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  1. Article ; Online: Tree root distribution modelling in different environmental conditions

    Perona, Paolo / Flury, Reto / Barry, D. Andrew / Schwarz, Massimiliano

    Ecological Engineering. 2022 Sept. 29, p.106811-

    2022  , Page(s) 106811–

    Abstract: The ability to predict the spatial distribution of tree root system variables (e.g., the Root system Area (RA), the maximum root diameter, the number of roots in diameter classes, the density of fine roots, etc.) under different environmental conditions ... ...

    Abstract The ability to predict the spatial distribution of tree root system variables (e.g., the Root system Area (RA), the maximum root diameter, the number of roots in diameter classes, the density of fine roots, etc.) under different environmental conditions is relevant to several scientific disciplines and to engineering practice. In this work, three well known analytical models from the literature are assembled into a unique framework called the Root Distribution Model (RDM). RDM models the expected vertical and horizontal distribution of coarse and fine root system variables for mature plants growing in different environmental conditions ranging from moderately humid to arid climates. All soil and moisture dynamic parameters are physically based, which make the model straightforward to calibrate via a single tuning parameter. At this investigative stage, it is shown that the model has the flexibility to represent a broad range of situations where soil moisture may result from precipitation inputs or from water level fluctuations due to either the presence of a water coarse or of deep aquifers or both. Accordingly, the distribution of the sectional RA may be either positively or negatively skewed, as well as show a peculiar bi-modal structure. The model can be used to study the impact of changing scenarios affecting precipitation, aquifer and channel hydrology.
    Keywords aquifers ; fine roots ; models ; root systems ; soil water ; trees ; Root distribution model ; Below-ground biomass ; Root system area ; Riparian vegetation ; Plant root modelling ; Ecohydraulics ; Ecohydrology ; 0000 ; 1111
    Language English
    Dates of publication 2022-0929
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 1127407-4
    ISSN 0925-8574
    ISSN 0925-8574
    DOI 10.1016/j.ecoleng.2022.106811
    Database NAL-Catalogue (AGRICOLA)

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  2. Book ; Thesis: Gestaltungsregeln für eine Kosten- und Leistungsrechnung der Kantone und Gemeinden

    Flury, Reto

    ein systemorientierter Ansatz

    2002  

    Author's details vorgelegt von Reto Flury
    Keywords Teilstaat ; Gemeinde ; Kostenrechnung ; Nonprofit-Management ; Verwaltungsreform ; Schweiz
    Language German
    Size IX, 300 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--St. Gallen, 2001
    ISBN 325806489X ; 9783258064895
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book ; Thesis: Gestaltungsregeln für eine Kosten- und Leistungsrechnung der Kantone und Gemeinden

    Flury, Reto

    ein systemorientierter Ansatz

    2002  

    Author's details vorgelegt von Reto Flury
    Keywords Teilstaat ; Gemeinde ; Kostenrechnung ; Nonprofit-Management ; Verwaltungsreform ; Schweiz
    Language German
    Size IX, 300 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @St. Gallen, Univ., Diss., 2001
    ISBN 325806489X ; 9783258064895
    Database ECONomics Information System

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  4. Article ; Online: CD25-T

    Solomon, Isabelle / Amann, Maria / Goubier, Anne / Arce Vargas, Frederick / Zervas, Dimitrios / Qing, Chen / Henry, Jake Y / Ghorani, Ehsan / Akarca, Ayse U / Marafioti, Teresa / Śledzińska, Anna / Werner Sunderland, Mariana / Franz Demane, Dafne / Clancy, Joanne Ruth / Georgiou, Andrew / Salimu, Josephine / Merchiers, Pascal / Brown, Mark Adrian / Flury, Reto /
    Eckmann, Jan / Murgia, Claudio / Sam, Johannes / Jacobsen, Bjoern / Marrer-Berger, Estelle / Boetsch, Christophe / Belli, Sara / Leibrock, Lea / Benz, Joerg / Koll, Hans / Sutmuller, Roger / Peggs, Karl S / Quezada, Sergio A

    Nature cancer

    2020  Volume 1, Issue 12, Page(s) 1153–1166

    Abstract: Intratumoral regulatory T cell (Treg) abundance associates with diminished anti-tumor immunity and poor prognosis in human cancers. Recent work demonstrates that CD25, the high affinity receptor subunit for IL-2, is a selective target for Treg depletion ... ...

    Abstract Intratumoral regulatory T cell (Treg) abundance associates with diminished anti-tumor immunity and poor prognosis in human cancers. Recent work demonstrates that CD25, the high affinity receptor subunit for IL-2, is a selective target for Treg depletion in mouse and human malignancies; however, anti-human CD25 antibodies have failed to deliver clinical responses against solid tumors due to bystander IL-2 receptor signaling blockade on effector T cells, which limits their anti-tumor activity. Here we demonstrate potent single-agent activity of anti-CD25 antibodies optimized to deplete Tregs whilst preserving IL-2-STAT5 signaling on effector T cells, and demonstrate synergy with immune checkpoint blockade in vivo. Pre-clinical evaluation of an anti-human CD25 (RG6292) antibody with equivalent features demonstrates, in both non-human primates and humanized mouse models, efficient Treg depletion with no overt immune-related toxicities. Our data supports the clinical development of RG6292 and evaluation of novel combination therapies incorporating non-IL-2 blocking anti-CD25 antibodies in clinical studies.
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Interleukin-2/pharmacology ; Mice ; Neoplasms ; Signal Transduction ; T-Lymphocytes, Regulatory
    Chemical Substances Antibodies, Monoclonal ; Interleukin-2
    Language English
    Publishing date 2020-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-020-00133-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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