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Book ; Online: The Many and the One : A Philosophical Study of Plural Logic

Florio, Salvatore / Linnebo, Øystein

2021

Keywords	Philosophy of language ; Philosophy: logic ; plurals, plural logic, set theory, mereology, higher-order logic, absolute generality, modality, singularism
Size	1 electronic resource (336 pages)
Publisher	Oxford University Press
Publishing place	Oxford
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021232277
ISBN	9780198791522 ; 0198791526
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Red Orange and Lemon Extract Ameliorates the Renal Oxidative Stress and Inflammation Induced by Ochratoxin A through the Modulation of Nrf2.

Longobardi, Consiglia / Damiano, Sara / Fabroni, Simona / Montagnaro, Serena / Russo, Valeria / Vaccaro, Emanuela / Giordano, Antonio / Florio, Salvatore / Ciarcia, Roberto

Toxins

2024 Volume 16, Issue 3

Abstract: Background: The presence of ochratoxin A (OTA) in food and feed is a public health concern. OTA intoxication is caused by several mechanisms, one of which consists of the alteration of the antioxidant activity of the cell due to the oxidative stress (OS) ...

Abstract	Background: The presence of ochratoxin A (OTA) in food and feed is a public health concern. OTA intoxication is caused by several mechanisms, one of which consists of the alteration of the antioxidant activity of the cell due to the oxidative stress (OS). In this context, the use of natural antioxidant substances could be a potential biological decontamination method of mitigating the negative outcomes induced by OTA. Methods: we aimed to investigate how a red orange and lemon extract (RLE), rich in anthocyanins, would affect OTA-treated rats. The current work sought to clarify the renal protective efficacy of RLE in an OTA-treated rat model (RLE (90 mg/kg b.w.); OTA (0.5 mg/kg b.w.)) by investigating, thorough Western blot analysis, the involvement of the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. The OS parameters and inflammatory status were evaluated by spectrophotometry. The inflammatory infiltrates in the kidney were evaluated by immunohistochemical assays. Results and conclusion: Our findings showed a significant increase in oxidative and inflammatory parameters after OTA exposure, while the OTA + RLE co-treatment counteracted both the inflammatory and OS damage through the modulation of the Nrf2 pathway.
MeSH term(s)	Animals ; Rats ; NF-E2-Related Factor 2 ; Anthocyanins ; Oxidative Stress ; Antioxidants ; Inflammation ; Kidney ; Ochratoxins
Chemical Substances	ochratoxin A (1779SX6LUY) ; NF-E2-Related Factor 2 ; Anthocyanins ; Antioxidants ; Ochratoxins
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins16030151
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Protective Effects of a Red Orange and Lemon Extract (RLE) on the Hepatotoxicity Induced by Ochratoxin A in Rats.

Longobardi, Consiglia / Damiano, Sara / Vaccaro, Emanuela / Ballistreri, Gabriele / Restucci, Brunella / Paciello, Orlando / Florio, Salvatore / Ciarcia, Roberto

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 3

Abstract: Ochratoxin A (OTA) is a highly potent mycotoxin that contaminates many kinds of food and feed sources. Its significant impact on human health and animal productivity makes it a topic of particular concern. The role of specific bioactive compounds used as ...

Abstract	Ochratoxin A (OTA) is a highly potent mycotoxin that contaminates many kinds of food and feed sources. Its significant impact on human health and animal productivity makes it a topic of particular concern. The role of specific bioactive compounds used as dietary antioxidants is believed to be substantial due to their capacity to act as free radical scavengers. Because of the well-known oxidative stress induced by OTA, the primary objective of this work was to evaluate the antioxidant effects of a standardized powder extract recovered from citrus processing waste, red orange and lemon extract (RLE), on liver damage induced by OTA in a rat model. This study aimed to examine the impact of oral administration of RLE (90 mg/kg b.w.) on hepatic function and oxidative balance in Sprague-Dawley rats (
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13030289
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Curcumin Modulates Nitrosative Stress, Inflammation, and DNA Damage and Protects against Ochratoxin A-Induced Hepatotoxicity and Nephrotoxicity in Rats

