix

    2000  

    Author's details vorgelegt von Felix Flohr
    Language German
    Size 67 Bl., Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2000 (Nur beschränkt für den Austausch)
    HBZ-ID HT013306784
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 MB 2374 order for loan Magazin

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  2. Article: [No title information]

    Berwinkel, Susanne / Flohr, Felix

    Ernährung & Medizin

    2023  Volume 38, Issue 03, Page(s) 108–114

    Abstract: Seit der ersten Erwähnung der Stoffwechselerkrankung Diabetes mellitus in der Antike hat es enorme Fortschritte gegeben. Die Blutzuckermessung mit Messstreifen rückt heute durch sensorbasierte kontinuierliche ... ...

    Abstract Seit der ersten Erwähnung der Stoffwechselerkrankung Diabetes mellitus in der Antike hat es enorme Fortschritte gegeben. Die Blutzuckermessung mit Messstreifen rückt heute durch sensorbasierte kontinuierliche Verfahren (CGM) zunehmend in den Hintergrund. Die CGM in Verbindung mit der automatisierten Insulindosierung gehört mittlerweile zur modernen Diabetestherapie.:
    Language German
    Publishing date 2023-09-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2133391-9
    ISSN 1438-9002 ; 1439-1635
    ISSN (online) 1438-9002
    ISSN 1439-1635
    DOI 10.1055/a-2100-0336
    Database Thieme publisher's database

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  3. Article ; Online: Erfolgreiche Therapie einer idiopathischen postinfantilen Riesenzellhepatitis mit einem Calcineurininhibitor.

    Hof, Teresa / Flohr, Felix / Thimme, Robert / Kurz, Philipp / Thiel, Jens

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 3, Page(s) 193–197

    Abstract: Introduction: Postinfantile giant cell hepatitis is a rare entity in adult hepatopathy caused by various etiologies that can be summarized by their characteristic giant cells in histopathologic examination. Frequently, association with autoimmune, ... ...

    Title translation A case of idiopathic postinfantile giant cell hepatitis treated with a calcineurin inhibitor.
    Abstract Introduction: Postinfantile giant cell hepatitis is a rare entity in adult hepatopathy caused by various etiologies that can be summarized by their characteristic giant cells in histopathologic examination. Frequently, association with autoimmune, infectious and hepatotoxic events is described. Therefore, therapy consists in treatment of underlying diseases and immunosuppression.
    History: We saw an 76-year-old patient due to histologically proven Postinfantile giant cell hepatitis. Despite administering budesonid as an initial attempt of treatment, no improvement in hepatitis was achieved. Hence, the patient was forwarded to us.
    Findings: Neither regarding the patient's history nor in laboratory and serological tests, nor in histopathological analysis of liver biopsies an underlying cause of giant cell hepatitis was identified.
    Therapy and course: Despite immunosuppressive therapy with glucocorticoids alone, cyclophosphamide and a monoclonal anti-CD20-antibody, giant cell hepatitis was not controlled. Hence, we started treatment with the calcineurin inhibitor Tacrolimus combined with low-dose prednisolone and thus were able to lower patient's liver values and stabilize hepatitis.
    Conclusion: The good effectiveness of tacrolimus in our patient underlines the important role of calcineurin inhibitors in treating Postinfantile giant cell hepatitis, although rarely reported to date.
    Language German
    Publishing date 2021-01-29
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1323-5057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Erfolgreiche Therapie einer idiopathischen postinfantilen Riesenzellhepatitis mit einem Calcineurininhibitor

    Hof, Teresa / Flohr, Felix / Thimme, Robert / Kurz, Philipp / Thiel, Jens

    DMW - Deutsche Medizinische Wochenschrift

    2021  Volume 146, Issue 03, Page(s) 193–197

    Abstract: Zusammenfassung: Die Riesenzellhepatitis ist eine seltene, ätiologisch heterogene Erkrankungsgruppe mit dem gemeinsamen histomorphologischen Merkmal multinukleärer Riesenzellen. Häufig assoziiert ist sie mit Autoimmun- und Viruserkrankungen sowie ... ...

    Abstract Zusammenfassung: Die Riesenzellhepatitis ist eine seltene, ätiologisch heterogene Erkrankungsgruppe mit dem gemeinsamen histomorphologischen Merkmal multinukleärer Riesenzellen. Häufig assoziiert ist sie mit Autoimmun- und Viruserkrankungen sowie Medikamenteneinnahme, weshalb die Therapie vornehmlich in der Behandlung der Grunderkrankung bzw. einer Immunsuppression besteht.
    Anamnese: Die Vorstellung des 76-jährigen Patienten erfolgte mit der extern histologisch gesicherten Diagnose einer postinfantilen Riesenzellhepatitis und frustranem Therapieversuch mit Budesonid zur weiteren Therapie.
    Untersuchung: Anamnestisch, laborchemisch, serologisch und histopathologisch ließ sich keine der Hepatitis zugrunde liegende Ursache eruieren.
    Therapie und Verlauf: Unter immunsuppressiver Therapie mit zunächst Glukokortikoiden in Monotherapie, später Cyclophosphamid sowie auch intermittierend einem Anti-CD20-Antikörper gelang keine Erkrankungskontrolle, weshalb die Therapie mit dem Calcineurininhibitor Tacrolimus in Kombination mit einer niedrigdosierten Glukokortikoid-Therapie begonnen wurde. Hierunter konnte die Erkrankung stabilisiert werden.
    Folgerung: Unsere Beobachtung einer guten Hepatitis-Kontrolle unter Tacrolimus unterstreicht die Rolle von Calcineurininhibitoren in der Behandlung der postinfantilen Riesenzellhepatitis, wobei über deren Einsatz bisher sehr wenige Daten vorliegen.
    Keywords postinfantile Riesenzellhepatitis ; T-Zellen ; Immunsuppression ; Calcineurininhibitor ; postinfantile giant cell hepatitis ; T-cells ; immunosuppression ; calcineurin inhibitor
    Language German
    Publishing date 2021-01-29
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1323-5057
    Database Thieme publisher's database

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  5. Article ; Online: Images in clinical medicine. Ectopic Cushing's syndrome.

