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Book ; Online: Valutazione ambientale strategica, piani urbanistici comunali e piani dei parchi

Floris, Maddalena / Isola, Federica / Lai, Sabrina / Leccis, Francesca / Leone, Federica / Marras, Martina / Zoppi, Corrado

Un quadro operativo per l'integrazione della Strategia regionale per lo sviluppo sostenibile della Sardegna

2023

Keywords	Environmental science, engineering & technology ; sustainable development ; park planning
Language	Italian
Size	1 electronic resource (144 pages)
Publisher	UNICApress
Publishing place	Cagliari
Document type	Book ; Online
Note	Italian
HBZ-ID	HT030649756
ISBN	9788833121031 ; 8833121038
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Measurement of glomerular filtration rate in patients undergoing renal surgery for cancer: eGFR vs mGFR in the era of precision medicine.

Trevisani, Francesco / Simeoni, Mariadelina / Bettiga, Arianna / Cinque, Alessandra / Floris, Matteo

Kidney & blood pressure research

2024

Abstract: Background: In the era of precision medicine, determining reliable renal function assessment remains a critical and debatable issue, especially in nephrology and oncology.: Summary: This paper delves into the significance of accurately measured ... ...

Abstract	Background: In the era of precision medicine, determining reliable renal function assessment remains a critical and debatable issue, especially in nephrology and oncology. Summary: This paper delves into the significance of accurately measured Glomerular Filtration Rate (mGFR) in clinical practice, highlighting its essential role in guiding medical decisions and managing kidney health, particularly in the context of renal cancer (RC) patients undergoing nephrotoxic anti-cancer drugs. The limitations and advantages of traditional GFR estimation methods, primarily using serum biomarkers like creatinine and cystatin C, are discussed, emphasizing their possible inadequacy in cancer patients. Specifically, newer formulae designed for GFR estimation in cancer patients may not perform at best in RC patients. The paper explores various methods for direct GFR measurement, including the gold standard inulin clearance and alternatives like iohexol plasma clearance. Key message: Despite the logistical challenges of these methods, their implementation is crucial for accurate renal function assessment. The paper concludes by emphasizing the need for continued research and innovation in GFR measurement methodologies to improve patient outcomes, particularly in populations with complex medical needs.
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1326018-2
ISSN	1423-0143 ; 1420-4096
ISSN (online)	1423-0143
ISSN	1420-4096
DOI	10.1159/000538854
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Searching for meaning in work and life: happiness, wellbeing and the future of organizations.

Floris, Michela / Casulli, Lucrezia / Ferrari, Laura

Frontiers in psychology

2023 Volume 14, Page(s) 1287404

Language	English
Publishing date	2023-09-25
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1287404
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Determinants of self-perceived quality of life in mildly disabled multiple sclerosis patients: a cross-sectional study.

Pilotto, Silvy / Floris, Matteo / Solla, Paolo / Pugliatti, Maura / Zarbo, Ignazio Roberto

Journal of neurology

2024

Abstract: Introduction: While the determinants influencing self-perceived health-related quality of life (spHRQoL) in persons with multiple sclerosis (pwMS) and severe physical impairment have been well investigated, their impact on pwMS with mild disability is ... ...