Longobardi, Consiglia / Damiano, Sara / Andretta, Emanuela / Prisco, Francesco / Russo, Valeria / Pagnini, Francesco / Florio, Salvatore / Ciarcia, Roberto

Antioxidants. 2021 Aug. 02, v. 10, no. 8

2021

Abstract: Ochratoxin A (OTA) is a fungal toxin of critical concern for food safety both for human health and several animal species, also representing a cancer threat to humans. Curcumin (CURC) is a natural polyphenol that has anti-apoptotic, anti-inflammatory, ... ...

Abstract	Ochratoxin A (OTA) is a fungal toxin of critical concern for food safety both for human health and several animal species, also representing a cancer threat to humans. Curcumin (CURC) is a natural polyphenol that has anti-apoptotic, anti-inflammatory, and antioxidant effects. The aim of this study was to investigate the cytoprotective effect of CURC against OTA-induced nephrotoxicity and hepatotoxicity through the study of the nitrosative stress, pro-inflammatory cytokines, and deoxyribonucleic acid (DNA) damage. Sprague Dawley rats were daily treated with CURC (100 mg/kg b.w.), OTA (0.5 mg/kg b.w), or CURC with OTA by oral gavage for 14 days. Our results demonstrated that OTA exposure was associated with significant increase of pro-inflammatory and DNA oxidative-damage biomarkers. Moreover, OTA induced the inducible nitric oxide synthase, (iNOS) resulting in increased nitric oxide (NO) levels both in kidney and liver. The co-treatment OTA + CURC counteracted the harmful effects of chronic OTA treatment by regulating inflammation, reducing NO levels and oxidative DNA damage in kidney and liver tissues. Histology revealed that OTA + CURC treatment determinates mainly an Iba1+ macrophagic infiltration with fewer CD3+ T-lymphocytes in the tissues. In conclusion, we evidenced that CURC exerted cytoprotective and antioxidant activities against OTA-induced toxicity in rats.
Keywords	DNA ; DNA damage ; T-lymphocytes ; antioxidants ; biomarkers ; curcumin ; cytokines ; food safety ; hepatotoxicity ; histology ; human health ; inducible nitric oxide synthase ; inflammation ; kidneys ; liver ; nephrotoxicity ; nitric oxide ; ochratoxin A ; polyphenols
Language	English
Dates of publication	2021-0802
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10081239
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Microalga

Ciarcia, Roberto / Longobardi, Consiglia / Ferrara, Gianmarco / Montagnaro, Serena / Andretta, Emanuela / Pagnini, Francesco / Florio, Salvatore / Maruccio, Lucianna / Lauritano, Chiara / Damiano, Sara

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 23

Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative disease that activates multiple signaling pathways, causing cells to produce higher levels of reactive oxygen species (ROS). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are a ... ...

Abstract	Chronic myeloid leukemia (CML) is a myeloproliferative disease that activates multiple signaling pathways, causing cells to produce higher levels of reactive oxygen species (ROS). Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are a major generator of ROS in leukemia, and marine natural products have shown promising activities for the treatment of hematopoietic malignancies. In the present study, we investigated the effect of the marine microalga Skeletonema marinoi (S.M.), a ubiquitous diatom that forms massive blooms in the oceans, on the human leukemia cell line K562. The effects of S.M. extract on cell viability, production of ROS, nitric oxide (NO), and apoptosis were examined. In this preliminary work, S.M. was able to decrease cell viability (p < 0.05) and increase apoptosis levels (p < 0.05) in K562 cells after 48 h of treatment. In addition, the levels of NOX, NO, and malondialdehyde (MDA) were reduced in K562-treated cells (p < 0.05), whereas the levels of SOD, CAT, and GPx increased during treatment (p < 0.05). Finally, analyzing Bax and Bcl-2 expression, we found a significant increase in the proapoptotic protein Bax and a sustained decrease in the antiapoptotic protein Bcl-2 (p < 0.05) in the K562-treated cells.
MeSH term(s)	Humans ; Apoptosis ; NADPH Oxidases/metabolism ; K562 Cells ; Reactive Oxygen Species/metabolism ; DNA Damage ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Diatoms/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics
Chemical Substances	NADPH Oxidases (EC 1.6.3.-) ; Reactive Oxygen Species ; Proto-Oncogene Proteins c-bcl-2
Language	English
Publishing date	2022-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27238270
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Zearalenone (ZEN) and Its Metabolite Levels in Tissues of Wild Boar (

