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  1. Article ; Online: Publisher Correction: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

    Horgue, Luis Flores / Assens, Alexis / Fodoulian, Leon / Marconi, Leonardo / Tuberosa, Joël / Haider, Alexander / Boillat, Madlaina / Carleton, Alan / Rodriguez, Ivan

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1156

    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36849-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author Correction: Generation of human islet cell type-specific identity genesets.

    van Gurp, Léon / Fodoulian, Leon / Oropeza, Daniel / Furuyama, Kenichiro / Bru-Tari, Eva / Vu, Anh Nguyet / Kaddis, John S / Rodríguez, Iván / Thorel, Fabrizio / Herrera, Pedro L

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2574

    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46525-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.

    Dietschi, Quentin / Tuberosa, Joël / Fodoulian, Leon / Boillat, Madlaina / Kan, Chenda / Codourey, Julien / Pauli, Véronique / Feinstein, Paul / Carleton, Alan / Rodriguez, Ivan

    Science advances

    2022  Volume 8, Issue 46, Page(s) eabn7450

    Abstract: Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered ... ...

    Abstract Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abn7450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

    Horgue, Luis Flores / Assens, Alexis / Fodoulian, Leon / Marconi, Leonardo / Tuberosa, Joël / Haider, Alexander / Boillat, Madlaina / Carleton, Alan / Rodriguez, Ivan

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2929

    Abstract: In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities ... ...

    Abstract In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.
    MeSH term(s) Animals ; Mammals ; Mice ; Odorants ; Olfactory Receptor Neurons/physiology ; Receptors, Odorant/genetics ; Sensory Receptor Cells ; Smell
    Chemical Substances Receptors, Odorant
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30511-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning.

    Chéreau, Ronan / Bawa, Tanika / Fodoulian, Leon / Carleton, Alan / Pagès, Stéphane / Holtmaat, Anthony

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 3245

    Abstract: Neurons in primary sensory cortex encode a variety of stimulus features upon perceptual learning. However, it is unclear whether the acquired stimulus selectivity remains stable when the same input is perceived in a different context. Here, we monitor ... ...

    Abstract Neurons in primary sensory cortex encode a variety of stimulus features upon perceptual learning. However, it is unclear whether the acquired stimulus selectivity remains stable when the same input is perceived in a different context. Here, we monitor the activity of individual neurons in the mouse primary somatosensory cortex during reward-based texture discrimination. We track their stimulus selectivity before and after changing reward contingencies, which allows us to identify various classes of neurons. We find neurons that stably represented a texture or the upcoming behavioral choice, but the majority is dynamic. Among those, a subpopulation of neurons regains texture selectivity contingent on the associated reward value. These value-sensitive neurons forecast the onset of learning by displaying a distinct and transient increase in activity, depending on past behavioral experience. Thus, stimulus selectivity of excitatory neurons during perceptual learning is dynamic and largely relies on behavioral contingencies, even in primary sensory cortex.
    MeSH term(s) Animals ; Behavior, Animal ; Calcium Signaling ; Choice Behavior ; Discrimination, Psychological ; Male ; Mice, Inbred C57BL ; Neurons/physiology ; Perception/physiology ; Reversal Learning/physiology ; Reward ; Sensation ; Somatosensory Cortex/physiology ; Time Factors
    Language English
    Publishing date 2020-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-17005-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Generation of human islet cell type-specific identity genesets.

    van Gurp, Léon / Fodoulian, Leon / Oropeza, Daniel / Furuyama, Kenichiro / Bru-Tari, Eva / Vu, Anh Nguyet / Kaddis, John S / Rodríguez, Iván / Thorel, Fabrizio / Herrera, Pedro L

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2020

    Abstract: Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity. Here, we ... ...

    Abstract Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity. Here, we conduct a thorough single-cell transcriptomics meta-analysis to identify robustly expressed markers used to build genesets describing the identity of human α-, β-, γ- and δ-cells. These genesets define islet cellular identities better than previously published genesets. We show their efficacy to outline cell identity changes and unravel some of their underlying genetic mechanisms, whether during embryonic pancreas development or in experimental setups aiming at developing glucose-responsive insulin-secreting cells, such as pluripotent stem-cell differentiation or in adult islet cell reprogramming protocols. These islet cell type-specific genesets represent valuable tools that accurately benchmark gain and loss in islet cell identity traits.
    MeSH term(s) Cell Differentiation/genetics ; Humans ; Insulin/genetics ; Insulin-Secreting Cells ; Islets of Langerhans ; Pluripotent Stem Cells
    Chemical Substances Insulin
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29588-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium

    Fodoulian, Leon / Tuberosa, Joel / Rossier, Daniel / Landis, Basile N. / Carleton, Alan / Rodriguez, Ivan

    bioRxiv

    Abstract: The recent emergence of the pathogenic SARS-CoV-2 initiated a worldwide health crisis. The entry of the virus into cells is mediated by the binding of the viral Spike protein to the angiotensin-converting enzyme-2 (ACE2), followed by its priming by the ... ...