Abstract	Introduction: While the determinants influencing self-perceived health-related quality of life (spHRQoL) in persons with multiple sclerosis (pwMS) and severe physical impairment have been well investigated, their impact on pwMS with mild disability is poorly addressed. We aimed to investigate possible drivers of spHRQoL among Sardinian pwMS with an EDSS lower than 2.5. Methods: A sample of 87 fully ambulatory (EDSS < 2.5) pwMS were included after screening for major cognitive impairment. spHRQoL was measured with the Italian version of 36-Item Short Form Health Survey (SF-36). The Physical Component Summary (PCS) and Mental Component Summary (MCS) were used as dependent variables for univariate analysis with Cognitive Behavioral Assessment (CBA) and specific individual factors as independent variables. Subsequent multivariate general linear models (GLMs) for PCS and MCS respectively were run after stepwise regression. Normative data referring to Italian population were used for comparison. Results: As compared to normative data, no statistically significant difference was found for PCS, while MCS was reduced. Multivariate GLMs showed a significant association between lower PCS scores and presence of psychosomatic symptoms, older age and fatigue (p < 0.05). Furthermore, a significant association was shown between lower MCS scores and presence of anxiety (p < 0.001). Conclusion: Mood, presence of psychosomatic symptoms, fatigue and age can have a relevant impact on spHRQoL in people with mildly disabling MS and should be considered in the management of such individuals.
Language	English
Publishing date	2024-03-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-024-12244-0
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Article ; Online: Radiopacity of Sodium Zirconium Cyclosilicate in Computed Tomography: a case of a patient with Hyperkalemia and kidney disease.

Angioi, Andrea / Floris, Matteo / Lepori, Nicola / Cabiddu, Gianfranca / Pani, Antonello

Renal failure

2023 Volume 45, Issue 2, Page(s) 2284839

Abstract: Sodium Zirconium Cyclosilicate (SZC) is commonly used for treating hyperkalemia because it sequesters gastrointestinal potassium ions, thereby reducing serum potassium levels. However, a less-discussed aspect of SZC is its radiopacity on x-ray-based ... ...

Abstract	Sodium Zirconium Cyclosilicate (SZC) is commonly used for treating hyperkalemia because it sequesters gastrointestinal potassium ions, thereby reducing serum potassium levels. However, a less-discussed aspect of SZC is its radiopacity on x-ray-based imaging techniques. The European Medicines Agency (EMA) has only vaguely addressed this issue. Radiopaque substances like SZC can interfere with diagnostic imaging, creating challenges for clinicians and radiologists. We present the case of a 34-year-old Italian male to illustrate these concerns.
MeSH term(s)	Humans ; Male ; Adult ; Hyperkalemia/etiology ; Potassium ; Kidney Diseases/complications ; Tomography/adverse effects
Chemical Substances	sodium zirconium cyclosilicate (D652ZWF066) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2023.2284839
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1331: Show issues

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Article: The Clinical and Molecular Features in the VHL Renal Cancers; Close or Distant Relatives with Sporadic Clear Cell Renal Cell Carcinoma?

Cinque, Alessandra / Minnei, Roberto / Floris, Matteo / Trevisani, Francesco

Cancers

2022 Volume 14, Issue 21

Abstract: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer syndrome caused by germline mutations in the VHL tumor suppressor gene, characterized by the susceptibility to a wide array of benign and malign neoplasms, including clear-cell ... ...

Abstract	Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer syndrome caused by germline mutations in the VHL tumor suppressor gene, characterized by the susceptibility to a wide array of benign and malign neoplasms, including clear-cell renal cell carcinoma. Moreover, VHL somatic inactivation is a crucial molecular event also in sporadic ccRCCs tumorigenesis. While systemic biomarkers in the VHL syndrome do not currently play a role in clinical practice, a new promising class of predictive biomarkers, microRNAs, has been increasingly studied. Lots of pan-genomic studies have deeply investigated the possible biological role of microRNAs in the development and progression of sporadic ccRCC; however, few studies have investigated the miRNA profile in VHL patients. Our review summarize all the new insights related to clinical and molecular features in VHL renal cancers, with a particular focus on the overlap with sporadic ccRCC.
Language	English
Publishing date	2022-10-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14215352
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Renal Oncocytoma: The Diagnostic Challenge to Unmask the Double of Renal Cancer.

Trevisani, Francesco / Floris, Matteo / Minnei, Roberto / Cinque, Alessandra

International journal of molecular sciences

2022 Volume 23, Issue 5

Abstract: Renal oncocytoma represents the most common type of benign neoplasm that is an increasing concern for urologists, oncologists, and nephrologists due to its difficult differential diagnosis and frequent overtreatment. It displays a variable neoplastic ... ...

