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  1. Article ; Online: Cellular Immunity of

    Cinege, Gyöngyi / Fodor, Kinga / Magyar, Lilla B / Lipinszki, Zoltán / Hultmark, Dan / Andó, István

    Cells

    2024  Volume 13, Issue 7

    Abstract: Coevolution of hosts and their parasites has shaped heterogeneity of effector hemocyte types, providing immune defense reactions with variable effectiveness. In this work, we characterize hemocytes ... ...

    Abstract Coevolution of hosts and their parasites has shaped heterogeneity of effector hemocyte types, providing immune defense reactions with variable effectiveness. In this work, we characterize hemocytes of
    MeSH term(s) Animals ; Drosophila ; Parasites ; Cell Differentiation ; Phagocytosis ; Immunity, Cellular
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070593
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  2. Article: Pszichológiai intervenciók traumatikus események után a poszttraumás stressz zavar megelőzésére. Szisztematikus irodalmi áttekintés.

    Fodor, Kinga Edit / Bitter, István

    Orvosi hetilap

    2015  Volume 156, Issue 33, Page(s) 1321–1334

    Abstract: Introduction: Because of the high prevalence of exposure to traumatic events and its negative consequences on mental health, the importance of effective interventions to prevent posttraumatic stress disorder has been emphasized.: Aim: The authors ... ...

    Title translation Psychological interventions following trauma to prevent posttraumatic stress disorder. A systematic review of the literature.
    Abstract Introduction: Because of the high prevalence of exposure to traumatic events and its negative consequences on mental health, the importance of effective interventions to prevent posttraumatic stress disorder has been emphasized.
    Aim: The authors wanted to evaluate the current status of evidence regarding early psychological interventions after traumatization.
    Method: A search was conducted in ProQuest PILOTS, PubMed, and Web of Science for early psychological interventions that were published between 2005 and 2015.
    Results: Twenty-one trials were identified, of which 6 presented immediate interventions (within 72 hours) and the rest early interventions within the first month. Based on these research findings immediate interventions are not effective, whilst multi-session cognitive behavior therapies could be effective in symptom reduction.
    Conclusions: Multi-session cognitive behavior therapy is preferred over immediate one session interventions especially over debriefing. A natural decline of symptoms was observed among controls and, therefore, targeted interventions are recommended only for people with higher risk for developing subsequent posttraumatic stress disorder.
    MeSH term(s) Clinical Trials as Topic/standards ; Cognitive Therapy/methods ; Humans ; Research Design/standards ; Stress Disorders, Post-Traumatic/etiology ; Stress Disorders, Post-Traumatic/prevention & control ; Time Factors ; Treatment Outcome ; Wounds and Injuries/psychology
    Language Hungarian
    Publishing date 2015-08-16
    Publishing country Hungary
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2015.30231
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  3. Article ; Online: Design and Characterization of a Multistage Peptide-Based Vaccine Platform to Target

    Bellini, Chiara / Vergara, Emil / Bencs, Fruzsina / Fodor, Kinga / Bősze, Szilvia / Krivić, Denis / Bacsa, Bernadett / Surguta, Sára Eszter / Tóvári, József / Reljic, Rajko / Horváti, Kata

    Bioconjugate chemistry

    2023  Volume 34, Issue 10, Page(s) 1738–1753

    Abstract: The complex immunopathology ... ...

    Abstract The complex immunopathology of
    MeSH term(s) Humans ; Animals ; Mice ; Mycobacterium tuberculosis ; Leukocytes, Mononuclear ; Antigens, Bacterial ; CD4-Positive T-Lymphocytes ; Tuberculosis/prevention & control ; Tuberculosis Vaccines ; CD8-Positive T-Lymphocytes ; Epitopes, T-Lymphocyte ; Peptides
    Chemical Substances Antigens, Bacterial ; Tuberculosis Vaccines ; Epitopes, T-Lymphocyte ; Peptides
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.3c00273
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  4. Article: A Convenient Synthetic Method to Improve Immunogenicity of

    Horváti, Kata / Pályi, Bernadett / Henczkó, Judit / Balka, Gyula / Szabó, Eleonóra / Farkas, Viktor / Biri-Kovács, Beáta / Szeder, Bálint / Fodor, Kinga

    Vaccines

    2019  Volume 7, Issue 3

    Abstract: Epitopes from different proteins expressed ... ...