    Abstract The recent emergence of the pathogenic SARS-CoV-2 initiated a worldwide health crisis. The entry of the virus into cells is mediated by the binding of the viral Spike protein to the angiotensin-converting enzyme-2 (ACE2), followed by its priming by the TMPRSS2 serine protease, both present on the cellular membrane of the target cells. In the respiratory tract, these targets are ciliated cells. Interestingly, various reports indicate an association between SARS-CoV-2 infection and anosmia, suggesting an alteration not restricted to the respiratory tissue, but that might also include the olfactory sensory epithelium. We explored this possibility by generating RNA-seq libraries from human neuroepithelium, in which we found significant expression of ACE2 and TMPRSS2. To determine whether specific cell types of this chemosensory tissue may coexpress both of the virus entry genes, we analyzed a scRNA-seq dataset. We determined that sustentacular cells, which are in direct contact with the external world and maintain the integrity of olfactory sensory neurons, represents a prime candidate for SARS-CoV-2 infection via the nose, and possibly for SARS-CoV-2-induced anosmia.
    Keywords covid19
    Language English
    Publishing date 2020-04-02
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2020.03.31.013268
    Database COVID19

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  8. Article ; Online: SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain.

    Fodoulian, Leon / Tuberosa, Joël / Rossier, Daniel / Boillat, Madlaina / Kan, Chenda / Pauli, Véronique / Egervari, Kristof / Lobrinus, Johannes A / Landis, Basile N / Carleton, Alan / Rodriguez, Ivan

    iScience

    2020  Volume 23, Issue 12, Page(s) 101839

    Abstract: Reports indicate an association between COVID-19 and anosmia, as well as the presence of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium may represent a target of the virus, we generated RNA-seq libraries from ... ...

    Abstract Reports indicate an association between COVID-19 and anosmia, as well as the presence of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium may represent a target of the virus, we generated RNA-seq libraries from human olfactory neuroepithelia, in which we found substantial expression of the genes coding for the virus receptor angiotensin-converting enzyme-2 (ACE2) and for the virus internalization enhancer TMPRSS2. We analyzed a human olfactory single-cell RNA-seq dataset and determined that sustentacular cells, which maintain the integrity of olfactory sensory neurons, express
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2020.101839
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  9. Article ; Online: Bipolar disorder: Functional neuroimaging markers in relatives.

    Piguet, Camille / Fodoulian, Leon / Aubry, Jean-Michel / Vuilleumier, Patrik / Houenou, Josselin

    Neuroscience and biobehavioral reviews

    2015  Volume 57, Page(s) 284–296

    Abstract: Neural models of anatomical and functional alterations have been proposed for bipolar disorders (BD). However, studies in affected patients do not allow disentangling alterations linked to the liability to BD from those associated with the evolution, ... ...

    Abstract Neural models of anatomical and functional alterations have been proposed for bipolar disorders (BD). However, studies in affected patients do not allow disentangling alterations linked to the liability to BD from those associated with the evolution, medication and comorbidities of BD. Explorations in high risk subjects allow the study of these risk markers. We reported and summarized all functional magnetic resonance imaging (fMRI) studies focusing on first-degree relatives of BD patients. We found 29 studies reporting neural correlates of working memory (WM), emotional processing, executive functions and resting state in relatives of BD patients, compared to healthy subjects. Overall, the same regions that have been involved in patients, such as the inferior frontal gyrus and limbic areas, seem to be functionally altered in high-risk subjects. We conclude that the same brain regions already implicated in the pathophysiology of the disease such as the amygdala are also associated with the risk of BD. However longitudinal studies are required to understand their implication in the transition to BD.
    MeSH term(s) Bipolar Disorder/physiopathology ; Brain/physiopathology ; Family ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2015.08.015
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  10. Article ; Online: SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium

    Fodoulian, Leon / Tuberosa, Joel / Rossier, Daniel / Boillat, Madlaina / Kan, Chenda / Pauli, Véronique / Egervari, Kristof / Lobrinus, Johannes A. / Landis, Basile N. / Carleton, Alan / Rodriguez, Ivan

    bioRxiv

    Abstract: Various reports indicate an association between COVID-19 and anosmia, suggesting an infection of the olfactory sensory epithelium, and thus a possible direct virus access to the brain. To test this hypothesis, we generated RNA-seq libraries from human ... ...

    Abstract Various reports indicate an association between COVID-19 and anosmia, suggesting an infection of the olfactory sensory epithelium, and thus a possible direct virus access to the brain. To test this hypothesis, we generated RNA-seq libraries from human olfactory neuroepithelia, in which we found substantial expression of the genes coding for the virus receptor angiotensin-converting enzyme-2 (ACE2), and for the virus internalization enhancer TMPRSS2. We analyzed a human olfactory single-cell RNA-seq dataset and determined that sustentacular cells, which maintain the integrity of olfactory sensory neurons, express ACE2 and TMPRSS2. We then observed that the ACE2 protein was highly expressed in a subset of sustentacular cells in human and mouse olfactory tissues. Finally, we found ACE2 transcripts in specific brain cell types, both in mice and humans. Sustentacular cells thus represent a potential entry door for SARS-CoV-2 in a neuronal sensory system that is in direct connection with the brain.
    Keywords covid19
    Publisher BioRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.03.31.013268
    Database COVID19

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