Abstract	Renal oncocytoma represents the most common type of benign neoplasm that is an increasing concern for urologists, oncologists, and nephrologists due to its difficult differential diagnosis and frequent overtreatment. It displays a variable neoplastic parenchymal and stromal architecture, and the defining cellular element is a large polygonal, granular, eosinophilic, mitochondria-rich cell known as an oncocyte. The real challenge in the oncocytoma treatment algorithm is related to the misdiagnosis due to its resemblance, at an initial radiological assessment, to malignant renal cancers with a completely different prognosis and medical treatment. Unfortunately, percutaneous renal biopsy is not frequently performed due to the possible side effects related to the procedure. Therefore, the majority of oncocytoma are diagnosed after the surgical operation via partial or radical nephrectomy. For this reason, new reliable strategies to solve this issue are needed. In our review, we will discuss the clinical implications of renal oncocytoma in daily clinical practice with a particular focus on the medical diagnosis and treatment and on the potential of novel promising molecular biomarkers such as circulating microRNAs to distinguish between a benign and a malignant lesion.
MeSH term(s)	Adenoma, Oxyphilic/diagnosis ; Carcinoma, Renal Cell/pathology ; Diagnosis, Differential ; Humans ; Kidney Neoplasms/pathology ; Nephrectomy
Language	English
Publishing date	2022-02-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23052603
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Article ; Online: Hydrolat of Helichrysum italicum promotes tissue regeneration during wound healing.

Serra, D / Bellu, E / Garroni, G / Cruciani, S / Sarais, G / Dessi, D / Pashchenko, A / Satta, R / Montesu, M A / Amler, E / Floris, M / Maioli, M

Physiological research

2024 Volume 72, Issue 6, Page(s) 809–818

Abstract: Wound healing is a dynamic process involving different cell types with distinct roles according to the stages of healing. Fibroblasts and stem cells actively participate in tissue regeneration. A proper stimulation could contribute to enhance wound ... ...

Abstract	Wound healing is a dynamic process involving different cell types with distinct roles according to the stages of healing. Fibroblasts and stem cells actively participate in tissue regeneration. A proper stimulation could contribute to enhance wound healing process-es. Helichrysum italicum (H. italicum) is a medical plant well described for its pharmacological, antimicrobial, and anti-inflammatory activities. Aim of the present work was to examine the effect of the hydrolat derivate from H. italicum on stem cells isolated from skin and fibroblasts in vitro in presence or absence of tissue damage. The viability and proliferation of all cell types cultured in dif-ferent conditions were analyzed by MTT and BrdU assays. Cell proliferation after wound was analyzed with scratch test. Also, the expression of the main genes involved in tissue repair was evaluated by RT-qPCR analysis. Here we describe the capability of hy-drolat of H. italicum to promote tissue regeneration after scratch test both in stem cells and in fibroblasts. Moreover, the gene ex-pression analysis revealed that, hydrolat of H. italicum is also able to enhance stemness related. In conclusion our results are en-couraging, highlighting novel regenerative properties of hydrolat of H. italicum and paving the way for future application of this wasting product in accelerating wound healing.
MeSH term(s)	Helichrysum ; Wound Healing ; Skin ; Anti-Inflammatory Agents/pharmacology ; Stem Cells ; Fibroblasts/metabolism
Chemical Substances	Anti-Inflammatory Agents
Language	English
Publishing date	2024-01-12
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1073141-6
ISSN	1802-9973 ; 0369-9463 ; 0862-8408
ISSN (online)	1802-9973
ISSN	0369-9463 ; 0862-8408
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Extreme shifts in habitat suitability under contemporary climate change for a high-Arctic herbivore

van Beest, Floris M. / López-Blanco, Efrén / Hansen, Lars H. / Schmidt, Niels M.

Climatic Change. 2023 Apr., v. 176, no. 4 p.31-31

2023

Abstract: Climate change is a major determinant of shifts in species’ distribution ranges and habitat suitability. The Arctic is one of the planet’s most rapidly warming regions, yet biogeographic responses to contemporary climate change remain unknown for most ... ...