    Abstract Epitopes from different proteins expressed by
    Language English
    Publishing date 2019-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines7030101
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  5. Article: Poszttraumás stressztünetek, diszfunkcionalis attitűdök és megküzdési módok -- egy klinikai minta explorativ vizsgálata.

    Fodor, Kinga Edit / Perczel Forintos, Dóra

    Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata

    2013  Volume 28, Issue 1, Page(s) 5–12

    Abstract: Introduction: In the present study specific characteristics of PTSD patients were explored in a clinical sample with particular regard to dysfunctional attitudes and coping strategies. The purpose was to draw attention to this rarely investigated but ... ...

    Title translation Posttraumatic stress symptoms, dysfunctional attitudes and ways of coping in a clinical sample of PTSD patients.
    Abstract Introduction: In the present study specific characteristics of PTSD patients were explored in a clinical sample with particular regard to dysfunctional attitudes and coping strategies. The purpose was to draw attention to this rarely investigated but presumably prevalent psychiatric disorder in the Hungarian population.
    Method: Twenty-two PTSD patients' retrospective data was analyzed who presented at our clinic for outpatient psychotherapy treatment. Patients were assessed on depressive, anxiety, hopelessness, and posttraumatic stress symptoms, as well as dysfunctional attitudes and coping strategies.
    Results: Thirty-two percent (n=7) of the sample is male and 68% (n=15) is female, the mean age is 34.77 years. Based on trauma type 40.9% (n=9) had a motor vehicle accident, 18.2% (n=4) lost a close relative, 18.2% (n=4) was a victim of sexual or physical assault. There is great variance in the duration since the trauma (2 months to 10 years). The results suggest that posttraumatic stress symptoms (PTSSs) are associated with the dysfunctional attitudes of need for achievement and external control, and with avoidant and conforming coping styles. Additionally, PTSSs were highly comorbid with depressive and anxiety symptoms.
    Conclusion: The results imply that PTSD patients in Hungary have similar characteristics as international findings indicate.
    MeSH term(s) Accidents, Traffic/psychology ; Adaptation, Psychological ; Adult ; Anxiety/epidemiology ; Attitude ; Comorbidity ; Death ; Depression/epidemiology ; Family ; Female ; Grief ; Humans ; Hungary ; Life Change Events ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Psychological Tests ; Psychotherapy ; Retrospective Studies ; Sampling Studies ; Sex Offenses/psychology ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/etiology ; Stress Disorders, Post-Traumatic/psychology ; Stress Disorders, Post-Traumatic/therapy
    Language Hungarian
    Publishing date 2013
    Publishing country Hungary
    Document type English Abstract ; Journal Article
    ISSN 0237-7896
    ISSN 0237-7896
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  6. Article ; Online: Novel Assay Platform to Evaluate Intracellular Killing of

    Horváti, Kata / Fodor, Kinga / Pályi, Bernadett / Henczkó, Judit / Balka, Gyula / Gyulai, Gergő / Kiss, Éva / Biri-Kovács, Beáta / Senoner, Zsuzsanna / Bősze, Szilvia

    Frontiers in immunology

    2021  Volume 12, Page(s) 750496

    Abstract: One of the main hallmarks of tuberculosis (TB) is the ability of the causative agent to transform into a stage of dormancy and the capability of long persistence in the host phagocytes. It is believed that approximately one-third of the population of the ...

    Abstract One of the main hallmarks of tuberculosis (TB) is the ability of the causative agent to transform into a stage of dormancy and the capability of long persistence in the host phagocytes. It is believed that approximately one-third of the population of the world is latently infected with
    MeSH term(s) Animals ; Antimicrobial Peptides/administration & dosage ; Antimicrobial Peptides/chemistry ; Antitubercular Agents/administration & dosage ; Antitubercular Agents/chemistry ; Biological Assay/methods ; Bronchi ; Cell Line ; Cell-Penetrating Peptides/administration & dosage ; Cell-Penetrating Peptides/chemistry ; Endocytosis ; Female ; Humans ; Isoniazid/administration & dosage ; Isoniazid/chemistry ; Mice, Inbred BALB C ; Monocytes/microbiology ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/growth & development ; Reproducibility of Results ; Spheroids, Cellular ; Tuberculosis/drug therapy ; Mice
    Chemical Substances Antimicrobial Peptides ; Antitubercular Agents ; Cell-Penetrating Peptides ; Isoniazid (V83O1VOZ8L)
    Language English
    Publishing date 2021-11-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.750496
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  7. Article ; Online: Novel Polycondensed Partly Saturated β-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of Their in vitro Antiproliferative Effects.