Longobardi, Consiglia / Damiano, Sara / Ferrara, Gianmarco / Montagnaro, Serena / Meucci, Valentina / Intorre, Luigi / Bacci, Samanta / Esposito, Luigi / Piscopo, Nadia / Rubino, Antonio / Raffaele, Antonio / Florio, Salvatore / Ciarcia, Roberto

Toxins

2023 Volume 15, Issue 1

Abstract: Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by the fungi of ... ...

Abstract	Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by the fungi of the
MeSH term(s)	Humans ; Animals ; Swine ; Zearalenone/toxicity ; Pilot Projects ; Mycotoxins/toxicity ; Estrogens, Non-Steroidal/toxicity ; Sus scrofa/metabolism
Chemical Substances	Zearalenone (5W827M159J) ; Mycotoxins ; Estrogens, Non-Steroidal
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins15010056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Oxidative Status and Histological Evaluation of Wild Boars' Tissues Positive for Zearalenone Contamination in the Campania Region, Southern Italy.

Damiano, Sara / Longobardi, Consiglia / Ferrara, Gianmarco / Piscopo, Nadia / Riccio, Lorenzo / Russo, Valeria / Meucci, Valentina / De Marchi, Lucia / Esposito, Luigi / Florio, Salvatore / Ciarcia, Roberto

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 9

Abstract: Zearalenone (ZEN) is a mycotoxin produced by fungi belonging to the ... ...

Abstract	Zearalenone (ZEN) is a mycotoxin produced by fungi belonging to the genera
Language	English
Publishing date	2023-09-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12091748
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Palatal Window for Treating an Incompletely Augmented Maxillary Sinus.

Florio, Salvatore / Suzuki, Takanori / Cho, Sang-Choon

Implant dentistry

2017 Volume 26, Issue 2, Page(s) 328–331

Abstract: Maxillary sinus augmentation through a lateral window is reported as one of the most predictable bone augmentation procedures before implant placement. The elevation of the membrane represents a delicate and crucial step that allows the creation of the ... ...

Abstract	Maxillary sinus augmentation through a lateral window is reported as one of the most predictable bone augmentation procedures before implant placement. The elevation of the membrane represents a delicate and crucial step that allows the creation of the space for the bone graft material. If the elevation is not completed, the regenerated bone might be inadequate for the implant placement. In this case, a new intervention will be necessary to complete the bone augmentation. Reaccessing from a lateral window, however, would be challenging due to thickness of the buccal boney wall because of the first grafting procedure; therefore, a different approach has to be used. The aim of this case report is to present the palatal window technique for treating incompletely augmented maxillary sinus. The detailed step-by-step diagnostic and surgical procedures are described, and the advantages and limitations of the technique are discussed through a review of the literature.
Language	English
Publishing date	2017-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1144907-x
ISSN	1538-2982 ; 1056-6163
ISSN (online)	1538-2982
ISSN	1056-6163
DOI	10.1097/ID.0000000000000563
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3646: Show issues

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Article: Curcumin Modulates Nitrosative Stress, Inflammation, and DNA Damage and Protects against Ochratoxin A-Induced Hepatotoxicity and Nephrotoxicity in Rats.