Abstract	Climate change is a major determinant of shifts in species’ distribution ranges and habitat suitability. The Arctic is one of the planet’s most rapidly warming regions, yet biogeographic responses to contemporary climate change remain unknown for most cold-adapted mammalian species. Using the maximum entropy machine learning algorithm and 40 years (1981–2020) of observation data of muskoxen (Ovibos moschatus) collected across the Northeast Greenland National Park (NGNP), we detect rapid northward shifts (69–108 km per decade) of high to medium suitable habitat coinciding with a southward shift (27 km per decade) of low suitable habitat. Biogeographic response rates accelerated after the start of the twenty-first century, when anomalies in temperature and precipitation became more frequent and intensified. Our study shows that contemporary climate change has led to extreme directional shifts in habitat suitability for the largest herbivore roaming the Arctic tundra when compared to other species from around the globe. The consequences of these extreme directional shifts in habitat suitability on local population persistence remain to be determined but gene flow and dispersal capacity across the rugged Arctic landscape are likely important drivers.
Keywords	Ovibos moschatus ; algorithms ; climate change ; gene flow ; geographical distribution ; habitats ; herbivores ; landscapes ; mammals ; national parks ; temperature ; tundra ; Arctic region ; Greenland
Language	English
Dates of publication	2023-04
Size	p. 31.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	751086-x
ISSN	0165-0009
ISSN	0165-0009
DOI	10.1007/s10584-023-03510-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Emergent interactions in the management of multiple threats to the conservation of harbour porpoises

Lusseau, David / Kindt-Larsen, Lotte / van Beest, Floris M.

Science of the Total Environment. 2023 Jan., v. 855 p.158936-

2023

Abstract: Human activities at sea are intensifying and diversifying. This is leading to more complex interactions of anthropogenic impacts requiring adaptable management interventions to mitigate their cumulative effects on biodiversity conservation and ... ...

Abstract	Human activities at sea are intensifying and diversifying. This is leading to more complex interactions of anthropogenic impacts requiring adaptable management interventions to mitigate their cumulative effects on biodiversity conservation and restoration objectives. Bycatch remains the dominant conservation threat for coastal cetaceans. Additionally, the indirect impact of repeated exposure to disturbances, particularly acoustic disturbances, can affect cetacean population growth and therefore conservation objectives. Pingers are used to ensonify nets to provide an effective mitigation of bycatch risk. As those become more prevalent across fisheries at risk to catch for example harbour porpoises, pingers become contributors to the anthropogenic noise landscape which may affect the vital rates of this species as well. Currently, we do not know how to best balance pinger prevalence to minimise both bycatch rate and the population consequences of acoustic disturbance (PCoD). Here we use an agent-based model to determine how pinger prevalence in nets can be adjusted to minimise bycatch rate and noise disturbance propagating to affect population growth for harbour porpoises. We show that counter-intuitively bycatch rate can increase at lower pinger prevalence. When ecological conditions are such that PCOD can emerge, higher prevalence of pingers can lead to indirect effects on population growth. This would result from condition-mediated decreased reproductive potential. Displacing fishing effort, via time-area closure, can be an effective mitigation strategy in these circumstances. These findings have important implications for current management plans which, for practical consideration, may lead to lower overall pinger prevalence at sea. This study also shows that estimating the reproductive potential of the species should be incorporated in bycatch monitoring programmes. We now need to better understand how physiological condition affect reproductive decisions and behavioural responses to noise in cetaceans to better appraise and estimate the cumulative impacts of bycatch and its mitigations.
Keywords	Cetacea ; acoustics ; biodiversity conservation ; bycatch ; environment ; humans ; landscapes ; models ; population growth ; risk ; Cumulative impact ; Conservation objective ; Management strategy ; PCoMS ; PCoD ; Harbour porpoise ; Phocoena phocoena ; Multi-agent based model
Language	English
Dates of publication	2023-01
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.158936
Database	NAL-Catalogue (AGRICOLA)

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