    Fodor, Kinga Judit / Hutai, Dániel / Jernei, Tamás / Takács, Angéla / Szász, Zsófia / Sulyok-Eiler, Máté / Harmat, Veronika / Oláh Szabó, Rita / Schlosser, Gitta / Hudecz, Ferenc / Kőhidai, László / Csámpai, Antal

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 7

    Abstract: Use of a Pictet-Spengler reaction of tryptamine and l-tryptophan methyl ester and subsequent reduction of the nitro group followed by further cyclocondensation with aryl aldehydes and formyl-substituted carboxylic acids, including ferrocene-based ... ...

    Abstract Use of a Pictet-Spengler reaction of tryptamine and l-tryptophan methyl ester and subsequent reduction of the nitro group followed by further cyclocondensation with aryl aldehydes and formyl-substituted carboxylic acids, including ferrocene-based components, furnished a series of diastereomeric 6-aryl-substituted 5,6,8,9,14,14b-hexahydroindolo[2',3':3,4]pyrido[1-
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Carbolines/chemical synthesis ; Carbolines/chemistry ; Carbolines/pharmacology ; Cell Line, Tumor ; Chemistry Techniques, Synthetic ; Density Functional Theory ; Ferrous Compounds/chemical synthesis ; Ferrous Compounds/chemistry ; Ferrous Compounds/pharmacology ; Humans ; Metallocenes/chemical synthesis ; Metallocenes/chemistry ; Metallocenes/pharmacology ; Models, Theoretical ; Molecular Conformation ; Molecular Structure ; Spectrum Analysis ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents ; Carbolines ; Ferrous Compounds ; Metallocenes ; ferrocene (U96PKG90JQ)
    Language English
    Publishing date 2020-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25071599
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  8. Article: First description of hypospadias and inguinal bilateral cryptorchidism in mouflon (Ovis Gmelini Musimon) - short communication.

    Beregi, Attila / Erdélyi, Károly / Fodor, Kinga / Molnar, Ladislav / Csányi, Sándor

    Acta veterinaria Hungarica

    2013  Volume 61, Issue 4, Page(s) 473–476

    Abstract: A mouflon showing severe weight loss and cachexia was examined. The animal had horns and a male-like body frame but the preputial fur was missing. The scrotum was completely absent. Both testicles were located next to the inguinal canal under the skin, ... ...

    Abstract A mouflon showing severe weight loss and cachexia was examined. The animal had horns and a male-like body frame but the preputial fur was missing. The scrotum was completely absent. Both testicles were located next to the inguinal canal under the skin, and appeared only slightly smaller than normal. The prepuce was located in a perianal position under the anus and it resembled a vulva. The penis was underdeveloped and curled up inside the prepuce like an enlarged clitoris. The bulbourethral region and the urinary bladder looked normal. The orifice of the urethra was located in its normal position, but the glans penis appeared deformed. Microscopic examination of the testicles revealed mild degeneration of the seminiferous tubules and a marked proliferation of the interstitial connective tissue with Leydig cells still present. There were no marked changes in the bulbar part of the penis but the apical part exhibited marked interstitial fibrosis. This is the first description of hypospadias and cryptorchidism in mouflon.
    MeSH term(s) Animals ; Cryptorchidism ; Hypospadias ; Male ; Penis ; Scrotum ; Sheep, Domestic
    Language English
    Publishing date 2013-12
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 605742-1
    ISSN 1588-2705 ; 0236-6290 ; 0365-8198
    ISSN (online) 1588-2705
    ISSN 0236-6290 ; 0365-8198
    DOI 10.1556/AVet.2013.036
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  9. Article ; Online: The factor structure of posttraumatic stress disorder symptoms among Rwandans exposed to the 1994 genocide: A confirmatory factor analytic study using the PCL-C.