Longobardi, Consiglia / Damiano, Sara / Andretta, Emanuela / Prisco, Francesco / Russo, Valeria / Pagnini, Francesco / Florio, Salvatore / Ciarcia, Roberto

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 8

Abstract	Ochratoxin A (OTA) is a fungal toxin of critical concern for food safety both for human health and several animal species, also representing a cancer threat to humans. Curcumin (CURC) is a natural polyphenol that has anti-apoptotic, anti-inflammatory, and antioxidant effects. The aim of this study was to investigate the cytoprotective effect of CURC against OTA-induced nephrotoxicity and hepatotoxicity through the study of the nitrosative stress, pro-inflammatory cytokines, and deoxyribonucleic acid (DNA) damage. Sprague Dawley rats were daily treated with CURC (100 mg/kg b.w.), OTA (0.5 mg/kg b.w), or CURC with OTA by oral gavage for 14 days. Our results demonstrated that OTA exposure was associated with significant increase of pro-inflammatory and DNA oxidative-damage biomarkers. Moreover, OTA induced the inducible nitric oxide synthase, (iNOS) resulting in increased nitric oxide (NO) levels both in kidney and liver. The co-treatment OTA + CURC counteracted the harmful effects of chronic OTA treatment by regulating inflammation, reducing NO levels and oxidative DNA damage in kidney and liver tissues. Histology revealed that OTA + CURC treatment determinates mainly an Iba1+ macrophagic infiltration with fewer CD3+ T-lymphocytes in the tissues. In conclusion, we evidenced that CURC exerted cytoprotective and antioxidant activities against OTA-induced toxicity in rats.
Language	English
Publishing date	2021-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10081239
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antioxidative Effects of Curcumin on the Hepatotoxicity Induced by Ochratoxin A in Rats

Damiano, Sara / Longobardi, Consiglia / Andretta, Emanuela / Prisco, Francesco / Piegari, Giuseppe / Squillacioti, Caterina / Montagnaro, Serena / Pagnini, Francesco / Badino, Paola / Florio, Salvatore / Ciarcia, Roberto

Antioxidants. 2021 Jan. 17, v. 10, no. 1

2021

Abstract: Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff, responsible for subchronic and chronic toxicity, such as nephrotoxicity, hepatotoxicity, teratogenicity, and immunotoxicity to both humans and several animal species. The ... ...

Abstract	Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff, responsible for subchronic and chronic toxicity, such as nephrotoxicity, hepatotoxicity, teratogenicity, and immunotoxicity to both humans and several animal species. The severity of the liver damage caused depends on both dose and duration of exposure. Several studies have suggested that oxidative stress might contribute to increasing the hepatotoxicity of OTA, and several antioxidants, including curcumin (CURC), have been tested to counteract the toxic hepatic action of OTA in various classes of animals. Therefore, the present study was designed to evaluate the protective effect of CURC, a bioactive compound with different therapeutic properties on hepatic injuries caused by OTA in rat animal models. CURC effects were examined in Sprague Dawley rats treated with CURC (100 mg/kg), alone or in combination with OTA (0.5 mg/kg), by gavage daily for 14 days. At the end of the experiment, rats treated with OTA showed alterations in biochemical parameters and oxidative stress in the liver. CURC dosing significantly attenuated oxidative stress and lipid peroxidation versus the OTA group. Furthermore, liver histological tests showed that CURC reduced the multifocal lymphoplasmacellular hepatitis, the periportal fibrosis, and the necrosis observed in the OTA group. This study provides evidence that CURC can preserve OTA-induced oxidative damage in the liver of rats.
Keywords	animal models ; antioxidant activity ; antioxidants ; bioactive compounds ; chronic toxicity ; curcumin ; dosage ; duration ; feeds ; fibrosis ; foods ; hepatitis ; hepatotoxicity ; histology ; humans ; immunotoxicity ; lipid peroxidation ; liver ; medicinal properties ; necrosis ; nephrotoxicity ; ochratoxin A ; oxidative stress ; protective effect ; rats ; teratogenicity ; testing
Language	English
Dates of publication	2021-0117
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10010125
Database	NAL-Catalogue (AGRICOLA)

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