    Flohr, Felix / Geddert, Helene

    The New England journal of medicine

    2011  Volume 365, Issue 25, Page(s) e46

    MeSH term(s) Cushing Syndrome/diagnosis ; Cushing Syndrome/etiology ; Humans ; Hydrocortisone/biosynthesis ; Male ; Mediastinal Neoplasms/complications ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/pathology ; Paraganglioma/complications ; Paraganglioma/diagnostic imaging ; Paraganglioma/pathology ; Radiography ; Young Adult
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2011-12-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm1010540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Charakterisierung funktioneller Domänen der antiviralen MxA-GTPase

    Flohr, Felix

    2000  

    Author's details vorgelegt von Felix Flohr
    Language German
    Size 1 Mikrofiche, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss (Nur beschränkt für den Austausch)--Freiburg (Breisgau), 2000
    Database Former special subject collection: coastal and deep sea fishing

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  7. Conference proceedings: Cushing-Syndrom durch ein mediastinales Paragangliom – eine interdisziplinäre Herausforderung

    Grun, Claudia / Geddert, Helene / Flohr, Felix / Ortlieb, Heribert

    2012  , Page(s) PO 1.6

    Event/congress 21. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie; Karlsruhe; Deutsche Gesellschaft für Thoraxchirurgie; 2012
    Keywords Medizin, Gesundheit
    Publishing date 2012-09-17
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/12dgt58
    Database German Medical Science

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  8. Article: Multiple endocrine neoplasia type 1 associated with a new germline Men1 mutation in a family with atypical tumor phenotype.

    Perakakis, Nikolaos / Flohr, Felix / Kayser, Gian / Thomusch, Oliver / Parsons, Lydia / Billmann, Franck / von Dobschuetz, Ernst / Rondot, Susanne / Seufert, Jochen / Laubner, Katharina

    Hormones (Athens, Greece)

    2016  Volume 15, Issue 1, Page(s) 113–117

    Abstract: Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary disorder associated with the development of endocrine tumors due to reduced expression of the tumor suppressor protein menin. Recent studies indicate a general ... ...

    Abstract Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary disorder associated with the development of endocrine tumors due to reduced expression of the tumor suppressor protein menin. Recent studies indicate a general role of menin in carcinogenesis, affecting the prevalence and clinical course of common non-endocrine tumors such as breast cancer, hepatocellular carcinoma and melanoma. Here we report a new germline missense mutation of Men1 in a German family with atypical tumor phenotype over three generations. Based on the type of mutation, we discuss possible changes in menin function leading to atypical tumorigenesis and present the clinical significance of such findings.
    Case presentation: A German family with a history of primary hyperparathyroidism presented to our Hospital for further evaluation. Members of the family demonstrated many different atypical tumors, such as renal cell carcinoma, papillary thyroid cancer and prostate cancer. DNA sequencing from peripheral blood revealed a novel mutation: Ser38Cys [TCC>TGC] in exon 2, codon 38 of Men1. This novel mutation is located in a region of menin which is responsible for interactions with the transcription factor JunD. This factor has recently been associated with prostate cancer. DNA sequencing of two of the atypical tumors (prostate cancer, papillary thyroid cancer) did not reveal a loss of heterozygosity, indicating an impact on menin expression and function in the heterozygous state, in line with results in +/-Men1 mutant mice developing prostate cancer.
    Conclusion: The results and clinical course of disease in this case indicate the potential role of menin in the development of non-endocrine or atypical-endocrine tumors in MEN1 patients. Further investigations are needed to clarify both the general role of menin and the importance of specific mutations in carcinogenesis. Nevertheless, in families with uncommon manifestations of the syndrome early diagnostic adjustments should be considered.
    MeSH term(s) Aged ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Multiple Endocrine Neoplasia Type 1/genetics ; Mutation, Missense ; Pedigree ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism
    Chemical Substances MEN1 protein, human ; Proto-Oncogene Proteins
    Language English
    Publishing date 2016-01
    Publishing country Greece
    Document type Case Reports ; Journal Article
    ZDB-ID 2075912-5
    ISSN 1109-3099
    ISSN 1109-3099
    DOI 10.14310/horm.2002.1626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hypothyroidism in patients with hepatocellular carcinoma treated by transarterial chemoembolization.

    Flohr, Felix / Harder, Jan / Seufert, Jochen / Blum, Hubert E / Spangenberg, Hans C

    Hepatology (Baltimore, Md.)

    2008  Volume 47, Issue 6, Page(s) 2144

    MeSH term(s) Aged ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/methods ; Cohort Studies ; Contrast Media/adverse effects ; Female ; Humans ; Hypothyroidism/chemically induced ; Hypothyroidism/diagnosis ; Liver Neoplasms/therapy ; Male ; Prevalence ; Retrospective Studies
    Chemical Substances Contrast Media
    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Letter
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.22347
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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