    Fodor, Kinga E / Pozen, Joanna / Ntaganira, Joseph / Sezibera, Vincent / Neugebauer, Richard

    Journal of anxiety disorders

    2015  Volume 32, Page(s) 8–16

    Abstract: The factor structure of posttraumatic stress disorder (PTSD) symptoms in Euro-American populations has been extensively studied, but confirmatory factor analytic studies from non-Western societies are lacking. Alternative models of DSM-IV symptoms were ... ...

    Abstract The factor structure of posttraumatic stress disorder (PTSD) symptoms in Euro-American populations has been extensively studied, but confirmatory factor analytic studies from non-Western societies are lacking. Alternative models of DSM-IV symptoms were tested among Rwandan adults (N=465) who experienced trauma during the 1994 genocide. A cluster random survey was conducted with interviews held in Rwandan households. PTSD was assessed with the Posttraumatic Stress Disorder Checklist-Civilian version. Competing models were the DSM-IV, emotional numbing, dysphoria, aroused intrusion, and dysphoric arousal models. Results showed that the emotional numbing, dysphoria, and dysphoric arousal models had almost identical, good fit indices and fit the data significantly better than the other models. The emotional numbing and dysphoric arousal models also exhibited good construct validity. Results suggest that the latent structure of PTSD symptoms in Rwanda are comparable to that found in Euro-American samples, thereby lending further support to the cross-cultural validity of the construct.
    MeSH term(s) Adolescent ; Adult ; Affective Symptoms/ethnology ; Affective Symptoms/psychology ; Aged ; Aged, 80 and over ; Arousal/physiology ; Cluster Analysis ; Diagnostic and Statistical Manual of Mental Disorders ; Factor Analysis, Statistical ; Female ; Genocide/psychology ; Humans ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Rwanda/ethnology ; Stress Disorders, Post-Traumatic/ethnology ; Stress Disorders, Post-Traumatic/psychology ; Young Adult
    Language English
    Publishing date 2015-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 619417-5
    ISSN 1873-7897 ; 0887-6185
    ISSN (online) 1873-7897
    ISSN 0887-6185
    DOI 10.1016/j.janxdis.2015.03.001
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  10. Article: Protection by humoral elements independent of virus neutralization activity against an influenza virus challenge.

    Sarkadi, Julia / Kuti, David / Jankovics, Mate / Pallinger, Eva / Fodor, Kinga / Kis, Zoltan / Gonczol, Eva / Visontai, Ildiko / Jankovics, Istvan

    The new microbiologica

    2017  Volume 40, Issue 3, Page(s) 180–189

    Abstract: To investigate the protective efficacy of a seasonal trivalent inactivated whole virion influenza vaccine (TIV) adjuvanted with aluminum phosphate (Fluval AB, referred to here as TIV+Al), we immunized mice with the TIV+Al, and as controls, with TIV, TIV+ ... ...

    Abstract To investigate the protective efficacy of a seasonal trivalent inactivated whole virion influenza vaccine (TIV) adjuvanted with aluminum phosphate (Fluval AB, referred to here as TIV+Al), we immunized mice with the TIV+Al, and as controls, with TIV, TIV+Al combined with Freund adjuvant (TIV+Al+F), inactivated A/PR/8/34(H1N1) (PR8) strain or PBS, and challenged them with a lethal dose of a mouse-adapted PR8 virus. Serum pools from immunized mice were passively transferred to recipient mice that were then challenged similarly. All actively immunized mice survived the challenge. Of recipient mice receiving serum from mice actively immunized with TIV, TIV+Al or TIV+Al+F, 20%, 80%, and 100% survived, respectively. Rates of mortality and morbidity of recipient mice were inversely proportional to the hemagglutination inhibition (HI) antibody level to the vaccine virus in the absence of detectable PR8-specific HI, neuraminidase inhibition (NI) and virus neutralization (VN) antibodies. No cross-reactivity was observed between vaccine and PR8 strains in in vitro HI, NI or VN assays. In splenocytes from TIV+Al-immunized mice production of IFN-γ or granzyme-B protein and mRNA expression increased (p<0.05). Thus, antibodies play a major role in the protection against a mismatched challenge infection independent of HI, NI and VN activity, but cellular immune responses may contribute to full protection in actively immunized mice.
    Language English
    Publishing date 2017-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 756168-4
    ISSN 1121-7138 ; 0391-5352
    ISSN 1121-7138 ; 0391-5352
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